New combo therapy shows promise against hard-to-treat kidney cancer

NCT ID NCT05043090

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen May 23, 2026 · Last updated May 23, 2026

Summary

This study tests whether a combination of two drugs, savolitinib and durvalumab, works better than the standard drug sunitinib for people with a rare type of kidney cancer called papillary renal cell carcinoma that has spread. The cancer must have a specific genetic change (MET-driven). About 148 adults who have not had prior treatment will take part. The main goal is to see if the combination slows cancer growth and helps people live longer.

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Contacts and locations

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Locations

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Boston, Massachusetts, 02215, United States
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New York, New York, 10065, United States
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CABA, C1426ANZ, Argentina
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Ciudad Autónoma Buenos Aires, 1125, Argentina
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Ciudad de Buenos Aires, C1120AAT, Argentina
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Ciudad de Buenos Aires, C1181ACH, Argentina
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La Plata, 1900, Argentina
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Rosario, S2002KDS, Argentina
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San Miguel de Tucumán, T4000IAK, Argentina
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Box Hill, 3128, Australia
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Macquarie University, 2109, Australia
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Belo Horizonte, 30120-320, Brazil
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Brasília, 70200-730, Brazil
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Cachoeiro de Itapemirim, 29308-065, Brazil
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Criciúma, 88811-508, Brazil
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Curitiba, 81520-060, Brazil
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Florianópolis, 88020-210, Brazil
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Fortaleza, 60130-241, Brazil
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Natal, 59075-740, Brazil
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Pelotas, 96020-080, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, 90110-270, Brazil
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Rio de Janeiro, 22250-905, Brazil
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Salvador, 40050-410, Brazil
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São Jose Do Rio Preto, 15090-000, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01327-001, Brazil
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São Paulo, 05652-900, Brazil
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Vitória, 29043-260, Brazil
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Calgary, Alberta, T2N 4N2, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Providencia, 7510032, Chile
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Santiago, 7500653, Chile
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Santiago, 8420383, Chile
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Temuco, 4810561, Chile
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Beijing, 100039, China
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Changsha, 410011, China
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Changsha, 410013, China
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Chongqing, 400030, China
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Harbin, 150049, China
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Jinan, 250012, China
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Nanjing, 210029, China
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Shanghai, 200032, China
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Shenyang, 110042, China
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Tianjin, 300060, China
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Zhengzhou, 450008, China
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Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Olomouc, 775 20, Czechia
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Prague, 100 34, Czechia
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Prague, 140 59, Czechia
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Prague, 15000, Czechia
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Prague, 180 81, Czechia
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Bordeaux, 33075, France
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Quimper, 29107, France
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Toulouse, 31059, France
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Villejuif, 94800, France
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Hamburg, 20246, Germany
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Hanover, 30625, Germany
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München, 81377, Germany
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Ulm, 89081, Germany
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Hong Kong, Hong Kong
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Shatin, 00000, Hong Kong
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Bangalore, 560027, India
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Belagavi, 590010, India
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Jaipur, 302002, India
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Mysore, 570001, India
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Nashik, 422004, India
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Haifa, 91096, Israel
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Petah Tikva, 49100, Israel
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Arezzo, 52100, Italy
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Avellino, 83100, Italy
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Bari, 70124, Italy
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Bologna, 40138, Italy
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Florence, 50134, Italy
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Meldola, 47014, Italy
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Milan, 20132, Italy
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Naples, 80131, Italy
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Padova, 35128, Italy
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Reggio Emilia, 42123, Italy
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Tricase, 73039, Italy
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Verona, 37134, Italy
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Aguascalientes, 20230, Mexico
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Monterrey, 64460, Mexico
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Querétaro, 76090, Mexico
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Toluca, 50090, Mexico
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Amsterdam, 1105 AZ, Netherlands
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Arnhem, 6815 AD, Netherlands
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Rotterdam, 3045 PM, Netherlands
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Gdansk, 80-952, Poland
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Gdynia, 81-519, Poland
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Krakow, 30-348, Poland
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Otwock, 05-400, Poland
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Poznan, 60-569, Poland
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Cluj-Napoca, 400015, Romania
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Cluj-Napoca, 400641, Romania
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Craiova, 200094, Romania
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Singapore, 169610, Singapore
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Daejeon, 35015, South Korea
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Goyang-si, 10408, South Korea
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Incheon, 405-760, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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A Coruña, 15006, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Barcelona, ?08041, Spain
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Córdoba, 14004, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Pamplona, 31008, Spain
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Seville, 41013, Spain
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Valencia, 46026, Spain
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Kaohsiung City, 83301, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 704, Taiwan
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Adana, 01120, Turkey (Türkiye)
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Ankara, 06100, Turkey (Türkiye)
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Ankara, 06200, Turkey (Türkiye)
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Ankara, 06590, Turkey (Türkiye)
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Cordaleo, 35575, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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Istanbul, 32098, Turkey (Türkiye)
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Istanbul, 34218, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Izmir, 35040, Turkey (Türkiye)
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Kazımkarabekir, 01230, Turkey (Türkiye)
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Dnipropetrovsk, 49005, Ukraine
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Leicester, LE1 5WW, United Kingdom
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London, EC1A 7BE, United Kingdom
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London, SW3 6JJ, United Kingdom

Conditions

Explore the condition pages connected to this study.

PAPILLARY RENAL CELL CARCINOMA