New drug shows promise in slowing kidney disease for IgA patients

NCT ID NCT05248659

ENROLLING_BY_INVITATION Disease control Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc. Source: ClinicalTrials.gov ↗

First seen May 14, 2026 · Last updated May 14, 2026

Summary

This study tests the long-term safety and effectiveness of sibeprenlimab, an experimental drug, in about 600 adults with IgA nephropathy—a kidney disease that can lead to kidney failure. Participants must have completed a prior sibeprenlimab study and may benefit from continued treatment. The goal is to see if the drug can safely slow kidney damage and reduce protein in urine over time.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

CISSS de la Monteregie centre-Centre de recherche Hopital Charles Lemoyne

Greenfield Park, Quebec, J4V 2H1, Canada
Clinica Nefrologica, Dialisi e Trapianto, IRCCS Ospedale Policlinico San Martino

Genova, 16132, Italy
Clinical Research Site

New Lambton Heights, New South Wales, 2305, Australia
Clinical Research Site #001

Fitzroy, Victoria, 3065, Australia
Clinical Research Site #003

Garran, Australian Capital Territory, 2605, Australia
Clinical Research Site #006

Saint Leonards, New South Wales, 2065, Australia
Clinical Research Site #010

St Albans, Victoria, 3021, Australia
Clinical Research Site #011

Liverpool, 2170, Australia
Clinical Research Site #012

Adelaide, South Australia, 5000, Australia
Clinical Research Site #013

Concord, New South Wales, 2139, Australia
Clinical Research Site #014

Kogarah, New South Wales, 2217, Australia
Clinical Research Site #020

Beijing, Beijing Municipality, 100034, China
Clinical Research Site #022

Nanchang, Jiangxi, 330006, China
Clinical Research Site #025

Yibin, Sichuan, 644002, China
Clinical Research Site #026

Jinan, Shandong, 250013, China
Clinical Research Site #028

Guangzhou, Guangdong, 510120, China
Clinical Research Site #030

Wuxi, Jiangsu, 214023, China
Clinical Research Site #036

Beijing, Beijing Municipality, 100029, China
Clinical Research Site #038

Chengdu, Sichuan, 610072, China
Clinical Research Site #044

Changsha, Hunan, 410011, China
Clinical Research Site #060

Hong Kong, 999077, Hong Kong
Clinical Research Site #061

Hong Kong, 999077, Hong Kong
Clinical Research Site #062

Kowloon, 999077, Hong Kong
Clinical Research Site #063

Shatin, 999077, Hong Kong
Clinical Research Site #064

Hong Kong, New Territories, Hong Kong
Clinical Research Site #070

Nadiād, Gujarat, 387001, India
Clinical Research Site #071

Kozhikode, Kerala, 673008, India
Clinical Research Site #073

Ahmedabad, Gujarat, 382421, India
Clinical Research Site #074

Thiruvananthapuram, Kerala, 695011, India
Clinical Research Site #075

New Delhi, National Capital Territory of Delhi, 1100060, India
Clinical Research Site #076

Lucknow, Uttar Pradesh, 226014, India
Clinical Research Site #077

Chandigarh, Punjab, 160012, India
Clinical Research Site #078

Afzalganj, Telangana, 500012, India
Clinical Research Site #079

Manipal, Karnataka, 576104, India
Clinical Research Site #080

Rajipet, Tamil Nadu, 632517, India
Clinical Research Site #081

Hyderabad, Deccan, 500082, India
Clinical Research Site #084

Pune, Maharashtra, 411057, India
Clinical Research Site #087

Bengaluru, Karnataka, 560099, India
Clinical Research Site #100

Seoul, Seoul Teugbyeolsi, 6351, South Korea
Clinical Research Site #102

Busan, Busan Gwang'yeogsi, 49241, South Korea
Clinical Research Site #103

Seoul, 3722, South Korea
Clinical Research Site #104

Anyang, 14060, South Korea
Clinical Research Site #105

Seoul, 134-727, South Korea
Clinical Research Site #106

Seoul, 5355, South Korea
Clinical Research Site #107

Seoul, 3080, South Korea
Clinical Research Site #108

Seoul, 5030, South Korea
Clinical Research Site #109

Hwaseong-si, 18450, South Korea
Clinical Research Site #110

Seongnam, 13620, South Korea
Clinical Research Site #111

Seoul, Seoul Teugbyeolsi, 18450, South Korea
Clinical Research Site #112

Daegu, Daegu Gwang'yeogsi, 41944, South Korea
Clinical Research Site #113

Gwangju, Gwangju Gwang'yeogsi, 61469, South Korea
Clinical Research Site #120

Kuantan, 25100, Malaysia
Clinical Research Site #121

Kuala Lumpur, 59100, Malaysia
Clinical Research Site #123

Kuala Lumpur, 50586, Malaysia
Clinical Research Site #124

Ipoh, Perak, 30450, Malaysia
Clinical Research Site #125

Kuala Lumpur, 56000, Malaysia
Clinical Research Site #126

Petaling Jaya, Selangor, 47150, Malaysia
Clinical Research Site #131

Quezon City, 1112, Philippines
Clinical Research Site #132

Quezon City, 1101, Philippines
Clinical Research Site #140

Singapore, 308433, Singapore
Clinical Research Site #141

Singapore, 169608, Singapore
Clinical Research Site #142

Singapore, 119074, Singapore
Clinical Research Site #150

Nugegoda, 10250, Sri Lanka
Clinical Research Site #151

Colombo, 8, Sri Lanka
Clinical Research Site #152

Kandy, 20000, Sri Lanka
Clinical Research Site #154

Kurunegala, 60000, Sri Lanka
Clinical Research Site #160

Keelung, 20104, Taiwan
Clinical Research Site #161

Kaohsiung City, 83301, Taiwan
Clinical Research Site #163

New Taipei City, 23561, Taiwan
Clinical Research Site #164

Taipei, 10002, Taiwan
Clinical Research Site #165

Taipei, 112202, Taiwan
Clinical Research Site #170

Bangkok, 10310, Thailand
Clinical Research Site #171

Din Daeng, 10400, Thailand
Clinical Research Site #172

Chiang Mai, 50200, Thailand
Clinical Research Site #173

Khon Kaen, 40002, Thailand
Clinical Research Site #175

Bangkok, 1, Thailand
Clinical Research Site #181

Hanoi, 0, Vietnam
Clinical Research Site #300

Calgary, Alberta, T2R 0X7, Canada
Clinical Research Site #305

Scarborough Village, Ontario, M1H 3G4, Canada
Clinical Research Site #320

Shelby, Michigan, 48315, United States
Clinical Research Site #323

Lauderdale Lakes, Florida, 33313, United States
Clinical Research Site #324

Houston, Texas, 77030, United States
Clinical Research Site #325

Los Angeles, California, 90027, United States
Clinical Research Site #330

Denver, Colorado, 80220, United States
Clinical Research Site #331

Worcester, Massachusetts, 01655, United States
Clinical Research Site #336

Birmingham, Alabama, 35233, United States
Clinical Research Site #346

Great Neck, New York, 11021, United States
Clinical Research Site #350

Columbus, Ohio, 43210, United States
Clinical Research Site #356

Lawrenceville, Georgia, 30046, United States
Clinical Research Site #361

Milwaukee, Wisconsin, 53213, United States
Clinical Research Site #369

Boston, Massachusetts, 02114, United States
Clinical Research Site #370

Palo Alto, California, 94304, United States
Clinical Research Site #373

Atlanta, Georgia, 30342, United States
Clinical Research Site #374

Dakota Dunes, South Dakota, 57029, United States
Clinical Research Site #401

Genk, 3600, Belgium
Clinical Research Site #405

Genk, 3600, Belgium
Clinical Research Site #413

Split, 21000, Croatia
Clinical Research Site #414

Zagreb, 10000, Croatia
Clinical Research Site #430

Nîmes, Gard, 30900, France
Clinical Research Site #432

Nantes, Loire-Atlantique, 44093, France
Clinical Research Site #433

Grenoble, Auvergne-Rhône-Alpes, 38043, France
Clinical Research Site #434

Sr Priest En Jarez, Pays de la Loire Region, 42270, France
Clinical Research Site #439

Limoges, New Aquitaine, 87000, France
Clinical Research Site #455

Mainz, Rhineland-Palatinate, 55131, Germany
Clinical Research Site #472

Heraklion, 71110, Greece
Clinical Research Site #482

Pécs, Baranya, 7624, Hungary
Clinical Research Site #493

Petach Tiqwa, 49100, Israel
Clinical Research Site #494

Ashkelon, 7830604, Israel
Clinical Research Site #495

Nahariya, 22100, Israel
Clinical Research Site #507

Piacenza, 29121, Italy
Clinical Research Site #509

Pavia, 27100, Italy
Clinical Research Site #512

Bologna, 40138, Italy
Clinical Research Site #530

Lodz, Łódź Voivodeship, 92-213, Poland
Clinical Research Site #535

Krakow, 31-513, Poland
Clinical Research Site #540

Braga, 4710-243, Portugal
Clinical Research Site #543

Porto, 4434-502, Portugal
Clinical Research Site #544

Porto, 4200-319, Portugal
Clinical Research Site #545

Carnaxide, 2790-134, Portugal
Clinical Research Site #561

Seville, 41013, Spain
Clinical Research Site #562

Seville, 41009, Spain
Clinical Research Site #563

Barcelona, 8907, Spain
Clinical Research Site #564

Ellenboro, 28040, Spain
Clinical Research Site #565

Córdoba, 14004, Spain
Clinical Research Site #566

Barcelona, 8035, Spain
Clinical Research Site #567

Barcelona, 8025, Spain
Clinical Research Site #570

Madrid, 28222, Spain
Clinical Research Site #573

Madrid, 28034, Spain
Clinical Research Site #581

Leicester, LE5 4PW, United Kingdom
Clinical Research Site #582

London, SE 5 9RS, United Kingdom
Clinical Research Site #584

London, E1 1FR, United Kingdom
Clinical Research Site #700

Chiba, Chiba, 260-8712, Japan
Clinical Research Site #703

Fukuoka, 812-8582, Japan
Clinical Research Site #705

Nagoya, Aichi-ken, 466-8560, Japan
Clinical Research Site #707

Urayasu-shi, Chiba, 279-002, Japan
Clinical Research Site #708

Tsukuba, Ibaraki, 305-8576, Japan
Clinical Research Site #709

Toyoake-shi, Aichi-ken, 470-1192, Japan
Clinical Research Site #712

Minatoku, 105-8471, Japan
Clinical Research Site #713

Kashihara, Nara, 634-8522, Japan
Clinical Research Site #714

Kawasaki-shi, Kanagawa, 213-8587, Japan
Clinical Research Site #715

Bunkyo, Tokyo, 113-8431, Japan
Clinical Research Site #716

Miyazaki, 889-1692, Japan
Clinical Research Site #717

Yufu, Oita Prefecture, 879-5593, Japan
Clinical Research Site #724

Kobe, Hyōgo, 650-0017, Japan
Clinical Research Site #726

Tochigi, 326-0843, Japan
Clinical Research Site #727

Nerima-ku, Tokyo, 177-8521, Japan
Clinical Research Site #800

Buenos Aires, C1280AEB, Argentina
Clinical Research Site #801

Córdoba, X5016LIG, Argentina
Clinical Research Site #802

Buenos Aires, C1425, Argentina
Clinical Research Site #820

Recife, Pernambuco, 50670-901, Brazil
Clinical Research Site #821

Joinville, Santa Catarina, 89227-680, Brazil
Clinical Research Site #822

São José do Rio Preto, So Paulo, 15090-000, Brazil
Clinical Research Site #823

São Paulo, 01246-903, Brazil
Clinical Research Site #824

Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
Clinical Research Site #831

Rio de Janeiro, 20550-010, Brazil
Radboud Universitair Medisch Centrum

Nijmegen, Gelderland, 6500 HB, Netherlands
Tel Aviv University Sackler School of Medicine - Meir Medical Center (MMC) (Meir Hospital)

Kfar Saba, 44281, Israel
Universitaetsklinikum Carl Gustav Carus

Dresden, Saxony, 1307, Germany
Vseobecna fakultni nemocnice v Praze

Prague, 12808, Czechia

Conditions

Explore the condition pages connected to this study.

IMMUNOGLOBULIN A NEPHROPATHY