New drug shows promise in slowing kidney disease progression

NCT ID NCT04573920

First seen Jun 08, 2026 ยท Last updated Jun 08, 2026

Summary

This study tests an oral drug called atrasentan in 103 adults with kidney diseases that cause protein leakage in urine, such as IgA nephropathy and FSGS. The goal is to see if atrasentan can lower protein levels and protect kidney function over 12 to 30 weeks. Participants must already be on stable blood pressure medication. This is an early-phase trial, so results will guide future research.

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Contacts and locations

Locations

  • Academic Medical Research Institute

    Los Angeles, California, 90022, United States

  • Baylor Scott and White

    Dallas, Texas, 75246, United States

  • Brookview Hills Research Assoc

    Winston-Salem, North Carolina, 27103, United States

  • Colorado Kidney Care Nephrology

    Denver, Colorado, 80230, United States

  • DaVita Clinical Research

    Las Vegas, Nevada, 89146, United States

  • Kidney Disease Medical Group

    Glendale, California, 91206, United States

  • Milwaukee Nephrologists SC

    Wauwatosa, Wisconsin, 53226, United States

  • Mountain Kidney And Hyper Associa

    Asheville, North Carolina, 28801, United States

  • North America Research Institute

    San Dimas, California, 91773, United States

  • Northwest Louisiana Nephrology Research

    Shreveport, Louisiana, 71101-4440, United States

  • Novartis Investigative Site

    Gosford, New South Wales, 2250, Australia

  • Novartis Investigative Site

    Herston, Queensland, 4029, Australia

  • Novartis Investigative Site

    Clayton, Victoria, 3168, Australia

  • Novartis Investigative Site

    Reservoir, Victoria, 3073, Australia

  • Novartis Investigative Site

    St Albans, Victoria, 3021, Australia

  • Novartis Investigative Site

    St Leonards, 2065, Australia

  • Novartis Investigative Site

    Roma, RM, 00165, Italy

  • Novartis Investigative Site

    Cheonan, Chungcheongnam-do, 330-721, South Korea

  • Novartis Investigative Site

    Anyang-si, Gyeonggi-do, 14068, South Korea

  • Novartis Investigative Site

    Seoul, Korea, 02841, South Korea

  • Novartis Investigative Site

    Seoul, 03722, South Korea

  • Novartis Investigative Site

    Seoul, 134 727, South Korea

  • Novartis Investigative Site

    Port de Sagunt, Valencia, 46520, Spain

  • Novartis Investigative Site

    Barcelona, 08035, Spain

  • Novartis Investigative Site

    Lugo, 27004, Spain

  • Novartis Investigative Site

    Madrid, 28009, Spain

  • Novartis Investigative Site

    Majadahonda, 28222, Spain

  • Novartis Investigative Site

    Sheffield, South Yorkshire, S10 2JF, United Kingdom

  • Novartis Investigative Site

    London, E1 1BB, United Kingdom

  • Prolato Clinical Research Center

    Houston, Texas, 77054, United States

  • Stanford U School Of Medicine

    Stanford, California, 94305, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • Uni of Minnesota Hos and Clinics

    Minneapolis, Minnesota, 55455, United States

Conditions

Explore the condition pages connected to this study.