New triple therapy could erase bladder tumors before surgery
NCT ID NCT06133517
First seen Mar 25, 2026 · Last updated Apr 28, 2026 · Updated 3 times
Summary
This study tests a combination of three drugs (sacituzumab govitecan, zimberelimab, and domvanalimab) given before and after bladder removal surgery for people with muscle-invasive bladder cancer who cannot take standard cisplatin chemotherapy. The main goal is to see if the treatment can completely eliminate the cancer by the time of surgery. About 70 adults will participate in this phase 2 trial.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Hospital Clinico Universitario de Valladolid
Valladolid, Valladolid, Spain
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Hospital Clínico San Carlos
Madrid, Madrid, Spain
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Hospital Duran i Reynals (ICO L´Hospitalet)
L'Hospitalet de Llobregat, Barcelona, Spain
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Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, Spain
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Hospital Universitario de Navarra
Pamplona, Navarre, Spain
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Hospital Virgen de la Salud
Toledo, Toledo, Spain
Conditions
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