Can a drug combo outperform standard therapy for a rare kidney cancer?

NCT ID NCT05678673

Ongoing Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether a combination of the experimental drug XL092 and the immunotherapy nivolumab can help people with advanced non-clear cell kidney cancer live longer without their disease worsening. Participants have not received prior treatment for their advanced cancer and will be randomly assigned to receive either the new combo or the standard drug sunitinib. The study aims to see if the new approach improves tumor shrinkage and delays cancer progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a combination of an experimental drug called XL092 and the immunotherapy nivolumab (Opdivo)
What this could lead to: If it works, this could offer a more effective first-line treatment option for people with a rare form of advanced kidney cancer.
What could go wrong: This is an early-phase 3 trial, so the combination may not prove better than the current standard. Side effects from the drug combo could be significant.

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Conditions

The condition(s) this trial relates to.

nonpapillary renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-CLEAR CELL RENAL CELL CARCINOMA

Contacts and locations

Locations

Exelixis Clinical Site #1

Duarte, California, 91010, United States
Exelixis Clinical Site #10

Seoul, 02841, South Korea
Exelixis Clinical Site #100

Elizabeth Vale, South Australia, 5112, Australia
Exelixis Clinical Site #101

São Paulo, 01246-000, Brazil
Exelixis Clinical Site #102

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Exelixis Clinical Site #103

Sofia, 1431, Bulgaria
Exelixis Clinical Site #104

Plovdiv, 4004, Bulgaria
Exelixis Clinical Site #105

Sofia, 1404, Bulgaria
Exelixis Clinical Site #106

Santiago, 7500921, Chile
Exelixis Clinical Site #107

Santiago, 8420383, Chile
Exelixis Clinical Site #108

Santiago, 7520378, Chile
Exelixis Clinical Site #109

Santiago, 8241479, Chile
Exelixis Clinical Site #11

Busan, 49201, South Korea
Exelixis Clinical Site #110

Zagreb, 10000, Croatia
Exelixis Clinical Site #111

Rijeka, 51000, Croatia
Exelixis Clinical Site #112

Olomouc, 77900, Czechia
Exelixis Clinical Site #113

Lyon, 08Rhone69373, France
Exelixis Clinical Site #114

Lille, 59020, France
Exelixis Clinical Site #115

Angers, Maine Et Loire, 49933, France
Exelixis Clinical Site #116

Frankfurt am Main, Hesse, 60590, Germany
Exelixis Clinical Site #117

Hamburg, 22763, Germany
Exelixis Clinical Site #118

Athens, 11528, Greece
Exelixis Clinical Site #119

Athens, 12462, Greece
Exelixis Clinical Site #12

Paris, 75013, France
Exelixis Clinical Site #120

Thessaloniki, 56403, Greece
Exelixis Clinical Site #121

Thessaloniki, 54622, Greece
Exelixis Clinical Site #122

Tripoli, 22131, Greece
Exelixis Clinical Site #123

Athens, 12462, Greece
Exelixis Clinical Site #124

Hong Kong, Hong Kong
Exelixis Clinical Site #125

Hong Kong, Hong Kong
Exelixis Clinical Site #126

Debrecen, 4032, Hungary
Exelixis Clinical Site #127

Budapest, 1122, Hungary
Exelixis Clinical Site #128

Budapest, 1082, Hungary
Exelixis Clinical Site #129

Milan, 20132, Italy
Exelixis Clinical Site #13

Daejeon, 35015, South Korea
Exelixis Clinical Site #130

Rozzano, Milano, 20089, Italy
Exelixis Clinical Site #131

Candiolo, Torino, 10060, Italy
Exelixis Clinical Site #132

Bari, 70124, Italy
Exelixis Clinical Site #133

Poznan, 60-569, Poland
Exelixis Clinical Site #134

Singapore, 168583, Singapore
Exelixis Clinical Site #135

Bratislava, 83310, Slovakia
Exelixis Clinical Site #136

Košice, 04190, Slovakia
Exelixis Clinical Site #137

Banská Bystrica, 97517, Slovakia
Exelixis Clinical Site #138

Barcelona, 8906, Spain
Exelixis Clinical Site #139

Madrid, 28009, Spain
Exelixis Clinical Site #14

Chermside, 4032, Australia
Exelixis Clinical Site #140

Madrid, 28033, Spain
Exelixis Clinical Site #141

Córdoba, 14004, Spain
Exelixis Clinical Site #142

Majadahonda, Madrid, 28220, Spain
Exelixis Clinical Site #143

Palma de Mallorca, Balearic Islands, 7120, Spain
Exelixis Clinical Site #144

Seville, 41009, Spain
Exelixis Clinical Site #145

Málaga, 29011, Spain
Exelixis Clinical Site #146

Phu Wiang, Changwat Khon Kaen, 40002, Thailand
Exelixis Clinical Site #147

Bangkok Noi, Bangkok, 10400, Thailand
Exelixis Clinical Site #148

Istanbul, 34890, Turkey (Türkiye)
Exelixis Clinical Site #149

Ankara, 6010, Turkey (Türkiye)
Exelixis Clinical Site #15

New York, New York, 10065, United States
Exelixis Clinical Site #150

Ankara, 6230, Turkey (Türkiye)
Exelixis Clinical Site #151

Istanbul, 34722, Turkey (Türkiye)
Exelixis Clinical Site #152

Ankara, 6800, Turkey (Türkiye)
Exelixis Clinical Site #153

Adana, 1230, Turkey (Türkiye)
Exelixis Clinical Site #154

Izmir, 35575, Turkey (Türkiye)
Exelixis Clinical Site #155

Ankara, 6590, Turkey (Türkiye)
Exelixis Clinical Site #156

Ankara, 06520, Turkey (Türkiye)
Exelixis Clinical Site #157

Adana, 1140, Turkey (Türkiye)
Exelixis Clinical Site #158

Sheffield, South Yorkshire, S10 2SJ, United Kingdom
Exelixis Clinical Site #159

London, SE1 9RT, United Kingdom
Exelixis Clinical Site #16

Goyang-si, 10408, South Korea
Exelixis Clinical Site #160

London, EC1M 6BQ, United Kingdom
Exelixis Clinical Site #161

Buffalo, New York, 14263, United States
Exelixis Clinical Site #162

San Francisco, California, 94115, United States
Exelixis Clinical Site #163

Aurora, Colorado, 80045, United States
Exelixis Clinical Site #164

Newport Beach, California, 92663, United States
Exelixis Clinical Site #17

Verona, 37134, Italy
Exelixis Clinical Site #18

Seville, 41013, Spain
Exelixis Clinical Site #19

Meldola, 47014, Italy
Exelixis Clinical Site #20

Seoul, 06591, South Korea
Exelixis Clinical Site #21

Seongnam-si, 13496, South Korea
Exelixis Clinical Site #22

Daegu, 42601, South Korea
Exelixis Clinical Site #23

Rzeszów, 35-021, Poland
Exelixis Clinical Site #24

Kuala Lumpur, 59100, Malaysia
Exelixis Clinical Site #25

Gyeonggi-do, 16247, South Korea
Exelixis Clinical Site #26

Brescia, 25123, Italy
Exelixis Clinical Site #27

Prague, 140 59, Czechia
Exelixis Clinical Site #28

Rennes, 35042, France
Exelixis Clinical Site #29

South Brisbane, 4101, Australia
Exelixis Clinical Site #3

Madrid, 28034, Spain
Exelixis Clinical Site #30

Naples, 80131, Italy
Exelixis Clinical Site #31

Dallas, Texas, 75246, United States
Exelixis Clinical Site #32

Busan, 49267, South Korea
Exelixis Clinical Site #33

Otwock, 05-400, Poland
Exelixis Clinical Site #34

Madrid, 28041, Spain
Exelixis Clinical Site #35

CABA, C1419GEP, Argentina
Exelixis Clinical Site #36

Marseille, 13385, France
Exelixis Clinical Site #37

Pavia, 27100, Italy
Exelixis Clinical Site #38

Le Mans, 72000, France
Exelixis Clinical Site #39

Itajaí, 88301-220, Brazil
Exelixis Clinical Site #4

Seoul, 03722, South Korea
Exelixis Clinical Site #40

Créteil, 94010, France
Exelixis Clinical Site #41

Strasbourg, 67200, France
Exelixis Clinical Site #42

Cleveland, Ohio, 44106, United States
Exelixis Clinical Site #43

São Paulo, 17210-120, Brazil
Exelixis Clinical Site #44

Buenos Aires, B7600FZO, Argentina
Exelixis Clinical Site #45

Bydgoszcz, 85-796, Poland
Exelixis Clinical Site #46

Putrajaya, 62250, Malaysia
Exelixis Clinical Site #47

Seoul, 05505, South Korea
Exelixis Clinical Site #48

Reggio Emilia, 42123, Italy
Exelixis Clinical Site #49

Gdansk, 80-219, Poland
Exelixis Clinical Site #5

Seongnam-si, 13620, South Korea
Exelixis Clinical Site #50

São José do Rio Preto, 15090-000, Brazil
Exelixis Clinical Site #51

Santa Fe, 2000, Argentina
Exelixis Clinical Site #52

Barcelona, 08041, Spain
Exelixis Clinical Site #53

Providencia, 7520378, Chile
Exelixis Clinical Site #54

Kuala Lumpur, 50586, Malaysia
Exelixis Clinical Site #55

Jacksonville, Florida, 32209, United States
Exelixis Clinical Site #56

Barcelona, 08035, Spain
Exelixis Clinical Site #57

Oviedo, 33011, Spain
Exelixis Clinical Site #58

New York, New York, 10029, United States
Exelixis Clinical Site #59

Reims, 51726, France
Exelixis Clinical Site #6

Seoul, 06351, South Korea
Exelixis Clinical Site #60

Roma, 00168, Italy
Exelixis Clinical Site #61

Brno, 602 00, Czechia
Exelixis Clinical Site #62

Girona, 17007, Spain
Exelixis Clinical Site #63

Pisa, 56126, Italy
Exelixis Clinical Site #64

Eindhoven, 631BM, Netherlands
Exelixis Clinical Site #65

Suresnes, 92150, France
Exelixis Clinical Site #66

Clermont-Ferrand, 63011, France
Exelixis Clinical Site #67

Paris, 75475, France
Exelixis Clinical Site #68

Barretos, 14784 400, Brazil
Exelixis Clinical Site #69

Passo Fundo, 99010-090, Brazil
Exelixis Clinical Site #7

Arezzo, 52100, Italy
Exelixis Clinical Site #70

Porto Alegre, 90110-270, Brazil
Exelixis Clinical Site #71

Helsinki, 00290, Finland
Exelixis Clinical Site #72

San Giovanni Rotondo, 71013, Italy
Exelixis Clinical Site #73

Valencia, 46009, Spain
Exelixis Clinical Site #74

Caen, 14076, France
Exelixis Clinical Site #75

Santander, 39008, Spain
Exelixis Clinical Site #76

Pierre-Bénite, 69310, France
Exelixis Clinical Site #77

Poznan, 02-781, Poland
Exelixis Clinical Site #78

Porto Alegre, 91350-200, Brazil
Exelixis Clinical Site #79

Eisleben Lutherstadt, 06295, Germany
Exelixis Clinical Site #8

Madrid, 28046, Spain
Exelixis Clinical Site #80

Poznan, 60-693, Poland
Exelixis Clinical Site #81

São Paulo, 01323-001, Brazil
Exelixis Clinical Site #82

Chiang Mai, 50200, Thailand
Exelixis Clinical Site #83

Bangkok, 10400, Thailand
Exelixis Clinical Site #84

Bangkok, 10330, Thailand
Exelixis Clinical Site #85

São Paulo, 01323-903, Brazil
Exelixis Clinical Site #86

Prague, 150 06, Czechia
Exelixis Clinical Site #87

Santo André, 09060-870, Brazil
Exelixis Clinical Site #88

Pilar, Buenos Aires, B1629ODT, Argentina
Exelixis Clinical Site #89

Viedma, Río Negro Province, R8500ACE, Argentina
Exelixis Clinical Site #9

Barcelona, 08036, Spain
Exelixis Clinical Site #90

Córdoba, X5004BAL, Argentina
Exelixis Clinical Site #91

Box Hill, Victoria, 3128, Australia
Exelixis Clinical Site #92

Sydney, New South Wales, 2145, Australia
Exelixis Clinical Site #93

Waratah, New South Wales, 2298, Australia
Exelixis Clinical Site #94

Albury, New South Wales, 2640, Australia
Exelixis Clinical Site #95

Macquarie, New South Wales, 2109, Australia
Exelixis Clinical Site #96

St Albans, Victoria, 3021, Australia
Exelixis Clinical Site #97

Camperdown, New South Wales, 3021, Australia
Exelixis Clinical Site #98

Liverpool, New South Wales, 2170, Australia
Exelixis Clinical Site #99

Douglas, Queensland, 4814, Australia

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