New antibody drug could open door to kidney transplants for Hard-to-Match patients
NCT ID NCT05092347
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called vonsetamig in 43 people with chronic kidney disease who are on dialysis and have very high levels of anti-HLA antibodies, making it nearly impossible to find a matching kidney donor. The drug aims to safely lower these antibodies so that a kidney transplant becomes possible. Researchers are also monitoring side effects and how the drug works in the body.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
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Comprehensive Transplant Center
Chicago, Illinois, 60611, United States
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Connie Frank Transplant Center at UCSF
San Francisco, California, 94143, United States
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John Hopkins Hospital
Baltimore, Maryland, 21224, United States
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Medstar Georgetown Transplant Institute - 2-PHC
Washington D.C., District of Columbia, 20007, United States
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New York University Langone Health
New York, New York, 10016, United States
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Penn Transplant Institute
Philadelphia, Pennsylvania, 19104, United States
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University of California Irvine
Orange, California, 92868, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
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Yale University of Medicine
New Haven, Connecticut, 06520, United States