Engineered immune cells aim to tame lupus without daily pills

NCT ID NCT07015983

Ongoing Disease control Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This phase 2 trial tests a one-time treatment called CC-97540, made from a patient's own immune cells engineered to target and calm the overactive immune system in lupus. The study enrolls 89 adults with active lupus (including kidney inflammation) who have not responded well to steroids and at least two other immunosuppressants. The main goal is to see if participants can achieve drug-free remission, meaning no lupus symptoms and no need for lupus medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CC-97540 (a type of CAR T-cell therapy that targets CD19 on immune cells)
What this could lead to: If successful, this could offer a new treatment option that allows people with lupus to stop taking daily medications and achieve long-term remission.
What could go wrong: This is an early phase 2 trial with only 89 participants, so results may not apply to everyone. CAR T-cell therapy can cause serious side effects like cytokine release syndrome and infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lupus nephritis systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUPUS ERYTHEMATOSUS, SYSTEMIC LUPUS NEPHRITIS

Contacts and locations

Locations

ASST Grande Ospedale Metropolitano Niguarda

Milan, Milano, 20162, Italy
Atlantic Health System Overlook Medical Center

Summit, New Jersey, 07901, United States
Baptist Memorial Hospital

Memphis, Tennessee, 38120, United States
Baylor Scott and White Research Institute

Dallas, Texas, 75246, United States
CHU Montpellier Lapeyronie Hospital

Montpellier, Hérault, 34295, France
Carolinas HealthCare System SouthPark

Charlotte, North Carolina, 28211, United States
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou

Rennes, 35033, France
Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria

Lisbon, Lisbon District, 1649-035, Portugal
Charité - Universitaetsmedizin Berlin - Campus Bejnamin Franklin

Berlin, 10117, Germany
Chiba University Hospital

Chiba, 260-8677, Japan
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Columbia University Irving Medical Center

New York, New York, 10032, United States
Columbia University Pediatrics

New York, New York, 10032, United States
Derriford Hospital, University Hospitals Plymouth NHS Trust

Crownhill, Plymouth, PL6 8DH, United Kingdom
Emory University School of Medicine

Atlanta, Georgia, 30322, United States
Florida Medical Clinic Orlando Health

Zephyrhills, Florida, 33542, United States
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore

Rome, Lazio, 00168, Italy
H.R.U Málaga - Hospital General

Málaga, 29011, Spain
Hadassah Medical Center

Jerusalem, 9112001, Israel
Hokkaido University Hospital

Sapporo, Hokkaido, 0608648, Japan
Hospital Aleman

Buenos Aires, Buenos Aires F.D., C1118AAT, Argentina
Hospital Clínico Universitario Virgen de la Arrixaca

Murcia, 30120, Spain
Hospital Italiano de Buenos Aires

ABB, Buenos Aires F.D., C1199ABB, Argentina
Hospital La Princesa

Madrid, 28006, Spain
Hospital Sant Joan de Déu

Esplugues de Llobregat, Barcelona [Barcelona], 08950, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [Barcelona], 08035, Spain
Hospital for Special Surgery

New York, New York, 10021, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Juntendo University Hospital

Bunkyo-ku, Tokyo, 113-8431, Japan
Keio university hospital

Shinjuku-ku, Tokyo, 1608582, Japan
King's College Hospital

London, London, City of, SE5 9RL, United Kingdom
Kyushu University Hospital

Fukuoka, 812-8582, Japan
Local Institution - 0011

Rochester, Minnesota, 55905, United States
Local Institution - 0021

São Paulo, São Paulo, 01409-001, Brazil
Local Institution - 0022

São Paulo, 05652-900, Brazil
Local Institution - 0038

Los Angeles, California, 90027, United States
Local Institution - 0047

Copenhagen, Capital Region, 2100, Denmark
Local Institution - 0051

Los Angeles, California, 90095, United States
Local Institution - 0058

São Paulo, São Paulo, 01509-010, Brazil
Local Institution - 0070

Pisa, Tuscany, 56126, Italy
Local Institution - 0073

Orlando, Florida, 32803, United States
Local Institution - 0077

Córdoba, X5016, Argentina
Local Institution - 0079

Atlanta, Georgia, 30322, United States
Local Institution - 0081

Toulouse, Haute-Garonne, 31059, France
Local Institution - 0082

New York, New York, 10016, United States
Local Institution - 0083

Philadelphia, Pennsylvania, 19104, United States
Local Institution - 0086

Baton Rouge, Louisiana, 70836, United States
Local Institution - 0088

Donostia / San Sebastian, Gipuzkoa, 20014, Spain
Local Institution - 0090

Metropolitan Borough of Wirral, Merseyside, L63 4JY, United Kingdom
Local Institution - 0091

Liverpool, L9 7AL, United Kingdom
Local Institution - 0093

Newport Beach, California, 92663, United States
Local Institution - 0094

Boston, Massachusetts, 02114, United States
Local Institution - 0096

Ann Arbor, Michigan, 48109, United States
Local Institution - 0098

Dallas, Texas, 75390-9068, United States
Local Institution - 0099

Toronto, Ontario, M5T 2S8, Canada
Local Institution - 0101

Manhasset, New York, 11030, United States
Local Institution - 0104

San Antonio, Texas, 78229, United States
Local Institution - 0106

Phoenix, Arizona, 85054, United States
Local Institution - 0107

Buenos Aires, B1629ODT, Argentina
Local Institution - 0108

Indianapolis, Indiana, 46250, United States
Local Institution - 0109

Strasbourg, 67098, France
Local Institution - 0110

Shreveport, Louisiana, 71101, United States
Local Institution - 0111

Stony Brook, New York, 11794, United States
Local Institution - 0132

Odense, Region Syddanmark, 5000, Denmark
Local Institution - 0134

Paris, Île-de-France Region, 75015, France
Local Institution - 0135

Winston-Salem, North Carolina, 27106, United States
Lucile Packard Children's Hospital

Palo Alto, California, 94304, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224, United States
Medizinische Universität Wien

Vienna, State of Vienna, 1090, Austria
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Narodowy Instytut Onkologii - Oddzial w Gliwicach

Gliwice, Silesian Voivodeship, 44-101, Poland
Northside Hospital

Atlanta, Georgia, 30342, United States
Odense Universitetshospital

Odense, Region Syddanmark, 5000, Denmark
Okayama University Hospital

Okayama, 700-8558, Japan
Osaka Metropolitan University Hospital

Osaka, 545-8586, Japan
Ospedale Pediatrico Bambino Gesù IRCCS

Rome, Roma, 00165, Italy
Pitie Salpetriere University Hospital

Paris, Île-de-France Region, 75013, France
Rheumazentrum Ruhrgebiet

Herne, 44649, Germany
Sheba Medical Center

Ramat Gan, Central District, 5262100, Israel
Swedish Medical Center

Seattle, Washington, 98122, United States
Szpital Specjalistyczny nr 1 w Bytomiu

Bytom, Silesian Voivodeship, 41-902, Poland
The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada
USF Health

Tampa, Florida, 33612, United States
UZ Leuven

Leuven, Vlaams-Brabant, 3000, Belgium
Uniklinikum Salzburg

Salzburg, 5020, Austria
Universitaetsklinikum Erlangen

Erlangen, 91054, Germany
Universitaetsklinikum Koeln

Cologne, 50937, Germany
Universitaetsklinikum Magdeburg

Magdeburg, Saxony-Anhalt, 39120, Germany
University College London Hospital

London, London, City of, NW1 2PG, United Kingdom
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States
University of Miami Hospital and Clinics, Sylvester Cancer Center

Miami, Florida, 33136, United States
Universitätsklinikum Leipzig

Leipzig, Saxony, 04103, Germany
Vancouver General Hospital

Vancouver, British Columbia, V5Z 1M9, Canada
Weill Cornell Medical College

New York, New York, 10065, United States
Yokohama City University Hospital

Yokohama, Kanagawa, 236-0004, Japan

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