New drug aims to protect kidneys in IgA nephropathy patients

NCT ID NCT03762850

Ongoing Disease control Sponsor: Travere Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests sparsentan, a new drug, against irbesartan (a standard treatment) in 406 adults with IgA nephropathy, a kidney disease. The goal is to see if sparsentan better protects kidney function over about 2 years. Participants must have significant protein in their urine and stable kidney function at the start.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sparsentan
What this could lead to: If successful, sparsentan could offer a new treatment option to slow kidney function decline in people with IgA nephropathy.
What could go wrong: This is a Phase 3 trial, but results are not yet final. The drug may not prove significantly better than existing treatments, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

IgA glomerulonephritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMMUNOGLOBULIN A NEPHROPATHY

Contacts and locations

Locations

Travere Investigational Site

Birmingham, Alabama, 35233, United States
Travere Investigational Site

Homewood, Alabama, 35209, United States
Travere Investigational Site

Glendale, California, 91206, United States
Travere Investigational Site

Montebello, California, 90640, United States
Travere Investigational Site

Northridge, California, 91324, United States
Travere Investigational Site

San Diego, California, 92103-6204, United States
Travere Investigational Site

San Diego, California, 92103, United States
Travere Investigational Site

Stanford, California, 94205, United States
Travere Investigational Site

Denver, Colorado, 80230, United States
Travere Investigational Site

Coral Springs, Florida, 33071, United States
Travere Investigational Site

Hollywood, Florida, 33021, United States
Travere Investigational Site

Miami, Florida, 33136, United States
Travere Investigational Site

Miami, Florida, 33186, United States
Travere Investigational Site

Winter Park, Florida, 32789, United States
Travere Investigational Site

Lawrenceville, Georgia, 30046, United States
Travere Investigational Site

Nampa, Idaho, 83687, United States
Travere Investigational Site

Hinsdale, Illinois, 60521, United States
Travere Investigational Site

Muncie, Indiana, 47303, United States
Travere Investigational Site

Kansas City, Kansas, 66160, United States
Travere Investigational Site

Louisville, Kentucky, 40202, United States
Travere Investigational Site

Boston, Massachusetts, 02215, United States
Travere Investigational Site

Springfield, Massachusetts, 01104, United States
Travere Investigational Site

Worcester, Massachusetts, 01608, United States
Travere Investigational Site

Minneapolis, Minnesota, 55404, United States
Travere Investigational Site

Reno, Nevada, 89511, United States
Travere Investigational Site

Fresh Meadows, New York, 11365, United States
Travere Investigational Site

New York, New York, 10032, United States
Travere Investigational Site

Cleveland, Ohio, 44106, United States
Travere Investigational Site

Columbus, Ohio, 43210, United States
Travere Investigational Site

Philadelphia, Pennsylvania, 19104, United States
Travere Investigational Site

Columbia, South Carolina, 29203, United States
Travere Investigational Site

El Paso, Texas, 79935, United States
Travere Investigational Site

Fort Worth, Texas, 76104, United States
Travere Investigational Site

Houston, Texas, 77054, United States
Travere Investigational Site

Lewisville, Texas, 75057, United States
Travere Investigational Site

San Antonio, Texas, 78207, United States
Travere Investigational Site

Salt Lake City, Utah, 84115, United States
Travere Investigational Site

Salt Lake City, Utah, 84132, United States
Travere Investigational Site

Tacoma, Washington, 98405, United States
Travere Investigational Site

Marshfield, Wisconsin, 54449, United States
Travere Investigational Site

Concord, New South Wales, 2139, Australia
Travere Investigational Site

Gosford, New South Wales, 2250, Australia
Travere Investigational Site

Kingswood, New South Wales, 2747, Australia
Travere Investigational Site

New Lambton Heights, New South Wales, 2305, Australia
Travere Investigational Site

Randwick, New South Wales, 2031, Australia
Travere Investigational Site

St Leonards, New South Wales, 2065, Australia
Travere Investigational Site

Birtinya, Queensland, 4575, Australia
Travere Investigational Site

Adelaide, South Australia, 5000, Australia
Travere Investigational Site

Reservoir, Victoria, 3073, Australia
Travere Investigational Site

Nedlands, Western Australia, 6009, Australia
Travere Investigational Site

Bonheiden, 2820, Belgium
Travere Investigational Site

Bruges, 8310, Belgium
Travere Investigational Site

Ghent, 9000, Belgium
Travere Investigational Site

Kortrijk, 8500, Belgium
Travere Investigational Site

Liège, 4000, Belgium
Travere Investigational Site

Roeselare, 8800, Belgium
Travere Investigational Site

Osijek, 31000, Croatia
Travere Investigational Site

Zagreb, 10000, Croatia
Travere Investigational Site

Prague, 10034, Czechia
Travere Investigational Site

Prague, 12808, Czechia
Travere Investigational Site

Tallinn, 10617, Estonia
Travere Investigational Site

Tallinn, 13419, Estonia
Travere Investigational Site

Tartu, 50406, Estonia
Travere Investigational Site

Marseille, Bouches-du-Rhone, 13005, France
Travere Investigational Site

Montpellier, Herault, 34295, France
Travere Investigational Site

Grenoble, Isere, 38043, France
Travere Investigational Site

Paris, Paris, 75015, France
Travere Investigational Site

Saint-Priest-en-Jarez, Pays de la Loire Region, 42270, France
Travere Investigational Site

Clermont-Ferrand, Puy De Dome, 63003, France
Travere Investigational Site

Créteil, 94010, France
Travere Investigational Site

Paris, 75475, France
Travere Investigational Site

Villingen-Schwenningen, Baden-Wurttemberg, 78052, Germany
Travere Investigational Site

Hanover, Lower Saxony, 30625, Germany
Travere Investigational Site

Aachen, North Rhine-Westphalia, 52074, Germany
Travere Investigational Site

Düsseldorf, North Rhine-Westphalia, 40210, Germany
Travere Investigational Site

Kaiserslautern, Rheinland Palatinate, 67655, Germany
Travere Investigational Site

Trier, Rheinland Palatinate, 54292, Germany
Travere Investigational Site

Kiel, Schleswig-Holstein, 23538, Germany
Travere Investigational Site

Kiel, Schleswig-Holstein, 24105, Germany
Travere Investigational Site

Jena, Thuringia, 07747, Germany
Travere Investigational Site

Berlin, 10117, Germany
Travere Investigational Site

Kwun Tong, Kowloon, Hong Kong
Travere Investigational Site

Lai Chi Kok, Kowloon, Hong Kong
Travere Investigational Site

Shatin, New Territories, Hong Kong
Travere Investigational Site

Tsuen Wan, New Territories, Hong Kong
Travere Investigational Site

Hong Kong, Hong Kong
Travere Investigational Site

Ranica, Bergamo, 24020, Italy
Travere Investigational Site

Milan, Lombardy, 20162, Italy
Travere Investigational Site

Bari, 70124, Italy
Travere Investigational Site

Catania, 95123, Italy
Travere Investigational Site

Catanzaro, 88100, Italy
Travere Investigational Site

Lecco, 23900, Italy
Travere Investigational Site

Modena, 41124, Italy
Travere Investigational Site

Pavia, 27100, Italy
Travere Investigational Site

Roma, 00168, Italy
Travere Investigational Site

Torino, 10126, Italy
Travere Investigational Site

Kaunas, LT-50009, Lithuania
Travere Investigational Site

Vilnius, LT-08661, Lithuania
Travere Investigational Site

Grafton, Auckland, 1142, New Zealand
Travere Investigational Site

Hamilton, 3200, New Zealand
Travere Investigational Site

Hastings, 4120, New Zealand
Travere Investigational Site

New Plymouth, 4310, New Zealand
Travere Investigational Site

Krakow, 31-559, Poland
Travere Investigational Site

Lodz, 93-347, Poland
Travere Investigational Site

Olsztyn, 10-124, Poland
Travere Investigational Site

Olsztyn, 10-561, Poland
Travere Investigational Site

Warsaw, 04-749, Poland
Travere Investigational Site

Wroclaw, 50-566, Poland
Travere Investigational Site

Coimbra, 3000-075, Portugal
Travere Investigational Site

Lisbon, 1069-166, Portugal
Travere Investigational Site

Lisbon, 1649-035, Portugal
Travere Investigational Site

Loures, 2674-514, Portugal
Travere Investigational Site

Setúbal, 2910-446, Portugal
Travere Investigational Site

Vila Nova de Gaia, 4434-502, Portugal
Travere Investigational Site

Seongnam-si, Gyeonggi-do, 13620, South Korea
Travere Investigational Site

Anyang-si, 14068, South Korea
Travere Investigational Site

Busan, 47392, South Korea
Travere Investigational Site

Incheon, 21565, South Korea
Travere Investigational Site

Seoul, 02841, South Korea
Travere Investigational Site

Seoul, 03080, South Korea
Travere Investigational Site

Seoul, 06273, South Korea
Travere Investigational Site

Seoul, 110-746, South Korea
Travere Investigational Site

Seoul, 120-752, South Korea
Travere Investigational Site

Seoul, 135-710, South Korea
Travere Investigational Site

Palma de Mallorca, Balearic Islands, 07120, Spain
Travere Investigational Site

Sagunto, Valencia, 46520, Spain
Travere Investigational Site

Barcelona, 08003, Spain
Travere Investigational Site

Barcelona, 08025, Spain
Travere Investigational Site

Barcelona, 08035, Spain
Travere Investigational Site

Barcelona, 08036, Spain
Travere Investigational Site

Madrid, 28007, Spain
Travere Investigational Site

Madrid, 28040, Spain
Travere Investigational Site

Madrid, 28041, Spain
Travere Investigational Site

Seville, 41009, Spain
Travere Investigational Site

Valencia, 46014, Spain
Travere Investigational Site

Valencia, 46017, Spain
Travere Investigational Site

Zaragoza, 50009, Spain
Travere Investigational Site

Hualien City, 970, Taiwan
Travere Investigational Site

Kaohsiung City, 807, Taiwan
Travere Investigational Site

Kaohsiung City, 81362, Taiwan
Travere Investigational Site

New Taipei City, 220, Taiwan
Travere Investigational Site

Taichung, 40705, Taiwan
Travere Investigational Site

Reading, Berkshire, RG1 5AN, United Kingdom
Travere Investigational Site

Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
Travere Investigational Site

Middlesbrough, Cleveland, TS4 3BW, United Kingdom
Travere Investigational Site

Derby, Derbyshire, DE22 3DT, United Kingdom
Travere Investigational Site

Brighton, East Sussex, BN2 5BE, United Kingdom
Travere Investigational Site

London, Greater London, E1 4AT, United Kingdom
Travere Investigational Site

London, Greater London, SE1 9RT, United Kingdom
Travere Investigational Site

Manchester, Greater Manchester, M13 9WL, United Kingdom
Travere Investigational Site

Salford, Greater Manchester, M6 8HD, United Kingdom
Travere Investigational Site

Preston, Lancashire, PR2 9HT, United Kingdom
Travere Investigational Site

Leicester, Leicestershire, LE5 4PW, United Kingdom
Travere Investigational Site

Edinburgh, Scotland, EH16 4SA, United Kingdom
Travere Investigational Site

Stoke-on-Trent, Staffordshire, ST4 6QG, United Kingdom
Travere Investigational Site

Glasgow, Strathclyde, G11 6NT, United Kingdom
Travere Investigational Site

Carshalton, Surrey, SM5 1AA, United Kingdom
Travere Investigational Site

Cardiff, West Glamorgan, CF14 4XW, United Kingdom
Travere Investigational Site

Birmingham, West Midlands, B9 5SS, United Kingdom
Travere Investigational Site

Liverpool, L9 7AL, United Kingdom
Travere Investigational Site

London, E1 1FR, United Kingdom
Travere Investigational Site

London, SE5 9RS, United Kingdom

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