New pill shrinks VHL kidney tumors in early trial

NCT ID NCT03401788

First seen Apr 14, 2026 · Last updated May 13, 2026 · Updated 3 times

Summary

This study tests a drug called belzutifan (PT2977) in 50 people with VHL syndrome who have kidney cancer. The goal is to see if the drug can shrink tumors. Participants take the drug by mouth and are monitored for response. This is a phase 2 trial, meaning it is still being studied for safety and effectiveness.

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Contacts and locations

Locations

  • Aarhus University Hospital

    Aarhus, Denmark

  • Cambridge University Hospital

    Cambridge, United Kingdom

  • Hospital Georges Pompidou

    Paris, France

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Pennsylvania Medical Center

    Philadelphia, Pennsylvania, 19104, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15232, United States

  • Vanderbilt Medical Center

    Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.