Immunotherapy plus radiation shows promise against bladder cancer

NCT ID NCT04241185

First seen May 02, 2026 · Last updated May 08, 2026 · Updated 2 times

Summary

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemoradiotherapy helps people with muscle-invasive bladder cancer live longer without their cancer returning or spreading. About 520 participants will receive either pembrolizumab or a placebo alongside chemoradiotherapy. The goal is to see if the combination improves bladder-intact event-free survival and overall safety.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 2. LF UK a FN Motol ( Site 0555)

    Prague, 150 06, Czechia

  • A.P.H. Paris. Hopital Bichat Claude Bernard ( Site 0115)

    Paris, 75018, France

  • AOU Careggi ( Site 0191)

    Florence, 50134, Italy

  • Advance Urology and Laparoscopic Center ( Site 0281)

    Ponce, 00716, Puerto Rico

  • AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlandoc ( Site 0004)

    Orlando, Florida, 32804, United States

  • Ankara Universitesi Tip Fakultesi. ( Site 0502)

    Ankara, 06100, Turkey (Türkiye)

  • Asan Medical Center ( Site 0200)

    Seoul, 05505, South Korea

  • Austin Health ( Site 0218)

    Heidelberg, Victoria, 3084, Australia

  • Azienda Ospedaliero - Universitaria Policlinico di Modena ( Site 0188)

    Modena, 41124, Italy

  • BAZ Megyei Korhaz. Klinikai Onkologia es Sugarterapias Centrum ( Site 0092)

    Miskolc, Borsod-Abauj Zemplen county, 3526, Hungary

  • Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 0095)

    Kecskemét, Bács-Kiskun county, 6000, Hungary

  • Baltimore VA Medical Center ( Site 0054)

    Baltimore, Maryland, 21201, United States

  • Bay Pines VA Medical Center ( Site 0055)

    Bay Pines, Florida, 33744, United States

  • Betsi Cadwaladr University Health Board ( Site 0447)

    Rhyl, Denbighshire, LL18 5UJ, United Kingdom

  • Bradford Hill Norte ( Site 7052)

    Antofagasta, 1240000, Chile

  • Bradfordhill-Clinical Area ( Site 7051)

    Santiago, Region M. de Santiago, 8420383, Chile

  • CHU Amiens Picardie Site Sud Amiens ( Site 0123)

    Amiens, Somme, 80000, France

  • Carolina Urologic Research Center ( Site 0002)

    Myrtle Beach, South Carolina, 29572, United States

  • Centro Hospitalar e Universitario de Coimbra ( Site 0306)

    Coimbra, 3000-075, Portugal

  • Centro Medico Integral De Cancerología (CEMIC) ( Site 0144)

    Quetzaltenango, 09002, Guatemala

  • Centro de Investigaciones Clinicas de Latinoamerica S.A. - CELAN ( Site 0146)

    Guatemala City, 01010, Guatemala

  • Chaim Sheba Medical Center ( Site 0087)

    Ramat Gan, 5262000, Israel

  • Chang Gung Medical Foundation.Linkou Branch ( Site 0212)

    Taoyuan, 333, Taiwan

  • Chi Mei Medical Center ( Site 0215)

    Tainan, Tainan, 71004, Taiwan

  • Chungnam National University Hospital ( Site 0203)

    Daejeon, Taejon-Kwangyokshi, 35015, South Korea

  • Cleveland Clinic - Hillcrest Hospital-Hillcrest Hospital Cancer Center ( Site 6012)

    Mayfield Heights, Ohio, 44124, United States

  • Cleveland Clinic Main ( Site 0062)

    Cleveland, Ohio, 44195, United States

  • Clinical oncology dispensary of Dnipro ( Site 0133)

    Dnipro, Dnipropetrovsk Oblast, 49055, Ukraine

  • Darlington Memorial Hospital NHS Trust ( Site 0446)

    Darlington, DL3 6HX, United Kingdom

  • Debreceni Egyetem Klinikai Kozpont ( Site 0097)

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • Ege University Medical Faculty ( Site 0508)

    Izmir, 35100, Turkey (Türkiye)

  • Erasmus MC ( Site 0182)

    Rotterdam, South Holland, 3015 GD, Netherlands

  • FALP ( Site 7056)

    Santiago, Region M. de Santiago, 7500921, Chile

  • Fairview Hospital-Moll Cancer Center ( Site 6013)

    Cleveland, Ohio, 44111, United States

  • Fakultni nemocnice Olomouc ( Site 0559)

    Olomouc, 77900, Czechia

  • Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0186)

    Milan, Lombardy, 20133, Italy

  • Fondazione Policlinico Universitario Campus Bio-Medico-Radiation Oncology ( Site 7041)

    Rome, Lazio, 00128, Italy

  • Froedtert and Medical College of Wisconsin ( Site 0022)

    Milwaukee, Wisconsin, 53226, United States

  • GenesisCare North Shore ( Site 0217)

    St Leonards, New South Wales, 2065, Australia

  • Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 0139)

    Kharkiv, Kharkivs’ka Oblast’, 61024, Ukraine

  • Grupo Medico Angeles ( Site 0143)

    Guatemala City, 01015, Guatemala

  • Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0504)

    Istanbul, 34722, Turkey (Türkiye)

  • HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 0106)

    Seville, 41013, Spain

  • Hadassah Medical Center. Ein Kerem ( Site 0086)

    Jerusalem, 9112001, Israel

  • Herlev og Gentofte Hospital. ( Site 0401)

    Herlev, Capital Region, 2730, Denmark

  • Hirosaki University Hospital ( Site 0602)

    Hirosaki, Aomori, 036-8563, Japan

  • Hospital Kuala Lumpur ( Site 0238)

    Kuala Lumpur, 50586, Malaysia

  • Hospital La Fe de Valencia ( Site 0105)

    Valencia, Valenciana, Comunitat, 46026, Spain

  • Hospital Pulau Pinang ( Site 0239)

    George Town, Pulau Pinang, 10990, Malaysia

  • Hospital Universiti Sains Malaysia ( Site 0237)

    Kubang Kerian, Kelantan, 16150, Malaysia

  • IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 0193)

    Bari, Apulia, 70124, Italy

  • Inova Schar Cancer Institute ( Site 6006)

    Fairfax, Virginia, 22031, United States

  • Institut Curie ( Site 0112)

    Paris, 75005, France

  • Institut Sainte Catherine ( Site 0121)

    Avignon, Provence-Alpes-Côte d'Azur Region, 84918, France

  • Institute of Science Tokyo Hospital ( Site 0601)

    Tokyo, 113-8519, Japan

  • Instituto Catalan de Oncologia - ICO ( Site 0103)

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 0249)

    Cluj-Napoca, Cluj, 400015, Romania

  • Institutul Oncologic-Oncologie Medicala ( Site 0256)

    Cluj-Napoca, 400015, Romania

  • Institutul Regional de Oncologie Iasi ( Site 0255)

    Iași, 700483, Romania

  • Istanbul Uni. Cerrahpasa Tip Fakultesi ( Site 0501)

    Istanbul, 34098, Turkey (Türkiye)

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0192)

    Naples, 80131, Italy

  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 0005)

    Hackensack, New Jersey, 07601, United States

  • Kaohsiung Chang Gung Memorial Hospital ( Site 0209)

    Kaohsiung City, 83301, Taiwan

  • Karadeniz Teknik Universitesi Tip Fakultesi ( Site 0503)

    Trabzon, 61080, Turkey (Türkiye)

  • Korea University Anam Hospital ( Site 0205)

    Seoul, 02841, South Korea

  • Kyiv City Clinical Oncology Center ( Site 0135)

    Kyiv, 03115, Ukraine

  • Liverpool Hospital ( Site 0220)

    Liverpool, New South Wales, 2170, Australia

  • MEDI-K ( Site 0142)

    Guatemala City, 01009, Guatemala

  • MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 0253)

    Bucharest, 013812, Romania

  • MNPE Regional Center of Oncology ( Site 0134)

    Kharkiv, Kharkivs’ka Oblast’, 61070, Ukraine

  • Mazowiecki Szpital Wojewódzki w Siedlcach ( Site 0154)

    Siedlce, Masovian Voivodeship, 08-110, Poland

  • MidLantic urology ( Site 0070)

    Bala-Cynwyd, Pennsylvania, 19004, United States

  • Monash Medical Centre ( Site 0216)

    Clayton, Victoria, 3168, Australia

  • Nagasaki University Hospital ( Site 0600)

    Nagasaki, 852-8501, Japan

  • National Cancer Center ( Site 0202)

    Gyeonggi-do, Kyonggi-do, 10408, South Korea

  • National Cheng Kung University Hospital ( Site 0208)

    Tainan, 704, Taiwan

  • National Taiwan University Hospital ( Site 0210)

    Taipei, 10002, Taiwan

  • Nemocnice Na Bulovce ( Site 0556)

    Prague, 180 81, Czechia

  • Netherlands Cancer Institute (NKI) ( Site 0183)

    Amsterdam, North Holland, 1066 CX, Netherlands

  • New York Oncology Hematology P.C ( Site 0024)

    Albany, New York, 12206, United States

  • New York University Perlmutter Cancer Center ( Site 0001)

    New York, New York, 10016, United States

  • North Estonia Medical Centre Foundation ( Site 0081)

    Tallinn, Harju, 13419, Estonia

  • Norton Cancer Institute ( Site 0044)

    Louisville, Kentucky, 40207, United States

  • Nottingham University Hospital NHS Trust ( Site 0250)

    Nottingham, Nottinghamshire, NG5 1PB, United Kingdom

  • ONCOCENTRO APYS-ACEREY ( Site 7054)

    Viña del Mar, Valparaiso, 2520598, Chile

  • Odense Universitetshospital ( Site 0403)

    Odense, Region Syddanmark, 5000, Denmark

  • Oncocentro Valdivia ( Site 7055)

    Valdivia, Los Ríos Region, 5112129, Chile

  • Oncomedica ( Site 0145)

    Guatemala City, 01010, Guatemala

  • Osaka Medical and Pharmaceutical University Hospital ( Site 0604)

    Takatsuki, Osaka, 569-8686, Japan

  • Ospedale Civile di Macerata ( Site 0190)

    Province of Macerata, 62100, Italy

  • Ospedale San Raffaele. ( Site 0194)

    Milan, 20132, Italy

  • PAN American Center Oncologic ( Site 0280)

    San Juan, Rio Piedras, 00935, Puerto Rico

  • Pauls Stradins Clinical University Hospital ( Site 0073)

    Riga, LV-1002, Latvia

  • Petz Aladar Megyei Oktato Korhaz ( Site 0099)

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • Pikeville Medical Center ( Site 0009)

    Pikeville, Kentucky, 41501, United States

  • Policlinica Oncomed SRL ( Site 0254)

    Timișoara, Timiș County, 300239, Romania

  • Rabin Medical Center ( Site 7032)

    Petah Tikva, 4941492, Israel

  • Rambam Health Care Campus-Oncology Division ( Site 0088)

    Haifa, 3109601, Israel

  • Roswell Park Cancer Institute ( Site 6009)

    Buffalo, New York, 14263, United States

  • Royal Preston Hospital ( Site 0449)

    Preston, Lancashire, PR2 9HT, United Kingdom

  • S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 0248)

    Craiova, Dolj, 200542, Romania

  • S.C. Radiotherapy Center Cluj S.R.L ( Site 0252)

    Cluj-Napoca, Cluj, 407280, Romania

  • SNPE National Cancer Institute ( Site 0136)

    Kyiv, 03022, Ukraine

  • Saint Francis Cancer Center ( Site 0026)

    Greenville, South Carolina, 29607, United States

  • Seoul National University Bundang Hospital ( Site 0204)

    Seongnam-si, Kyonggi-do, 13620, South Korea

  • Severance Hospital Yonsei University Health System ( Site 0201)

    Seoul, 03722, South Korea

  • Sir Charles Gairdner Hospital ( Site 0223)

    Nedlands, Western Australia, 6009, Australia

  • Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 0091)

    Kaposvár, 7400, Hungary

  • Soroka Medical Center-Oncology ( Site 7031)

    Beersheba, 8400000, Israel

  • Sourasky Medical Center ( Site 0089)

    Tel Aviv, 6423906, Israel

  • South Devon Healthcare Foundation Trust. Torbay Hospital ( Site 0444)

    Torquay, Devon, TQ2 7AA, United Kingdom

  • Summit Medical Group Cancer Center ( Site 6008)

    Florham Park, New Jersey, 07932, United States

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 0153)

    Krakow, Lesser Poland Voivodeship, 31-826, Poland

  • Szpital Wojewodzki im.M.Kopernika. ( Site 0152)

    Koszalin, West Pomeranian Voivodeship, 75-581, Poland

  • T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Baki-Istanbul Bakirkoy Sadi Konuk Training ( Site 0510)

    Istanbul, 34147, Turkey (Türkiye)

  • Taichung Veterans General Hospital ( Site 0213)

    Taichung, 407, Taiwan

  • Taipei Veterans General Hospital ( Site 0211)

    Taipei, 11217, Taiwan

  • Tartu University Hospital ( Site 0079)

    Tartu, Tartu, 51014, Estonia

  • The Royal Marsden NHS Foundation Trust. ( Site 0442)

    London, London, City of, SW3 6JJ, United Kingdom

  • Tokyo Metropolitan Komagome Hospital ( Site 0606)

    Tokyo, 113-8677, Japan

  • Ukranian Center of TomoTherapy ( Site 0140)

    Kropyvnytskiy, Kirovohrad Oblast, 25011, Ukraine

  • Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 0302)

    Lisbon, 1449-005, Portugal

  • Unidade Local de Saude Loures-Odivelas - Hospital Beatriz Angelo ( Site 0303)

    Loures, Lisbon District, 2674-514, Portugal

  • Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 0305)

    Lisbon, 1649-035, Portugal

  • University College London Hospitals NHS Foundation Trust ( Site 0445)

    London, London, City of, NW1 2PG, United Kingdom

  • University Malaya Medical Centre ( Site 0236)

    Kuala Lumpur, 59100, Malaysia

  • University of Health Sciences,Gulhane School of Medicine-Oncology ( Site 0509)

    Ankara, 06010, Turkey (Türkiye)

  • University of Tsukuba Hospital ( Site 0605)

    Tsukuba, Ibaraki, 305-8576, Japan

  • Urology San Antonio Research ( Site 6010)

    San Antonio, Texas, 78229, United States

  • Washington Cancer Institute at MedStar Washington Hospital Center ( Site 0041)

    Washington D.C., District of Columbia, 20010, United States

  • Washington University ( Site 0003)

    St Louis, Missouri, 63110, United States

  • West Virginia University - Charleston Area Medical Center ( Site 6003)

    Charleston, West Virginia, 25304, United States

  • Westchester Medical Center ( Site 6014)

    Valhalla, New York, 10595, United States

  • Winthrop University Hospital ( Site 0069)

    Mineola, New York, 11501, United States

Conditions

Explore the condition pages connected to this study.