Cell therapy aims to fix stubborn bladder leaks after failed surgery

NCT ID NCT03104517

Ongoing Disease control Sponsor: Cook MyoSite Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new treatment called AMDC-USR (iltamiocel) for women who still have stress urinary incontinence after having surgery for it. The treatment uses the patient's own muscle cells injected into the urinary sphincter to strengthen it. Half of the 96 participants get the cell injection, half get a placebo, and researchers track how many leaking episodes they have.

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Conditions

The condition(s) this trial relates to.

female stress incontinence Lower Urinary Tract Symptoms nocturnal enuresis Urinary Incontinence Urinary Incontinence, Stress urinary system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STRESS URINARY INCONTINENCE

Contacts and locations

Locations

AccuMed Research Associates

Garden City, New York, 11530, United States
American Association of Female Pelvic Medicines Research Institute

Westlake Village, California, 91361, United States
Atrium Health

Charlotte, North Carolina, 20207, United States
Bennett Institute of Urogynecology and Incontinence

Grand Rapids, Michigan, 49456, United States
Cedar Health Research

Irving, Texas, 75062, United States
Cleveland Clinic/Glickman Institute-Q10

Cleveland, Ohio, 44195, United States
Columbia University Irving Medical Center

New York, New York, 10032, United States
Del Sol Research Management, LLC

Tucson, Arizona, 85715, United States
Derriford Hospital

Plymouth, Devon, PL6 8DH, United Kingdom
Houston Methodist Hospital

Houston, Texas, 77030, United States
Magee Women's Hospital of UPMC

Pittsburgh, Pennsylvania, 15213, United States
MedStar Georgetown Hospital Department of Urology

Washington D.C., District of Columbia, 20007, United States
Northwell Health/The Arthur Smith Institute for Urology

Lake Success, New York, 11042, United States
San Diego Clinical Trials

La Mesa, California, 91942, United States
Sanford Female Pelvic Medicine and Reconstructive Surgery Clinic

Sioux Falls, South Dakota, 57105, United States
Stanford Hospital and Clinics

Stanford, California, 94305, United States
UCLA Women's Health Clinical Research Unit/Department of OBGYN

Los Angeles, California, 90095, United States
University of Kansas Health System

Kansas City, Kansas, 66160, United States
University of New Mexico Women's Care Clinic

Albuquerque, New Mexico, 87131, United States
Vanderbilt University Medical Center, Dept. of Urologic Surgery

Nashville, Tennessee, 37232, United States
Virginia Mason Medical Center

Seattle, Washington, 98101, United States

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