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Blood marker may flag surgery danger for seniors

NCT ID NCT06959446

Knowledge-focused Sponsor: Chinese PLA General Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at nearly 30,000 older adults (65+) having non-cardiac surgery to see if levels of homocysteine, a natural amino acid, could predict serious complications like kidney injury or death. Researchers measured homocysteine before and after surgery. The goal was to see if changes in this marker could help identify high-risk patients early, allowing doctors to take preventive steps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors identify elderly patients at higher risk for complications after surgery, leading to better monitoring and care.
What could go wrong
This is an observational study, not a treatment trial. It can show links but cannot prove cause and effect. Results may not apply to all patients or surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

29,156 people

The number who actually took part.

Started

Jan 2014

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

An observational study using data from the First Medical Center of Chinese PLA General Hospital, an electronic medical record-based data set of 29156 older patients (≥ 65 years) who had surgery between January 2014 to December 2023

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: •Hospitalized older (≥ 65 years) patients underwent non-cardiac surgery Exclusion Criteria: * Without preoperative Hcy data (n= 44115) * Neurosurgery (n= 3343) * Kidney or renal artery surgery (n= 2478) * Chronic kidney disease (n=577)

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Conditions

The condition(s) this trial relates to.

acute kidney injury Homocysteinemia hyperhomocysteinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AKI - acute kidney injury Elderly Homocysteinemia Mortality Postoperative

More trials for these conditions

Other studies related to the condition(s) this trial covers.