Syndromic disease

This early-phase trial tests whether adding arsenic trioxide to a standard stem cell transplant can prevent the cancer from coming back in people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The study enrolls about 20 patients whose cancers have …

This phase 2 trial tests whether a single injection of EO2002, made from magnetic human corneal endothelial cells, can safely improve vision in people with corneal edema caused by endothelial dysfunction. Participants receive either a low or high dose of cells or a placebo inject…

This phase 3 trial compares two drug combinations for adults with a high-risk form of myelodysplastic syndrome (MDS-IB2) or newly diagnosed acute myeloid leukemia (AML) that is either secondary to prior treatment or occurs in older age. One group receives a standard regimen of az…

This study tests whether bone marrow from deceased donors can be used to treat people with blood cancers like leukemia and lymphoma. Participants receive a transplant of cryopreserved marrow from a deceased donor or standard cells from a living donor. The goal is to see if the de…

This study tests whether bimekizumab, a drug already approved for other skin conditions, can help heal wounds in people with pyoderma gangrenosum (PG), a rare and painful skin disorder. Adults with PG will receive injections of bimekizumab every few weeks for 24 weeks. The main g…

This study tests whether adjusting chemotherapy doses for each patient can improve outcomes after a stem cell transplant for blood cancers caused by a RUNX1 gene mutation. Up to 98 people aged 4 to 70 with these cancers will receive a transplant from a half-matched donor. The goa…

This trial tests whether specific care strategies used in the intensive care unit after cardiac arrest can improve neurological recovery and survival. Adults who remain comatose after their heartbeat is restored will be cared for using either head elevation or a near-supine posit…

This phase 3 trial is testing whether an investigational drug called UBT251 can reduce the severity of obstructive sleep apnea in people who are obese and do not use positive airway pressure (PAP) therapy. Participants will receive weekly injections of UBT251 or a placebo for 52 …

This pilot study tests whether an herbal supplement called Biocidin REMOVE can clear small intestinal bacterial overgrowth (SIBO) in adults with irritable bowel syndrome (IBS). SIBO involves an overgrowth of bacteria in the small intestine, which can worsen IBS symptoms. About 40…

This trial tests whether adding a single infusion of zuberitamab to standard steroid therapy can help children aged 1 to 18 with newly diagnosed steroid-sensitive nephrotic syndrome stay relapse-free longer. Participants receive either standard steroids alone or steroids plus zub…

This phase 2 trial is investigating whether adding a ketogenic diet and/or high-dose intravenous vitamin C to standard chemoradiotherapy and immunotherapy can improve outcomes for patients with locally advanced rectal cancer that is mismatch repair proficient (pMMR/MSS). The stud…

This study compares three treatments for obstructive sleep apnea: positive airway pressure (CPAP), a dental device that moves the jaw forward, and a combination of two medications (atomoxetine and oxybutynin). About 2,400 adults with sleep apnea will be randomly assigned to one o…

This trial is testing an investigational drug called mizagliflozin to see if it can prevent low blood sugar (hypoglycemia) in people who experience this condition after bariatric surgery. The study will include adults who had Roux-en-Y bariatric surgery more than a year ago and h…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This Phase 2 trial tests a combination of two drugs—blinatumomab (given as a shot under the skin) and olverembatinib (a pill)—in 60 adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). The goal is to see if this combo can control the disease safely. Pa…

This study tests a new way to treat a fast-growing blood cancer called BCR-ABL positive B-cell acute lymphoblastic leukemia. About 80 adults will receive two drugs: ponatinib pills and blinatumomab injections under the skin. The goal is to see if this combination can control the …

This study tests whether a traditional Chinese herb called Polygonatum sibiricum, or Huangjing, can help reduce visceral fat—the deep belly fat around organs that raises risks for diabetes, fatty liver, and heart disease. Adults with visceral obesity will receive either the herb …

This phase 1b trial tests an experimental drug called ST316 in adults with familial adenomatous polyposis (FAP) who have already had their colon removed but still develop new polyps. The study aims to see if ST316 is safe and can reduce the number and size of polyps that grow bac…

This trial tests whether an experimental drug called efgartigimod can reduce nerve damage and pain in adults with Sjogren's disease. Participants will receive either the drug or a placebo as a subcutaneous injection. The study measures changes in neuropathy symptoms and quality o…

This trial tests whether adding the immunotherapy drugs cemiplimab (with or without fianlimab) to standard chemotherapy before chemoradiation can improve outcomes for people with advanced nasopharyngeal cancer. About 60 adults with non-metastatic, EBV-positive nasopharyngeal carc…

This study looks at whether a newer opioid painkiller, oliceridine, is less likely than the standard sufentanil to cause breathing problems after surgery in people at high risk of obstructive sleep apnea. About 851 adults with known or suspected sleep apnea will receive one of th…

This trial tests whether an experimental cell therapy called agenT-797 is safe for people receiving a stem cell transplant for blood cancers like leukemia or myelodysplastic syndrome. Participants get an infusion of agenT-797 about a week after their transplant. The main goal is …

This trial tests whether using a colorimetric carbon dioxide (CO₂) detector to guide non-invasive breathing support (ventilation) improves care for premature infants born before 32 weeks. The detector changes color to show how well the baby is exhaling CO₂, which may help doctors…

This trial tests a new device called VividFlo, a small implant placed under the eye's surface to help drain fluid and lower pressure in people with glaucoma. The study involves 10 adults with glaucoma in one eye, who will receive the implant during surgery. Researchers will track…

This early-stage trial is evaluating an investigational drug called QLS2404, given as an injection, to see if it is safe and tolerable. The study first tests single doses in healthy volunteers, then moves to multiple doses in people with systemic lupus erythematosus or primary Sj…

This study tests whether a new auto-adjusting positive airway pressure (APAP) device with a feature called Kairos PAP (KPAP) works better than a standard APAP device with expiratory pressure relief (EPR) for people with obstructive sleep apnea. Participants, who already use PAP t…

This study looks at whether luspatercept, a drug given as first-line treatment, can help adults with low-risk myelodysplastic neoplasms (MDS) who need regular red blood cell transfusions. Researchers will follow about 190 participants for up to 2 years to see how often they achie…

This early-phase trial is testing an experimental drug called VTRU200 in people with certain blood cancers that have returned or not responded to standard treatments, including acute myeloid leukemia, high-risk myelodysplastic syndromes, and diffuse large B-cell lymphoma after CA…

This Phase 3 trial tests whether a disc made from donated human amnion membrane can help people with moderate to severe dry eye disease. The disc is placed on the eye and compared to standard care like lubricating drops and a bandage lens. The study will enroll 40 adults who have…

This study tests whether personalized ventilator settings can reduce lung injury in adults with severe respiratory failure who are on ECMO (a heart-lung machine). Researchers will use esophageal manometry or electrical impedance tomography to tailor the ventilator's positive pres…

This phase 2 trial is testing whether an investigational drug called arumakimig can improve symptoms of VEXAS syndrome, a rare genetic autoinflammatory condition. The study will compare arumakimig against a placebo in about 120 adults with VEXAS, with the goal of seeing if the dr…

This trial tests the drug mercaptopurine in people with hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a rare genetic condition that raises the risk of skin, uterine, and kidney tumors. The study aims to find the safest dose and see if the drug can shrink kidney canc…

This trial tests whether antiplatelet medications, specifically clopidogrel and aspirin, can reduce inflammation in the blood vessels of people with psoriasis or psoriatic arthritis. Participants take each drug or a placebo for four weeks, and researchers measure changes in infla…

This study tests whether the drug ganaxolone can reduce seizures in children aged 6 months to 2 years with CDKL5 deficiency disorder, a rare genetic condition causing hard-to-control seizures. Twenty children will receive either ganaxolone or a placebo alongside their usual seizu…

This trial investigates whether a sensitive blood test (Signatera) can detect when it is safe to pause immunotherapy in people with advanced solid tumors like lung cancer, melanoma, and colorectal cancer. Participants are randomly assigned to either continuous standard immunother…

This phase 2 trial is testing whether the combination of avutometinib and defactinib can stop or shrink malignant peripheral nerve sheath tumors (MPNST) that have returned or cannot be removed with surgery. The study enrolls people over 12 years old with relapsed, refractory, met…

This study tests whether pacing the heart from a specific spot (posterosuperior bundle) can lower the chance of atrial fibrillation (AF) in people with sinus node dysfunction (a slow or irregular heartbeat). About 300 adults who need a pacemaker will be randomly assigned to get p…

This Phase 3 trial is testing whether an experimental drug called adimanebart can help people aged 12 and older with certain congenital myasthenic syndromes (CMS) feel better and do daily activities more easily. Participants are randomly assigned to receive either adimanebart or …

This study looks at people with COMISA, a condition where obstructive sleep apnea and insomnia occur together. Many people with this combination struggle to use CPAP, a standard treatment for sleep apnea, consistently. The study will compare those who take daridorexant, a sleep a…

This study tests whether a daily probiotic supplement, Bifidobacterium adolescentis PRL2019, can reduce pain in young people aged 9 to 25 with juvenile fibromyalgia, a condition marked by widespread musculoskeletal pain. Participants will take the probiotic or a placebo for 12 we…

This clinical trial is testing whether an experimental eye drop called OT202 can improve symptoms and repair the eye surface in people with moderate to severe dry eye. About 842 adults aged 30 to 75 with a history of dry eye will receive either OT202 or a placebo drop three times…

This trial tests an experimental oral drug, ofirnoflast, in adults with lower-risk myelodysplastic syndromes (MDS) who have anemia and need regular red blood cell transfusions. The goal is to see if the drug can reduce or eliminate transfusion needs and improve blood counts. Part…

This phase 3 trial tests a drug called tralesinidase alfa in 14 children aged 1-5 with Sanfilippo syndrome type B, a rare genetic disease that causes severe brain damage. The drug is given directly into the brain fluid to replace a missing enzyme. The goal is to see if it can slo…

This trial tests whether heart attack patients who have had complete artery-opening procedures can safely stop aspirin after 3-6 months and continue with only a P2Y12 inhibitor. The goal is to see if this approach reduces bleeding problems without increasing the risk of another h…

This phase 2 trial is testing whether an experimental drug called DDY391 can reduce disease activity and improve symptoms like dryness, pain, and fatigue in people with Sjögren's disease. About 344 participants will receive either DDY391 at one of three dose levels or a placebo f…

This trial investigates whether adding a PCSK9 inhibitor to a high-intensity statin can reduce liver fat—measured by a non-invasive FibroScan—in diabetic patients who have recently had a heart attack or unstable angina. Half the participants will receive the combination therapy, …

This phase 2 trial tests whether using a comprehensive geriatric assessment to guide treatment selection can reduce side effects and improve outcomes in adults aged 60 and older with newly diagnosed acute myeloid leukemia. Participants are classified as fit, vulnerable, or frail,…

This trial tests whether a hybrid cardiac telerehabilitation program — combining in-person sessions, live video workouts, and remote monitoring — can improve adherence to exercise rehab in people with coronary artery disease or stable heart failure. Participants are randomly assi…

This trial investigates whether eating purple-fleshed potatoes daily for four weeks can improve blood pressure and other heart health markers in men with prehypertension. Participants will consume either purple or white potato puree in a crossover design, with measurements taken …

This trial tests whether a miniscrew-assisted rapid palatal expander (MARPE) can reduce obstructive sleep apnea severity in people aged 16 to 60. Participants are randomly assigned to receive either standard care alone or standard care plus the expander, which widens the upper ja…

This phase II trial tests an experimental drug called QLS7305 in people with several kidney diseases driven by overactivation of the complement system, a part of the immune system. The drug is a small interfering RNA (siRNA) designed to reduce production of complement protein C3,…

This phase 1 trial is testing an experimental drug called ATG-201 in adults with systemic lupus erythematosus, systemic sclerosis, or Sjögren's disease. ATG-201 is designed to bind to specific proteins on immune cells, potentially quieting the overactive immune response that driv…

This pilot study tests whether an antioxidant cocktail called Rett-T can improve motor function in children and adolescents with Rett syndrome, a rare genetic disorder that affects movement and coordination. Participants, aged 2 to 21 and at least partially able to walk, will rec…

This trial investigates whether a 12-week supervised exercise program, done during regular hemodialysis sessions, can improve postural problems like hunched back and forward head posture in adults with end-stage renal disease. Participants will be randomly assigned to either the …

This trial tests whether a gradual dosing schedule of cannabidiol oral solution (CBD-OS) can help reduce seizures in adults with Lennox-Gastaut syndrome, a severe form of epilepsy. Participants will take CBD oil alongside their usual seizure medications. The study measures how ma…

This phase 2 trial is testing whether an oral drug called ICP-488 can reduce disease activity in people with primary Sjögren's syndrome, an autoimmune condition that causes dry eyes, dry mouth, and fatigue. About 240 adults aged 18 to 70 with moderate-to-active disease will recei…

This trial tests whether an AI system can help doctors choose better ventilator settings for children (ages 1 month to 18 years) in the pediatric ICU who need a breathing machine. Half of the children will receive standard care, while the other half will have their ventilator adj…

This trial tests whether inebilizumab, an antibody that wipes out certain immune cells called B cells, can improve physical function in adults with ME/CFS that started after an infection. Participants receive three infusions over six months, and the study measures changes in mobi…

This trial tests whether removing the tonsils at the same time as implanting a hypoglossal nerve stimulator improves treatment for obstructive sleep apnea in adults whose airway collapses from the side during sleep. Participants are randomly assigned to receive the nerve stimulat…

This phase 2 trial is testing whether combining an experimental drug called S-531011 with a precise radiation technique known as RadScopal can help control metastatic colorectal cancer that has not responded to prior treatments. The study enrolls about 30 adults with advanced dis…

This trial investigates whether continuous positive airway pressure (CPAP) can help adults with sickle cell disease recover faster from acute chest syndrome, a serious lung complication. Participants who need extra oxygen are randomly assigned to receive either standard oxygen al…

This phase 3 trial tests whether roxadustat, an oral drug that stimulates red blood cell production, can help people with myelodysplastic syndromes (MDS) who need frequent blood transfusions. Participants with very low, low, or intermediate risk MDS and a high transfusion burden …

This early-stage trial is testing an experimental drug called AMX-883, taken by mouth, for people with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or not responded to standard treatments. The study will first test AMX-883 alone, th…

This study tests whether a daily supplement called Enzymax DuoBiotics can ease symptoms of irritable bowel syndrome (IBS) in adults. The supplement combines digestive enzymes that break down food in the stomach with a probiotic and prebiotic that support gut bacteria in the intes…

This trial tests whether adding a clinical pharmacist to dental care can improve how oral mucosal disorders — such as oral lichen planus, recurrent canker sores, burning mouth syndrome, oral thrush, and herpes infections — are managed. Dentists in some clinics will get pharmacist…

This trial tests a cryotherapy procedure that freezes and destroys excess fat in the upper airway to reduce airway collapse during sleep. It enrolls adults with moderate-to-severe obstructive sleep apnea who cannot use standard treatments like CPAP. The study measures whether the…

This trial investigates whether keeping magnesium levels in the upper normal range can lower the amount and duration of norepinephrine, a drug that raises blood pressure, in adults with septic shock. Participants are randomly assigned to receive individualized magnesium infusions…

This trial tests several drugs in people with NF2-related schwannomatosis, a condition that causes tumors on nerves and in the brain. The study uses a flexible 'platform' design to evaluate treatments for four tumor types: vestibular schwannomas, non-vestibular schwannomas, menin…

This phase II trial tests whether a personalized dendritic cell vaccine targeting the Survivin protein can improve survival in people with newly diagnosed glioblastoma, an aggressive brain cancer. Participants receive the vaccine alongside standard chemotherapy after surgery. The…

This pilot trial tests whether a special cartridge placed in a blood-filtering machine can improve outcomes for people with septic shock, a severe and often deadly infection response. The cartridge is designed to remove inflammatory molecules from the blood, which may reduce orga…

This study tests whether a traditional Chinese herbal formula called Hewei Anchang Formula can ease overlapping symptoms of functional dyspepsia (indigestion) and diarrhea-predominant irritable bowel syndrome (IBS-D). Researchers will give 120 adults either the herbal granules or…

This pilot study tests an implantable device that stimulates the hypoglossal nerve to keep the airway open during sleep. It is for adults with moderate-to-severe obstructive sleep apnea who have tried but cannot tolerate a CPAP machine. The goal is to see if the device is safe an…

This phase 3 trial tests whether an experimental drug called NPI-001 can slow the loss of light-sensing cells in the eyes of adults with Usher syndrome, a genetic condition that causes both hearing and vision loss. About 80 participants take either NPI-001 or a placebo twice dail…

This study tests a combination of four drugs—sotoclax, carfilzomib, lenalidomide, and dexamethasone (called SonKRd)—in people newly diagnosed with multiple myeloma that has a specific genetic change called t(11;14). Participants must be healthy enough for a stem cell transplant. …

This pilot study tests a personalized lifestyle program called PRISM for adults with metabolic syndrome and insulin resistance. Participants follow a time-restricted eating schedule (eating all meals within an 8-hour window) and are later assigned extra lifestyle changes like phy…

This phase 2 trial tests whether a once-weekly oral combination of decitabine-cedazuridine and venetoclax is safer and as effective as standard therapy for people with relapsed or refractory acute myeloid leukemia, high-risk myelodysplastic syndrome, or high-risk myeloproliferati…

This trial investigates whether a blood-filtering device called CytoSorb can reduce damage to blood vessels in people with septic shock, a life-threatening condition. The device removes inflammatory molecules from the blood. Researchers will measure changes in a marker of vessel …

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This study tests whether a modified version of the Crohn's Disease Exclusion Diet (CDED) can ease symptoms of non-constipation irritable bowel syndrome (IBS) better than the standard low FODMAP diet. About 150 adults with moderate-to-severe IBS will follow one of the two diets fo…

This phase 2 trial tests an experimental oral drug called CBP-0276 in adults with active psoriatic arthritis, a condition causing joint pain, swelling, and skin plaques. Participants receive either a low dose (200 mg), a high dose (800 mg), or a placebo daily for 24 weeks. The ma…

This trial tests the drug selumetinib in people with NF2-related schwannomatosis, a genetic condition that causes non-cancerous tumors on nerves, often leading to hearing loss. The study includes both adults and children whose tumors cannot be surgically removed or are growing. R…

This trial tests whether combining two drugs—luvometinib (a targeted therapy) and serplulimab (an immunotherapy)—can shrink tumors and improve hearing in people with NF2-related schwannomatosis. Participants have progressive vestibular schwannomas or meningiomas that are not suit…

This study investigates whether combining high-intensity interval training (HIIT) with intermittent fasting (14-hour fast, 10-hour eating window) can reduce insulin resistance in obese women with polycystic ovary syndrome (PCOS). Participants will follow a supervised exercise pro…

This study tests an experimental therapy called GKL-006RTU, made from a type of immune cell (iNKT cells), for people with moderate to severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. The trial has two parts: first, a small group receives the c…

This trial tests whether tocilizumab, an anti-inflammatory drug, can stop the progression of calciphylaxis—a rare condition where calcium buildup blocks skin blood vessels, causing painful, non-healing wounds. Ten adults with calciphylaxis and end-stage kidney disease will receiv…

This trial tests a device called Nucleocore that removes cell-free DNA (cfDNA) from the blood of people with septic shock. High cfDNA levels are linked to severe inflammation and worse outcomes. The study enrolls adults aged 18-65 with septic shock and elevated cfDNA, and measure…

This trial investigates whether therapeutic plasma exchange — a procedure that filters the blood to remove harmful substances — can reduce deaths in critically ill children with severe sepsis or septic shock. Participants are randomly assigned to receive either standard sepsis ca…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This trial tests a comprehensive self-management program for adults with irritable bowel syndrome (IBS). The program includes education, symptom tracking, relaxation, diet advice, and problem-solving over eight sessions. Researchers want to see if it is feasible and acceptable, a…

This study tests whether adding hands-on cooking classes to standard Mediterranean diet advice helps adults aged 30-60 with metabolic syndrome improve their health. Participants receive either diet counseling alone or counseling plus culinary training, including recipe booklets a…

This study tests whether a combination of dexamethasone, intravenous immunoglobulin (IVIG), and extra donor immune cells can safely lower harmful antibodies that attack donor stem cells in half-matched (haploidentical) transplants. The trial enrolls 60 adults aged 18–65 with bloo…

This trial tests a new gene therapy called FOXP3-T4 for people with IPEX syndrome, a rare genetic condition that causes severe immune problems. The therapy involves taking a patient's own immune cells, modifying them in the lab to work better, and giving them back via a single in…

This study explores whether a carefully designed, low-impact exercise program is safe and practical for people with vascular Ehlers-Danlos syndrome (vEDS), a rare condition that weakens blood vessels and organs. Researchers are working with patients and doctors to create a 12-wee…

This study tests a stepwise injection plan for adults with joint hypermobility and instability who haven't improved enough with physical therapy. The first step uses dextrose prolotherapy to stimulate healing in ligaments. If that doesn't reduce pain by at least 40%, participants…

This trial investigates whether edaravone dexborneol sublingual tablets can improve blood-brain barrier function in people with CADASIL, a genetic condition that causes small strokes and cognitive decline. About 60 adults aged 18 to 80 with confirmed CADASIL will be observed for …

This early-phase trial tests a new therapy called META 10-19 for people with autoimmune hemolytic anemia (AIHA) that has not responded to standard treatments. AIHA is a condition where the immune system mistakenly destroys red blood cells, causing anemia. META 10-19 uses a patien…

This study tests whether pelvic floor muscle training (PFMT) with a handheld biofeedback device can improve erectile function and sexual quality of life in men with functional hypogonadism (low testosterone) and erectile dysfunction. Participants are randomly assigned to PFMT wit…

This study tracks people with severe eosinophilic asthma who already take Fasenra (benralizumab) every 8 weeks. Participants use electronic monitors on their regular inhalers and a study-provided rescue inhaler (AirSupra) to see if asthma control stays steady throughout the dosin…

This early-stage trial tests a new drug called JR-446 in 12 children under 6 with MPS IIIB, a rare genetic disorder that damages the brain and body. The main goal is to see if the drug is safe and tolerable. Researchers will also measure changes in certain substances in the body …

This trial investigates whether giving obese women with polycystic ovary syndrome (PCOS) a GLP-1 receptor agonist (a drug that helps control appetite and blood sugar) along with healthy lifestyle education for 12 weeks before starting fertility treatment can improve their chances…

This clinical trial investigates whether Jingfang Granules, a traditional Chinese herbal medicine, can safely and effectively reduce symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D) in people with a specific pattern called cold-dampness disturbing spleen syndrome…

This trial investigates whether lemborexant, a sleep medication, can reduce the number of breathing pauses in adults with moderate obstructive sleep apnea who have a low arousal threshold (wake up easily). Participants take either lemborexant or a placebo daily for 30 days in thr…

This study compares two treatments—albumin and fresh frozen plasma—for children with idiopathic nephrotic syndrome who have fluid buildup that doesn't respond to standard diuretics. The goal is to see which approach resolves swelling faster and more safely. Fifty-six children age…

This trial investigates whether patients with acute coronary syndrome can safely stop taking aspirin soon after a heart stent procedure and continue with only a potent antiplatelet drug (ticagrelor or prasugrel). The standard approach is to take both aspirin and a P2Y12 inhibitor…

This study tests whether a proactive, pharmacist-led telephone program can help people who have had a heart attack reach safer cholesterol levels. Participants receive pharmacist calls, repeat blood tests, and medication adjustments based on national guidelines. The goal is to se…

This study tests whether adding a drug called inclisiran to standard cholesterol-lowering therapy (statins) helps people who recently had a heart attack or unstable angina lower their LDL ('bad') cholesterol more than statins alone. About 300 adults in Saudi Arabia will receive e…

This trial tests whether a less intensive antiplatelet therapy is safer and as effective as standard dual therapy for people with spontaneous coronary artery dissection (SCAD), a rare cause of heart attack in women aged 30–55. Unlike typical heart attacks, SCAD involves a tear in…

This study tests whether special blood purification devices can help people with septic shock, a life-threatening condition where infection causes organ failure. The trial includes adults aged 18 to 80 with severe septic shock. Depending on their level of endotoxins, patients rec…

This study tests the drug upadacitinib (Rinvoq) in 30 people with rare genetic disorders that overactivate the JAK-STAT immune pathway. The trial has four phases over 12 months, including an open-label phase to find the best dose and a randomized withdrawal phase to compare the d…

This study tests an oral drug, AV078, in people aged 12 and older with tuberous sclerosis complex (TSC) whose seizures are not controlled by standard medications. Participants are randomly assigned to receive AV078 or a placebo for 12 weeks. The goal is to see if AV078 safely red…

This study tests an investigational drug called XTMAB-16 in people with pulmonary sarcoidosis, a condition that causes inflammation and scarring in the lungs. The trial aims to see if the drug can improve lung function (measured by forced vital capacity) and quality of life. Part…

This study tests a new way of using a breathing machine (ventilator) called time-controlled adaptive ventilation (TCAV) in people with severe lung injury from pneumonia. The goal is to see if TCAV reduces fluid buildup in the lungs compared to standard ventilation. The trial invo…

This pilot study tests a temporary, flexible tube called a duodenal-jejunal bypass sleeve. It is placed in the upper intestine using an endoscope and left for 3 months to help with weight loss and improve metabolic syndrome. The study involves 20 adults with obesity or excess wei…

This study looks at two different chemotherapy combinations given before a half-matched stem cell transplant in adults with myelodysplastic syndrome (MDS). One regimen is designed for people aged 55 and older to reduce side effects, while the other is a standard stronger regimen …

This trial investigates whether adding bortezomib and sitagliptin to standard post-transplant cyclophosphamide can prevent graft-versus-host disease (GvHD) in adults with blood cancers receiving a stem cell transplant. Participants receive the drug combination after transplant, w…

This study compares two common treatments for moderate obstructive sleep apnea: a custom mouth device that moves the jaw forward (MAD) and a machine that blows air through a mask (CPAP). Researchers want to see how well each treatment improves breathing during sleep and reduces d…

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This study tests whether the drug metyrapone can safely lower cortisol levels in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands produce too much cortisol. Participants will receive either metyrapone or a placebo for a short period, and…

This study tests a new drug called EPN-701 for calciphylaxis, a rare condition causing painful skin sores with no approved treatment. About 60 adults with moderate to severe pain and at least one open sore will receive the drug. The main goals are to see if EPN-701 safely reduces…

This phase 2 trial tests whether adding bexmarilimab, an antibody that targets Clever-1, to standard azacitidine chemotherapy improves outcomes for adults with newly diagnosed higher-risk myelodysplastic syndromes (HR-MDS). Participants are randomly assigned to receive one of two…

This study tests a new injectable drug called depemokimab in 30 children aged 6 to 11 with asthma that involves a specific type of inflammation. The drug is given alongside their usual asthma medicines to see how the body processes it, how well it works, and if it is safe. The go…

This phase 2 trial tests whether eye drops containing infliximab, a drug that blocks a key inflammatory protein, can safely improve severe dry eye in people with Sjögren's syndrome. 38 adults will receive either the active drops or a steroid drop for 6 weeks. The study measures s…

This study tests whether giving personalized maintenance therapy after a stem cell transplant can prevent cancer from coming back in people with certain blood cancers. About 450 adults with myeloid cancers who have signs of disease before transplant will be assigned to treatment …

This study tests if a monthly injection of Compound Betamethasone (Diprospan) works better than daily prednisone pills for people with early-stage pulmonary sarcoidosis. About 126 participants will receive either the injection or pills for 24 weeks, with lung function tests and s…

This study investigates whether a supervised, adapted physical activity program can improve how the body burns fat during walking in women with overweight or obesity, both with and without polycystic ovary syndrome (PCOS). Researchers will compare changes in fat oxidation and oth…

This study tests whether removing a specific type of immune cell (naive T cells) from a donor's stem cell graft can prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the recipient's body. The trial enrolls people with non-malignant blood di…

This phase 3 trial tests whether adding a platelet-boosting drug (rhTPO) to standard cyclosporine therapy can safely raise platelet counts in 78 adults with lower-risk myelodysplastic syndromes (MDS) who have very low platelets. The goal is to reduce bleeding and the need for pla…

This pilot study tests a new dialysis catheter coated with Endexo technology, designed to resist blood clots and reduce infections. Researchers will compare its performance to older catheters in 50 adults with end-stage kidney disease. If successful, it could improve quality of l…

This study compares two common ways to access the blood for dialysis: a tunneled catheter (a tube placed in a large vein) versus a surgically created fistula (connecting an artery to a vein). The trial will enroll 220 patients aged 60 or older (or younger but with multiple health…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This study looks at whether icosapent ethyl, a purified fish oil medication, can reduce inflammation and improve heart structure in people with coronary artery disease. Researchers will follow 420 patients for one year, comparing those who receive standard care plus icosapent eth…

This study tests a new medicine called empasiprubart in teenagers aged 12 to 17 who have a rare nerve disease called CIDP. The goal is to find the right dose and see if the drug is safe and helps control the disease. Participants will receive the drug for about 27 months and be f…

This phase 2 trial tests whether adding two drugs (SHR2554 and azacitidine) to standard chemotherapy before a stem cell transplant can help people with high-risk or relapsed/refractory acute leukemia or myelodysplastic syndromes. About 180 participants aged 15-60 will be randomly…

This phase 2 trial is testing a new way to treat adults newly diagnosed with a specific type of acute lymphoblastic leukemia (Ph-negative B-ALL). Instead of standard high-dose chemotherapy, patients receive a mix of low-dose chemo plus several targeted drugs (inotuzumab ozogamici…

This study compares a moderate statin (pitavastatin) combined with ezetimibe against high-intensity statins (atorvastatin or rosuvastatin) in patients aged 75+ with coronary artery disease who need a stent. The goal is to see if the combo is just as good at preventing heart attac…

This early-stage trial tests R-3750, a live biotherapeutic product, in 20 adults with late-stage acute respiratory distress syndrome (ARDS). The main goal is to see if it is safe and tolerable, while also checking for signs of improved lung function and less need for a ventilator…

This early-stage study tests a new injection called CM336 in 30 adults with active Sjogren's syndrome. The main goal is to check safety and how the body handles the drug. Researchers will also look for signs that it helps control the disease. This is a Phase 1 trial, so it's one …

This trial tests a new automated radiation method that precisely targets bone marrow and lymph nodes before a stem cell transplant. The goal is to kill cancer cells while reducing damage to healthy tissues. Participants have high-risk myeloid cancers like acute myeloid leukemia o…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This trial investigates whether adding selinisole to standard chemotherapy drugs (azacitidine and venetoclax) can improve outcomes for people with newly diagnosed, high-risk myeloid tumors that have a TP53 mutation. These tumors are aggressive and hard to treat. The study will me…

This study compares myo-inositol alone versus myo-inositol plus alpha-lactalbumin in 82 women with PCOS who want to conceive. Over 12 weeks, researchers will track pregnancy rates, menstrual regularity, and metabolic changes. The goal is to see if adding alpha-lactalbumin improve…

This study tests whether adding brain-challenging exercises (like reacting to lights while moving) to standard physical therapy helps people recover better after shoulder stabilization surgery. Thirty-two adults who had surgery for shoulder instability will be randomly assigned t…

This study tests two experimental drugs, goflikicept and olokizumab, in 52 adults with Still's disease, a rare inflammatory condition. The goal is to see if these drugs can quickly bring the disease under control and keep it from flaring up. Participants will receive either the s…

This phase 2 trial tests a combination of two drugs—becotatug vedotin (a targeted therapy) and pucotenlimab (an immunotherapy)—as a first treatment for advanced head and neck squamous cell carcinoma. It is for patients whose cancer has returned or spread and who cannot tolerate p…

This early-stage trial tests a new drug called LP-118 alongside standard treatments for adults newly diagnosed with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). The study will enroll 26 people to find the safest dose and see if the combination helps control the d…

This study tests a drug called all-trans retinoic acid (ATRA) as a first treatment for hemophagocytic lymphohistiocytosis (HLH), a rare but life-threatening condition where the immune system goes into overdrive. ATRA is an oral medication already used for other blood diseases and…

This study tests a drug called pelacarsen in people who recently had a heart attack and have high levels of Lp(a), a type of fat in the blood that raises heart risk. The goal is to see if the drug can safely lower Lp(a) levels and improve heart health. About 240 adults in the US …

This phase 2 trial tests the drug chidamide (Tucidinostat) in 15 people aged 60 or older with intermediate-to-high-risk myelodysplastic syndromes (MDS), a bone marrow disorder that can lead to leukemia. Participants take chidamide orally twice a week for up to 3 months. The study…

This early-phase study tests a new drug (ATRN-119) combined with a standard chemotherapy (decitabine) in 27 adults with acute myeloid leukemia or high-risk myelodysplastic syndrome that has a TP53 gene change. The main goals are to find a safe dose and see if the combo can shrink…

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This study tests a new medicine called Boya IVIG in 50 people with primary immunodeficiency (CVID or XLA), a condition where the body can't fight infections well. Participants get the drug every 21 or 28 days for a year to see if it keeps serious bacterial infections below one pe…

This study compares two types of tonsil surgery for adults with obstructive sleep apnea and enlarged tonsils. One surgery removes the tonsils completely, while the other removes only part of them. The goal is to see if the less invasive approach works just as well at improving br…

This study tests whether insulin eye drops can protect the optic nerve in people with open-angle glaucoma. Researchers will give 90 participants either insulin drops or placebo daily for up to 12 months. The main goal is to check safety, but they will also measure vision changes …

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

This early-stage study tests a new tablet, FXS0683, in 228 adults with blood cancers like lymphoma or leukemia that returned or didn't respond to standard therapy. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will be clo…

This study will test if a smart pill bottle cap, called FORTISKAP™, helps people with serious lung diseases like pulmonary fibrosis, sarcoidosis, and pulmonary hypertension take their oral medications more consistently. About 100 participants will either use the smart cap or rece…

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This first-in-human trial tests a genetic drug called TS1-ASO in 5 children with Timothy Syndrome, a rare condition causing severe heart and brain problems. The drug is injected into the spine to target the genetic root of the disease. The main goal is to check safety and how the…

This study tests a new tool called the Snouda Metabolic Score (SMS) that helps doctors identify the specific metabolic problems driving Type 2 Diabetes in each patient. 150 adults will follow a personalized 24-week lifestyle and nutrition plan based on their SMS results. The goal…

This study tests whether using a patient's genetic information to choose anti-platelet drugs can lower bleeding risks compared to standard care. About 1,760 high-risk patients receiving a heart stent will be assigned to either a personalized drug plan or usual therapy. The goal i…

This trial tests a gene therapy for FHL3, a rare immune disorder caused by a gene mutation. Instead of a donor stem cell transplant, patients receive their own stem cells that have been corrected with a healthy gene. The goal is to restore immune function while avoiding transplan…

This study tests whether a new wire-free imaging method called μFR can help doctors decide which blocked heart arteries need stents after a heart attack. About 350 patients with multiple blocked arteries will be randomly assigned to standard care or μFR-guided treatment. The goal…

This study tests whether a high-flow nasal cannula (HFNC) — a soft tube that delivers warm, humidified air through the nose — works as well as the standard CPAP mask for children with moderate-to-severe obstructive sleep apnea. About 258 children aged 2 to 18 will use one of the …

This study tests whether a drug called colesevelam, normally used for high cholesterol, can help lower levels of PFAS (often called 'forever chemicals') in the blood of veterans. About 50 veterans with high PFAS levels will receive either the drug or a placebo for a period, and r…

This early-phase study tests a new treatment called IASO206 for people whose autoimmune hemolytic anemia (AIHA) has not responded to standard therapies. AIHA is a condition where the immune system mistakenly destroys red blood cells, causing fatigue and other symptoms. The study …

This Phase 2 trial tests whether adding benralizumab (a drug already used for asthma) to standard corticosteroid treatment can help people with DRESS syndrome recover faster and spend fewer days in the hospital. DRESS is a rare, severe allergic reaction to certain medications tha…

This study tests whether ondansetron, a drug typically used for nausea, can reduce the strong urge to breathe in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. By lowering this drive, the drug may prevent patients from overworking their lungs an…

This study looks at how to best give muscle relaxants to patients with severe lung failure (ARDS) who are on a breathing machine. It compares giving the drug as a steady drip versus as separate shots. The goal is to see which method is safer and works better, and to plan a larger…

This study tests a new drug called BL-M11D1 in 92 adults with a type of blood cancer called myelodysplastic syndromes (MDS) that has returned or not improved with standard treatments. The goal is to find the best dose and see if the drug is safe and can shrink or eliminate cancer…

This study looks at whether setting a pacemaker to a personalized rate of 75 beats per minute, instead of the usual 50-60, can improve heart function and blood flow to the brain in people with high blood pressure and a slow heart rate. About 70 patients aged 65 and older will be …

This Phase 2 trial tests whether adding the drug nogapendekin alfa inbakicept (NAI) to standard sepsis care can improve survival in critically ill adults with sepsis and persistently low lymphocyte counts (a sign of immune suppression). About 50 participants will be randomly assi…

This study tests a targeted radiation technique (TMLI) combined with two chemotherapy drugs before a stem cell transplant in people aged 50 and older with acute myeloid leukemia or myelodysplastic syndrome that has not responded to treatment or has returned. The goal is to see if…

This study tests whether combining a nerve-stimulating implant with two medications (atomoxetine and oxybutynin) can improve breathing during sleep more than either treatment alone. Twenty-four adults with obstructive sleep apnea who already have the implant will try each combina…

This early study will test a new way to use deep brain stimulation (DBS) in 4 adults with Lennox-Gastaut syndrome, a severe form of epilepsy. The device will automatically adjust stimulation based on whether the person is awake or asleep. Researchers want to see if this personali…

This study tests whether a sedative called dexmedetomidine can improve survival in people with refractory septic shock, a life-threatening condition where blood pressure stays dangerously low despite standard treatments. The drug aims to calm an overactive stress response that ma…

This study compares a new stent that releases sirolimus and ascorbic acid (vitamin C) to a standard everolimus-releasing stent in over 2,000 people with coronary artery disease. The goal is to see if the new stent is as good at preventing heart-related complications like death, h…

This study is looking at whether a blood test called Galleri can help detect ovarian cancer early in people with BRCA1 or BRCA2 gene changes, who are at higher risk. Participants will give a blood sample and answer questionnaires about their experience. The study will also check …

This trial tests whether a special ultrasound technique can detect heart muscle ischemia (reduced blood flow) in people with suspected acute coronary syndrome. The approach uses microbubbles that stick to activated immune cells and blood vessel linings, potentially revealing infl…

This study tests whether combining several advanced genetic analysis techniques can find the cause of intellectual disability or neurodevelopmental disorders in people who have already had standard genetic testing with no answer. Participants will have their existing genetic data…

This trial compares two blood-test strategies for diagnosing heart attacks in people with chest pain: the standard approach of testing at arrival and again 3 hours later, versus an accelerated approach testing at arrival and again after just 1 hour. The goal is to see whether the…

This trial tests whether performing a sleep study at home through primary care is more cost-effective than the standard hospital-based approach for diagnosing obstructive sleep apnea. Adults with suspected apnea will be randomly assigned to either home testing via their local hea…

This trial tests whether a new ultra-rapid genetic test, using third-generation sequencing, can diagnose familial lymphohistiocytosis (FHL) in children within 5 days instead of the usual 6-8 weeks. FHL is a rare, life-threatening genetic condition where the immune system attacks …

This study tests whether annual liquid biopsies (from blood, urine, stool, and vaginal swabs) can safely replace colonoscopies every 18 months for people with Lynch syndrome. 2,000 participants will be split into two groups: one gets standard care (colonoscopy every 18 months), t…

This study tests whether a combination of blood markers, ultrasound, and genetic information can accurately diagnose metabolic dysfunction-associated steatotic liver disease (MASLD) in children aged 8 to 18 with obesity. Each child provides a blood sample, undergoes a liver ultra…

This trial tests whether a 4-electrode tablet-based ECG (DigitalCardio) can record heart activity as quickly and clearly as the standard 10-electrode ECG. About 50 cardiology patients will undergo both methods in random order. Researchers will measure recording time and compare t…

This study tests whether an automated algorithm called SmartWedge can accurately measure pulmonary artery occlusion pressure (PAOP) in intensive care patients with septic shock. PAOP is a key measurement for guiding treatment, but manual readings can vary. The trial compares the …

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This study compares a new home sleep apnea screening device to the gold-standard in-lab sleep test. Researchers will measure how well the home device detects breathing pauses and oxygen drops in adults referred for a sleep study. The goal is to see if the home test is accurate en…

This study will test a new, non-invasive device that measures blood flow and oxygen levels in the brains of newborn babies. Researchers will compare babies who were exposed to opioids before birth with those who were not. The goal is to see if the device can detect signs of opioi…

This study aims to validate a new blood test that uses artificial intelligence to detect disseminated intravascular coagulation (DIC) early in patients with septic shock. DIC is a severe clotting disorder that often leads to death, but current diagnostic methods are complex and r…

This study will test whether a new, continuous method of measuring heart function (using pressure waves) matches the current standard method (thermodilution) in 43 ICU patients with septic shock. Both methods use the same catheter already placed for treatment. The goal is to see …

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potent…

This study will compare a new radioactive tracer, 18F-AmBF3TATE, to the standard tracer 68Ga-DOTATATE for PET scans in people with neuroendocrine tumors. The goal is to see if the new tracer is as good or better at finding tumors. About 51 participants will receive both tracers a…

This study aims to create an artificial intelligence system that can automatically analyze confocal microscopy images of the cornea to diagnose dry eye disease. Researchers will collect eye scans from 75 adults (healthy and with dry eye) to train and test the AI. The goal is to r…

Extremely preterm infants often have breathing issues that current monitors may miss. This study tests a wireless acoustic sensor placed on the baby's throat to more accurately detect pauses, shallow breaths, and irregular patterns. Researchers will compare the sensor to standard…

This study tests whether a simple, 1-minute electrocardiogram (ECG) analyzed by artificial intelligence can accurately detect significant blockages in the heart's arteries. Researchers will compare the AI's predictions against standard imaging tests in 400 adults. If successful, …

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This trial tests whether cleaning the chewing surfaces of children's teeth with a fine erythritol powder spray (Guided Biofilm Therapy) before applying a protective sealant helps the sealant stay in place longer than the standard rotary-brush polishing. Each child aged 6–10 will …

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This study explores whether offering HIV prevention medication (PrEP) through pharmacies can help more young women aged 18-24 in Tanzania access and consistently use it. Researchers compare four different pharmacy-based service models to standard care, and later test cost-sharing…

This pilot study tests whether a simple program of brief, frequent movement throughout the day can help reduce cardiometabolic risk in rural women. Participants wear a Fitbit that reminds them to move each hour and complete health assessments before and after the 12-week program.…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This study tests whether a special pacifier, called CURAPROX, can reduce the severity of obstructive sleep apnea (OSA) in infants with Down syndrome. Fifty infants will be enrolled at one month old, with half using the pacifier and half not. At six months, sleep tests will measur…

This phase III trial tests whether a vaccine made from a person's own immune cells can prevent cancer in 372 adults with Lynch syndrome, a genetic condition that raises cancer risk. Participants receive either the vaccine or a placebo and are monitored for tumor development. The …

This trial tests whether giving patients a prescription for haloperidol to use as needed at home can help control symptoms of cannabinoid hyperemesis syndrome — a condition marked by severe nausea, vomiting, and abdominal pain from heavy cannabis use. The goal is to see if having…

This study tests whether two hands-on therapies—muscle energy technique and myofascial release—can improve pain, muscle strength, and activation in people with piriformis syndrome, a condition where a deep buttock muscle irritates the sciatic nerve. About 72 adults aged 18–65 wit…

This pilot study tests whether N-acetylcysteine (NAC), an antioxidant supplement, can reduce repetitive and self-injurious behaviors in people with Cornelia de Lange syndrome (CdLS). Ten participants aged 13–35 will receive both NAC and a placebo in random order over 18 weeks. Th…

This study tests whether taking dronabinol (a cannabis-derived medication) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. Th…

This study tests whether a 15-week well-being program can improve mood, reduce IBS symptoms, and boost quality of life in 150 adults with Irritable Bowel Syndrome. Participants will attend weekly one-hour sessions and be followed for up to 9 months. The goal is to see if focusing…

This pilot study tests a new preservative-free eye drop called NOX-01 in people with mild to moderate dry eye who are having cataract surgery. The drop is designed to lubricate and protect the eye surface, potentially reducing the dry eye symptoms that often occur after surgery. …

This study will compare two sedative drugs, remimazolam and dexmedetomidine, in 60 adults with obstructive sleep apnea undergoing drug-induced sleep endoscopy. The goal is to see which drug provides more stable sedation, fewer side effects like low heart rate or low blood pressur…

This trial tests whether a new type of dental splint—made with both hard and soft 3D-printed materials—can improve comfort and outcomes for people with temporomandibular joint (TMJ) disorders. It compares the hybrid splint to conventional chairside splints and standard 3D-printed…

This trial compares two types of exercise—calisthenics (bodyweight moves like squats and planks) and cycling—to see how they affect inflammation and quality of life in young women with irritable bowel syndrome (IBS). Participants, aged 18 to 25, will follow an exercise program wh…

This trial tests whether a daily supplement containing curcumin (from turmeric) and piperine (from black pepper) can reduce pain and improve quality of life in women with fibromyalgia. Participants will be randomly assigned to receive either the active supplement or a placebo for…

This trial tests whether a single application of Kinesio Taping can quickly reduce symptoms and improve grip strength and hand dexterity in adults with thoracic outlet syndrome, a condition where nerves or blood vessels are compressed in the shoulder area. Participants are random…

This study tests a 4-month personalized digital program (PASS) to help people with obstructive sleep apnea start and continue using positive airway pressure (PAP) therapy. Sixty overweight, inactive adults newly diagnosed with sleep apnea will be randomly assigned to either the P…

This trial tests whether a personalized rehabilitation program called Movement Pattern Training can help people with polymyalgia rheumatica (PMR) reduce pain and improve their ability to do daily activities. The program includes motivational interviewing, activity-specific traini…

This study tests two different CPAP devices for people newly diagnosed with obstructive sleep apnea. One device uses a feature called KPAP, the other uses EPR. Researchers will compare how well each device controls breathing pauses during sleep and how patients feel about their s…

This pilot study explores whether a personalized telerehabilitation program can help adults who notice cognitive slips in daily life. Participants include older adults and adults with Ehlers-Danlos Syndrome who report subjective cognitive complaints. Over six weeks, they receive …

This trial tests whether washing out the jaw joint (arthrocentesis) works as well as Botox injections for treating painful temporomandibular joint (TMJ) disorders. Adults with TMJ pain that hasn't improved with standard care will be randomly assigned to one of the two procedures.…

This trial tests whether adding mandala coloring sessions to usual care can reduce pain, fatigue, and sleep troubles in adults with fibromyalgia. Sixty participants will be randomly assigned to either eight supervised coloring sessions over four weeks or to continue their routine…

This early-stage trial is testing an experimental drug called QLS2319 for cancer cachexia — the severe weight loss and muscle wasting that can happen with advanced cancer. The study first gives a single dose to healthy volunteers to check safety, then gives multiple doses to peop…

This trial tests whether two simple distractions — watching a betta fish or playing with a hand puppet — can lower pain, fear, and anxiety in children aged 5 to 7 during a blood draw. One group will use the fish, another the puppet, and a third will receive standard care. Researc…

This study adapts a psychosocial support program called Caregiver Speaks for parents of children with Rett syndrome. Delivered through a private Facebook group over six weeks, the program aims to reduce caregiver stress and improve well-being. Researchers will test whether the ap…

Pseudo-angina is chest pain that feels like a heart attack but comes from muscle knots, not the heart. This trial tests whether two hands-on treatments—Graston Technique (using a stainless-steel tool to massage muscles) and local ischemic compression (sustained finger pressure on…

This trial tests whether a wearable device that gently stimulates the vagus nerve through the ear can reduce pain and PTSD symptoms in veterans who have both conditions. Participants receive six sessions of a brief PTSD therapy along with either active or sham stimulation over fo…

This trial tests whether pain reprocessing therapy (PRT) — a brief psychological treatment that combines education, cognitive restructuring, and body-focused techniques — can reduce chronic pain. Adults with persistent pain lasting over three months are randomly assigned to full …

This study looks at whether adding a continuous saltwater mist to warm, humidified air can make thick lung mucus easier to clear. 35 adults hospitalized with lung conditions like COPD or cystic fibrosis will receive both treatments on separate days. Researchers will measure mucus…

Fibromyalgia causes widespread pain, sleep problems, and fatigue. This trial tests whether a structured breathing technique called box breathing — inhaling, holding, exhaling, and pausing for 4 seconds each — can improve sleep quality, pain, and comfort. Sixty adults with fibromy…

This study tests whether a full-spectrum screen bar light can reduce eye fatigue and dry eye symptoms after two hours of computer work. Healthy adults aged 18 to 35 who use screens at least four hours daily will be randomly assigned to use the light or a standard screen without i…

This phase 2 trial tests whether a traditional Chinese herbal formula called Huanghou Zhixie Diwan can reduce abdominal pain and diarrhea in people with irritable bowel syndrome (IBS-D). About 120 adults aged 18 to 65 who meet specific diagnostic criteria will receive either the …

This study tests whether a four-week online mindfulness-based education program can help women with Polycystic Ovary Syndrome (PCOS) manage menstrual symptoms, lower stress, and improve quality of life. About 78 women with PCOS will be randomly assigned to either the program or r…

This study tests whether a low dose of aripiprazole, a drug used for psychiatric conditions, can reduce fatigue and improve thinking in adults with Long COVID or other post-infection syndromes. About 138 participants will receive either the drug or a placebo for 8 weeks, then swi…

This study tests whether adding a gentle electrical stimulation to the ear — targeting the vagus nerve — can improve pain and function in adults with complex regional pain syndrome type I (CRPS-I) affecting the hand or arm. All participants receive standard rehabilitation, but ha…

This study tests whether adding a gentle muscle-release technique called Strain Counter-Strain to standard Rocabado exercises provides better relief for people with temporomandibular joint (TMJ) dysfunction. The trial includes 44 adults aged 20 to 50 with mild to moderate TMJ pai…

This phase 1 trial tests whether low-energy focused ultrasound can safely and temporarily reduce tics in people with Tourette syndrome. Twenty participants aged 16 and older receive ultrasound to deep brain regions or the motor cortex, or a sham treatment, across four sessions. T…

This study looks at whether starting CPAP therapy early for people with suspected obstructive sleep apnea (OSA) can improve their daytime sleepiness and quality of life while they wait for a formal sleep study. Participants are adults with strong signs of OSA, such as loud snorin…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study looks at whether a 12-session weekly yoga program, added to usual medical care, can help adults with systemic autoimmune and inflammatory diseases (like lupus) feel less tired, have less pain, and improve their mood. Researchers will also check if yoga helps people sti…

This study investigates whether major ozone autohemotherapy — a procedure where a small amount of blood is mixed with ozone and returned to the body — can improve pain, fatigue, sleep, and muscle health in women with fibromyalgia. Sixty participants will receive either exercise a…

This study tests whether adding a muscle relaxant (rocuronium) to standard painkiller (fentanyl) helps doctors place breathing tubes in newborns on the first try, without causing dangerous drops in oxygen or heart rate. About 102 premature or sick babies in a Brazilian NICU will …

This study tests whether an artificial intelligence (AI) and computer vision system can help people with fibromyalgia perform effective exercise at home. Participants use a smartphone or tablet app that watches their movements and gives real-time feedback, with or without added r…

This study compares a new eye drop (perfluorohexyloctane) with a standard one (sodium hyaluronate) for people whose eyes get dry from using screens for more than 6 hours a day. Participants aged 18 to 70 with mild to moderate dry eye will use the drops four times daily for 8 week…

This study compares two manual therapy techniques—myofascial release and post-isometric relaxation—for treating piriformis syndrome, a condition where a muscle in the buttock presses on the sciatic nerve, causing pain, numbness, and tingling. Twenty-six adults aged 20 to 50 with …

This pilot study compares recorded gut-directed hypnosis to an educational recording for hospitalized patients with chronic gut problems, such as irritable bowel syndrome or inflammatory bowel disease. Participants listen to the recordings over the phone while in the hospital for…

This study tests whether the drug zoledronate can reduce pain in children aged 4 to 17 with chronic recurrent multifocal osteomyelitis (CRMO), a rare auto-inflammatory bone disease. The 30 participants have not responded to standard anti-inflammatory drugs. They will receive eith…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve symptoms and quality of life for adults with constipation-predominant irritable bowel syndrome (IBS-C). Participants use an ear clip for 30 minutes daily over 60 days. The trial c…

This study tests whether adding motivational interviewing (a type of counseling) to a home exercise program can improve pain and arm function in people with thoracic outlet syndrome (TOS). Seventy adults with TOS will be randomly assigned to either exercise alone or exercise plus…

This study tests a self-guided digital psychology app, called Manage My Pain, along with weekly email reminders, for people with fibromyalgia or chronic pelvic pain who are on a waitlist for specialized pain care. The goal is to see if this approach is feasible and acceptable, an…

This study tests whether acoltremon eye drops can improve symptoms and tear production in people with dry eye disease over 12 months. Sixty adults will be randomly assigned to receive either the active drug or a standard artificial tear. Researchers will track changes in eye disc…

This study looks at whether a gel-like filler placed in the tear ducts can improve dry eye symptoms and make eye measurements more accurate before cataract surgery. About 65 adults with dry eye disease will be observed. The goal is to see if treating dry eye first leads to better…

This study will test whether guided walks in a forest can reduce chronic pain and improve quality of life in 70 adults with fibromyalgia. Participants will take slow, sensory-focused walks in nature, while researchers measure pain levels and medication use. The goal is to see if …

This study compares two types of artificial tears for dry eye disease: one with preservatives and one without. Researchers want to see which is safer and more effective over 8 weeks. About 80 adults with dry eye will take part, and neither they nor their doctors will know which t…

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This Phase 3 trial tests whether CAM-101 eye drops can reduce eye discomfort and corneal damage in people with moderate to severe dry eye. About 475 adults will receive either CAM-101 or a placebo for 9 weeks, then all participants can switch to CAM-101 for a year. The study aims…

This study looks at whether semi-permanent ear acupuncture can help women with fibromyalgia feel less pain and improve how their nervous system works. Thirty women aged 35 to 64 will get weekly treatments for five weeks. Researchers will measure pain sensitivity and heart rate ch…

This study tests a hands-on technique called manual diaphragmatic release in 60 women with fibromyalgia who are not very active. The goal is to see if it improves exercise capacity, breathing muscle strength, symptoms, and quality of life. Participants will be randomly assigned t…

This study compares a new eyelid support plate to a standard glass rod for eyelid massage in people with dry eye from meibomian gland dysfunction. 142 adults will receive either the new device or standard massage, plus eye drops, over 8 weeks. The goal is to see which method bett…

This study compares two muscle energy techniques—post-isometric relaxation and reciprocal inhibition—for treating piriformis syndrome, a condition causing buttock pain and limited movement. Researchers will enroll 42 adults aged 25-40 with confirmed piriformis syndrome and modera…

This study compares two exercise approaches—short 'exercise snacks' spread throughout the day versus traditional aerobic exercise—in adults with moderate to severe obstructive sleep apnea. Researchers will measure sleep quality, daytime sleepiness, and physical function over 8 we…

This study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …

This study tests whether an internet-based cognitive behavioral therapy (iCBT) program is feasible and helpful for adults with functional gastrointestinal disorders (FGID), like irritable bowel syndrome (IBS). Thirty participants will complete a 10-week online program with therap…

This study tests an experimental eye drop called RCI001 in 200 adults with dry eye disease. Participants will use the drops or a placebo for 4 weeks. The goal is to see if RCI001 reduces eye discomfort and damage to the eye's surface better than placebo. The study is not yet recr…

This study tests whether adding low-level laser therapy to a minor bone-poking procedure (micro-osteoperforations) can speed up tooth movement in people with braces. About 33 patients aged 12-30 will have their canine teeth retracted after premolar extraction. The goal is to shor…

This study tests a 5-day online Theta Healing program—including meditation, visualization, and self-compassion exercises—in 142 women with PCOS. The goal is to see if it reduces fertility anxiety and improves body image compared to usual care alone. Results will be measured 6 wee…

This study tests whether a 12-week program of hamstring strengthening exercises can reduce knee looseness and pain in people with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorders (HSD). Twenty participants will attend two supervised exercise classes p…

This study tests whether shining specific light wavelengths (635, 940, or 1064 nm) on the jaw muscles can reduce pain and improve jaw function in people with chronic jaw muscle disorder (TMD). About 45 adults with moderate-to-severe jaw pain lasting over 3 months will receive sev…

This study is testing a special probiotic supplement in 30 adults aged 50-65 who have ongoing bowel issues like constipation, irritable bowel syndrome, or stomach pain. The goal is to see if the probiotic can improve gut immunity, balance gut bacteria, and ease symptoms like bloa…

This study will test whether sensory motor training for neck muscles, combined with nerve gliding exercises, can improve hand grip strength in 50 post-menopausal women with fibromyalgia-related neck pain. Participants will do laser-guided neck movements and nerve stretches for fo…

This study tests whether injecting botulinum toxin (like Botox) into the piriformis muscle can reduce pain and improve quality of life in people with piriformis muscle syndrome. About 108 adults who have had buttock or leg pain for at least 3 months and haven't gotten relief from…

This study tests a small device called the Serene Sleep Palatal Implant, placed in the soft palate to reduce snoring and mild-to-moderate obstructive sleep apnea. About 26 adults will be split into two groups based on their condition. The main goal is to check safety, like whethe…

This study tests whether light physical activity after meals can improve blood sugar levels in adults with metabolic syndrome and prediabetes. Twenty-five participants will try three routines in random order: sitting, a 15-minute walk, or brief resistance exercises like squats ev…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with mild to moderate chronic fatigue syndrome. 74 participants will receive either real treatment or a sham (placebo) for 60 sessions over 3 months. Researchers wi…

This study will test if a mobile app that gives personalized Mediterranean diet advice can help women with PCOS improve their cholesterol, weight, and overall health. Sixty women will be split into two groups: one using the app and one getting standard lifestyle advice. The goal …

This study looks at two treatments for a jaw joint condition called disc displacement without reduction, which causes pain and trouble opening the mouth. Fifty-two adults who haven't gotten better with standard care will be randomly assigned to get either arthroscopic surgery alo…

This study tests whether Changji'an capsules, a traditional Chinese medicine, can reduce diarrhea and stomach pain in people with irritable bowel syndrome (IBS) where diarrhea is the main symptom. About 636 adults aged 18 to 65 will take the capsule or a placebo for 8 weeks. The …

This study tests whether a culturally tailored text-message program can help Spanish-speaking Hispanic adults with obstructive sleep apnea use their positive airway pressure (PAP) machine more consistently. Fifty adults will receive automated texts that offer support, troubleshoo…

This study tests whether modafinil, a drug used for sleep disorders, can reduce severe fatigue in adults with inactive inflammatory bowel disease (IBD). Sixty participants will take either modafinil or a placebo for 8 weeks, starting at 100 mg daily with possible dose increases. …

This study tests whether taking a daily hot bath (40-42°C for 20 minutes) at home can reduce epileptic seizures in children with CDKL5 deficiency disorder. The trial will include 34 children aged 6 months to 14 years whose seizures are not controlled by medication. Researchers wi…

This study tests which injection mixture works better for people with a displaced jaw joint (TMJ) that still clicks and moves. Twenty adults will receive either a mix of hyaluronic acid and steroids or hyaluronic acid and platelet-rich plasma after a joint washout. The goal is to…

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study tests whether a newer 'splintless' jaw surgery is more accurate and safer than the standard method for treating obstructive sleep apnea. About 66 adults with moderate to severe sleep apnea who cannot use CPAP will be randomly assigned to one of the two surgeries. Resea…

This study tests a device called TearCare that warms the eyelids and manually clears blocked oil glands in young adults (ages 18-29) with dry eye disease. 45 participants will receive one treatment and be checked after 4 weeks to see if symptoms and tear film stability improve. T…

This study tests whether an AI chatbot, combined with nurse support, can help adults with early-stage cardiovascular-kidney-metabolic (CKM) syndrome better manage their symptoms. 72 participants will either use the chatbot plus nurse feedback or standard symptom tracking alone. T…

This study will observe 300 adults who have cataract surgery to see which of three tear substitute eye drops works best for reducing dry eye and discomfort. The drops contain different combinations of sodium hyaluronate, dexpanthenol, trehalose, and amino acids. Researchers will …

This study looks at whether adding sodium bicarbonate (baking soda) to a standard lidocaine injection can provide better pain relief for people with myofascial pain syndrome, a condition causing muscle pain and trigger points. Thirty adults will be randomly assigned to receive ei…

This study looks at whether giving people with obstructive sleep apnea (OSA) access to their nightly oxygen levels can improve their experience with a mouthpiece device (MAD). About 120 adults with mild to severe OSA will either get standard care or also see their oximetry data t…

This study tests whether a structured blinking exercise can improve dry eye symptoms in adults with glaucoma who use eye drops. 45 participants will perform 15 close-squeeze-open blinks three times daily for two weeks. Researchers will measure symptom changes and tear film stabil…

This study tests a brief sleep-focused workshop for people with PMDD who have trouble sleeping. The workshop teaches about sleep and simple strategies to improve it. Researchers want to see if it's practical and helpful, using sleep diaries and activity watches. 72 participants w…

This study asks whether swapping a beef burger for a plant-based pea burger changes how the body handles fats and sugar after a meal. Ten adults with metabolic syndrome (and a BMI of 25 or higher) will eat both types of burgers on separate occasions in a crossover design. Researc…

This study evaluates whether an investigational eye imaging device, UNITY DX, can measure the thickness of the cornea and its epithelial layer as accurately and consistently as a commercially available device. About 110 participants with normal or abnormal corneas will undergo mu…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study evaluates whether several sleepiness questionnaires are reliable for children and adolescents aged 6 to 17. It includes three groups: children from the general population, those with sleep disorders or conditions like narcolepsy or ADHD, and healthy volunteers. The goa…

This study is testing whether an artificial intelligence model can predict which critically ill patients in the intensive care unit (ICU) are at risk of developing multiple organ dysfunction syndrome (MODS), a serious complication where two or more organs fail. Researchers will c…

This study looks at whether brain activity patterns, measured by EEG, can help predict long-term thinking problems in people with sepsis. Researchers will monitor brain waves for 72 hours in 78 ICU patients with different types of inflammation. They will then track cognitive func…

This study investigates whether DNA methylation patterns in blood immune cells can predict which patients with Polymyalgia Rheumatica (PMR) will relapse when corticosteroid treatment is tapered. Researchers will analyze blood samples from 50 PMR patients to see if specific immune…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study investigates Marsili syndrome, a rare genetic condition that reduces sensitivity to pain and injury. Researchers will apply heat, pressure, itch-inducing substances, and knee injections to a small group of people with the condition, measuring their pain and itch respon…

This study looks at whether the amount of air a person breathes in on their own matches the amount they breathe when using a non-invasive ventilation (NIV) mask. It involves 30 adults with acute respiratory failure who are in intensive care. Researchers will measure tidal volume …

This study explores whether a non-invasive, painless skin measurement called electrical bioimpedance can help monitor acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). About 25 adults who are already scheduled for a bone marrow biopsy will also receive this skin te…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study looks at whether certain proteins in the blood, which signal brain injury, can predict memory and thinking problems in people who survive sepsis or septic shock. Researchers will measure these biomarkers in 210 adults admitted to intensive care and check their cognitiv…

This study compares two ways of giving the same experimental biosimilar drug, DRL_AB, which is designed to work like abatacept for autoimmune conditions. Healthy male volunteers receive a single dose either through an autoinjector or a prefilled syringe. Researchers measure how m…

This study looks at how a procedure called temporomandibular joint arthrocentesis—a washout of the jaw joint—affects the masseter muscle, a key chewing muscle. Researchers will use ultrasound and strain elastography to measure the muscle's thickness and elasticity before and afte…

This study compares different bedside methods for choosing the optimal ventilator pressure (PEEP) in patients with moderate-to-severe acute respiratory distress syndrome (ARDS). The goal is to see if these methods give similar results and which one best balances keeping lungs ope…

This study investigates how common malnutrition and sarcopenia (muscle loss) are in children and adolescents with primary ciliary dyskinesia (PCD), a rare genetic condition affecting the lungs. Researchers will measure grip strength, body composition, and nutritional risk in 15 p…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study asks whether children and adolescents with primary ciliary dyskinesia (PCD) — a rare condition affecting the lungs — have poorer nutrition and muscle health than healthy children their age. Researchers will measure hand grip strength, jump power, and other physical and…

This study explores whether polycystic ovary syndrome (PCOS) independently contributes to fatty liver disease in adolescent girls, beyond the effects of obesity. Researchers will compare three groups of girls aged 10–18: those with PCOS and obesity, those with obesity alone, and …

This study aims to better understand tuberculosis (TB) across its entire spectrum—from early, symptom-free infection to active disease and after treatment. Researchers will recruit TB patients and their close contacts to analyze immune responses and identify biomarkers that could…

Sepsis happens when the body's immune response spirals out of control, damaging organs and causing about 1 in 5 deaths worldwide. This study follows 500 adults hospitalized with sepsis to track how their immune systems change over time. Researchers will collect blood samples and …

This study looks at whether a hormone called preptin, which is released alongside insulin, is linked to insulin resistance in women with polycystic ovary syndrome (PCOS). Researchers will measure preptin levels in 60 women diagnosed with PCOS and compare them to markers of insuli…

This observational study tests whether wearable sensors and digital health tools can reliably measure falls, movement, speech, and thinking skills in people with progressive supranuclear palsy, Parkinson's disease, or multiple system atrophy. Participants wear a pendant sensor an…

This study uses a novel ingestible mini-pill to collect bacteria samples from different parts of the gut in people with Sjögren's disease and healthy volunteers. By comparing these samples with mouth and stool bacteria, researchers hope to understand how the microbiome relates to…

This pilot study tests whether a new index, based on changes in hemoglobin levels after a standard fluid infusion, can measure capillary leak in people with septic shock. Researchers will compare this index to known markers of blood vessel damage in 100 ICU patients. If it works,…

This study follows 100 adults with myotonic dystrophy (types 1 or 2) for two years to understand how muscle stiffness, daily function, and heart health change over time. Researchers will look back at up to 18 months of past medical records and then track participants with clinic …

This study compares survival and other outcomes in patients with acute leukemia or myelodysplastic syndrome who received a stem cell transplant with a personalized dose of an immune-suppressing drug (r-ATG) to similar patients from a large registry who received standard treatment…

This study looks at whether the force of mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) can damage the brain. Researchers will measure a protein called S100B in the blood, which is a sign of brain injury, and track thinking and memory problems …

This study looks at whether the stiffness of the cornea influences how much astigmatism (blurring from an irregularly shaped cornea) develops after cataract surgery in people with pseudoexfoliation syndrome, a condition that weakens eye tissues. Researchers will measure corneal b…

This study follows 70 adults aged 50 and older who are having routine cataract surgery. Half have pseudoexfoliation syndrome, a condition that can weaken eye tissues, and half do not. Researchers measure corneal stiffness before surgery and at several points afterward to see whet…

Septic shock is a life-threatening condition with high mortality. This study investigates whether patients with septic shock have a deficiency of angiotensin II, a hormone that helps regulate blood pressure. Researchers will measure hormone levels in blood and urine samples from …

This study investigates whether obstructive sleep apnea is linked to metabolic associated fatty liver disease (MAFLD) in adults. Researchers will measure sleep apnea severity using overnight sleep tests and liver fat using a special ultrasound-like scan. The goal is to see if wor…

This study investigates whether nerve ultrasound patterns and biomarkers in blood and spinal fluid can predict how people with chronic inflammatory demyelinating polyneuropathy (CIDP) respond to treatment. Researchers will follow 30 adults with CIDP, including newly diagnosed and…

This study looks at whether brown adipose tissue (brown fat), which burns energy as heat, can predict how well people with obesity respond to the weight loss drug semaglutide (Wegovy). Eighty adults starting semaglutide will have PET/CT scans before and after 24 weeks of treatmen…

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study looks at two bedside methods to measure how much of the lung can be reopened in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. It also compares four different ways to set the ventilator's positive end-expiratory pressure (PEEP). The g…

This study will check if two common brain monitors used during anesthesia (BIS and Sedline) give accurate readings in children with severe seizure disorders. Researchers will compare these monitors to a standard EEG in 40 children under 16. The goal is to make anesthesia safer fo…

This study tracks how Sanfilippo syndrome type C, a rare genetic disorder that affects the brain, progresses over time. Caregivers of children and young adults aged 1 to 25 will record videos of daily activities and answer questionnaires using a smartphone app every six months fo…

This study looks for VEXAS syndrome, a recently discovered genetic condition, in adults over 50 who are hospitalized with unexplained fever, inflammation, or blood abnormalities. Researchers will screen participants using clinical exams and genetic testing of the UBA1 gene. The g…

This observational study looks at whether combining genetic information with standard clinical data can better predict who will develop multiple sclerosis after a first episode of optic neuritis (inflammation of the optic nerve). Researchers will follow 180 people aged 16 and old…

This study investigates whether Doppler ultrasound, a non-invasive imaging technique, can measure blood flow to the gut in patients with septic shock. The goal is to see if these measurements correlate with how well the body clears lactate (a marker of tissue oxygen debt), the se…

This study looks at how the drug vasopressin affects the heart and blood flow in people with septic shock, a life-threatening condition from severe infection. Researchers want to see if different patients respond differently based on their specific heart and blood vessel status. …

This study looks at how exercise and a saltwater mist (hypertonic saline) affect mucus clearance in people with primary ciliary dyskinesia (PCD), a rare lung condition where tiny hairs in the airways don't work properly. Researchers will measure how fast the lungs clear inhaled p…

This study looks at how atrial cardiomyopathy—a condition where the heart's upper chambers are damaged—relates to cardiovascular-kidney-metabolic (CKM) syndrome, a cluster of heart, kidney, and metabolic problems. Researchers will use non-invasive tests like ECG, echocardiography…

This study aims to create a tool that predicts which patients are likely to have persistent pain after lumbar spine surgery, a condition known as failed back surgery syndrome. Researchers will combine routine blood tests, MRI scans, and psychological questionnaires from 150 adult…

This study looks at how people feel emotionally when they go through cancer genetic testing, and whether talking to a psychologist helps. It follows 220 adults who are having their first genetic counseling session. Some choose to use the psychological support offered, while other…

This study investigates how the bodies of women with Polycystic Ovary Syndrome (PCOS) respond to sugar compared to women without the condition. Participants drink a sugary solution, and blood and urine samples are analyzed using advanced technology to track changes in proteins, m…

This study looks at how women with fibromyalgia experience pain, focusing on the brain's ability to control pain signals. Researchers will measure pain thresholds and responses to repeated stimuli in 82 participants. The goal is to better understand the condition, not to test a n…

This study looks at whether having surgery in the morning versus the afternoon changes how well the sedative ciprofol works and how smoothly patients recover. Researchers will compare adults having non-emergency surgery starting between 8-11 AM or 2-5 PM. The goal is to see if th…

This study investigates why colorectal adenomas (precancerous polyps) sometimes return after being surgically removed. Researchers will collect tissue samples from 30 patients and use advanced genetic sequencing to compare polyps that recur with those that do not. The goal is to …

This study looks at how resilience and pain sensitivity influence physical function in people with fibromyalgia compared to healthy volunteers. Researchers will measure walking distance using a 6-minute walk test and compare it to self-reported resilience scores. No treatment is …

This study observes how the bodies of people with septic shock respond to fluid loading, a common treatment. Researchers track markers of blood flow and fluid buildup to see which patients improve and which get worse. The goal is to find better ways to give fluids without causing…

This study examines how a type of immune cell called gamma delta T cells adapt and function in critically ill patients, both with and without sepsis. Researchers will compare these cells in healthy people, non-septic ICU patients, and septic ICU patients. The goal is to understan…

This study surveys 1,000 adults with Restless Legs Syndrome (RLS) to find out how often pain is part of their symptoms and how it affects their daily lives. Participants fill out an online questionnaire about their medical history, sleep, pain, and quality of life. The goal is to…

This study looks at how obstructive sleep apnea (OSA) affects thinking skills like attention and memory, and how those changes relate to quality of life. Adults newly diagnosed with OSA will take an overnight sleep test, followed by computer tasks and questionnaires. Their result…

This study follows 100 adults with advanced heart failure for 2 years to understand how kidney function changes over time and how it relates to serious heart events like death or need for a transplant. Researchers will collect blood, urine, and stool samples, along with quality-o…

This study collects blood samples and health data from 1,200 adults with ARDS in intensive care. Researchers aim to identify biological markers that can group patients into subtypes and predict how they will respond to different treatments. The goal is to improve care for this li…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study tests whether people with fibrotic interstitial lung disease can use home monitoring devices—like a spirometer, pulse oximeter, and scale—to help detect serious lung events such as flare-ups or hospitalizations. About 200 participants will use these devices connected t…

This study looks at whether a small pressure sensor placed in the leg during surgery can help doctors spot a rare but serious problem called acute compartment syndrome. Teens aged 10 to 21 with a broken shinbone will have the sensor monitor pressure for at least 18 hours after th…

This study looks at whether the recruitment-to-inflation ratio (R/I ratio), a measurement used to guide ventilator settings in patients with acute respiratory distress syndrome (ARDS), gives the same result when repeated in the same patient. Researchers will measure it twice in 8…

This study will look at data from 918 adults who had planned heart surgery to find out why some develop atrial fibrillation, a common and serious irregular heartbeat. The researchers will also examine whether newer anesthesia methods, like a nerve block, might help protect agains…

This study looks at how sepsis affects the bone marrow, where immune cells are made. Researchers will compare bone marrow samples from 45 people: those with sepsis, other critically ill patients, and healthy volunteers. The goal is to understand why sepsis can weaken the immune s…

This study looks at whether using a cousin as a stem cell donor works as well as using a sibling for people with blood cancers. Researchers will compare survival, relapse, and side effects like graft-versus-host disease in patients who received a transplant from either a cousin o…

This study will follow 100 health science students for at least 10 years to understand why some people with very flexible joints (hypermobility) develop chronic pain, fatigue, and other health issues while others do not. Researchers will measure balance, heart rate, and quality o…

This observational study will follow 200 adults with Brugada Syndrome who need anesthesia for surgery or other procedures. Researchers want to see how often dangerous heart rhythms occur during and up to 30 days after anesthesia. They will also check if certain anesthetic drugs o…

This study looks at how esmolol, a drug that slows the heart rate, affects the smallest blood vessels in people with septic shock—a severe infection that can lead to organ failure. Researchers will measure changes in blood flow under the tongue and other key pressures in the circ…

This study looks at how the sedative dexmedetomidine affects the smallest blood vessels in people with septic shock, a life-threatening condition caused by severe infection. Researchers will measure blood flow in the tongue's tiny vessels and other key blood pressure indicators b…

This study tests whether the drug papaverine can improve blood flow in the smallest blood vessels of people with septic shock. Septic shock causes widespread inflammation and poor circulation, which can damage organs. The trial will give papaverine intravenously to 20 adults in t…

This pilot study will test a drug called anisodamine in 20 adults with septic shock who are on a ventilator. The goal is to see if the drug can improve blood flow in small blood vessels and help with a phenomenon called 'vascular waterfall.' This is a very early study to gather i…

This study looks at whether a tumor's DNA repair status (MMR) changes how well the presence of cancer cells in lymph vessels predicts spread to lymph nodes in stomach cancer. Researchers will review medical records of 3,000 patients who had surgery. The goal is to improve risk as…

This study will collect blood samples and medical information from 600 adults with rare diseases affecting blood vessels in the brain and eye, such as CADASIL and cavernous angioma. The goal is to create a long-term biobank that researchers can use to find biomarkers and better u…

This study observes 150 infants and toddlers having cleft lip or palate repair to understand how often breathing complications occur and what factors increase risk. Researchers will use standard airway scoring tools to see if they can predict problems like laryngospasm or low oxy…

This study will test whether smelling a pleasant food odor (madeleine scent) before drinking a sugary solution changes how the body handles blood sugar. Twenty adults, some with obesity and mild insulin resistance and some without, will each undergo two sessions: one with the sce…

This study explores whether a noninvasive technique called transcranial electrical stimulation can reduce pain and improve quality of life in people with fibromyalgia. Participants receive daily sessions of mild electrical pulses to the scalp over four weeks, targeting different …

This study follows 45 adults with alpha-1 antitrypsin deficiency (a genetic condition that can cause liver damage) to learn how the disease progresses. Researchers will analyze stored blood and liver tissue samples to find biomarkers and understand the molecular pathways involved…

This study follows 40 adults who recently had laparoscopic sleeve gastrectomy for obesity. Over 6 months, researchers will measure changes in blood sugar, cholesterol, gut barrier markers, and digestive symptoms. The goal is to understand how the surgery affects gut health and me…

This study will follow 400 people recently diagnosed with polymyalgia rheumatica, a condition causing shoulder and hip pain. Researchers will track symptoms, treatments, and outcomes over 5 years to better understand the disease and improve diagnosis. Participants will provide bl…

This study looks at how a gas called nitric oxide, given through a mask or nasal tubes, changes the way air and blood flow match in the lungs of people with ARDS (a serious lung injury). Researchers will use a special imaging technique (EIT) to see these changes right away. The g…

This observational study will collect existing lab results and medical history from 100 women aged 18 to 45 with PCOS. No treatments or interventions are given. The goal is to identify distinct hormonal and metabolic patterns that could help explain the condition and guide future…

This study looks at the best way to help prostate cancer survivors learn about and get genetic testing for inherited cancer risks. About 500 participants will be randomly assigned to a digital guide, a printed guide, or standard care. Researchers will track who requests testing a…

This study checks whether two short questionnaires can accurately measure physical fitness in children aged 10–18 with juvenile idiopathic arthritis or familial Mediterranean fever. Researchers will compare the questionnaire results with standard fitness tests. If the questionnai…

This study looks at how whole-body heat therapy (hyperthermia) changes body temperature, pain sensitivity, and pain during movement in 60 people—half with chronic widespread pain (like fibromyalgia) and half healthy. Participants will receive six heat sessions over three weeks. T…

This study looks at babies with a common type of birthmark (infantile hemangioma) on the lower back, bottom, or genital area. The goal is to find the best size cutoff for the birthmark to decide which babies should be screened for LUMBAR syndrome, a condition that can involve hid…

This study will use a painless ultrasound to examine tongue stiffness, thickness, and other features in 80 adolescents aged 12-18 with obesity and sleep-disordered breathing. Participants are already enrolled in a weight-loss program. The goal is to better understand how the tong…

This study looks at how smell helps newborns find and latch onto the breast for breastfeeding. Researchers will use a special machine to track odors from mothers and babies in real time. The goal is to understand the role of scent in early bonding and feeding, which could help im…

This observational study will enroll 200 people—100 with Parkinson's disease, 50 with related conditions, and 50 healthy controls—to find molecular markers in blood, urine, and stool that can distinguish Parkinson's from atypical parkinsonism. Participants provide samples and und…

This study looks at whether adding a measure of gut function to a standard organ failure score can better predict which critically ill patients are at highest risk of dying. Researchers will follow 800 adults in Turkish ICUs, using only routine data—no extra tests or treatments. …

Denys-Drash syndrome is a rare genetic condition that causes kidney failure in early childhood, often requiring a transplant. Past research suggests these children have a much higher chance of developing a type of lymphoma after transplant compared to other kids. This study will …

This study is testing a new blood test called AlloHeme that looks for tiny traces of a patient's own cells after a stem cell transplant. The goal is to see if the test can predict whether leukemia or MDS will come back before it happens. About 400 adults who have had or will have…

This small pilot study tests whether a Chinese herbal medicine called Shenfu Injection can improve blood flow in people with septic shock, a life-threatening condition. Twenty adults in the ICU will receive the injection, and doctors will measure changes in circulation and oxygen…

This study looks at how metabolic health (measured by a simple blood test) relates to artery stiffness and daily blood pressure changes in 800 adults. Researchers will use routine tests and non-invasive measurements to find better ways to identify people at higher risk for heart …

This study aims to find out how much dental interns in Egypt know about pediatric obstructive sleep apnea, a common but often missed sleep disorder in children. Researchers will survey 350 interns using a questionnaire to assess their knowledge, attitudes, and practices. The goal…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study will check if people with Lynch syndrome, a genetic condition that raises cancer risk, have more gum disease than the general population. Researchers will look at dental records from 25 adults with Lynch syndrome. The goal is to see if gum disease is a hidden health is…

This study follows 60 adults who had jaw surgery (maxillomandibular advancement) for obstructive sleep apnea. Some develop central or mixed sleep apneas after surgery, and researchers want to see if these breathing issues get better, stay the same, or get worse over a year. Parti…

This study explores whether a technique called LIBS, which maps chemical elements in lung tissue, can help doctors identify possible environmental or workplace causes of chronic lung diseases. Researchers will analyze stored biopsy samples from 70 adult patients using LIBS and an…

This study tests whether using a CT scan to plan a heart stent procedure (PCI) makes it faster, safer, and more effective than the usual approach. About 200 adults with coronary artery disease will either get CT-guided planning or standard care. Researchers will compare procedure…

This study looks at whether measuring the fluorescence of certain white blood cells (neutrophils) can help doctors quickly identify sepsis patients at risk of severe complications like organ failure or septic shock. Researchers will analyze blood samples from 492 adults in the em…

This 5-year study will follow 2,800 overweight or obese Chinese adults aged 18-60 to see how their health changes over time. Participants will use a smartphone app to track their data and get lifestyle support. The goal is to understand who develops diabetes or complications, and…

This study follows 250 patients receiving stem cell transplants to better understand engraftment syndrome, an early inflammatory complication. Researchers will track how different types of this syndrome relate to the risk of graft-versus-host disease and overall recovery. The goa…

This study will test whether a special ultrasound score, called OTUS, can accurately track disease activity in people with Takayasu arteritis, a rare condition that causes inflammation of the large arteries. Researchers will follow 100 patients with active disease, performing ult…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study looks at whether a finger-stick device (Coaguchek) can accurately measure blood thickness in people with antiphospholipid syndrome who take blood thinners. Currently, these patients need regular blood draws from a vein, which is inconvenient. The study will compare fin…

This study tests a program to help people with inherited cancer gene mutations (like BRCA or Lynch syndrome) stick to recommended cancer screening schedules. Researchers will interview 80 female participants and provide standard care to see if this approach improves adherence and…

This study is a registry that will collect medical information and blood samples from 500 adults with myelodysplastic syndromes (MDS) and related conditions. The goal is to learn more about how these diseases develop and progress over time. Participants will not receive any exper…

This study looks at whether fertility treatments change irritable bowel syndrome (IBS) symptoms in women. Researchers will follow 120 women—60 with PCOS starting IVF and 60 freezing eggs for social reasons. Participants fill out questionnaires about gut symptoms, anxiety, and dep…