Can calming the nervous system save lives in septic shock?
NCT ID NCT07569536
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a sedative called dexmedetomidine can improve survival in people with refractory septic shock, a life-threatening condition where blood pressure stays dangerously low despite standard treatments. The drug aims to calm an overactive stress response that makes blood vessels less responsive to pressure-raising medications. About 360 adults will be randomly assigned to receive either dexmedetomidine plus usual care or usual care alone, and researchers will track who is alive after 30 days.
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Conditions
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As listed by the trial registrant
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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APHP - Hôpital Raymond-Poincaré - Service de Médecine intensive-réanimation
Garches, 92380, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU Amiens-Picardie - Service de médecine intensive-réanimation
Amiens, 80054, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU Dijon Bourgogne - Service de médecine intensive et réanimation
Dijon, 21000, France
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CHU de Rennes - Service de médecine intensive et réanimation
Rennes, 35033, France
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Centre Hospitalier Chalon-sur-Saône - Service de réanimation et surveillance continue
Chalon-sur-Saône, 71321, France
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Centre Hospitalier Départemental de Vendée - Service de réanimation polyvalente
La Roche-sur-Yon, 85925, France
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Centre Hospitalier Intercommunal de Toulon - Service de réanimation polyvalente
Toulon, 83100, France
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Centre Hospitalier Le Mans - Service de réanimation médico-chirurgicale
Le Mans, 72037, France
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Centre Hospitalier de Dieppe - Service de réanimation et unité de soins continus
Dieppe, 76202, France
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HOPITAL NORD FRANCHE-COMTE - Service de réanimation
Trévenans, 90400, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Hôpital Edouard Herriot - Service de Médecine intensive - reanimation
Lyon, 69003, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Nord - CHU Saint Etienne - Service de médecine intensive
Saint-Priest-en-Jarez, 42270, France
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Hôpital Saint Joseph Saint Luc - Service de réanimation
Lyon, 69007, France
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Hôpital de l'archet - Service de médecine intensive et réanimation
Nice, 06200, France
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Hôpital de la Croix Rousse - Service de médecine intensive et réanimation
Lyon, 69004, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Médipôle Hôpital Privé Lyon Villeurbanne- Service de réanimation polyvalente
Villeurbanne, 69100, France
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Nouvel Hôpital Civil - Service de médecine intensive et réanimation
Strasbourg, 67091, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Service d'Anesthésie - Médecine Intensive - Réanimation Hôpital Lyon Sud
Pierre-Bénite, 69310, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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