Syndromic disease

This study follows over 14,000 adults with sleep apnea who are prescribed positive airway pressure (PAP) therapy. It investigates whether using telemonitoring—where the device sends usage data to their doctor remotely—helps people use the therapy more consistently and effectively…

This phase III trial is testing whether taking oral azacitidine as a maintenance therapy after an allogeneic stem cell transplant can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Participants are randomly assigned to receive…

This trial tests whether insulin eye drops can improve the ocular surface in people with moderate-to-severe dry eye disease. Participants will receive either insulin eye drops or artificial tears for up to a year. The study measures changes in dry eye symptoms and tear production…

This trial asks whether taking magnesium oxide for three months before the fertility drug letrozole can improve ovulation rates in women with insulin-resistant polycystic ovary syndrome (PCOS). About 60 subfertile women aged 18–35 will either receive magnesium oxide followed by l…

This trial tests whether adding structured telemonitoring—weekly text messages and video calls—to standard conservative care helps people with temporomandibular disorder (TMD)-related jaw pain. Participants receive behavioral counseling, habit reversal training, and home exercise…

This study looks at whether a higher dose of dexamethasone, a steroid given to pregnant women at risk of early birth, helps preterm babies' lungs mature better. Researchers are comparing babies born between 26 and 36 weeks whose mothers received either 12 mg or 6 mg of dexamethas…

This study tested cyclosporin 0.1% eye drops in 25 adults with moderate to severe dry eye disease that didn't get better with artificial tears. The goal was to see if the drops reduce eye dryness and redness. Participants used the drops alongside their usual tear substitutes for …

This phase 1 trial is testing an investigational drug called AEB1102 in adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or stopped responding to standard treatments. AEB1102 is a modified human enzyme that breaks down arginine, an amin…

This study tests whether a diabetes drug called dapagliflozin can help people with heart failure who also develop kidney injury recover faster. About 30 adults will take the drug or usual care for three days. The main goal is to see if a larger trial is possible, not to prove the…

This study tests whether a supplement made from brown algae and chromium picolinate, when added to a calorie-controlled Mediterranean diet, can reduce fat buildup in the liver. Adults with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic syndrome wil…

This early-stage trial is testing an experimental drug called APX005M in 32 children with brain tumors that have come back or are hard to treat, including a type of brain stem glioma. The drug works by activating the immune system to attack cancer cells. The main goals are to fin…

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This trial tests whether giving an inhaled steroid (budesonide) to newborns with meconium aspiration syndrome can speed up their recovery. Meconium aspiration happens when a baby breathes in a mixture of meconium and amniotic fluid during birth, causing lung inflammation and brea…

This trial is testing whether a chemotherapy drug called treosulfan, given in different doses along with fludarabine, can safely prepare patients with advanced blood cancers for a stem cell transplant. The study focuses on patients who are not eligible for the standard, more inte…

This trial is testing whether a higher dose of the fertility drug letrozole (10 mg) works better than the standard lower dose (5 mg) for stimulating ovulation in infertile women with polycystic ovary syndrome (PCOS). About 86 women aged 18-35 with PCOS will take one of the two do…

This phase 2 trial is testing whether two investigational drugs, AD109 and AD504, taken as a pill at bedtime, can reduce the number of breathing pauses in people with obstructive sleep apnea. The study compares these drugs against atomoxetine (an existing medication) and a placeb…

This trial follows women with polycystic ovary syndrome (PCOS) who take metformin, a standard diabetes medication, for six months. Researchers track changes in insulin resistance, iron levels, erythropoietin, cholesterol, and blood counts at three and six months. The goal is to s…

This early-stage trial tests a combination of two drugs, venetoclax and azacitidine, in people with a serious type of myelodysplastic syndromes (MDS) who have not had treatment before. The goal is to find the safest dose and see how well the drugs work together to control the dis…

This study compares two different mandibular advancement devices—oral appliances that hold the jaw forward during sleep—to see which works better for people with mild-to-moderate obstructive sleep apnea. Participants will wear each device for three months, with a two-week break i…

This trial is testing an experimental drug called BST-236 in adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have come back or not improved after initial treatment. Participants receive BST-236 as a one-hour intravenous infusion for six …

This study looked at whether a custom-made hip spacer can help people with infected hip replacements. 25 patients had their infected hip implant removed and replaced with a temporary custom spacer, followed by antibiotics. After the infection cleared, they received a new permanen…

This pilot study tests a new laser device for treating open-angle glaucoma and ocular hypertension. The device uses a laser through the sclera (the white of the eye) to lower eye pressure, avoiding the need for a lens to touch the cornea. Researchers will check how safe the proce…

This study tested a new oral medication called iptacopan in 34 adults with a rare disease called atypical hemolytic uremic syndrome (aHUS), which causes blood clots, low platelets, and kidney damage. The goal was to see if the drug could improve blood counts and kidney function w…

This study asks whether adding a medically supervised ketogenic diet to occupational therapy can help children aged 4 to 7 with ARX gene mutations and drug-resistant epilepsy. Twenty children will take part: half follow the ketogenic diet while the other half do not, and both gro…

This study tests whether a specially designed mobile app can help women with Polycystic Ovary Syndrome (PCOS) improve their eating and exercise habits. About 92 women will either use the app or receive a pamphlet with advice. The goal is to see if the app leads to better weight m…

This trial tests three different injection combinations for people with a painful jaw joint condition called TMJ internal derangement. Participants receive one injection of hyaluronic acid mixed with either platelet-rich plasma, tenoxicam, or a corticosteroid. The study measures …

This phase 3 trial is testing a drug called setmelanotide in people with obesity linked to certain gene variants (POMC, PCSK1, LEPR, NCOA1, or SH2B1). About 296 participants, aged 6 to 65, will receive either the drug or a placebo to see if it helps reduce body weight. The study …

This trial tests whether a standardized ashwagandha (Withania somnifera) extract, combined with vitamin D and folate, can improve depression, stress, sleep, and metabolic health in women with polycystic ovary syndrome (PCOS). Participants will take either the ashwagandha blend or…

This trial tests whether a freezing balloon, called cryoballoon ablation, can safely and effectively remove non-cancerous but potentially precancerous growths (adenomas) in the duodenum, the first part of the small intestine. The study includes people with sporadic adenomas or th…

This trial tests whether a single yogurt drink made from vegetable proteins rich in leucine, cysteine, and arginine can improve blood vessel function and reduce inflammation in older adults with cardiometabolic risk. Participants, aged 65 and older, will consume either the vegeta…

This study tests whether a DASH diet—a plan rich in fruits, vegetables, and low-fat dairy—can help menopausal women with metabolic syndrome lose weight and improve health markers like blood pressure, cholesterol, and blood sugar. Researchers will also check if certain gene variat…

This pilot trial is asking whether injecting magnesium sulfate into the jaw joint after a standard washout procedure (arthrocentesis) can reduce pain and improve jaw function better than the usual treatments. It compares magnesium sulfate against hyaluronic acid (a common injecti…

This phase 2 trial tests a powerful mix of short-course radiation, chemotherapy (mFOLFOX6), an immunotherapy (PD-1 antibody), and a targeted drug (cetuximab or bevacizumab, depending on genetic markers) in people with high-risk rectal cancer that is mismatch repair proficient (pM…

This trial tests whether the type of physical activity—resistance, endurance, or a mix—combined with a low-calorie diet can reduce belly fat and cardiovascular risk in people with metabolic syndrome. Adults aged 50-70 with metabolic syndrome are randomly assigned to one of three …

This trial tests whether a program using a consumer wearable device—which tracks oxygen levels during sleep—along with personalized weekly reports can help adults with obstructive sleep apnea use their positive airway pressure (PAP) therapy more consistently. Participants who are…

This early-phase study tests an oral antiviral drug called letermovir in 12 infants born with symptomatic congenital cytomegalovirus (CMV) infection. The goal is to find the right dose and see if it safely lowers the amount of virus in the body. Babies also receive standard treat…

This study looks at the best time to add the drug vasopressin for people with septic shock—a life-threatening drop in blood pressure from infection. About 2,050 adults will be treated using either an earlier or later threshold for starting vasopressin. The goal is to see which ap…

This trial tests whether taking polyphenol supplements with a meal can reduce how much iron the body absorbs in people with iron overload disorders like genetic hemochromatosis and dysmetabolic iron overload syndrome. Participants eat a standardized iron-rich meal with either pol…

This study follows adolescents and young adults (ages 12–21) with sickle cell disease who take hydroxyurea, a medication that helps prevent pain crises and other complications. The researchers are testing whether a mobile app called HU-Go can help these patients build a consisten…

This trial tests whether an oral probiotic supplement called MetBroma can safely reduce symptoms of irritable bowel syndrome (IBS) and improve quality of life. Adults aged 18 to 60 with an IBS diagnosis will take the probiotic capsule twice a day, and researchers will track chang…

This pilot trial tests whether a smartphone app called MED-Go can help adolescents and young adults with sickle cell disease take their daily hydroxyurea more consistently. Participants aged 12 to 21 will use the app for 12 weeks, and researchers will measure how often they log t…

This trial tests whether taking a daily supplement of cornelian cherry fruit for six months can improve markers of heart, blood vessel, eye, and bone health in people with metabolic syndrome. Participants will receive either the cherry supplement or a placebo, and researchers wil…

This trial tests whether time-restricted eating (TRE) — limiting all food intake to an 8-10 hour daily window — can improve blood sugar control and metabolic health in people with metabolic syndrome or prediabetes. Participants are randomly assigned to either standard nutritional…

This early-phase trial is testing whether burosumab, a drug already approved for X-linked hypophosphatemia (XLH), can safely raise phosphate levels in a single patient with cutaneous skeletal hypophosphatemia syndrome (CSHS). Both conditions involve abnormally high FGF23 activity…

This study looked at whether inositol, a natural supplement, can improve ovulation in women with polycystic ovary syndrome (PCOS) who did not respond to the fertility drug letrozole. 36 women aged 18-35 took part. The researchers compared inositol to metformin, another common tre…

This trial tests whether a drug called IHL-42X can reduce breathing pauses during sleep in people with obstructive sleep apnea who cannot tolerate or do not use a CPAP machine. The study has two parts: first, a short dose-finding phase to pick the best dose, then a longer phase c…

This study tracks about 450 adults with active psoriatic arthritis who are prescribed upadacitinib (RINVOQ) by their doctor. Researchers will follow participants for up to 24 months to see how well the drug controls joint and skin symptoms when used alone or with methotrexate in …

This trial tests whether taking estradiol (a form of estrogen) for about 10 days before starting ovarian stimulation can help women with polycystic ovary syndrome (PCOS) have more synchronized follicle growth and better IVF outcomes. Sixty women with PCOS undergoing ICSI are rand…

This trial investigates whether one month of daily vitamin E, folic acid, or both can improve hormone profiles and reduce symptoms like excess hair growth in women with polycystic ovary syndrome (PCOS). Researchers will measure changes in key reproductive hormones and a protein c…

This phase 3 trial tests whether risankizumab, an injectable biologic, can reduce joint pain and swelling in adults with moderately to severely active psoriatic arthritis who have not responded to or cannot tolerate other biologic treatments. Participants receive either risankizu…

This trial investigates whether gentle electrical stimulation of the ear (specifically the vagus nerve area) during emergency heart attack treatment can reduce heart muscle damage and improve recovery. Researchers are enrolling 110 adults having their first major heart attack who…

This trial tests a device called the aura6000 that stimulates a nerve in the neck to keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. Participants are randomly assigned to have the devic…

This study tested whether a seaweed-derived supplement called Aquamin® can reduce gut permeability (often called 'leaky gut') in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy volunteers. Thirty-five adults took Aquamin capsules for 90 days. R…

This study explores whether drinking water kefir daily for two months can improve reproductive health and cholesterol levels in women aged 18–25 with polycystic ovary syndrome (PCOS). Participants follow a calorie-controlled diet, with one group also consuming kefir. Researchers …

This study tests two types of pit and fissure sealants (Fisseal and Prevent Seal) applied after treating teeth with one of two remineralizing agents (Biflourid or MI Paste). The goal is to see which combination best keeps the sealant in place and prevents cavities from forming or…

This phase 4 trial tests whether a daily combination of myo-inositol and D-chiro-inositol (with folic acid) can improve menstrual regularity and hormone levels in women with polycystic ovary syndrome (PCOS). Sixty women aged 18–45 with PCOS will receive either the inositol combin…

This study tests whether adding a modified traditional Chinese herbal formula, Huanglian Wendan Decoction, to standard lifestyle and drug therapy can reduce oxidative stress in people with metabolic syndrome. About 180 adults will receive either standard care alone or standard ca…

This phase III trial tests whether the drug tipifarnib can prevent acute myeloid leukemia (AML) from coming back in patients who are already in remission. Participants include adults over 60 in first remission, those in second or later remission, or those who achieved remission a…

This trial tests whether the Chinese herbal tablet Changyanning can reduce diarrhea and abdominal pain in people with diarrhea-predominant irritable bowel syndrome (IBS-D). About 240 adults aged 18 to 65 with moderate to severe symptoms will receive either the herbal tablet or a …

This phase 3 trial investigates whether the drug tolvaptan can safely and effectively correct low sodium levels in patients with hyponatremia, a condition where the body's sodium-water balance is off. The study enrolls adults with mild to moderate hyponatremia who are either euvo…

This study tests whether the drug tolvaptan can safely bring sodium and water levels back to normal in people with low blood sodium (hyponatremia). Participants take a daily tablet or a placebo for a set period. The trial focuses on patients whose hyponatremia is due to excess bo…

This study tests an experimental drug called BPN14770 (zatolmilast) in men aged 18 to 45 with Fragile X syndrome, a genetic condition that causes intellectual disability and behavioral challenges. The trial compares the drug against a placebo to see if it improves cognitive abili…

This trial compares two methods of giving hydrocortisone to adults with septic shock—a life-threatening drop in blood pressure due to infection. One group receives the steroid as a continuous drip, the other as intermittent shots every six hours. Researchers track 28-day survival…

This trial compares two noninvasive breathing support methods—heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP)—in premature infants (born at 28-34 weeks) with moderate respiratory distress syndrome. The goal is to see which …

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This study looked at over 17,000 people who had a heart attack to compare two blood thinners: prasugrel and ticagrelor. Hospitals switched from ticagrelor to prasugrel in a stepwise way to see which drug better prevents death, another heart attack, or stroke. The goal is to find …

This study tests whether Miebo eye drops, used before and after cataract surgery, can improve the accuracy of lens measurements and final vision in people with dry eye. Participants apply the drops four times daily for about 30 days before surgery and again for 30 days after. The…

This study tests whether a four-week digital health education program delivered via WhatsApp can improve quality of life in women with polycystic ovary syndrome (PCOS). Seventy women aged 18–45 with PCOS are randomly assigned to receive either the digital program—30 structured me…

This study tests whether psyllium fiber bars can help postmenopausal women with irritable bowel syndrome and diarrhea who experience accidental bowel leakage. Researchers will examine changes in gut bacteria and stool chemicals to see if fiber improves symptoms. The study involve…

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether newborns with neonatal abstinence syndrome (NAS) who receive a high-calorie formula for two weeks gain weight better than those on standard formula. The babies are managed using the Eat, Sleep, Console approach. The main goal is to see how much weight the…

This study tests a 5-week community-based program that teaches protective behavioral strategies to reduce alcohol use in men aged 35–44 with hazardous drinking habits in rural Vietnam. Participants learn to set safe drinking limits, choose nonalcoholic drinks, and plan ahead, wit…

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This study tests a drug called FT-2102 (olutasidenib) in people with acute myeloid leukemia or myelodysplastic syndrome whose cancers have a specific IDH1 gene mutation. The drug is given alone or combined with standard chemotherapy drugs (azacitidine or cytarabine). The goal is …

This study tested whether adding the drug ZARNESTRA to standard radiation therapy can slow tumor growth in people with glioblastoma, an aggressive brain cancer. Twenty-seven patients took the drug daily starting a week before radiation and continuing through treatment. The main g…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This study tested two drugs, plerixafor and G-CSF, in 20 people with WHIM syndrome, a rare genetic condition that causes frequent infections and warts. Participants received each drug for a year and tracked their infections. The goal was to see which drug better reduced infection…

This study looked at whether follow-up visits by phone or video are as safe as in-person visits for people who had a heart attack and received a stent. 88 patients were split into two groups: one had telemedicine check-ups at 1, 3, and 6 months, and the other had standard office …

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This study tests the long-term safety of maralixibat, an oral medication, in children with progressive familial intrahepatic cholestasis (PFIC), a rare liver disease that causes intense itching. Participants who completed a prior study will receive maralixibat twice daily. Resear…

This study tested a herbal extract from a Himalayan plant (Nepeta adenophyta) in 116 women with PCOS. Participants took either the herb, the standard drug metformin, or both for 4 months. The goal was to see if the herb could help restore regular menstrual cycles and improve meta…

This study tests whether a graft made from a patient's own or donor stem cells can repair the cornea's surface in people with limbal stem cell deficiency, a condition that causes pain, scarring, and vision loss. A small biopsy of limbal tissue is taken from a healthy eye or donor…

This study tested a daily pill called E7820 in 12 adults with relapsed or treatment-resistant acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia. All participants had specific mutations in splicing factor genes. The goal was to see if the drug c…

This study tested the drug RAD001 (everolimus) in 29 patients with relapsed or hard-to-treat blood cancers like leukemia, lymphoma, and myelofibrosis. The goal was to find the safest highest dose and see if it helps control the disease. It was a small early-phase trial at a singl…

This phase II trial tested whether inhaling low doses of carbon monoxide (200 ppm for 90 minutes daily for 3 days) is safe and helpful for people with acute respiratory distress syndrome (ARDS), a severe lung condition. Only 4 intubated adults participated, making this a very sma…

This study reviewed medical records of 37 adults with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) who took asciminib because other treatments stopped working or caused side effects. Researchers wanted to see how many patients achieved complete remission within th…

This study looked at whether giving a sedative called propofol to very premature babies (under 32 weeks) before a less invasive breathing treatment (LISA) is safe and reduces the need for a breathing machine. The trial involved 233 infants with breathing problems. Researchers com…

This phase 3 trial tested whether abatacept, a drug that calms the immune system, can control polymyalgia rheumatica (a painful inflammatory condition) without the need for long-term steroids. Thirty-four adults with early disease received either abatacept or a placebo for 12 wee…

This study tested two approaches to help women with PCOS who did not ovulate after standard letrozole treatment. One group took letrozole for 7 days instead of 5, and the other took letrozole plus inositol. The goal was to see which method led to more ovulations and pregnancies. …

This study tested whether a once-monthly injection of buprenorphine works as well as daily pills to treat opioid use disorder in 140 pregnant women. The goal was to see if the monthly shot could reduce illicit opioid use during pregnancy and after birth. Results help doctors choo…

This study tested whether bars made with polyunsaturated fatty acids could improve cholesterol and fat levels in people with metabolic syndrome. 60 adults aged 40-65 with high BMI and abnormal cholesterol took part. The goal was to see if these bars could help control dyslipidemi…

This study tested whether early hemofiltration, a continuous dialysis procedure, could improve survival in children who develop respiratory failure after a bone marrow transplant. Only 6 children took part. The idea was to filter out inflammatory molecules that drive lung damage.…

This Phase 3 trial tested a drug called efzofitimod in 268 adults with pulmonary sarcoidosis, a condition that causes lung inflammation. Participants received either the drug or a placebo every 4 weeks for 48 weeks. The main goal was to see if the drug could help people safely re…

This study tested whether N-acetylcysteine (NAC), an antioxidant drug, can improve motor skills and learning in children with neurofibromatosis type 1 (NF1). Twenty-five children aged 8 to 16 took NAC or a placebo for 8 weeks. The goal was to see if NAC is safe and helps with mov…

This study tested a new way to treat blood cancers like leukemia in 16 adults who did not have a standard bone marrow donor. Doctors used a single unit of cord blood that was grown in a lab to increase the number of stem cells before transplant. The goal was to see if this method…

This study tested a new surgical technique in 12 patients with newly diagnosed glioblastoma, an aggressive brain cancer. Surgeons placed a tissue flap from the scalp into the brain tumor cavity to bypass the blood-brain barrier, which normally blocks many treatments. The main goa…

This study tested whether adding dapagliflozin (a diabetes drug) or metformin to the standard fertility drug letrozole helps women with polycystic ovary syndrome (PCOS) ovulate and become pregnant. 200 women participated. The goal was to see if these combinations improve ovulatio…

This study tested giving chemotherapy before surgery to children with Wilms tumor, a rare kidney cancer. The goal was to shrink tumors so surgeons could remove less kidney tissue, helping preserve kidney function. 249 children took part, and the approach aimed to reduce the need …

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This study tested the safety of a drug called maralixibat in 27 infants under 12 months old with Alagille syndrome or progressive familial intrahepatic cholestasis (PFIC), two rare liver diseases that cause bile buildup. The drug is given as an oral solution and aims to reduce bi…

This Phase 3 study tested guselkumab, a drug given by injection, in 741 adults with active psoriatic arthritis. The goal was to see if it reduces joint pain and swelling. Participants received either guselkumab or a placebo. The main measure was a 20% improvement in arthritis sym…

This study tested whether giving a more powerful antiplatelet drug (prasugrel or ticagrelor) for one month after a heart attack, along with a standard blood thinner, could reduce heart attacks, strokes, and deaths in people with atrial fibrillation. The 602 participants were then…

This phase 2 trial tested a combination of intravenous busulfan, etoposide, and low-dose total-body irradiation before a donor stem cell or bone marrow transplant in 30 patients with advanced leukemia or myelodysplastic syndromes. The goal was to see how well this regimen control…

This study tested whether removing a specific type of immune cell (naïve T cells) from donor stem cell grafts could prevent graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. The trial enrolled 84 patients who received high- or medium-intensity chemo…

This study looked at whether a traditional Chinese herbal mixture (Zishen Qingre Lishi Huayu) can help women with polycystic ovary syndrome (PCOS) ovulate more regularly. The trial involved 126 women aged 20 to 40 and used a double-blind, placebo-controlled design to measure ovul…

This phase 2 trial tested two drugs, selumetinib and sirolimus, in 21 people with advanced malignant peripheral nerve sheath tumors (MPNST), a rare cancer often linked to neurofibromatosis type 1. The goal was to see if the combination could shrink or stabilize tumors. The study …

This study tested whether adding the drug tocilizumab to standard care could reduce the risk of graft-versus-host disease (GVHD) after a cord blood transplant in adults with blood cancers. GVHD is a serious complication where donor cells attack the patient's body. Tocilizumab blo…

This study tested a new type of pacemaker that doesn't use wires (leads) to help both the upper and lower chambers of the heart beat in sync. It involved 464 people with slow heart rhythms who needed a pacemaker. The main goals were to see if the device was safe and worked well a…

This phase 2 trial tested a biologic drug called RC18 in 42 people with primary Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth. Participants received weekly injections of either RC18 (at 160 mg or 240 mg) or a placebo for 24 weeks. The goal was to see if…

This study tested whether giving a single high dose of vitamin B12 (5 grams) to 20 adults with septic shock is feasible and safe. Patients received either vitamin B12 or a placebo (saline) alongside standard care. The main goal was to see if the study procedures could be complete…

This study tested a device called VasQ that wraps around a surgically created blood vessel connection (fistula) used for dialysis in people with kidney failure. The device is designed to improve blood flow and reduce complications. 144 patients received the device and were follow…

This study looked at how safe and effective weekly weight loss injections (like Mounjaro) are for adults with Bardet-Biedl Syndrome (BBS), a rare genetic condition that often causes severe obesity. Researchers compared weight changes in 300 patients who took the medication versus…

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This pilot study tested whether adding krill oil to standard metformin therapy improves metabolic health in women with PCOS and obesity. Fifty-four women were split into three groups: metformin alone, krill oil alone, or both together for 8 weeks. Researchers measured changes in …

This study tested the Inspire system, a device that stimulates a nerve in the neck to keep the airway open during sleep. It involved 44 adults in Singapore with moderate-to-severe obstructive sleep apnea who could not use CPAP. The main goal was to confirm the device works proper…

This study looked at 88 adults in China with lower-risk myelodysplastic syndromes (MDS) who had not received prior treatment with erythropoiesis-stimulating agents. They were given luspatercept, and researchers tracked how many became free from red blood cell transfusions and whe…

This Phase 2 trial tested a drug called CFZ533 (iscalimab) in 273 adults with Sjögren's syndrome, an autoimmune disease causing dryness, pain, and fatigue. Participants received either the drug or a placebo for 24 weeks. The study measured changes in disease activity and symptoms…

This study followed 591 adults with eosinophilic granulomatosis with polyangiitis (EGPA) across Europe to see how well mepolizumab 300mg every 4 weeks works over the long term in everyday medical practice. Researchers looked at disease control, lung function, and safety by review…

This study tested whether adding dapagliflozin (a diabetes drug) or metformin to the standard ovulation drug letrozole helps women with PCOS ovulate and become pregnant more often. 500 women aged 20-40 with PCOS and infertility took part. The goal was to see if these combinations…

This study tested a drug called pamiparib, given with radiation therapy, for people with a fast-growing brain cancer called glioblastoma. It included 50 patients, some newly diagnosed and some whose cancer had come back. The goal was to see how much drug reaches the tumor and whe…

This phase 2 trial tested sodium valproate, a drug used for seizures, in 41 children with Rubinstein-Taybi syndrome (RTS), a rare genetic condition causing intellectual disability. Participants aged 6 to 21 received either the drug or a placebo for one year. Researchers measured …

This phase 2 trial tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had cardiometabolic risks (like obesity and high cholesterol). The goal was to see if orticumab could safely reduce skin plaques and inflammation linked to heart disease. Par…

This early-stage study tested a new drug called LYT-200 in 101 adults whose acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) had come back or stopped responding to treatment. The main goals were to check the drug's safety and find the right dose. While not…

This early-stage study tested a single dose of mesenchymal stromal cells in 7 COVID-19 patients with severe acute respiratory distress syndrome (ARDS) who were on ventilators. The main goal was to check safety, looking for serious side effects like heart problems or blood clots w…

This study tested the drug D-cycloserine in a single patient with a rare genetic form of hereditary spastic paraplegia. The goal was to see if the drug is safe and can slow the disease by lowering certain fats (sphingolipids) in the body. The patient also took pyridoxine to help …

This study is testing whether a blood test can tell apart the DNA from a vanishing twin and the living twin in pregnancies where one twin stops developing. The goal is to improve non-invasive prenatal screening for chromosome conditions like trisomy 21, 18, and 13 in the survivin…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This study is testing whether measuring a protein called copeptin in the blood, alongside the standard troponin test, can help doctors quickly rule out a heart attack in people arriving at the emergency room with chest pain. Participants with chest pain that started within the la…

This study tests a new, less invasive way to measure stomach acid using a small wireless capsule (SmartPill) that patients swallow. It compares the capsule's accuracy to the standard method, which involves a tube placed through the nose into the stomach. The study includes health…

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study compares two techniques for evaluating upper airway collapse in people with obstructive sleep apnea: the standard office-based Müller's maneuver and drug-induced sleep endoscopy (DISE), which is performed under light sedation. The goal is to see whether DISE provides m…

This study tests whether a wearable home sleep apnea device called WatchPAT200 can accurately detect central sleep apnea in people who take narcotic medications. Participants wear the device during an overnight lab sleep study, and results are compared to the standard in-lab test…

This study evaluates whether a smartwatch and smartphone can accurately screen for obstructive sleep apnea (OSA). Adults suspected of having OSA will wear a smartwatch and smartphone while undergoing standard overnight sleep monitoring in a hospital. The results from the devices …

This study tested whether a urine test measuring two proteins (TIMP2 and IGFBP7) can tell which septic shock patients will recover normal kidney function within 72 hours. Researchers analyzed data from 77 patients in French ICUs. The goal is to help doctors decide who needs aggre…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study looked at whether a new blood test called the pan-immune-inflammation value (PIN) can help measure disease activity in people with Behçet's syndrome. Researchers compared 80 Behçet's patients to healthy controls. The goal is to find a simple, non-invasive way to monito…

This study looked at whether monitoring oxygen levels at home for 14 nights gives a more accurate diagnosis of obstructive sleep apnea than the standard single-night test in a hospital. Researchers enrolled 130 adults with suspected sleep apnea. They compared results from home mo…

This study tested a wearable device called SUNRISE to see if it can accurately screen for obstructive sleep apnea in people with diabetes or chronic lung disease. Researchers compared its results to standard sleep testing in 37 adults. The goal is to make sleep apnea screening ea…

This study tested a wearable ring device (Belun Ring) to see if it can accurately screen for obstructive sleep apnea. 70 adults wore the ring during a standard overnight sleep test. The ring measures oxygen levels, pulse, and movement to estimate breathing disruptions. Researcher…

This study tested whether a special lung MRI can replace CT scans for diagnosing idiopathic pulmonary fibrosis (IPF), a scarring lung disease. Researchers compared MRI to standard CT in 60 patients to see if MRI could spot the same key signs of IPF without using radiation. The go…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This trial tests whether giving azithromycin—a common antibiotic—twice a year to young children in Niger can reduce deaths. It compares giving the drug to all children aged 1-59 months versus only to infants 1-11 months, who are at highest risk. The study also checks how these ap…

This trial tests whether giving the steroid budesonide directly into the windpipe, together with surfactant, can prevent bronchopulmonary dysplasia — a chronic lung disease — in very preterm infants (born before 32 weeks or weighing under 1500 grams) who have respiratory distress…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested a drug called abatacept, given as a shot under the skin, to prevent a serious complication called graft-versus-host disease (GVHD) in 29 adults with blood cancers. Participants received a stem cell transplant from a half-matched donor. The goal was to see if aba…

This study tested whether taking vitamin C before and after planned upper limb surgery could prevent complex regional pain syndrome (CRPS), a chronic pain condition. Nearly 1,000 adults participated, receiving either vitamin C or a placebo. The goal was to see if vitamin C reduce…

This study tested three methods of keeping teeth dry while applying protective sealants to prevent cavities in children's permanent molars. Thirty children at high risk for cavities took part, and each method was compared for how long it took, how well the sealant stayed on after…

This study compares four treatments—clonazepam, capsaicin, photobiomodulation (light therapy), and alpha-lipoic acid—against a placebo for burning mouth syndrome. Researchers will enroll 150 adults with daily oral burning for over 3 months. The goal is to see which approach best …

This trial tests whether TECAR therapy, a non-invasive device that delivers energy to painful areas, can reduce pain in people with fibromyalgia. About 46 adults with fibromyalgia will receive either real or sham TECAR sessions twice a week for three weeks. Researchers will measu…

This study is testing a new eye drop that combines trehalose, sodium hyaluronate, and NAAGA without preservatives. It will enroll 30 adults with dry eye disease who are either new to treatment or unhappy with their current drops. Over 6 months, researchers will track changes in s…

This trial tests a new inflatable cushion called the BathMat, designed to help reposition patients lying on their stomachs (proned) in the ICU. Proning helps patients with severe breathing problems get more oxygen, but repositioning them every few hours currently requires at leas…

This study tested whether a dietary supplement containing digestive enzymes (Galactol®) could reduce bloating after meals in people with irritable bowel syndrome (IBS). 300 adults were randomly assigned to take the enzyme supplement plus a low-FODMAP diet, or just the diet alone,…

This study tests an electronic program that combines mindfulness and music therapy for people undergoing stem cell transplants for blood cancers. The goal is to see if it improves quality of life and reduces symptoms like pain. About 60 adults will participate, and the program in…

This study tested two techniques for washing out the jaw joint (arthrocentesis) in 30 adults with TMJ disorders. One method used a single needle, the other a catheter. Researchers measured pain and how wide patients could open their mouths. The goal was to see which approach prov…

This study tested a skin cream designed to improve skin elasticity and volume in 35 healthy adults with signs of facial aging. Participants applied the cream and were measured for changes in skin firmness and fullness. The goal was to see if the cream could help reduce the effect…

This study tested a new medicine called BXCL501 to see if it can safely reduce the unpleasant symptoms people feel when they stop taking opioids. 225 adults with opioid use disorder took part. The medicine was given as a film under the tongue, and researchers measured withdrawal …

This study is testing two new artificial tear formulas to see if they are safe and well-tolerated in people with moderate dry eye disease. Researchers will monitor for side effects and eye health in 148 participants who already use artificial tears. The goal is to find better opt…

This study looks at whether auto-captioning glasses are easy and helpful for adults with NF2-related schwannomatosis who have hearing loss. Eighteen participants will use the glasses for 12 weeks and report their experience through surveys and interviews. The goal is to see if th…

This trial tests whether injecting a mix of ketamine and lidocaine into the skin, a technique called mesotherapy, can reduce neuropathic pain in people with complex regional pain syndrome type 1 (CRPS1). Participants receive four sessions of either the drug mixture or lidocaine a…

This study tests whether a noninvasive device that stimulates the vagus nerve can reduce pain and other symptoms in women with fibromyalgia. Participants will receive either the nerve stimulation, standard medical treatment, or both, to see which approach works best. The goal is …

This trial tests whether combining proprioceptive neuromuscular facilitation (a type of stretching that improves flexibility and strength) with core strengthening exercises can help people with Guillain-Barré syndrome recover balance, muscle strength, and the ability to perform d…

This study tests whether MRI scans can predict how much people with jaw joint problems improve after a single injection of hyaluronic acid combined with platelet-rich plasma (PRP) made from their own blood. Adults aged 18–45 with TMJ internal derangement who haven't improved with…

This study looks at whether tai chi exercises and wearable fitness trackers can help people who have survived a heart attack (acute coronary syndrome) become more physically active. About 70 adults who are currently inactive will take part. The goal is to see if this approach is …

This study compares two eye drops—SYSTANE PRO and MIEBO—to see if SYSTANE PRO works as well as MIEBO for treating dry eye disease. About 260 adults with moderate dry eye will use one of the two drops for one month. The main goal is to measure changes in dry eye symptoms using a s…

This trial tests whether a 12-week ketogenic diet program, delivered entirely online, is practical and acceptable for adults with Long COVID who also have ME/CFS and dysautonomia. Participants follow a low-carb, high-fat diet with vitamin B1 and electrolyte support, plus weekly v…

This trial tests whether taking magnesium can reduce stress in people with fibromyalgia, a condition marked by widespread pain and fatigue. Participants will be randomly assigned to receive magnesium or a placebo, and researchers will measure stress levels along with pain, sleep,…

This trial tests a computer-based tool called PAINRelieveIt for adults with sickle cell disease, a condition that causes intense pain episodes. The tool has three parts: one helps patients report their pain, another educates them about pain management, and a third helps doctors c…

This study explores whether an AI-powered chatbot can deliver personalized sleep coaching to Black/African American adults aged 18-25 who have poor sleep and at least one cardiometabolic risk factor. The chatbot uses principles of cognitive-behavioral therapy for insomnia (CBT-I)…

This trial tests whether high-intensity or preferred-intensity resistance training better improves quality of life in women with fibromyalgia. Participants will complete 16 supervised sessions of each type, with a washout period in between. Researchers will measure disease impact…

This trial tests whether shining red and infrared LED light on the jaw and neck muscles can reduce pain and improve movement in people with temporomandibular joint (TMJ) disorders. About 32 adults with TMJ pain will receive either real LED therapy or a placebo treatment over six …

This trial tests whether daily creatine supplements can reduce pain, fatigue, and muscle weakness in people with fibromyalgia. Eighty adults diagnosed with fibromyalgia will receive either creatine or a placebo for a set period. Researchers will measure changes in pain levels, mu…

This study tests an 8-week program called PhYoMind, which blends physiotherapy, yoga postures, breathing exercises, and mindfulness, against home exercise alone in 40 adults with fibromyalgia. The goal is to see if the combined approach reduces disability, pain, fatigue, and stre…

This trial investigates whether using Systane Complete eye drops twice a day works as well as using Thealoz Duo eye drops four times a day for adults with mild to moderate dry eye disease. Over 30 days, participants will use one of the two regimens and report symptom changes thro…

This trial tests whether JASPER, a play-based behavioral intervention, can improve social communication and play skills in infants (12–36 months) with tuberous sclerosis complex (TSC). Caregivers learn strategies during daily and weekly sessions to support their child's developme…

This trial compares two diets—low-FODMAP and lactose- and gluten-free—in adults with irritable bowel syndrome (IBS). Each participant tries both diets for four weeks, with a one-week break in between, to see which one better reduces gut symptoms and improves mental health. The go…

This study looks at whether joining a private social media group with others who have fibromyalgia can improve feelings of loneliness, hopelessness, and overall well-being. Researchers analyzed data from over 1,000 adults with fibromyalgia who participated in an online support co…

This study investigates whether Tongluo Kaibi Tablets, a traditional Chinese herbal medicine, can reduce pain and improve quality of life in people with fibromyalgia syndrome. The trial enrolls 150 adults aged 18 to 75 who meet fibromyalgia criteria and have significant pain. Par…

This study tested whether doing exercise in a virtual reality headset can improve quality of life, thinking, and mood in people with fibromyalgia. Thirty adults with fibromyalgia took part in a crossover trial where everyone tried both virtual reality exercise and regular exercis…

This study tests whether a daily postbiotic supplement called PosBion® can ease symptoms and improve quality of life in adults with irritable bowel syndrome (IBS). Participants take two sachets of the supplement each day for 12 weeks. Researchers measure changes in IBS symptoms, …

This study tested whether an injection of platelet-rich plasma (PRP) made from a patient's own blood can reduce pain and clicking in the jaw joint (TMJ) and improve mouth opening. Thirty adults with a slipped jaw disc were randomly assigned to receive PRP, a steroid with anesthet…

This study investigates whether combining spinal cord stimulation with a specific exercise program can reduce pain and improve quality of life in people with persistent back pain after surgery (failed back surgery syndrome). Participants will be randomly assigned to receive eithe…

This study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce pain, fatigue, and mood problems while improving walking in adults with fibromyalgia. Participants receive either real rTMS or a sham version to se…

This study tests whether a 9-week relaxation response mind-body program can improve quality of life and reduce symptoms in people with irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). Participants attend weekly group sessions that include breathing exercises, m…

This study looked at whether extra family support helps children with Down syndrome and obstructive sleep apnea use their positive airway pressure (PAP) machine more regularly. 27 children aged 6-18 were split into two groups: one received standard care, the other got a family-in…

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The st…

This study tests whether virtual reality training can help children aged 6 to 16 with the childhood form of myotonic dystrophy type 1 (DM1) improve their ability to understand others' thoughts and emotions. Participants engage in social scenarios in a virtual environment, guided …

This Phase 3 trial tested rebamipide eye drops in 762 people with dry eye lasting at least 6 months. Participants received either rebamipide or placebo drops for 26 weeks. The goal was to see if the drops could reduce eye surface damage and discomfort better than placebo.

This study tested a 16-session web-based resistance training program for people with fibromyalgia. Researchers measured balance, muscle performance, and symptoms in 13 adults. The goal was to see if a home-based exercise program could improve physical function and ease fibromyalg…

This early study tested a dexamethasone eye insert placed by a doctor against a standard steroid gel for treating allergy and dry eye symptoms in 36 people with keratoconus who wear gas permeable contact lenses. The goal was to see if the insert improves signs like eyelid bumps a…

This study tested two simple treatments for snoring in people with mild sleep apnea: low-level laser therapy applied to the mouth and soft palate, and oropharyngeal exercises (like tongue and throat workouts). 180 adults aged 40-55 took part. The goal was to see which approach re…

This study tested whether injecting botulinum toxin (Botox) into jaw muscles can reduce pain and improve mouth opening in people with temporomandibular joint (TMJ) myofascial pain. 118 adults with at least moderate pain for over a month received injections in their masseter and t…

This study compared two painkillers, oliceridine and morphine, in 252 adults undergoing laparoscopic colorectal surgery. The goal was to see if oliceridine causes less nausea and vomiting after surgery. Patients used a pump to control their pain medicine for up to 3 days after th…

This study tested whether a mild electrical current applied to the head (called transcranial electrostimulation, or TES) can help control pain after major sleep apnea surgery. 45 patients received TES along with standard care. The goal was to see if TES reduces pain and the need …

This study followed 53 adults with non-dystrophic myotonic disorders who were taking Namuscla (mexiletine) to manage muscle stiffness. Researchers monitored side effects and how often patients needed to reduce their dose or stop treatment over up to 36 months. The goal was to see…

This study tested a 24-session program for 100 adults with fibromyalgia. The program brings together nurses, doctors, physiotherapists, nutritionists, and mental health experts to teach self-management skills. Researchers measured quality of life, pain impact, and mood over 12 mo…

This study explores whether practicing tai chi, a gentle mind-body exercise, can reduce symptoms of irritable bowel syndrome with constipation (IBS-C). Adults aged 18 to 70 with IBS-C will take part in tai chi sessions and report their symptom severity and satisfaction. The goal …

This study tested whether using Systane PRO eye drops consistently for 30 days can relieve symptoms of dry eye disease and improve daily functioning. Thirty-three adults with mild to moderate dry eye took part. The main goal was to see if their eye comfort scores improved from th…

This study tested two non-invasive breathing machines in 49 newborns (born at 33 weeks or later) with respiratory distress. One machine is the standard nasal CPAP, and the other is a newer device called nasal high frequency percussive ventilation. Researchers measured brain oxyge…

This study investigates whether an online Pilates program designed for people with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorder can reduce pain and improve function. Participants follow 25-minute guided videos three times a week for eight weeks. Researche…

This early-stage study tested a combination of two drugs (etanercept and mifepristone) in 20 male veterans with Gulf War Illness. The goal was to see if the treatment is safe and can help reset the body's systems to reduce symptoms like fatigue, pain, and memory problems. Results…

This study tested whether taking 1,000 mg of glycine daily for six months could improve memory and thinking in older adults. Fifty-nine participants took the supplement, and researchers measured changes in a brain health marker and cognitive test scores. The goal was to see if th…

This study tested a self-guided online program for people with psoriasis. 348 adults were split into two groups: one got the app plus their regular treatment, the other got regular treatment alone. The main goal was to see if the app improved quality of life over 12 months.

This Phase 3 trial tested rebamipide eye drops in 755 people with dry eye for at least 6 months. Participants received either rebamipide or placebo drops for up to 52 weeks. The goal was to see if the drops could reduce eye surface damage and ease discomfort.

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This study tested whether osteopathic manual therapy (a hands-on treatment) could reduce symptoms of alcohol withdrawal in hospitalized adults. 26 patients were enrolled and their withdrawal symptoms were measured using standard questionnaires. The goal was to see if adding osteo…

This study tested a 12-week remotely-supervised rehabilitation program for 60 men aged 25-65 with moderate to severe obstructive sleep apnea. The goal was to see if the program could improve breathing pauses during sleep, daytime sleepiness, and overall quality of life. Participa…

This study tested two ways of positioning patients with severe lung injury (ARDS) who are on ventilators and placed face-down (prone) to help breathing. The goal was to see if a 'swimmer' position—where the head is turned and one arm is bent—causes fewer severe pressure sores tha…

This pilot study tested whether a TENS device, placed on the forehead, is safe and practical for treating chronic eye pain in 39 veterans. Participants used the device at home for 6 months. The goal was to see if it reduces pain and to prepare for a larger trial.

This early study tests whether RCI001 eye drops are safe and tolerable in 40 healthy adult men. Participants receive either the active eye drops or a placebo, and researchers monitor for side effects and how the drug behaves in the body. This is a first step toward possibly devel…

This study tested whether CAM-101 eye drops are safe and can help relieve dry eye in people who developed the condition after a bone marrow transplant (graft-versus-host disease). 64 adults received either a low or high dose of CAM-101 or a placebo drop four times a day for six w…

This study tested whether a dietary supplement called Nutritears, containing lutein, zeaxanthin, curcuminoids, and vitamin D3, can improve dry eye symptoms. 131 adults with dry eye syndrome took either the supplement or a placebo daily for 8 weeks. Researchers measured tear produ…

This study tested whether a drug called acetazolamide can improve sleep-disordered breathing in women traveling to high altitude (3600 m). 303 healthy adults participated in a randomized, placebo-controlled trial. The main goal was to see if the drug reduced drops in oxygen level…

This study looked at how the brain processes pain in people with fibromyalgia compared to healthy individuals. Researchers tested whether a non-invasive procedure called transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate the brain, could reduce pain …

This study looked at whether surgery to fix a blocked nose can improve snoring and sleep apnea in adults. Thirty people with nasal obstruction and sleep apnea had surgery. The main goal was to see if their breathing pauses during sleep (measured by the apnea-hypopnea index) got b…

This completed study tested a laser device (BTL-043) on 31 adults with temporomandibular joint (TMJ) pain. Participants received four 20-minute laser sessions over a few weeks. Researchers measured pain levels, jaw movement, and daily function at 1 and 3 months after treatment to…

This study tested two ways to warm the eyelids for people with dry eyes caused by meibomian gland dysfunction. Fifteen adults used a USB-powered warm compress and a self-heating eye mask for two weeks each. Both devices improved tear stability and comfort, but the USB-powered ver…

This completed study looked at whether giving a continuous nerve block along with intensive physical and occupational therapy can improve recovery in people with Complex Regional Pain Syndrome type 1 (CRPS 1). The study enrolled 30 patients and followed them for up to a year. The…

This study tested whether personalized guidance from a dietitian on a low-FODMAP diet works better than just giving patients a standard brochure for managing irritable bowel syndrome (IBS). Fifty adults with IBS followed the diet for 8 weeks. Researchers measured symptom severity…

This study tested whether a 14-day course of the sleep medication eszopiclone could help people with both insomnia and obstructive sleep apnea use their CPAP machine more consistently. Sixty participants were randomly assigned to receive either eszopiclone or a placebo. The resea…

This study tested whether adding virtual reality to motor imagery exercises (mentally practicing movements) can better reduce pain and disability in people with post-stroke shoulder hand syndrome. Forty adults aged 40-70 who had a stroke at least 3 months ago took part. The main …

This pilot study tested whether a digital platform offering two carbohydrate-reduced diets (low FODMAP or low-carb) could help adults with irritable bowel syndrome (IBS). 32 participants used the app for four weeks, reporting their symptoms and quality of life. The goal was to se…

This study tested whether acupressure, a technique that applies pressure to specific points on the body, can reduce anxiety and improve vital signs like blood pressure and heart rate in people hospitalized with acute coronary syndrome (ACS). Sixty-eight adults with a first-time A…

This study compared two therapies—myofeedback and neuromuscular electrical stimulation—to see which better improves arm and hand function in children aged 6 to 14 who have one-sided weakness (hemiplegia) after brain tumor surgery. Forty-five children participated, and researchers…

This study tested a single dose of SPG601 in 10 adult men with Fragile X syndrome to see if it improves symptoms like attention and behavior. Participants were randomly assigned to receive either the drug or a placebo, and neither they nor their doctors knew which they got. The g…

This study tested whether using a CPAP machine (a device that helps you breathe during sleep) can also improve oral frailty (weakness in the mouth) and dysphagia (trouble swallowing) in people with obstructive sleep apnea. Researchers followed 450 adults aged 50 and older for six…

This study tested whether people with diabetic foot ulcers can safely change their own dressings compared to having a nurse do it. Sixty adults with mild to moderate ulcers were randomly assigned to either self-dressing or nurse-led dressing. The researchers tracked healing time,…

This study tested whether a high-flow oxygen system (Optiflow) works better than a standard oxygen mask for patients with breathing failure. About 100 adults in intensive care who needed non-invasive ventilation (NIV) took part. The goal was to see if Optiflow keeps oxygen levels…

This study tested a drug called ecopipam in 40 children aged 7 to 17 with Tourette's syndrome. The goal was to see if it could reduce the frequency and severity of their motor and vocal tics. The drug works by blocking certain dopamine receptors in the brain. The main measure was…

This pilot study tested whether rimegepant (Nurtec), a drug used for migraines, can reduce chronic abdominal pain in people with irritable bowel syndrome (IBS). Thirty-nine adults with non-constipation IBS took either the drug or a placebo for 28 days. Researchers measured change…

This study looked at whether taking Korean ginseng extract daily for eight weeks could reduce fatigue and improve exercise performance in healthy adults aged 20 to 50. Sixty participants were randomly assigned to receive either the ginseng extract or a placebo. The researchers me…

This study looked at 52 adults with EGPA (a rare inflammatory disease) and severe chronic sinusitis with nasal polyps. They received mepolizumab 300 mg every 4 weeks. The goal was to see if the drug reduces polyp size and improves symptoms like nasal congestion and sense of smell…

This study looked at whether aerobic dance exercises can improve symptoms and quality of life in women with fibromyalgia. Forty-four women were split into two groups: one did aerobic dance sessions led by a physiotherapist, and the other did standard postural exercises. Researche…

This study tested whether massage and progressive muscle relaxation exercises can reduce the frequency and severity of muscle cramps in people undergoing hemodialysis. 79 patients participated, and the goal was to see if these non-drug approaches offer relief. The findings could …

This study tested how comfortable two prescription steroid eye drops feel right after use. Forty adults with eye inflammation or dry eye received one drop of Flarex in one eye and one drop of Lotemax SM in the other. They rated comfort and vision impact at 30 seconds, 5 minutes, …

This pilot study tested whether people experiencing alcohol withdrawal can be safely treated at home using telemedicine. Thirty adults who wanted to quit drinking received remote monitoring and symptom-triggered medication over three days. The goal was to see if this approach kep…

This study tested whether a mindfulness program could help teenagers with obstructive sleep apnea use their CPAP machine more regularly. 37 teens aged 13-18 with moderate to severe sleep apnea took part. The program taught skills like awareness and resilience, and the researchers…

This study tested whether a short course of the steroid dexamethasone can reduce the severity of obstructive sleep apnea in children aged 2 to 10. Ten children with moderate-to-severe sleep apnea received either the drug or a placebo for three days. The goal was to see if the ste…

This study tested whether adding functional electrical stimulation (FES)-assisted cycling to standard rehab helps stroke survivors with Complex Regional Pain Syndrome (CRPS). Forty participants either received FES cycling plus conventional therapy or conventional therapy alone fo…

This study tested a mineral mouth rinse (THERAVEX®) in 116 adults with primary burning mouth syndrome, a condition causing ongoing mouth pain. Participants rinsed with the mineral solution or a placebo for 8 weeks. The main goal was to see if the rinse reduced burning pain intens…

This study looked at whether wearing compression stockings during the day for 28 days could reduce the number of breathing pauses (apneas) per hour in people with moderate to severe sleep apnea. The idea is that stockings prevent fluid from building up in the legs and moving to t…

This study will check if a new scoring system called SOFA-2 can better predict which ICU patients are likely to die within 30 days, compared to the current standard. Researchers will also measure how common sepsis and septic shock are in Turkish intensive care units. About 2,500 …

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This completed study by the National Human Genome Research Institute looked at 207 people with Moebius syndrome or similar congenital facial weakness disorders, along with their family members. Researchers aimed to better understand the genetic and clinical features of these cond…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study searched for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afr…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study looked at people with three rare genetic conditions—xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD)—that affect the body's ability to repair DNA. Researchers examined 709 participants to understand how these defects relate to cancer ri…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This study looks at 377 adults with severe lung failure (ARDS) who were treated with prone positioning (lying face down to help breathing). Researchers will use computer models to predict which patients are at highest risk of dying in the ICU. The goal is to help doctors make bet…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study looks at how often sleep disorders—like poor sleep quality, sleep apnea, and restless legs syndrome—occur in people with fibromyalgia. Researchers will use questionnaires to screen patients in specialized pain clinics across France. They will also ask doctors how they …

This study tests whether non-invasive brain stimulation (rTMS) can alter gut activity in healthy people and those with functional dyspepsia or IBS. Researchers will measure stomach rhythms, heart rate, and fullness thresholds after applying rTMS to the motor cortex. It is an earl…

This study looked at 20 people with CADASIL, a rare genetic disease that damages brain arteries and causes migraines, strokes, and dementia. Researchers used blood tests, skin biopsies, eye exams, and brain scans to learn more about how the disease works. The goal was to better u…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study evaluates whether prismaLINE PAP devices accurately count breathing events (apneas and hypopneas) compared to the gold-standard polysomnography (PSG) in people with sleep apnea. Participants will use a full face mask during a titration night, where the device briefly l…

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study looks at how scar tissue (fibrosis) forms in the heart in conditions like aortic stenosis, heart damage from chemotherapy, and carcinoid syndrome. Researchers will use special PET scans to see active scarring early. About 180 adults will take part to help improve detec…

This study investigates the link between the physical structure of the upper airway and its tendency to collapse during sleep, which is a key factor in obstructive sleep apnea. Researchers will measure airway collapsibility using a special pressure device, and assess anatomy via …

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…

This completed pilot study in Yomitan Village, Okinawa tested three simple, low-cost approaches to reduce stress and encourage healthy habits in 45 adults with overweight or pre-metabolic syndrome. Participants were randomly assigned to receive health leaflets, wear functional cl…

This study looked at how having fibromyalgia changes body measurements and sleep patterns in people with obstructive sleep apnea. Researchers measured neck, waist, and hip sizes, and used sleep tests and ultrasound to compare 77 participants. The goal was to better understand the…

This study investigates whether chronic neck pain changes how the neck works in people with temporomandibular disorders (TMD), and whether those neck changes relate to jaw function, mouth opening, and jaw pain. Researchers will compare 67 adults with TMD—some with chronic neck pa…

This study looks at how oral isotretinoin, a common acne treatment, affects the surface of the eye and the meibomian glands, which produce the oily layer of tears. Researchers will measure tear film stability, gland structure, and dry eye symptoms in 60 acne patients before and a…

This trial investigates whether a recruitment maneuver—a brief procedure to open collapsed lung areas—affects blood levels of sRAGE, a marker of lung cell injury, in patients with diffuse acute respiratory distress syndrome (ARDS). The study involves 24 mechanically ventilated IC…

This trial investigates how replacing animal proteins with plant proteins in the diet influences metabolism. Adults with early signs of metabolic syndrome (like high triglycerides or slightly elevated blood pressure) will follow a controlled diet for four weeks, either predominan…

This study looks at whether certain proteins linked to the RAGE receptor—found in lung fluid and blood—are elevated in ICU patients with acute lung injury or ARDS. Researchers will measure these proteins in 60 mechanically ventilated patients within the first day of injury and tr…

This study tests whether gradually tilting patients with acute respiratory distress syndrome (ARDS) upright—from lying flat to a 90° seated position—improves how their lungs handle mechanical ventilation. Researchers will measure lung pressure, aeration, and oxygen levels at each…

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study looks at a nerve in the neck called the ansa cervicalis, which controls muscles that help keep the airway open. Researchers will measure the nerve's size and shape in 50 adults having neck surgery for head and neck cancer. They will also test how stimulating the nerve …

This study is testing whether a specific gene variant (MC4R rs17782313) and metabolic health status influence how men with obesity respond to a 12-week exercise and diet program. Forty men aged 18 to 59 with obesity will be classified as having metabolically healthy or unhealthy …

This study reviews records from 240 people who experienced cardiac arrest outside a hospital and were treated by an emergency medical service in Switzerland. The goal is to identify which factors, such as initial heart rhythm, response time, and whether CPR was started by a bysta…

This study investigates whether genetic differences and altered pain processing contribute to fibromyalgia, a condition marked by widespread pain and increased sensitivity to painful stimuli. Researchers will compare 260 adults with fibromyalgia to a matched control group, measur…

This study tested a school program called SocLaLola that uses a comic book to teach children aged 8-11 about pain. The goal was to see if it improves kids' understanding of pain and reduces their fear of moving. Eighty-two students from two primary schools took part. The program …

This study aims to understand how inflammation and the dominance of mutant blood cells drive VEXAS syndrome, a rare and severe autoinflammatory disease. Researchers will analyze blood and bone marrow samples from VEXAS patients and healthy controls to identify key mechanisms and …

This study looks back at medical records of people who had an allogeneic stem cell transplant to see whether romiplostim helped their platelets recover faster. Platelets are blood cells that help clotting, and low counts are common after transplant. The researchers will compare p…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This completed study followed 945 people, mostly children and young adults with severe eczema or related allergic conditions, along with their relatives. Researchers observed how these diseases progress over up to a year, using tests like allergy skin pricks, blood draws, and lun…

This completed study looked at how to best find and manage tumors in people with Zollinger-Ellison syndrome, a rare condition that causes too much stomach acid. Researchers used imaging tests and tissue samples to locate tumors and check for a related genetic condition called MEN…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study looked at people with neurofibromatosis type 1 (NF1) to better understand how harmless tumors (plexiform neurofibromas) turn into a rare cancer called MPNST. Ten participants had MRI, PET scans, and tumor biopsies. Researchers tested whether a special PET scan (FLT PET…

This study looks for genetic changes linked to progressive familial intrahepatic cholestasis (PFIC) in adults with unexplained bile flow problems. Researchers will collect health information and blood samples from 150 participants across Spain during a single visit. The goal is t…

This study investigates whether fibromuscular dysplasia (FMD), a condition that causes abnormal growth in artery walls, is more common in people who have had a spontaneous coronary artery dissection (SCAD) — a tear in a heart artery that can cause a heart attack, often in young w…

This study looks at whether the 'circle method' — a way to measure the aortic valve — can help doctors choose the right size replacement valve for people with bicuspid aortic valves who are getting a TAVI procedure. Researchers will review past cases to see if patients whose valv…

This study is testing whether following a Mediterranean-style diet based on U.S. dietary guidelines improves heart health more when combined with weight loss. Researchers will provide all meals for 70 adults with obesity or excess body fat for eight weeks. Participants will be sp…

This study investigates whether individual physiological traits that cause obstructive sleep apnea (OSA) can predict how well CPAP therapy works. Researchers will follow adults newly diagnosed with OSA who are starting CPAP, measuring factors like arousal threshold and breathing …

This trial investigates whether a non-invasive light-based technique (near-infrared spectroscopy) can reliably measure intestinal oxygen levels as a proxy for abdominal pressure in infants. Researchers will compare these readings with standard bladder pressure measurements in 30 …

This study tests whether a teaching approach called ARCS (Attention, Relevance, Confidence, Satisfaction) can improve nursing students' ability to perform cardiovascular physical exams. One hundred second-year nursing students will receive either standard training or standard tra…

Septic shock is a life-threatening condition where infection leads to dangerously low blood pressure. Many patients also develop disseminated intravascular coagulation (DIC), a disorder that causes abnormal blood clotting throughout the body. This study will follow 60 adults in t…

Women who become pregnant after weight-loss (bariatric) surgery have a higher chance of delivering smaller-than-expected babies. This study tests whether tracking blood sugar fluctuations with a continuous glucose monitor during each trimester can help predict which babies will b…

This study surveys Indonesian sports science undergraduates to understand how self-esteem, anxiety, sleep habits, and social media use relate to feelings of being a fraud (impostor phenomenon). Researchers aim to identify which psychological, behavioral, and structural factors mo…

This pilot study tests whether a multi-ingredient whey supplement can reduce fructose malabsorption in healthy adults after hiking under heat stress. Eight participants will consume fructose and have their breath hydrogen measured as a marker of malabsorption, both before and aft…

This study tests whether a very short sleep survey, called the Sleep Vital Sign, can help primary care doctors recognize sleep disorders like sleep apnea, insomnia, and restless leg syndrome. About 1,260 adults visiting their Kaiser Permanente doctor will fill out the survey, whi…

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matche…

This study looks at whether measuring oxygen and carbon dioxide differences in the blood can help predict which sepsis patients in the ICU are at highest risk of dying within 28 days. Researchers will track these levels in 88 intubated patients with sepsis who have a central veno…

This study looks at whether placing patients face-down (prone) to help them breathe can damage nerves in the shoulder area. Researchers will use electrical tests to check for nerve injury in adults with severe lung failure who are sedated and on a ventilator. The goal is to find …

This study looks at how well joints like the shoulder, knee, ankle, elbow, and wrist work after orthopedic surgery in people with Ehlers-Danlos syndrome, a condition that affects connective tissue. Researchers are using standard joint function scores to measure outcomes in 200 ad…

This study looks at immune cell patterns in people with three types of nephrotic syndrome—membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis. Researchers aim to see if certain immune cells can serve as biomarkers to track how well a patient res…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study investigates whether a blood test measuring how platelets clump under high shear forces can distinguish a first acute coronary syndrome from a recurrent one. Researchers will enroll 97 adults with unstable angina or early heart attack. The goal is to see if this test o…

This study investigates whether closing the mouth during sleep improves or worsens breathing in people with obstructive sleep apnea. Researchers use drug-induced sleep endoscopy to measure airflow through the nose and mouth separately, then briefly close the mouth every other bre…

This study investigates whether environmental and occupational exposures influence the risk of developing tumors in people who carry an SDHx gene mutation. Researchers will compare two groups of mutation carriers: those who have had a tumor and those who have not. The goal is to …

This study investigates why COVID-19 causes severe lung injury (ARDS) by looking at tiny blood vessels in the lungs. Researchers will compare 39 patients with COVID-19 ARDS to those with ARDS from other causes. They measure 'alveolar dead space' — lung areas that get air but not …

This study uses French national health data to compare the risk of major heart problems—like heart attack, stroke, and death—in people with Takayasu arteritis versus similar people without the disease. It also looks at how steroid use may affect these risks. The goal is to better…

This study tests whether a tool called the HEART score can accurately predict the risk of serious heart problems in people who come to the emergency room with chest pain. The HEART score uses medical history, EKG results, age, risk factors, and a blood test to classify patients a…

This study looks at whether cardiac autonomic neuropathy (nerve damage that affects heart rate control) changes the heart's electrical recovery time (QT interval) in people having coronary artery bypass surgery. Researchers will test nerve function before surgery and measure hear…

This study investigates the genetic causes of pediatric Evans syndrome, a rare autoimmune condition where the immune system attacks blood cells. Researchers analyze blood samples from affected children and their families to find known or new mutations. The goal is to better under…

This study investigates whether electrical impedance tomography (EIT) — a non-invasive imaging technique — can help doctors choose the best ventilator settings for each patient with acute respiratory distress syndrome (ARDS). Researchers will compare different methods of setting …

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study looks at how isotretinoin, a vitamin A-based acne medication, affects eye structures and tear production in people with severe cystic acne. Participants receive standard treatment and undergo eye exams, including dry eye tests and advanced imaging, before and during th…

This study looks at whether the neck-to-waist ratio can help identify patients with high blood pressure and a specific type of heart attack. Researchers measured body shapes of 238 adults arriving at the emergency room with chest pain. The goal is to see if simple body measuremen…

This study followed 55 people with dental implants for 5 years to see if their history of gum disease (aggressive, chronic, or none) affected implant health. Participants received regular dental cleanings. Researchers measured bone loss, gum inflammation, and implant survival. Th…

This study looked at 54 people with primary Sjögren's syndrome who also had muscle inflammation. Researchers wanted to see how many met the official criteria for inflammatory myopathies. The goal was to better understand and classify muscle disease in Sjögren's patients.

This study tested a decision algorithm to help doctors diagnose the cause of eosinophilia (high levels of a type of white blood cell). The algorithm guides which tests to do and in what order. Researchers enrolled 53 patients and measured how many followed the algorithm correctly…

This study analyzed health records of over 118,000 adults with obesity, type 2 diabetes, and related heart, kidney, and liver conditions. Researchers compared people who added a second type of diabetes drug (GLP-1 or SGLT2) early to those who did not. The goal was to see if early…

This study tested a non-invasive imaging method called electrical impedance tomography (EIT) to measure airway opening pressure in 6 adults with acute lung injury or ARDS. The goal was to see if EIT could detect where and when small airways open during a slow breath, which might …

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This study looked back at 80 French patients with calciphylaxis, a rare and often fatal condition causing painful skin ulcers, mostly in people with severe kidney disease. Researchers aimed to describe patient characteristics, how doctors diagnose and treat the condition, and wha…

This study looked at whether asking children with developmental language disorder to repeatedly recall new words helps them learn better than just hearing the words. Twenty-seven 4- and 5-year-olds learned made-up words during storybook reading. The goal was to see if retrieval p…

This study tested whether simpler ultrasound measurements can accurately predict left ventricular function in patients with septic shock. Researchers enrolled 80 patients and compared standard heart function tests (LVEF and GLS) with easier-to-collect parameters like mitral annul…

This completed study looked at red and white blood cells in people with a rare blood disorder called PNH who also have bone marrow failure. Over 5,500 participants aged 10 and older with aplastic anemia or related conditions provided blood samples. The goal was simply to learn mo…

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…

This study follows children in France diagnosed with severe autoimmune cytopenia—conditions where the immune system attacks blood cells. Researchers will track their health over time to see who achieves remission and what factors influence their recovery. The goal is to better un…

This study investigates why people develop obstructive sleep apnea (OSA) and whether the underlying cause affects how they respond to different treatments. Researchers will test three approaches—CPAP, a sleep medication (eszopiclone), and supplemental oxygen—in adults with OSA. T…

This study looked at 526 adults with sepsis who had normal blood pressure to see if a simple measure called the diastolic shock index (DSI) and a blood test for lactate could predict which patients would need medication to support their blood pressure within 6 hours. Researchers …

This study looked at how sleep quality improves when people with obstructive sleep apnea start using a CPAP machine. Researchers used a special headband to track deep sleep at home for 7 nights before and 9 nights after starting treatment. The goal was to see how quickly sleep ge…

This study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…

This study compared 80 women with and without fibromyalgia to measure muscle strength, muscle thickness, vitamin D levels, and sleep quality. Researchers used advanced tools like isokinetic dynamometers and ultrasound to find differences between the groups. The goal was to better…

This study reviewed records of 630 adults who survived a cardiac arrest and were treated in an ICU in Italy over 14 years. Researchers compared outcomes across three time periods when different official treatment guidelines were in use. The goal was to see if newer guidelines led…

This study looked at colon tissue samples from 200 people with irritable bowel syndrome (IBS) to understand why their gut barrier may be leaky. Researchers tested whether substances released by mast cells (a type of immune cell) can damage the gut lining and nerves. The goal is t…

This study looked at whether a narrower oxygen saturation target range helps an automated oxygen control system work better for very low birth weight infants on breathing support. Eleven babies were randomly assigned to either a 3% or a shifted 3% target range. The goal was to se…

This study explored how Ramadan intermittent fasting changes gut bacteria and intestinal barrier function in healthy adults. Researchers followed 79 participants from Italy and Lebanon before, during, and after the fasting month. They collected blood and stool samples to measure …

This completed study from France examined whether a specific type of immune cell (innate CD8+ T cells) is linked to how quickly resistance mutations develop in patients with chronic myeloid leukemia or Philadelphia-positive acute lymphoblastic leukemia. Researchers analyzed blood…

This completed study looked at whether a breathing treatment called Intrapulmonary Percussive Ventilation (IPV) can improve lung stiffness (compliance) in critically ill children who are on breathing machines. Researchers measured lung function before and after one IPV session in…

This study looked at health records from over 5,000 adults to see if having an H. pylori stomach infection is linked to metabolic syndrome—a cluster of conditions like high blood sugar, high blood pressure, and excess belly fat. Researchers compared people with and without the in…

This study looked at a protein called FSTL-1 in the blood of 80 adults with Behcet's disease. The goal was to see if higher or lower levels of this protein are linked to how active the disease is. No treatments were tested; the study only measured and compared protein levels with…

This study tested whether a specific ultrasound-based algorithm could help doctors better manage fluids in patients with septic shock. The trial involved 136 intensive care patients and compared the algorithm to standard care over the first 4 days. The goal was to see if the algo…

This completed study surveyed 566 adolescents aged 14 to 16 to understand how jaw pain (temporomandibular disorders) relates to other painful conditions like headaches, neck pain, and back pain. Researchers used anonymous questionnaires to identify common co-occurring health issu…

This study looked for hidden genetic changes in 10 children with developmental delays who had a balanced chromosomal translocation (a rearrangement of DNA that appears normal under a microscope). Researchers used high-resolution DNA microarrays to check for tiny missing or extra …

This study followed 53 adults with overweight or obesity who were already receiving standard lifestyle-based weight loss care at a clinic. Researchers measured changes in body weight, fat mass, blood sugar, cholesterol, and other health markers before and after weight loss. The g…

This study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…

This study looked at whether measuring hepcidin, a hormone that controls iron levels, in the blood of 114 patients with severe sepsis or septic shock could predict who would die within 28 days. Researchers also tracked deaths at 90 days and infections acquired in the hospital. Th…

This study compared two methods for measuring bioavailable testosterone in the blood: the standard lab test (radioimmunoassay) and a mathematical calculation. Researchers included 270 men and women aged 18 to 90. The goal was to see if the calculation matches the lab test closely…

This study looked at a thin layer of proteins and sugars that lines blood vessels, called the glycocalyx, in 28 people having heart surgery. The goal was to see if changes in this layer relate to fluid leaking out of blood vessels, which can cause swelling. By measuring glycocaly…

This study uses a non-invasive light-based technique called near-infrared spectroscopy (NIRS) combined with EEG to measure blood flow changes in the brains of children aged 3 to 6 years during infantile epilepsy spasms. The goal is to better understand what happens in the brain b…

This completed study reviewed the medical records of 210 people with aortitis (inflammation of the aorta) or retroperitoneal fibrosis (scar tissue in the abdomen). The goal was to find patterns in symptoms, lab tests, and imaging that could help doctors tell different types of th…

This study tested a new strategy for collecting patient-reported outcome measures (PROMs) to make them more relevant and less burdensome. Researchers compared usual PROMs with an enhanced version in 200 English- and Spanish-speaking patients. The goal was to see if the new approa…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This early study tested whether a small electrode placed near the nerve that controls tongue movement could help people with obstructive sleep apnea. Fourteen adults who already needed surgery took part. The main goal was to see if the approach was safe and could make the tongue …

This study looked at how patients and healthcare professionals experienced a new way of organizing primary care, where different health workers work together as a team. Researchers interviewed 48 patients and staff at one health centre in France. The goal was to understand what w…

This study tested whether stimulating certain nerves or muscles in the throat can improve breathing in people with obstructive sleep apnea. Researchers placed temporary electrodes and measured airflow during sleep in 35 adults. The goal was to see if this approach is feasible and…

This early study tested whether a small electrode placed near the tongue nerve could be safely used in people with obstructive sleep apnea. 14 adults who could not use CPAP took part. The goal was simply to see if the nerve could be reached and stimulated, not yet to treat the co…

This study looked at 100 people with primary Sjögren's syndrome to understand how the disease affects their physical, emotional, and social well-being. Researchers used questionnaires and simple tests to measure symptoms like fatigue, pain, swallowing problems, and mood. A health…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study looked at the medical records of one person from a sleep clinic to see if their breathing problems were due to a condition called dysanapsis (where airways are smaller than normal) rather than true asthma. The goal was to better understand why some people with sleep ap…

This study surveyed 231 adults with Lynch syndrome, an inherited condition that raises bowel cancer risk. Researchers wanted to find out how many people follow the UK recommendation of a colonoscopy every two years, and what makes it harder or easier to keep up with these check-u…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This study looked at 545 people with hereditary cancer syndromes and their relatives. It compared the usual method of asking patients to share testing information with family members to a new method where a registry also sends reminders. The goal was to see if the registry-aided …

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study looked at 103 adults with narcolepsy or obstructive sleep apnea to see if anxiety, social, or work factors affect their ability to stay awake during a standard test. Participants filled out an anxiety questionnaire before the test. The goal is to better understand why …

This study looked at 88 women newly diagnosed with primary hypothyroidism (underactive thyroid) to see if taking levothyroxine to normalize thyroid hormones also improves metabolic health. Researchers measured special proteins called adipokines, which are linked to fat tissue and…

This study tested a special MRI technique called magnetic resonance elastography (MRE) to see if it can detect scarring in transplanted kidneys. Researchers compared MRE results with traditional biopsy samples from 73 kidney transplant patients. The goal was to find a non-invasiv…

This study looked at 20 adults who wear an artificial eye to see if it causes more dry eye symptoms and damage to the tiny oil glands in the eyelids. Researchers compared the artificial eye side with the healthy eye side using special imaging and questionnaires. The goal was to u…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study examined spinal fluid from 32 children with tethered spinal cord to see if inflammation plays a role in the condition. Researchers collected fluid samples during surgery and looked for markers of inflammation. The goal was to better understand how the spinal cord gets …

This study follows 87 women who had chronic low back pain 13 years ago to see how their pain, daily activities, and ability to work have changed. Researchers are looking for patterns that might predict who will improve or worsen over time. The goal is to better understand the lon…

This completed study looked at how immune cells recover in 61 adults who received a stem cell transplant for blood cancers. Researchers measured the function of T and NK cells by testing their cytokine profiles after stimulation. The goal was to see if these measurements could he…

This study looked at how hormones and birth control pills affect knee ligament looseness in healthy women. Researchers measured knee laxity in 45 women at two points in their menstrual cycle, comparing those on hormonal contraceptives to those not. The goal was to better understa…

This study looked at how four different drinks—two prebiotic sodas, regular Coca-Cola, and Diet Coke—affect hunger, blood sugar, insulin, and appetite hormones in healthy men aged 18-40. Ten participants visited the lab four times, each time drinking one of the beverages in a ran…

This completed study investigated whether air pollution affects flare-ups in people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis. Researchers followed 86 patients for 6 months, asking them to complete weekly questionnaires about their symptoms. They a…

This study looked at 13 adults who had been on a breathing tube for at least 2 days and were at risk for breathing trouble after the tube was removed. Researchers compared two types of noninvasive breathing support: one that senses the patient's own breathing signals (NAVA) and o…

This study looked at whether neck muscle activity during sleep affects breathing recovery in 17 COVID-19 patients who were on ventilators in the ICU. Researchers used sleep tests and activity monitors to track sleep quality and breathing patterns. The goal was to understand why s…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This study looked at how the body's natural endocannabinoids (similar to cannabis compounds) interact with the stress hormone cortisol in people with Cushing's syndrome, a condition of high cortisol. Researchers measured blood levels of these compounds in 40 participants, includi…

This study collected information from over 15,000 people hospitalized with cardiomyopathy, a heart muscle disease. Researchers looked at how much these hospital stays cost and what the money was spent on. The goal was to understand the real-world financial impact and help manage …

This study looked at whether immune cells from the intestine play a role in Sjogren's syndrome, an autoimmune disease that causes dry eyes and mouth. Researchers examined saliva gland samples from 57 adults suspected of having Sjogren's. The goal was to better understand the dise…

This study looked at 100 women with Polycystic Ovary Syndrome (PCOS) to understand how the condition impacts their quality of life and mental health. Researchers examined factors like age, weight, how long it took to get a diagnosis, and history of anxiety or depression. Particip…

This study tracked 555 adults hospitalized with acute coronary syndrome (a serious heart condition) to see how quickly they called for help and what factors influenced their recovery. Researchers focused on delays in calling an ambulance and how those delays affected short- and l…

This study looked at brain activity in the frontal cortex of 14 people with Tourette syndrome using a 24-hour portable EEG. Participants pressed a button each time they had a tic, so researchers could compare brain signals with and without tics. The goal was to identify which bra…

This study looked at 395 adults with obstructive sleep apnea to see if a new tool called the Baveno classification agrees with the standard sleep test (polysomnography) for deciding treatment. Researchers compared symptoms and health records against sleep lab results. The goal is…

This completed study tested whether an AI system could improve how ventilators are set for children (ages 1 month to 18 years) in the pediatric ICU with breathing problems like pneumonia or respiratory failure. Researchers compared AI-generated recommendations to the actual adjus…

This study looked at whether certain gene changes (in the TCF7L2 gene) make ICU patients with organ failure more likely to develop high blood sugar. Nearly 1,000 adults in the ICU were checked for these gene changes and their blood sugar levels. The goal was to understand the lin…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This study tested a digital health platform to help people with a hereditary risk of breast and ovarian cancer share their genetic test results with family members. Researchers worked with 128 participants in Switzerland and Korea to see if the tool reduced distress and improved …

This study looked at different types of immune cells (eosinophils) in the blood of people with asthma, chronic sinusitis with nasal polyps, or both, compared to healthy volunteers. The goal was to find patterns that could help doctors choose the best targeted therapy for each pat…

This study looked at 30 women with PCOS who had trouble ovulating. Researchers measured a hormone called AMH while giving low doses of FSH to see if a drop in AMH happens when an egg follicle starts to grow. The goal was to better understand why ovulation fails in PCOS, not to te…

This study looked at 42 infants who had surgery for a rare birth defect called esophageal atresia type III. Researchers gave the babies a sugary drink to see how often they developed dumping syndrome, a condition causing rapid blood sugar changes. The goal was to find out how com…

This completed study looked at nearly 7,000 adults with inflammatory joint diseases like rheumatoid arthritis and psoriatic arthritis. Researchers compared two versions of a standard health survey (EQ-5D-3L and EQ-5D-5L) to see which one better measures health and quality of life…

This study looked at two ways to help children with Developmental Language Disorder (DLD) improve their grammar: recast therapy (where a therapist corrects the child's speech) and reading specially designed stories. Researchers worked with 137 children aged 4-9 to see how well th…

This study looked at 10 adults with moderate-to-severe ARDS who were on breathing machines. Researchers used a non-invasive imaging method (EIT) to adjust ventilator pressure settings and then checked how the heart's right side responded using ultrasound. The goal was to find the…

This study looked back at the medical records of 168 adults who survived a cardiac arrest and were treated in the intensive care unit. Researchers wanted to find early signs that could predict which patients were more likely to die within 30 days or six months. By analyzing lab r…