New eye drops aim to soothe dry eye sufferers
NCT ID NCT00201955
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tested rebamipide eye drops in 762 people with dry eye lasting at least 6 months. Participants received either rebamipide or placebo drops for 26 weeks. The goal was to see if the drops could reduce eye surface damage and discomfort better than placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
rebamipide eye drops
What this could lead to
If it works, this could provide a new treatment option to ease dry eye symptoms and improve eye surface health.
What could go wrong
This is a completed Phase 3 trial, but results may not show a clear benefit over placebo. Dry eye is complex, and what works for some may not work for all.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Study site
Houston, Texas, 77002, United States
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Advanced Healthcare Clinical Research Center
Milwaukee, Wisconsin, 21209, United States
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Benchmark Research
San Francisco, California, 94102, United States
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Bend Medical Clinic
Bend, Oregon, 97701, United States
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Black Hills Regional Eye Institute
Rapid City, South Dakota, 57701, United States
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Bossier Optical, Inc.
Bossier City, Louisiana, 71111, United States
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Carolina Eye Associates
Southern Pines, North Carolina, 28387, United States
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Cincinnati Eye Institute
Cincinnati, Ohio, 45242, United States
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Clinical Research Laboratories
Piscataway, New Jersey, 08854, United States
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Colorado Eye Associates, PC
Colorado Springs, Colorado, 80907, United States
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Comprehensive Opthalmology & Optical Services
Cleveland, Ohio, 44115, United States
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Cornerstone Research Care
High Point, North Carolina, 27262, United States
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Corona Research Consultants, Inc.
El Paso, Texas, 79904, United States
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Danbury Eye Physicians and Surgeons, P.C.
Danbury, Connecticut, 06810-4005, United States
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Depremont Eye Specialists
Gulfport, Mississippi, 39507, United States
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Eye Care Associates
Bethpage, New York, 11021, United States
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Eye Clinic of South Texas
San Antonio, Texas, 78209, United States
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Family Eye Centers
New Orleans, Louisiana, 70127, United States
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Florida Ophthalmic Institute
Gainesville, Florida, 32605-3192, United States
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Florida Wellcare Alliance, L.C.
Inverness, Florida, 34452, United States
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Glaucome-Cataract Consultants
Pittsburgh, Pennsylvania, 15243, United States
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Harold Helms, MD
Birmingham, Alabama, 35205, United States
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Harvey and Bernice Jones Eye Institute
Little Rock, Arkansas, 72205, United States
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Heartland Research Associates, LLC
Wichita, Kansas, 67207, United States
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Horizon Eye Care - Clinical Research Dept.
Charlotte, North Carolina, 28211, United States
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Houston Eye Associates
Houston, Texas, 77125, United States
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I Care! Eye Care!
Flagstaff, Arizona, 860001, United States
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Magnolia Research Group, Inc.
Ocala, Florida, 34471, United States
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Medical Center Ophthalmology
Houston, Texas, 77030, United States
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Medical Eye Center
Medford, Oregon, 97504, United States
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Michael Bernstein, MD
Birmingham, Alabama, 35216, United States
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Minnesota Eye Associates
Minneapolis, Minnesota, 55404, United States
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Mt. Sinai Medical Center School of Medicine
New York, New York, 10029, United States
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Ophthalmic Consultants of Long Island
New York, New York, 11570, United States
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Ophthalmic Consultants of Long Island
Valley Stream, New York, 11581, United States
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Ophthalmic Research Associates, Inc.
North Andover, Massachusetts, 01845, United States
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Ophthalmology Associates
Princeton, New Jersey, 08540, United States
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Ophthmalmic Consultants of Long Island
Lynbrook, New York, 11563, United States
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Opthalmology Associates
Creve Coeur, Missouri, 63141, United States
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Philadelphia Eye Associates
Philadelphia, Pennsylvania, 19148, United States
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Physician Research Network
Houston, Texas, 77002, United States
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Radiant Research - West Palm Beach
West Palm Beach, Florida, 33407, United States
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Rochester Ophthalmological Group
Rochester, New York, 14618, United States
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Shettle Eye Center
Largo, Florida, 33770, United States
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Southeast Clinical Research Associates
Charlotte, North Carolina, 28210, United States
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Southern California Clinical Research, Inc.
San Marino, California, 91108, United States
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Stevenson Medical Surgical Eye Center
New Orleans, Louisiana, 70119, United States
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Sun Research Institute
San Antonio, Texas, 78205, United States
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Suncoast Clinical Research, Inc.
New Port Richey, Florida, 34652, United States
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Taustine Eye Center
Louisville, Kentucky, 40217, United States
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The University of Texas Medical Branch
Galveston, Texas, 77555, United States
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Total Eye Care, P.A.
Memphis, Tennessee, 38119, United States
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Tukio Institute for Clinical Research
North Miami Beach, Florida, 33169, United States
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United Medical Research Institute
Inglewood, California, 90301, United States
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University of Pittsburg Eye and Ear Institute
Pittsburgh, Pennsylvania, 15233, United States
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Valley Clinical Research Center
Easton, Pennsylvania, 18045, United States
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Vision Incorporated
Savannah, Georgia, 31406, United States
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Welborn Clinic
Evansville, Indiana, 47714, United States
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Western Wake Eye Center, P.A.
Cary, North Carolina, 27511, United States
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Wichita Clinic, PA
Wichita, Kansas, 67208, United States