New eye drops aim to soothe dry eye sufferers
NCT ID NCT00201981
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tested rebamipide eye drops in 755 people with dry eye for at least 6 months. Participants received either rebamipide or placebo drops for up to 52 weeks. The goal was to see if the drops could reduce eye surface damage and ease discomfort.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
rebamipide eye drops
What this could lead to
If it works, this could provide a new treatment option to ease dry eye symptoms and improve eye surface health.
What could go wrong
This is a completed Phase 3 trial, but results may not show significant benefit over placebo. Dry eye is complex and individual responses vary.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Access Eye Research Center
Fredericksburg, Virginia, 22405, United States
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Alabama Research Center, LLC
Birmingham, Alabama, 35209, United States
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American Eye Institute
Los Angeles, California, 90048, United States
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Axia Research
Salt Lake City, Utah, 84107, United States
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Brazosport Eye Institute
Lake Jackson, Texas, 77566, United States
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Buena Vista Eye Care Center
Phoenix, Arizona, 85012, United States
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Centennial Eye Associates
Centennial, Colorado, 80112, United States
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Clinical Research Center of Nevada
Las Vegas, Nevada, 89104, United States
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Clinical Research Institute of Southern Oregon
Medford, Oregon, 97504, United States
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Clinical Research Source, Inc.
Perrysburg, Ohio, 43551, United States
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Clinical Research of West Florida, Inc.
Tampa, Florida, 33603, United States
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Comprehensive Opthalmology & Optical Services
Cleveland, Ohio, 44115, United States
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Corneal Consultants of Colorado
Littleton, Colorado, 80120, United States
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Danial Long, MD
Gretna, Louisiana, 70056, United States
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Eye Associates International
Ormond Beach, Florida, 32174, United States
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Eye Associates of New Mexico
Albuquerque, New Mexico, 87109, United States
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Eye Center Northeast
Bangor, Maine, 04401, United States
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Eye Clinic of Austin
Austin, Texas, 78731, United States
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Eye Clinic of San Diego
San Diego, California, 92103, United States
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Ft. Lauderdale Eye Institute
Sunrise, Florida, 33351, United States
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Glaucoma Consultants and Center for Eye Research
Mt. Pleasant, South Carolina, 29464, United States
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Glaucoma Consultants of the Capital Region
Slingerlands, New York, 12159, United States
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Gulf Coast Research Associates, Inc.
Baton Rouge, Louisiana, 70808, United States
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Healthcare Partners Medical Group
Torrance, California, 90503, United States
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Hernando Eye Institute
Brooksville, Florida, 34613, United States
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Hope research Institute
Phoenix, Arizona, 85006, United States
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International Eye Center
Tampa, Florida, 33603, United States
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John Moran Eye Center, University of Utah
Salt Lake City, Utah, 84132, United States
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Kentucky Lions Eye Center
Louisville, Kentucky, 40222, United States
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Krieger Eye Institute
Baltimore, Maryland, 21215, United States
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Lakeview Optical
New Orleans, Louisiana, 70124, United States
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Marvin E. Greenberg, MD PA 7
Tamarac, Florida, 33321, United States
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Mississippi Eye Associates
Ocean Springs, Mississippi, 39564, United States
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Montana Medical Research, LLC
Missoula, Montana, 59804, United States
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New England Eye Center
Boston, Massachusetts, 02111, United States
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Northwest Corneal Services
Portland, Oregon, 97223, United States
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Omni Eye Services
Atlanta, Georgia, 30342, United States
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Opticare Eye Health Center
Waterbury, Connecticut, 06708, United States
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Orellana Retina Associates, PLLC
Raleigh, North Carolina, 27612, United States
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Peter C. Donshik, MDPC
Bloomfield, Connecticut, 06002, United States
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Physicians Research Options, LC
Sandy City, Utah, 84070, United States
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Pinellas Eye Center
Pinellas Park, Florida, 33781, United States
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Pivotel Research Center
Peoria, Arizona, 85381, United States
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Radiant Research
Scottsdale, Arizona, 85251, United States
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Radiant Research - Irvine
Irvine, California, 92618, United States
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Radiant Research, Inc. - Lake Worth
Lake Worth, Florida, 33461, United States
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Sall Eye Research Center
Artesia, California, 90701-5653, United States
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Scripps Clinic Medical Group, Inc.
La Jolla, California, 92037, United States
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St. Luke's Eye Institute
Amarillo, Texas, 79106, United States
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Sun Valley Arthritis Center, Ltd.
Glendale, Arizona, 85308, United States
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Suncoast Clinical Research, Inc.
New Port Richey, Florida, 34652, United States
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Surgical Eye Associates, PA
Houston, Texas, 77055, United States
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The Eye Associates
Bradenton, Florida, 34209, United States
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The Eye Institute - Lahey Clinic North
Peabody, Massachusetts, 01960, United States
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The Wilmer Eye Institute
Lutherville, Maryland, 21093, United States
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University Eye Surgeons
Maryville, Tennessee, 37803, United States
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University Hospitals of Cleveland
Cleveland, Ohio, 44106-5068, United States
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University of Kentucky, Department of Ophthamology
Lexington, Kentucky, 40536-0293, United States
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Vision Surgery and Laser Center
Roseburg, Oregon, 97470, United States
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West Hills Vision Center
Moon Township, Pennsylvania, 15108, United States
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Western New York Eye Center
Orchard Park, New York, 14127, United States
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Western States Clinical Research, Inc.
Wheat Ridge, Colorado, 80033, United States