A hormone head start: could estrogen before IVF boost pregnancy chances in PCOS?
NCT ID NCT07727863
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
This trial tests whether taking estradiol (a form of estrogen) for about 10 days before starting ovarian stimulation can help women with polycystic ovary syndrome (PCOS) have more synchronized follicle growth and better IVF outcomes. Sixty women with PCOS undergoing ICSI are randomly assigned to receive either estradiol pretreatment or no pretreatment. Researchers will measure follicle size consistency, hormone doses needed, and pregnancy rates to see if this simple step makes a difference.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- estradiol valerate (a form of estrogen) taken as a pill before starting ovarian stimulation
- What this could lead to
- If effective, this simple hormone pretreatment could improve egg quality and pregnancy rates in women with PCOS undergoing IVF.
- What could go wrong
- This is a small, single-center trial, so results may not apply broadly. Estrogen therapy carries risks like blood clots, and the benefit over standard care is unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for IVF OUTCOMES are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cairo University
Cairo, Cairo Governorate, 12111, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could body fat, not BMI, be the key to IVF success?
- IVF showdown: which drug combo gives more usable embryos?
- AI could predict which sperm will lead to a baby
- Light therapy may boost IVF success for older women
- AI vs. doctors: who decides when to trigger ovulation in IVF?
- Red light therapy for IVF embryos: a new hope for fertility?