Blood test may untangle vanishing twin puzzle to screen the survivor
NCT ID NCT05004337
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This study is testing whether a blood test can tell apart the DNA from a vanishing twin and the living twin in pregnancies where one twin stops developing. The goal is to improve non-invasive prenatal screening for chromosome conditions like trisomy 21, 18, and 13 in the surviving twin. Researchers will collect blood samples from women with dizygotic twin pregnancies and use genetic analysis to develop a new algorithm that can measure each twin's DNA separately. If it works, this could lead to more accurate prenatal screening for these pregnancies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SNP-based non-invasive prenatal testing (NIPT) using a blood sample
- What this could lead to
- If successful, this could improve prenatal screening for women with vanishing twin pregnancies, giving clearer information about the health of the surviving twin.
- What could go wrong
- The study is small and early, and the algorithm may not be accurate enough for all cases. There is also a risk of false results, which could cause unnecessary worry.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beaumont
Royal Oak, Michigan, 48073, United States
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Cedar Health Research
Irving, Texas, 75039, United States
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Center for Fetal Medicine & Women's Ultrasound
Los Angeles, California, 90048, United States
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Christiana Care
Newark, Delaware, 19718, United States
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Columbia University
New York, New York, 10032, United States
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Emerald Coast ObGyn
Panama City, Florida, 32405, United States
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Hackensack
Neptune City, New Jersey, 07753, United States
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Icahn School of Medicine at Mount Sinai Hospital
New York, New York, 10029, United States
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Lehigh Valley Health Network
Allentown, Pennsylvania, 18103, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Montefiore Medical Center
The Bronx, New York, 10461, United States
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NYU Langone
New York, New York, 10022, United States
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NYU Long Island
Mineola, New York, 11501, United States
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St. Peter's University Hospital
New Brunswick, New Jersey, 08901, United States
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Stanford
Palo Alto, California, 94304, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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University of Kansas
Kansas City, Kansas, 66160, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Weill Cornell Medicine
New York, New York, 10065, United States
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Yale
New Haven, Connecticut, 06511, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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