Can a rare mutation that blocks pain reveal new painkiller targets?
NCT ID NCT07755930
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This study investigates Marsili syndrome, a rare genetic condition that reduces sensitivity to pain and injury. Researchers will apply heat, pressure, itch-inducing substances, and knee injections to a small group of people with the condition, measuring their pain and itch responses. The goal is to understand how this mutation alters pain sensing, which could point toward new targets for pain treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Histamine, cowhage, capsaicin 8% patch, and hypertonic saline knee injections are used to provoke pain and itch sensations for measurement.
- What this could lead to
- If this works, it could uncover new targets for painkillers by revealing how a rare genetic mutation blocks pain.
- What could go wrong
- This is a very small study (4 people) focused on understanding, not treatment. Results may not apply to the general population.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University Selma Lagerløfs Vej 249 9260 Gistrup, Denmark
Gistrup, Aalborg, 9260, Denmark