Hidden genetic syndrome may explain mysterious inflammation in older adults

NCT ID NCT07708688

Not yet recruiting Knowledge-focused Sponsor: Centre Hospitalier Universitaire Vaudois Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study looks for VEXAS syndrome, a recently discovered genetic condition, in adults over 50 who are hospitalized with unexplained fever, inflammation, or blood abnormalities. Researchers will screen participants using clinical exams and genetic testing of the UBA1 gene. The goal is to find out how common VEXAS syndrome is in this group and describe its symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal how many older adults with unexplained inflammation actually have VEXAS syndrome, leading to better diagnosis and awareness.
What could go wrong: This is a small observational study in one region of Italy, so findings may not apply to other populations. It only estimates prevalence and does not test any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

VEXAS syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VEXAS SYNDROME

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

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