Scientists map cellular secrets of recurring colon polyps to prevent future cancer

NCT ID NCT07683312

Not yet recruiting Knowledge-focused Sponsor: Zhongshan Hospital Xiamen University Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study investigates why colorectal adenomas (precancerous polyps) sometimes return after being surgically removed. Researchers will collect tissue samples from 30 patients and use advanced genetic sequencing to compare polyps that recur with those that do not. The goal is to identify cell types and biological pathways linked to recurrence and build a risk prediction model that could help doctors personalize follow-up care and explore microbiome-based prevention strategies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a risk prediction model and biomarker panel to personalize follow-up schedules and suggest microbiome-based treatments to prevent recurrence.
What could go wrong: This is a small, early-stage observational study with only 30 participants, so findings may not apply to everyone. It aims to understand mechanisms, not test a treatment, so direct patient benefits are uncertain.

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Conditions

The condition(s) this trial relates to.

carcinoma colorectal adenoma polyposis syndrome, hereditary mixed, 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL ADENOMA AND CARCINOMA

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