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Eye stiffness after cataract surgery: does pseudoexfoliation make a difference?

NCT ID NCT07719101

Knowledge-focused Sponsor: Kata Culina Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study follows 70 adults aged 50 and older who are having routine cataract surgery. Half have pseudoexfoliation syndrome, a condition that can weaken eye tissues, and half do not. Researchers measure corneal stiffness before surgery and at several points afterward to see whether the two groups respond differently. The goal is to better understand how pseudoexfoliation affects the eye's healing after cataract removal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If clear differences emerge, surgeons may adjust their technique or follow-up for patients with pseudoexfoliation syndrome to reduce complications.
What could go wrong
This is a small observational study, not a treatment trial. It measures eye stiffness, not vision outcomes, so the practical impact may be limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults with age-related cataract scheduled for routine phacoemulsification cataract surgery. Participants will be enrolled into either the pseudoexfoliation syndrome group or the control group and followed for 30 days after surgery

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adults aged 50 years and older * presence of age-related cataract requiring phacoemulsification cataract surgery * presence of pseudoexfoliation syndrome (PEX group) or absence of pseudoexfoliation syndrome (control group) * ability and willingness to provide written consent Exclusion Criteria: * previous ocular surgery, * corneal disease, * glaucoma or ocular hypertension, * dry eye disease (Schirmer test \<10 mm, tear break-up time \<5 seconds or positive fluorescein staining), * high refractive error (myopia \> -6.00 D or hyperopia \> +5.00 D), * unilateral pseudoexfoliation when the eye scheduled for surgery showed Adults no signs of PEX, * intraoperative or postoperative complications, * any ocular disease that could influence corneal biomechanics

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Conditions

The condition(s) this trial relates to.

cataract exfoliation syndrome exfoliation syndrome, susceptibility to

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cataract Pseudoexfoliation syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Eye Clinic Medic Jukic

    Split, Splitsko-dalmatinska County, 21000, Croatia

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