CATARACT

This study tests a new multifocal lens (LuxHighAdd) for cataract surgery, comparing it to a standard monofocal lens. About 57 people aged 50+ with cataracts in both eyes will receive the lens in both eyes. The goal is to see if the new lens improves near vision without harming di…

This study tests whether placing a capsular tension ring (CTR) during cataract surgery helps keep the artificial lens more stable in people with retinitis pigmentosa (RP). Each of the 88 participants will get the ring in one eye, while the other eye serves as a comparison. Resear…

This study is testing a special laser called ELIOS to treat glaucoma at the same time as cataract surgery. The laser creates tiny channels in the eye to help fluid drain and lower eye pressure. About 46 adults with both cataracts and open-angle glaucoma will take part. The goal i…

This study is testing a new robotic system called ORYOM to see if it can safely perform cataract surgery. Twenty adults between 55 and 80 years old who need cataract surgery will take part. The main goal is to see if the robot can complete the surgery without needing to switch to…

This study tests a device called the Tran cannula, used during cataract surgery to clean away debris from the eye's drainage system in patients with pseudoexfoliative glaucoma. The goal is to see if it lowers eye pressure better than standard irrigation. Fifty-eight adults with b…

This study tests a small device called iStent that is placed in the eye during cataract surgery to help lower pressure in people with open-angle glaucoma. Sixty adults with both glaucoma and cataracts will be enrolled. The goal is to see if the iStent is safe and effective at red…

This study is checking the long-term safety of the IC-8 Apthera lens, which is implanted during cataract surgery. It focuses on a common complication called posterior capsule opacification (PCO), where the lens capsule becomes cloudy. Researchers will follow 435 people for 24 mon…

This study tests special lens implants that correct both cataracts and presbyopia (age-related blurry near vision) in patients with additional eye structure issues like lens dislocation or inflammation. About 320 adults will receive these lenses during cataract surgery, with doct…

This Phase 3 trial tests a new eye drop called PRO-232, which combines an antibiotic (moxifloxacin) and a steroid (dexamethasone) in one bottle. It aims to see if this single drop works as well as using two separate drops to prevent infection and control inflammation after catara…

This study tests whether making tiny arcuate incisions on the cornea during cataract surgery, combined with a special light-adjustable lens, can better correct pre-existing astigmatism. About 60 adults will receive this treatment and be followed to see how much their vision impro…

This early-stage trial tests a new treatment called EO2002, which uses magnetic human corneal cells injected into the eye during or after cataract surgery. The goal is to see if it is safe and tolerable for patients with low corneal cell counts. The study involves 32 participants…

This study compares two types of trifocal toric lens implants used during cataract surgery to correct both cataracts and astigmatism. About 138 adults with cataracts and regular astigmatism will receive one of the two lenses. The main goal is to see which lens provides better int…

This phase 3 trial tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with glaucoma or high eye pressure. About 400 participants will receive either the implant with a special lens or standard eye drops. The goal is to see if…

This study tests a bimatoprost implant placed inside the eye during cataract surgery to lower eye pressure in people with glaucoma or high eye pressure. About 400 participants will receive either the implant plus a special lens or standard eye drops. The goal is to see if the imp…

This study is testing a new device called the Veritas Vision System for cataract surgery. The goal is to see if it uses less energy and causes less damage to the cells on the inside of the eye. Researchers will follow 50 adults for 3 months after surgery to check eye health and v…

This study tests special eye drops made with stem cells to see if they can help people with dry eye disease and cataracts. Researchers will give 300 adults these drops three times a day for 12 weeks. They will check if the drops improve tear film, reduce symptoms, and clear up th…

This study compares three different NSAID eye drops (bromfenac, nepafenac, and diclofenac) to see which one best prevents cystoid macular edema, a type of swelling that can blur vision after cataract surgery. About 150 adults having cataract surgery will be randomly assigned to o…

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

This study will enroll 500,000 people with high myopia and cataracts to develop an artificial intelligence model that helps doctors calculate the correct lens power and grade cataracts more accurately. The goal is to improve vision outcomes and reduce complications after surgery.…

This study is testing whether artificial intelligence can analyze eye images to better detect and predict vision-threatening changes in people with high myopia (severe nearsightedness). Researchers will collect eye scans from 1,000 patients and use AI to identify a condition call…

This study tests a new type of lens called Clareon TruPlus, used during cataract surgery to replace the eye's natural lens. Researchers want to see how well it improves vision and how satisfied patients are up to 3 months after the procedure. The study involves 40 adults over 40 …

This study tests the Clareon TruPlus lens in 35 adults over 45 who need cataract surgery and previously had laser eye surgery for nearsightedness. The lens is designed to improve vision at various distances and reduce the need for glasses. Participants will be followed for 3 mont…

This study looks at whether playing binaural beats (a type of sound) through earphones during cataract surgery can help older patients feel more satisfied and comfortable. About 60 people aged 65 and older will take part, with half listening to the sounds and half wearing earphon…

This study compares three sedation approaches—using dexmedetomidine, propofol, or both—during cataract surgery in 1,000 adults. Researchers will measure how well each method sedates patients, affects heart rate and blood pressure, and causes side effects like nausea. The goal is …

This study looks at whether Systane COMPLETE artificial tears can improve dry eye symptoms and help doctors better predict cataract surgery outcomes. About 140 cataract patients with dry eye will use the drops before and after surgery. Researchers will measure changes in eye shap…

This study looks at whether taking an oral anti-anxiety medication (Alprazolam) before cataract surgery can reduce pain and anxiety and improve satisfaction. Researchers will follow 250 adults having surgery on their second eye. The goal is to find a safe, convenient way to make …

This study looks at whether taking Xanax (a mild anti-anxiety medication) 30 minutes before cataract surgery can reduce pain and anxiety and improve satisfaction with the anesthesia. Researchers will compare Xanax to a placebo in 400 adults having cataract surgery at National Tai…

This study tests whether using Systane COMPLETE eye drops before cataract surgery can improve dry eye symptoms and help with surgical planning. About 150 adults aged 20-85 with dry eye who need cataract surgery will use the drops regularly before their operation. Researchers will…

This study tests whether a medication given as a nose spray (dexmedetomidine) can keep blood pressure stable in elderly patients with high blood pressure who are having cataract surgery. About 126 people aged 65 and older will take part. The goal is to see if the spray reduces da…

This study looks at whether using a stress ball during cataract surgery can lower patients' pain and fear and increase their satisfaction. About 60 adults having their first cataract surgery will be asked to squeeze a stress ball during the procedure. Researchers will measure pai…

This study tests a new type of artificial lens (LuxBoost) for people having cataract surgery. The goal is to see if it improves vision at far, middle, and close distances compared to a standard lens. About 58 adults aged 50 and older with cataracts in both eyes will take part.

This study tests whether having a researcher hold the patient's hand or giving them a stress ball to squeeze can reduce pain and anxiety during cataract surgery. 108 adults having their first cataract surgery will be randomly assigned to one of three groups: hand holding, stress …

This study compares two types of special lenses (Rayone EMV and Vivinex Impress XY1-EM) used in cataract surgery to improve vision at different distances. About 100 adults with age-related cataracts will receive these lenses in both eyes. The goal is to see which lens provides be…

This study tests whether a 10-minute educational video can reduce anxiety and improve self-care knowledge in people having cataract surgery. About 118 adults will be randomly assigned to watch the video or receive only standard instructions. Researchers will measure anxiety level…

This study looks at whether giving melatonin under the tongue before cataract surgery can reduce anxiety and help older adults relax. Sixty people aged 60 and older will receive either melatonin or a placebo. The goal is to find a safer alternative to standard sedatives that may …

This study looks at how well a specific lens implant (Clareon PanOptix Pro) works during cataract surgery for people who previously had LASIK or PRK to correct nearsightedness. About 40 adults aged 45 and older will receive the implant in both eyes and be followed for 3 months. T…

This study looks at how well a new type of cataract lens works for people who had LASIK surgery in the past. Cataracts cause blurry vision, and this lens is designed to help with seeing clearly at all distances. The study will involve 30 adults aged 50 and older who need cataract…

This study tests whether keeping the eye at a lower pressure during cataract surgery helps reduce swelling and improve vision right after the procedure. About 105 people with cataracts will have one eye operated on with a standard pressure system and the other with a lower pressu…

This study tests a gel placed in the tear ducts before cataract surgery to see if it helps dry eye symptoms. Sixty adults with dry eye will receive the gel and be followed for up to 5 months. The main goal is to measure tear film stability, a key sign of eye moisture.

This study compares two types of advanced lens implants (Clareon Vivity and PureSee) used in cataract surgery. Researchers want to see which lens provides better vision at far, intermediate, and near distances. The trial involves 80 adults aged 50 and older who need cataract surg…

This study investigates whether a small RNA molecule called tRF-31 is linked to the severity of age-related cataracts. Researchers will collect lens tissue from 200 adults undergoing routine cataract surgery and measure tRF-31 levels. The goal is to see if higher or lower levels …

This study looks at whether dry eye disease affects the accuracy of corneal measurements needed for cataract surgery planning. 400 cataract patients will be divided into those with and without dry eye. Those with dry eye will use sodium hyaluronate eye drops for two weeks. Resear…

This study is testing a new device called Unity DX that measures the eye's shape and focus. The goal is to collect data to help plan cataract surgeries more accurately. About 400 people having cataract treatment will participate. This is a data-gathering study, not a treatment it…

This study follows 60,000 people with cataracts, including those with high myopia (severe nearsightedness), to see how their vision changes after cataract surgery. Researchers will also look at genetic and environmental factors that might affect cataract development and surgical …

This study looks at whether improving how hospital wards and operating rooms work together can reduce waiting times for cataract surgery. Researchers will observe 360 patients aged 20 and older at a single eye hospital, track delays and errors, then test new procedures to see if …

This study is testing whether a simple vision screening program in general practice can help detect vision loss early in adults over 70 who have at least one chronic condition. Participants will have three vision tests done by their GP or nurse, then visit a collaborating opticia…

This study looks at 90 cataract patients who also have an epiretinal membrane (a thin layer on the retina). Researchers want to see if a special "functional" lens implant helps them see better without glasses compared to a standard lens. Participants will have their vision checke…

This study looks at fluid and tissue samples from the eyes of people with glaucoma and cataracts, and compares them to samples from people with cataracts only. The goal is to find chemical and protein patterns that could help doctors diagnose or track glaucoma better in the futur…

This study tracks 400 adults with cataracts to see how three different toric intraocular lenses rotate after surgery. Rotation is measured at several follow-up visits over three months. The goal is to find which lens stays most stable and help doctors choose the best option for e…

This study involves 80 adults who have had cataract surgery and received special lens implants that correct presbyopia (age-related blurry near vision). Researchers will use a 3-D eye scanner and a wavefront sensor to measure how well these lenses focus light onto the retina. The…

This study is testing a new way to measure eye pressure during cataract and glaucoma surgery. Researchers will use a special sensor to track pressure changes and see if this helps predict and prevent problems after surgery. The study involves 150 adults having these surgeries at …

This study compares two surgical systems used for combined cataract and vitrectomy eye surgeries. The UNITY VCS system is being tested against the CONSTELLATION system to see which one surgeons find more efficient in real-world operating rooms. About 180 adults needing combined e…

This study looks at a hand-held laser used during cataract surgery to see if it keeps the risk of capsule tears below 2%. Researchers will review medical records of 446 adults who had cataract surgery with this laser as part of their regular care. The goal is to confirm how safe …

This study is a patient registry that collects information from 300 people who have had or will have cataract surgery with different types of artificial lens implants. The goal is to compare how well people see at various distances after surgery with each lens type. No new treatm…

This study is looking at how general anesthesia affects blood pressure and eye pressure in people aged 65-85 having cataract surgery. Researchers will also check if frailty plays a role. The goal is to better understand these changes to improve safety for older patients.

This study tests a special microscope that takes live 3D images inside the eye during surgery. It aims to help surgeons see better when treating conditions like retinal detachment, macular holes, and cataracts. About 262 people will take part, including healthy volunteers and sur…

This study tests three AI chatbots—ChatGPT 4o, GPT-5, and DeepSeek—on their ability to read eye scans from 100 cataract patients. The AI will try to extract key measurements, recommend the right lens implant, and predict vision after surgery. No treatment is given; the goal is to…

This study will compare different laser techniques used in eye surgeries for cataracts and myopia. Researchers want to see which method causes less inflammation and oxidative stress, and leads to better vision recovery. 1,000 patients will be followed for three months after surge…