Can mixing lens types sharpen vision after cataract surgery?
NCT ID NCT06002399
First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time
Summary
This trial tests whether combining two different types of artificial lenses during cataract surgery improves vision compared to using the same lens in both eyes. Half of the 50 participants will receive a standard monofocal lens in both eyes, while the other half will get a monofocal lens in one eye and an extended depth-of-focus (EDOF) lens in the other. Researchers will measure vision at various distances, contrast sensitivity, and reading speed, and ask participants about their quality of vision. The goal is to see if the mix offers better everyday vision without the downsides of EDOF lenses in both eyes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Combination of a monofocal intraocular lens (IOL) in one eye and an extended depth-of-focus (EDOF) IOL in the other eye, compared to bilateral monofocal IOLs
- What this could lead to
- If it works, this could offer cataract patients a way to get better intermediate vision without the drawbacks of having EDOF lenses in both eyes.
- What could go wrong
- This is a small, early-stage trial with 50 participants, so results may not apply to everyone. The combination might not improve vision enough to matter, and there could be unexpected visual side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Nov 2023
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged between 50 and 90 years with bilateral cataract without concomitant exclusion criteria Exclusion Criteria: * prior refractive surgery * patients with corneal opacities, retinopathy, opticopathy, glaucoma, uveitis and amblyopia * patients with corneal astigmatism greater than 3 diopters (D) * patients with expected postoperative astigmatism higher than 0.50D * prior ocular surgery in the last six months * patients with prior unilateral cataract surgery
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UZ Brussel
Brussels, Brussel Hoofdstedelijk Gewest, 1090, Belgium
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