Stroke disorder

This study tests a new virtual reality (VR) walking therapy for people who have had a stroke within the past 1 to 6 months. Participants will use either a fully immersive VR system that lets them walk over ground in realistic environments, or a semi-immersive VR system on a tread…

This study tests whether exercise using electrical stimulation can improve muscle strength and endurance in people with lower limb paralysis from conditions like spinal cord injury, stroke, or multiple sclerosis. Participants will use devices that send electrical signals to their…

This trial tests whether a computer-based rehabilitation system called NeuroTechR3 can help people improve arm and hand function after a stroke. Participants will play upper extremity rehabilitation games on a computer for 30 minutes, three times a week. The study measures change…

This study looks at whether doing a small surgery early to remove blood from a deep brain bleed helps patients more than standard medical care. About 600 adults aged 18 to 70 with a specific type of brain bleed will take part. The goal is to see which approach leads to better rec…

This study explores whether a robotic device that amplifies a person's own walking movements can help improve balance in people who have had a stroke. Participants with chronic stroke (more than 6 months ago) will do two treadmill walking sessions—one in a normal environment and …

This trial tests whether placing a stent in a narrowed or blocked neck artery during emergency stroke treatment helps people recover better than just removing the clot in the brain. About 15-20% of severe strokes involve both a brain clot and a neck artery blockage. The study wil…

This phase 2 trial is testing whether TAK-755, a lab-made protein that helps break up blood clots, is safe and effective for people who have had an acute ischemic stroke. About 222 adults aged 18 to 80 will receive either TAK-755 or a placebo, along with standard stroke care, and…

This study tests a single injection of stem cells (B2065) given within 36 hours of a stroke. The goal is to see if it is safe and might help patients recover better. Fifty-four adults with moderate to severe stroke will receive either the stem cells or a placebo, and be followed …

This trial tests whether combining aerobic exercise with a targeted reading therapy, called Phono-Motor Therapy, can improve reading skills in people who have reading difficulties after a stroke. Participants will receive both interventions, and researchers will measure changes i…

This study looks at whether successfully restoring blood flow in the brain using the Tigertriever device, a tool that removes clots during a stroke, may also help protect cognitive abilities like memory and attention. Researchers will follow 424 adults aged 18 to 75 who had a lar…

This trial tests whether a gentle electrical stimulation applied to the ear—called transcutaneous auricular vagus nerve stimulation—can help people recover consciousness after surgery for a spontaneous brain hemorrhage. The study will include 160 adults aged 18 to 75 who remain i…

This trial tests whether adding metacognitive training—exercises that help people think about their own thinking—to standard word-finding rehabilitation can improve language skills in people with chronic aphasia after a stroke. The study involves 18 participants who will receive …

This study compares standard medical care to a new, less invasive surgery for people with a severe bleeding stroke. The surgery uses a small tube to drain the blood clot and delivers clot-busting medicine directly into the brain. Researchers want to see if this approach helps pat…

This trial investigates whether giving a low dose of the clot-busting drug alteplase directly into the brain artery, right after successful mechanical clot removal, can improve recovery in people with a severe stroke caused by a large vessel blockage. About 416 adults who have ha…

This trial tests whether adding self-administered hand therapy at home, using a videogame controller called the Twirlstone, can improve hand dexterity and coordination in stroke survivors. Participants, who are within six weeks of a stroke and have arm or hand weakness, will eith…

This trial tests whether a non-invasive device that stimulates the vagus nerve through the ear can reduce harmful spasms in brain arteries that often occur days after an aneurysm rupture. The study will enroll 10 adults who have had this type of bleeding in the brain and will rec…

This study tests whether a structured rehabilitation program called HABIT-ILE, which combines intensive arm, hand, and leg exercises, can improve balance and coordination in people recovering from a stroke. The trial will include 44 stroke survivors aged 40 to 60, who will be ran…

This study compares two procedures used to treat unruptured wide-neck brain aneurysms: flow diverter stents and stent-assisted coiling. Researchers will follow 274 adults from three centers in China who receive one of these treatments as part of routine care. The main question is…

This study is testing a device called a flow modulator to treat wide-necked brain aneurysms. The device is placed inside the artery to redirect blood flow away from the aneurysm, helping it close off. Researchers will check if the device is safe and effective in 214 adults over 1…

This study tests whether vestibular-oriented balance training or motor dual-task training, added to standard physiotherapy, better improves balance and reduces fall risk in people who had a stroke at least six months ago. About 50 participants will be randomly assigned to one of …

This study tests a new device and technique (ADAPT 2.0) for removing blood clots in people having an acute ischemic stroke. The goal is to see if it can restore blood flow more completely and safely than current methods. About 750 adults who are already scheduled for clot removal…

This study compares catheter ablation (a procedure to fix irregular heartbeats) with standard medical care in 646 adults who have both atrial fibrillation and a recent brain bleed. The goal is to see if ablation reduces the risk of death, stroke, or blood clots. Participants must…

This early-stage study tests whether a drug called anisodine hydrobromide is safe for people having a stroke caused by a blocked large artery in the brain. About 92 adults aged 18 to 80 who are already scheduled for a clot-removal procedure will receive the drug. The main goal is…

This study tests whether the drug clevidipine can lower blood pressure quickly and steadily in people having a bleeding stroke (intracerebral hemorrhage). High blood pressure can make the bleeding worse, so getting it under control fast is critical. The trial will compare clevidi…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study tests whether closing a small pouch in the heart (the left atrial appendage) with a device is safer and as effective as long-term blood thinners for people with atrial fibrillation who have already had a brain bleed. About 530 participants will be randomly assigned to …

This study looks at two ways to treat a type of stroke caused by a blockage in a smaller branch of a brain artery. One group receives a procedure to remove the clot (thrombectomy) plus standard medical care, while the other group receives medical care alone. The goal is to see if…

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This program allows doctors to request NanO₂, an investigational drug that may help deliver oxygen to tissues, for patients with serious or life-threatening conditions like glioblastoma, respiratory distress, or ischemic stroke. It is for patients who have exhausted other treatme…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and emergency treatment to open a blocked artery. About 438 participants will be randomly assigned to start blood thinners within 4 days or between 5-14 days after the st…

This program gives children with brain disorders like cerebral palsy or stroke access to umbilical cord blood infusions. The treatment uses donated cord blood cells to help repair brain damage. Kids up to age 26 with normal immune function may qualify. The goal is to improve symp…

This trial investigates whether combining repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise can treat depression and improve walking in people who have had a stroke. Participants will receive either real or sham rTMS along with exercise sessions over 12 we…

This study compares two treatments for small ischemic strokes (lacunar strokes): a combination of antiplatelet drugs (pills) versus the standard clot-busting drug tPA given through an IV. The goal is to see if the pill combo works just as well but causes fewer bleeding problems. …

This trial investigates whether giving clot-busting drugs (tenecteplase or alteplase) to people who have an ischemic stroke while taking direct oral anticoagulants (blood thinners) is safe and effective. About 906 adults who had a stroke within 48 hours of taking a DOAC will be r…

This study tests whether adding butylphthalide (a neuroprotective drug) to standard clot-busting tenecteplase helps people with mild but disabling stroke recover better. About 1,062 adults aged 18-80 who can be treated within 4.5 hours of symptoms will receive either the combo or…

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This trial tests whether a wrist-hand rehabilitation robot that uses both brain and muscle signals can help people with chronic stroke recover better than one using muscle signals alone. Forty-eight participants will receive 20 training sessions with the robot, which provides ele…

This trial compares two rehabilitation approaches—neurodevelopmental technique (NDT) and mirror therapy—to see which better improves coordination, leg function, and walking ability in people recovering from a sub-acute stroke. Forty adults aged 45 to 65 with hemiplegia (weakness …

This trial is testing whether vitamin D supplements can improve bone density, body composition, strength, walking speed, and physical performance in people hospitalized with neurological disorders like stroke, spinal cord injury, or traumatic brain injury. Participants will recei…

This study tests an implanted electrical stimulation device designed to improve movement, standing, and walking in people with paralysis from spinal cord injury, stroke, multiple sclerosis, or traumatic brain injury. The device sends electrical signals to muscles in the trunk and…

This trial investigates whether a procedure to remove blood clots from arteries in the back of the brain can improve recovery in people who had a stroke more than 24 hours ago but within the last 7 days. Participants will either receive standard medication alone or the clot-remov…

This study follows 3,000 ischemic stroke patients who also have cerebral microbleeds — tiny spots of old blood in the brain. Researchers are tracking how different antithrombotic drugs (blood thinners) affect the number of microbleeds and the risk of future strokes or brain bleed…

This trial tests whether flushing a stent-graft with carbon dioxide before implanting it in the aorta can reduce the number of tiny air bubbles that travel to the brain during the procedure. These bubbles are a major cause of stroke and silent brain damage in patients undergoing …

This pilot trial tests whether a substance made from stem cells — called mesenchymal stem cell secretome — can improve cognitive recovery in people who have had an ischemic stroke. Participants aged 40 to 75 with mild-to-moderate cognitive impairment will receive either standard …

This trial tests whether a new high-power short-duration radiofrequency ablation technique (90 watts for 4 seconds) is safer and more effective than the standard low-power approach (35 watts for 10-15 seconds) for treating atrial fibrillation. The study includes adults with parox…

This trial tests whether adding rhythmic auditory stimulation (like a metronome) to task-oriented training improves lower limb function, balance, and motivation in people recovering from a stroke. Participants, aged 40 to 60 with a first-time stroke within the past six months, wi…

This trial tests whether practicing walking while doing a second task — like talking or carrying something — improves balance and reduces fall risk more than simply repeating walking exercises. The study enrolls adults aged 40 to 70 who had a stroke 6 months to 1 year ago and sti…

This trial investigates whether adding deep, slow breathing exercises and a gentle neck-release technique to standard physical therapy can improve heart rate control, movement, thinking, and mood in people who have had a stroke. The study includes 54 adults who had a first stroke…

This large trial compares robot-assisted rehabilitation to traditional one-on-one physiotherapy for people who have had a stroke. Researchers are measuring how well each approach helps patients regain independence in daily activities, as well as costs and patient satisfaction. Th…

This study compares two types of telerehabilitation for stroke survivors: a motor relearning program that focuses on retraining specific tasks versus conventional physical therapy delivered remotely. Researchers will measure changes in motor function and balance in adults aged 40…

This trial compares two rehabilitation approaches — task-oriented training and hand-arm bimanual intensive therapy — in stroke survivors with mild to moderate arm weakness. The goal is to see which method better improves gross and fine motor skills and the ability to perform dail…

This study tests a wearable rehabilitation robot designed for stroke survivors with severe leg paralysis. The robot guides patients through motor relearning and passive stretching exercises while they are still in bed during the early acute phase after a stroke. The goal is to se…

This trial tests whether a structured arm therapy program delivered through video calls can improve upper limb function in people who had a stroke at least six months ago, compared with the same therapy given in a clinic. Sixty-eight participants will receive modified Constraint-…

This trial tests whether adding electrical muscle stimulation to a standard motor relearning program improves arm function more than the program alone in people recovering from a subacute stroke. Thirty-six participants will receive either the combined therapy or the program only…

This study tests whether a filter device called the Sentinel Cerebral Protection System can prevent stroke and brain injury during ablation for atrial fibrillation (an irregular heartbeat). The device is placed in the arteries to catch debris that might break loose during the pro…

This trial tests whether a hip-assisted wearable robot can help stroke survivors improve their walking through at-home training sessions. Eight adults who have had a stroke and walk with a spastic hemiplegic gait will use the robot during four 30-minute sessions over two weeks, g…

This trial investigates an unapproved medical device designed to help control a specific disease. Participants receive the device to see if it can reduce symptoms or manage the condition. The study focuses on safety and effectiveness in people with the disease.

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve balance and body control in people who have had a stroke. Twenty-two participants will receive either the stimulation plus balance training or balance training alone. The goal is …

This study compares two common procedures—radiofrequency and cryoablation—for treating persistent atrial fibrillation, a heart rhythm disorder that raises stroke risk. Researchers will track 158 adults over 24 months to see which method better prevents strokes, transient ischemic…

This study explores whether computer-generated guidance can help people who have had a stroke improve their movement patterns. Participants practice daily tasks like reaching, either in a lab with advanced sensors or at home using a tablet. The goal is to see if home-based techno…

This study tests whether a robot can help people who had a stroke 1 to 12 months ago improve movement and feeling in their arm and hand. Participants first receive gentle, robot-guided stretching, then practice active movements with the robot, which can assist or resist as needed…

This trial tests whether apixaban, a newer blood thinner with fixed dosing, works as well as warfarin for dissolving dangerous blood clots in the heart's main pumping chamber. Adults with a confirmed left ventricular thrombus are randomly assigned to receive either apixaban or wa…

This trial tests whether febuxostat, a drug typically used for gout, can improve recovery in people with a brain bleed (intracranial hemorrhage) who are treated without surgery. Participants take febuxostat or standard care for three months. The study measures consciousness level…

This trial compares two strategies to prevent another stroke in people with severe narrowing of a major brain artery. One group receives a drug-eluting stent (a mesh tube that releases medication to keep the artery open) along with aggressive blood-thinning medication. The other …

This study investigates whether a personalized, technology-based rehabilitation program can improve arm movement and function in people who have had a stroke. Participants will receive the technology-enhanced therapy three times a week for about a month, alongside standard care. …

This trial tests a new device called the P3 Occluder System designed to close a patent foramen ovale (PFO) — a small opening between the upper chambers of the heart. The study includes adults aged 18 to 65 who have had a stroke possibly linked to a PFO. Participants receive the i…

This trial investigates whether a non-invasive brain stimulation technique called tACS, applied during speech therapy, can help people recover language abilities after a stroke. The study includes 120 adults who have had a left-hemisphere stroke and experience aphasia (difficulty…

This study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants …

This trial investigates whether two medications—colchicine (an anti-inflammatory) and deferoxamine (an iron chelator)—can prevent further brain injury after a hemorrhagic stroke. Up to 2,000 adults aged 18–80 with a spontaneous brain bleed will receive one of four treatments: sta…

This trial is testing several different treatments for stroke, including different doses of a clot-busting drug called tenecteplase and blood pressure management strategies. It aims to find which treatments or combinations work best to improve recovery and reduce disability. The …

This phase 3 trial tests whether tegoprazan, a stomach acid blocker, can prevent gastrointestinal complications like bleeding and ulcers in people who have had an ischemic stroke and are taking antiplatelet drugs (blood thinners). About 1,500 adults in South Korea will receive ei…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This trial tests three different blood pressure management strategies in people who have had a stroke and received endovascular therapy (a procedure to remove a clot). The goal is to find the safest and most effective way to lower blood pressure after treatment to improve recover…

This study investigates whether adding neuromuscular electrical stimulation (NMES) to reactive balance training helps people who have had a stroke recover more effectively from slips and trips. Participants, who are at least six months post-stroke and able to walk on a treadmill,…

This study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can reduce inflammation and brain swelling after a hemorrhagic stroke (intracerebral hemorrhage). The trial enrolls adults with a specific type of brain bleed and compares the ac…

This early-stage trial tests a new drug called SNE-101 in people who have had an acute ischemic stroke within the past five days. The main goal is to see if SNE-101 is safe and tolerable, and to find the highest safe dose. The study also looks at whether SNE-101 can improve motor…

This study compares three different devices that cause controlled slips and trips to train the body's reactive balance. Healthy young adults, healthy older adults, and stroke survivors will undergo repeated perturbation training to improve stability and limb support. The goal is …

This trial investigates the safety and effectiveness of using a stent along with coil embolization to treat ruptured brain aneurysms. The procedure is performed within a week of the bleeding event in patients aged 18 to 80 with wide-neck aneurysms. Researchers are monitoring for …

This trial investigates a 'maximal medical treatment' bundle for people with intracerebral hemorrhage (bleeding in the brain). The bundle includes rapid blood pressure control, reversal of blood thinners, and a drug to reduce bleeding, all delivered within the first 72 hours in a…

This study tests whether the antibiotic minocycline can improve recovery in people having an ischemic stroke. About 934 adults will receive either minocycline or a placebo, in addition to standard clot-busting medication. The goal is to see if minocycline leads to better function…

This study tests whether giving a second dose of the clot-busting drug prourokinase can help stroke patients who have a blocked medium or large artery and don't show improvement one hour after the first dose. About 122 adults will be enrolled within 4.5 hours of stroke onset. The…

This study tests whether giving the drug milrinone directly into the brain's arteries, followed by a 72-hour IV drip, can prevent brain damage in people who develop artery spasms after a bleeding stroke from a burst aneurysm. The trial will enroll 306 adults across multiple hospi…

This early-stage trial compares a new investigational drug, CG-0255, to the established blood thinner Plavix in 136 healthy adults aged 18-55. The goal is to see if CG-0255 is processed by the body similarly to Plavix and has the same effect on preventing blood clots. Participant…

This study tests whether starting virtual reality-based rehabilitation within 24 hours of an acute ischemic stroke can improve arm muscle strength, thinking skills, and motivation to exercise. One hundred adults recently diagnosed with stroke will be randomly assigned to either v…

This study tests a structured problem-solving approach called CO-OP (Cognitive Orientation to daily Occupational Performance) for adults who have had a stroke or traumatic brain injury. Participants learn a 'Goal-Plan-Do-Check' strategy to tackle everyday tasks like dressing or c…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This trial tests a new clothing-like robotic arm that detects muscle signals to help people who have had a stroke move their arm and hand. The device supports coordinated movements of the shoulder, elbow, wrist, and fingers during 20 one-hour training sessions. The study includes…

This study compares two rehabilitation techniques—mirror therapy and modified constraint-induced movement therapy—to see which better improves arm function in people who had a stroke. Sixteen participants with hemiplegia (weakness on one side) will be randomly assigned to one of …

This study tests whether adding GM1, a natural brain substance, to standard clot-removal treatment helps people recover better after a severe stroke. About 868 adults in China who have a blocked artery in the front part of the brain will receive either GM1 or a placebo daily for …

This study tests whether the drug sivelestat sodium, given alongside standard clot-removal surgery, can help people recover better after a major stroke. The trial will include 868 adults aged 18-80 with large-vessel blockage in the front part of the brain. The goal is to see if t…

This study tests whether using a nicardipine infusion (a fast-acting blood pressure drug) can help more stroke patients with brain bleeding reach a safe blood pressure within one hour of arriving at the hospital. About 88 adults with acute intracerebral hemorrhage and high blood …

This study compares a new 'virtual stroke unit' approach to standard stroke unit care for people with a stroke who are not eligible for a clot removal procedure. The virtual unit uses video calls and monitoring equipment to let a specialist team at a main hospital help guide care…

This study tests a drug called tenecteplase (TNK) for people who have had a stroke caused by a blood clot in the brain. The drug is given up to 24 hours after symptoms start, using only a simple CT scan to decide who can get it. The goal is to see if TNK helps people recover bett…

This study tests a new device called CHORDS that catches loose debris during a heart valve replacement procedure (TAVR). The debris can travel to the brain and cause a stroke. The trial will compare CHORDS to an existing device in 240 people with severe aortic stenosis. Participa…

This study compares two blood thinner strategies after left atrial appendage closure (LAAC) in people with atrial fibrillation. Sixty participants will receive either aspirin alone or aspirin plus clopidogrel for three months. The goal is to see which approach better prevents sma…

This study tests whether the Luna EMG rehabilitation robot can help people who had a stroke more than a year ago improve arm movement. Five participants will use the robot for 30 minutes per session as part of their rehab. The goal is to see if the robot can make arm movements sm…

This study tests whether infliximab (Remicade), a drug used for arthritis and other inflammatory conditions, can shrink a specific type of brain aneurysm called a dolichoectactic vertebrobasilar (DVB) aneurysm. These aneurysms are difficult to treat with surgery or stents, and th…

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with chronic stroke move their arms and legs again. Only 3 participants will be implanted with electrodes on the brain and spine. The main goal is to check safety, but researche…

This early-stage trial tests whether stem cells from the placenta, given through an IV, are safe and might help people recover from a recent stroke. About 24 participants will receive either the stem cells or a placebo. Researchers will track their recovery over two years, focusi…

This study tests whether a clot-busting drug called tenecteplase can help people who have a stroke affecting the back part of the brain. Participants must start treatment between 4.5 and 24 hours after their first symptoms. The goal is to see if the drug improves recovery and dai…

This study tests a nurse-led program called BEST CARE ICTUS_HC for adults hospitalized with acute stroke in hospitals without specialized stroke units. The program includes staff training, swallowing tests, and environmental adaptations to help with attention and safety. Research…

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This study compares two exercise programs—sensorimotor training and dual-task training—against standard physical therapy for stroke survivors. The goal is to see which approach best improves balance, mobility, and reduces fall risk. Fifty-four participants who had a stroke at lea…

This study tests whether giving hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) soon after emergency clot removal can improve recovery in people with severe stroke. Researchers plan to enroll 420 adults aged 18–80 who had a large-vessel blockage stroke …

This study tests whether adding mental imagery training to robotic hand exercises improves arm and hand function in people who had a stroke at least 6 months ago. Forty participants will receive either robotic hand training alone or combined with mental imagery over 7 weeks. The …

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study tests whether robot-assisted foot and ankle training, combined with virtual reality, can help people with chronic stroke walk faster and improve balance. Thirty participants will either receive this robotic therapy or standard manual training, plus usual rehab, for 6 w…

This study is tracking how well a device called NeVa VS works to open narrowed brain arteries in people who had a bleeding aneurysm. The device is already approved for this use, and researchers want to see how it performs in routine care. About 200 adults will be followed to meas…

This study tests whether the antibiotic minocycline can improve recovery in people who have had a major stroke and undergone a procedure to remove a blood clot from a large brain artery. Even when the clot is successfully removed, many patients still have significant disability. …

This study tests whether combining a brain-computer interface training with audio cues played during sleep can improve arm function in people who had a stroke at least 6 months ago. 70 participants will practice moving a cursor on a screen using muscle signals, then hear related …

This study tests whether adding the antibiotic minocycline to standard stroke treatment can improve recovery in people who had a severe stroke in the back of the brain. After a clot is removed, brain inflammation can limit healing. Minocycline may reduce that inflammation. The tr…

This study tests whether giving patients electrical muscle stimulation and high-protein shakes soon after a type of stroke (aneurysmal subarachnoid hemorrhage) can prevent muscle loss and improve recovery. Thirty adults will receive the combo therapy or standard care. The main go…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This study tests whether starting heart rhythm control therapy soon after a stroke can prevent future strokes, heart-related deaths, or hospital stays in people with atrial fibrillation. About 1,746 participants will receive either early comprehensive treatment or usual care. The…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel blockage in the front part of the brain will be randomly ass…

This study looks at whether a 15-week lifestyle program combining weight management and exercise can improve walking and daily function in obese veterans who had a stroke at least six months ago. Researchers will measure changes in walking distance, daily steps, and overall recov…

This study is testing a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it is safe and helpful for people who have had a severe bleeding stroke called aneurysmal subarachnoid hemorrhage. About 25 adults in the intensive care unit will rec…

This study is testing whether a device that uses mild electrical pulses to stimulate arm muscles and the tongue can help stroke survivors regain arm movement. Researchers will enroll 288 participants, including stroke patients with arm weakness and healthy controls. The main goal…

This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which pati…

This study is testing a drug called Mexidol in people who have had an ischemic stroke (a stroke caused by a blocked blood vessel in the brain). The goal is to see if Mexidol can reduce the size of the brain injury and improve recovery. The trial will involve 120 adults aged 18 to…

This study tests whether a mild brain stimulation technique called tDCS, combined with treadmill training, can improve walking in people who have had a stroke. Researchers will enroll 100 adults who are at least 3 months past their first stroke and have trouble walking. The goal …

This study tests an experimental drug called QD202 in people who have had an acute ischemic stroke and received clot-busting medication. The drug is designed to cross into the brain and protect nerve cells. About 120 participants will receive either QD202 or a placebo daily for 5…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This study looks at whether people with atrial fibrillation can safely stop taking long-term blood thinners after a procedure that closes off a part of the heart called the left atrial appendage. Participants will get a reduced dose of the blood thinner apixaban for just 3 months…

This study tests whether giving dornase alfa (a drug already used for cystic fibrosis) daily for up to 14 days after a brain bleed from a ruptured aneurysm can help people recover better. The goal is to see if more patients can live independently at 6 months. The trial will enrol…

This study tests whether tilting a stroke patient's head down 15 degrees for 30-90 minutes before a clot removal procedure can improve blood flow to the brain. About 118 adults with a specific type of stroke will be randomly assigned to either the head-down tilt or standard posit…

This trial is testing a drug called tenecteplase for people with a severe stroke caused by a blockage in the basilar artery at the back of the brain. About 688 participants will receive either tenecteplase or standard care within 24 hours of symptoms starting, followed by a clot-…

This study tests whether starting lumbar drainage and injecting the clot-busting drug urokinase early after a severe brain bleed improves patients' recovery. About 424 adults with a first-time severe aneurysmal subarachnoid hemorrhage will be randomly assigned to get either the a…

This phase 3 trial tests whether adding tocilizumab, an anti-inflammatory drug, to standard emergency stroke treatment improves outcomes for people with a severe stroke in the back of the brain. About 348 adults will receive either tocilizumab or a placebo by IV right before a pr…

This study tests a new treatment for people who have had a stroke caused by a blood clot in the brain. A weak electrical current is applied through electrodes on the scalp to increase blood flow and protect brain tissue. The goal is to find the safest and most effective dose. The…

This study compares a procedure to remove blood clots (endovascular therapy) with standard medical care for people who have had a mild stroke caused by a blockage in a large brain artery. About 264 adults with mild symptoms (NIHSS score 2-5) will be enrolled within 24 hours of st…

This study compares two ways to reach a blood clot in the basilar artery, a key vessel at the back of the brain, during a stroke. One method uses the femoral artery in the groin, the other uses the radial artery in the wrist. Researchers want to see which approach leads to better…

This Phase II trial tests a drug called LT3001 in 300 people who have had an acute ischemic stroke. Participants receive either a high or low dose of LT3001 or a placebo by IV infusion within 24 hours of their stroke. The study aims to see if the drug is safe and helps improve re…

This study compares two approaches for treating moderate brain hemorrhages: AI-assisted minimally invasive surgery to remove the clot versus standard medical care. About 680 patients will be randomly assigned to one of the two groups. The goal is to see which method leads to bett…

This study tests whether a balloon angioplasty procedure can prevent early neurological decline in people who have had a minor stroke due to a narrowed brain artery. The trial will enroll 100 adults who have already received standard medication but still show fluctuating or worse…

This study looks at whether high-dose statins can reduce or stabilize fatty plaques in the brain's arteries that cause strokes. About 100 recent stroke patients will get intensive statin therapy and have their arteries scanned with a special MRI. The goal is to see if the plaques…

This study tests whether a simple, non-invasive treatment called remote ischemic preconditioning (RIC) can improve blood flow around blocked arteries in people who have had a stroke. RIC involves inflating a blood pressure cuff on the arms for short periods to trigger the body's …

This study tests whether lying in a slight head-down position (20 degrees) can help people recover from a moderate stroke caused by narrowed arteries. Researchers will compare this position plus standard care to standard care alone in 600 participants. The goal is to see if more …

This study tests if briefly stopping and restarting blood flow in the neck after a stroke procedure can help the brain heal better. About 120 adults who had a major stroke and received emergency treatment to reopen a blocked artery will be randomly assigned to get this extra ther…

This study tests whether a simple, non-invasive treatment called remote ischemic conditioning (RIC) can help people recover better after a moderate stroke in the back part of the brain. RIC involves briefly inflating a blood pressure cuff on the arm to restrict blood flow, then r…

This study looks at whether adding evolocumab (a powerful cholesterol-lowering drug) to standard statin therapy helps people recover better after a stroke caused by hardening of the large arteries. Researchers will follow 1000 adults aged 18-80 for 90 days, comparing those who ge…

This study is testing a device called EmboTrap II, which is used to remove blood clots from the brain in people having a stroke. The goal is to see if it is safe and works well at restoring blood flow. About 100 participants will be followed to track outcomes like bleeding and su…

This study looks at 180 adults with moderate to severe narrowing of brain arteries who have high LDL cholesterol. Researchers want to see if improving cholesterol management can lower the chance of having a stroke. Participants will not receive any experimental treatment; instead…

This study tests whether using remote-controlled CT scans at local medical centers, guided by a hospital stroke team via video call, can speed up treatment for stroke patients. About 52 participants with suspected stroke will be randomly assigned to either this new approach or st…

This study looks at whether a structured weight loss program, with or without added exercise, can improve physical function and emotional well-being in obese veterans who have had a stroke. Researchers will enroll 130 participants aged 35-85 who had a stroke at least 6 months ago…

This pilot study is testing whether a noninvasive device that sends mild electrical pulses through the skin to the spinal cord can help improve arm and hand function in people with stroke or spinal cord injury. Researchers will measure changes in nerve activity and movement skill…

This study tests whether a single procedure that combines two heart treatments—pulmonary vein isolation (to correct irregular heartbeat) and left atrial appendage occlusion (to block a clot-prone area)—can prevent future strokes and major bleeding better than standard blood thinn…

This phase 3 trial tests whether a single injection of BXOS110, given within 3 hours of an acute ischemic stroke, can reduce overall disability compared to a placebo. About 1112 adults aged 18-85 with moderate to severe stroke are being enrolled. The main goal is to see if more p…

This study is testing a device called the NeVa stent retriever to see how well it can remove blood clots in people having a severe stroke. The goal is to restore blood flow to the brain in a single pass. The study will enroll 600 adults who are already scheduled to have this proc…

This study looks at two ways to prevent another stroke in older adults who have a hole in the heart (PFO) and had a stroke from an unknown cause. One option is a procedure to close the hole, plus lifelong blood thinners. The other is taking blood thinners alone. Researchers will …

This study tests whether a bedside monitoring device, placed on the head right after a mechanical thrombectomy for acute ischemic stroke, can predict which patients will have poor neurological outcomes. The device uses near-infrared spectroscopy to measure brain oxygen levels and…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study looks at 200 adults who have had an ischemic stroke or transient ischemic attack (TIA). Each participant will receive two types of imaging: a non-contrast magnetic resonance angiography (NC-MRA) and a carotid Doppler ultrasound. The goal is to see how well these two me…

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This trial tests a new portable brain scanner designed to quickly detect bleeding in the brain (hemorrhagic stroke) using harmless radio waves. The helmet-like device could offer a faster, more accessible alternative to CT or MRI scans in emergency settings. Researchers will enro…

This study evaluates a portable, low-field MRI device (Hyperfine Swoop) for diagnosing stroke in people arriving at the emergency department with symptoms lasting less than 12 hours. Participants receive the low-field scan in addition to standard CT imaging. The goal is to see if…

This study is developing and testing an artificial intelligence (AI) model to help diagnose a specific type of stroke called branch atheromatous disease (BAD)-related stroke. BAD strokes are hard to identify because symptoms are not specific, and diagnosis requires combining clin…

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

This study looks at whether monitoring brain blood flow during stroke treatment can predict if a patient will recover well. Researchers will track 129 stroke patients for 90 days after treatment. The goal is to find a way to identify early on who might need extra care.

This study tests a new way to check for bleeding after stroke surgery using a special ultrasound through a clear skull implant. It aims to see if this method is as accurate as a CT scan, which is the current standard but is expensive and time-consuming. About 25 adults who had a …

This study compares two ways of performing the Valsalva maneuver during a heart ultrasound to detect a patent foramen ovale (PFO), a small hole in the heart that can cause strokes. About 488 stroke patients will be asked to do both a standard self-directed maneuver and a goal-dir…

This large study tests whether a smartphone app can help prevent strokes by detecting atrial fibrillation (an irregular heartbeat) early. Adults aged 65 and older in Austria are randomly assigned to use the 'Pulskontrolle' app for pulse checks or to receive usual care. If the app…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This study tests whether a smarter electrical stimulation device can help people recover arm and hand movement after a stroke. Participants with moderate arm weakness will be randomly assigned to receive either standard cyclic stimulation or a new EMG-triggered stimulation that r…

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This study tests two advanced rehabilitation methods—robot-assisted walking training and visual feedback balance training—to see which better improves balance and walking in people who have had a stroke. About 60 adults with subacute or chronic stroke will participate in 4 weeks …

This study explores whether listening to music on purpose, for one hour a day, can improve mental health in people who had a stroke at least six months ago. Sixty participants will be randomly assigned to listen to either music or an audiobook at home for four weeks. Researchers …

This trial tests whether Occupational Performance Coaching (OPC) can help adults who have had a stroke and finished rehabilitation get back to activities they value. Participants are randomly assigned to receive OPC or an attention control, both delivered virtually. The study mea…

This study tests whether adding a mild brain stimulation technique (tDCS) to a standard arm therapy (constraint-induced therapy) helps people who had a stroke more than therapy alone. Forty adults with chronic stroke and mild-to-moderate arm weakness will be randomly assigned to …

This study tests whether a digital program called Sleepio, which uses cognitive behavioral therapy for insomnia, can improve sleep in stroke survivors. Researchers will also see if better sleep helps with learning motor skills overnight. About 100 adults who have had a stroke and…

This study tests whether a gentle electrical current applied to the scalp (tDCS) combined with computer-based cognitive training can improve memory, attention, and thinking in people who had a mild stroke. About 60 participants will receive either real tDCS or a sham (fake) versi…

This study tests whether virtual reality (VR) training in a simulated home environment can improve arm and hand function in people recovering from a stroke. Researchers will compare VR-based task-oriented training to standard therapy in 86 participants. They will also use brain s…

This trial tests whether a new method of clearing mucus from the airways—using intermittent suction through a breathing tube—works better than the standard continuous suction method in comatose patients who have had a stroke. About 600 participants will be randomly assigned to on…

This study tests whether adding action observation (watching movements) and motor imagery (imagining movements) to standard physical therapy can improve balance, daily function, and quality of life in people who had a stroke within the last year. About 56 participants will be ass…

This study tests whether a home-based telerehabilitation program, using games, exercises, and video calls with therapists, can improve arm function and reduce disability in people who had a stroke 90-150 days ago. 202 participants will be randomly assigned to receive telerehabili…

This study is testing a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults who have had a stroke manage anxiety and depression. About 10 participants aged 40-79 will use the app and provide feedback on how easy and helpful it is. The goal is to…

This trial tests whether a non-invasive electrical stimulation applied to specific acupoints on the fingers can improve memory, attention, and decision-making in people who have had a stroke. Adults aged 35 to 80 with mild to moderate cognitive impairment after an ischemic stroke…

This phase 2 trial tests whether an oral drug called BMS-986368 can reduce spasticity—muscle tightness and spasms—in adults who had a stroke 4 to 18 months ago. The drug works by boosting natural compounds in the body that calm overactive nerves. Researchers will measure changes …

This study tests whether applying gentle vibration to the bottom of the foot can improve walking speed and balance in people who have had a stroke. Fifty-eight participants will be randomly assigned to receive either real vibration or a placebo (no vibration) for 30 minutes a day…

This trial tests a partially self-supervised version of constraint-induced movement therapy (sCIMT) for adults with arm and hand weakness after a stroke. Over two weeks, participants complete up to 30 hours of therapy, with about one-third guided by a therapist and two-thirds don…

This study tests a low-intensity brain stimulation method called kTMP to help people who had a stroke at least 12 months ago improve arm and hand movement. About 12 adults aged 18-80 with moderate arm weakness will receive kTMP alongside motor rehabilitation. The goal is to see i…

This trial tests whether six months of group singing can improve mood, quality of life, and language recovery in stroke survivors with aphasia, while also supporting their personal caregivers. Half of the participants will attend weekly singing sessions; the other half will recei…

This pilot trial tests whether a six-week behavioral program focused on morning activation can improve mood and daily functioning in adults who have had a stroke and struggle with depressive symptoms. Participants are randomly assigned to either the morning activation program or …

This study tests whether giving caregivers of palliative care patients a single training session on using a PEG feeding tube before the patient leaves the hospital can lower the caregivers' burden, stress, and improve their quality of life. Researchers will compare trained caregi…

This study tests whether combining augmented reality (AR) balance exercises with a gentle brain stimulation technique (tDCS) can improve balance and movement in people who have had a stroke. About 28 chronic stroke survivors with balance issues will be split into two groups: one …

This study tests a 6-week program where stroke survivors do balance exercises while also performing mental tasks, like naming words or reacting to sounds. The goal is to see if this dual-task training improves stability and mobility better than standard balance exercises alone. 2…

This early-phase trial aims to see if taking a combination of three common drugs (Telmisartan, Metformin, and Cilostazol) can help chronic stroke survivors gain more movement in their arms and hands during robot-assisted therapy. Fifty adults who had an ischemic stroke at least s…

This pilot study tests whether watching special videos can help people recover leg movement after a stroke. Twelve participants will use a video system that shows their good leg moving, while they try to copy the movement with their affected leg. They will do this 5 times a week …

This study looks at whether an intravenous lidocaine infusion can safely reduce moderate to severe headache pain in people recovering from a non-traumatic subarachnoid hemorrhage (a type of brain bleed). Twenty adult participants with favorable neurological status will receive li…

This study tests whether a smartphone app that combines daily mood and activity surveys with artificial intelligence can help people recovering from a stroke manage depression, thinking difficulties, and daily functioning. Participants use the app for a period, answer brief surve…

This pilot study tests whether the Voiceitt app can help people with speech impairments caused by conditions like cerebral palsy, stroke, ALS, or Parkinson's disease communicate more effectively. Participants use the app to see if it improves speech clarity and daily communicatio…

This study tests a wearable robotic knee device (AKO-R) to help people who have had a stroke walk more symmetrically. Twenty participants will do treadmill and overground walking with the device. Researchers will check safety and measure improvements in step length and stance tim…

This study compares two types of speech therapy for people with aphasia, a language disorder often caused by stroke. One therapy, called Semantic Feature Analysis (SFA), helps people name objects by describing their features. The other adds metacognitive strategy training (SFA+MS…

This study tests whether adding immersive virtual reality (VR) to robotic walking rehabilitation is tolerable for people who cannot walk after a stroke. Thirty non-walking stroke patients will try both standard robotic rehab and VR-enhanced sessions. Researchers will measure moti…

This trial tests a wearable robot called ENMS-BSF that combines soft muscles, electrical stimulation, and balance feedback to correct foot drop and foot inversion after a stroke. Sixty people who had a stroke at least six months ago and have mild-to-moderate walking problems will…

This study compares a home-based telerehabilitation program (Tele-CPASS) to standard in-person therapy for improving arm and hand function after a stroke. Forty-two recent stroke survivors with arm weakness will be randomly assigned to receive 20 hours of either remote or in-pers…

This study tests whether a non-invasive brain stimulation technique called TMS, combined with language therapy, can improve speech in people who have aphasia after a stroke. Researchers will compare real TMS to a sham (fake) version in 63 participants who had a stroke 2 to 6 week…

This study looks at whether adding a modified form of cognitive behavioral therapy (a type of talk therapy) to standard occupational or speech therapy can improve emotional well-being and daily functioning in stroke survivors. The trial will enroll 80 adults who had a stroke at l…

This study looks at whether a regular exercise program can improve the benefits of botulinum toxin (Botox) injections for arm stiffness after a stroke. About 70 stroke survivors with arm spasticity will receive Botox and then be randomly assigned to either a prescribed exercise r…

This study looks at urinary problems in people recovering from a stroke. Researchers compare patients with and without bladder issues and test two simple behavioral approaches: for those with thinking difficulties, training to go to the toilet immediately when they feel the urge;…

This study tests whether adding telerehabilitation (home-based, supervised and independent arm exercises) to usual care improves arm function and reduces disability after a stroke. Twenty adults in Brazil who had a stroke about 4 months ago will participate. The goal is to see if…

This study tests a mixed-reality system called RehAtt to help people recover movement after a stroke. Ten participants with one-sided weakness will use the system for arm, walking, and balance exercises. Researchers will interview them to see if the system is easy, motivating, an…

This study tests whether combining low-intensity resistance training with blood flow restriction therapy can improve arm strength, reach, and sensation in people who have had a stroke. Researchers will enroll 64 adults aged 50–70 who are at least one month post-stroke. The goal i…

This study tests whether lower limb sensorimotor training (exercises that improve touch and movement awareness) or whole-body vibration therapy (standing on a vibrating platform) can help stroke survivors aged 50-65 improve their balance and reduce fear of falling. Fifty-two part…

This study tests if pairing a gentle, non-invasive brain stimulation (tDCS) with personalized physical therapy can help people with cerebellar damage (from stroke, tumor, or degeneration) improve movement and daily function. About 30 adults aged 18-75 will participate. The goal i…

This study tests whether adding a wearable vibratory device to standard physiotherapy helps improve arm function in people with hemiplegia (paralysis on one side) after a stroke. Thirty adults who had a stroke 3 to 6 months ago will be split into two groups: one gets usual therap…

This study tests whether combining a non-invasive brain stimulation technique (rTMS) with machine-assisted hand exercises can help stroke survivors regain arm and hand movement. Researchers will enroll 54 adults aged 40-80 who had a first stroke within the past year. Participants…

This study tests whether vagus nerve stimulation (VNS) paired with rehabilitation can improve leg and walking function in people who have had an ischemic stroke. Researchers will enroll 24 adults who are already approved for VNS therapy for arm problems. The goal is to see if thi…

This study tests whether adding motor imagery—mentally rehearsing movements without actually moving—to standard physical therapy can improve arm function in stroke survivors. About 51 adults who had a stroke at least 3 months ago will be split into three groups: standard rehab al…

This study tests a training method called MINT that helps stroke survivors reduce abnormal muscle co-activation in their legs. The goal is to improve walking speed and endurance. Researchers will enroll 72 adults who had a stroke at least 6 months ago and have moderate to severe …

This study tests a therapy where chronic stroke patients watch videos of hand and arm activities, then practice those movements. Researchers want to see if watching one-handed or two-handed actions works better for improving arm function, daily living skills, and quality of life.…

This study tests whether watching and copying hand movements during video calls can improve arm function, daily activities, and quality of life in people who had a stroke at least 6 months ago. Thirty participants will be assigned to either this video-based therapy or standard in…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This small study tests whether electrical stimulation of the spinal cord can improve arm and leg movement in people who had a stroke at least 6 months ago. Only 6 participants with limited recovery will receive the treatment. The goal is to see if it is safe and helps with daily …

This study tests whether combining brain stimulation (rTMS) with a brain-computer interface can help people who had a stroke more than 6 months ago regain arm movement. The brain-computer interface translates thoughts of moving into electrical muscle stimulation. The trial will e…

This study tests whether a special swallowing exercise using a pressure-measuring ball can help older stroke patients with swallowing problems. Participants will do the exercises at home twice daily for 12 weeks. The goal is to see if it improves swallowing function and quality o…

This study tests whether adding a gentle electrical current to the brain (tDCS) during intensive arm therapy helps women recover arm movement after a stroke. Twenty-four women will receive either real or fake stimulation over two weeks. The goal is to see if the combo improves ar…

This early study tests a device that uses your own breathing to trigger mild electrical stimulation, aiming to reduce hand stiffness and improve hand movement in people who had a stroke at least 6 months ago. Only 4 participants with moderate hand tightness will be enrolled. The …

This pilot study tests a device called BreEStim that uses breathing to control electrical stimulation of hand muscles. Four people who had a stroke at least 6 months ago and have moderate hand tightness will try one session. The goal is to see if it reduces finger stiffness and i…

This study tests a home grip assistance glove (SaeboGlove) to help stroke survivors use their weaker arm in everyday tasks. About 100 adults who had a stroke more than three months ago and have trouble opening their hand will try the glove at home. Researchers will compare how we…

This study tests a special hand device that helps people who had a stroke and cannot open their hand to grab things. The device is designed to let users control it themselves to pick up, move, and release objects like a glass or spoon. Researchers will compare how well 30 partici…

This study tests a gentle, non-invasive brain stimulation technique called tACS to see if it can improve hand and arm movement in people who have had a stroke. Researchers will enroll 14 adults who are at least 6 months past their stroke and have some finger movement. The goal is…

This study compares two physical therapy approaches—rhythmic guided movements and static muscle contractions—to see which better improves arm function, strength, and coordination in people who had a stroke 1 to 6 months ago. Forty participants aged 40 to 60 with arm weakness on o…

This early study tests a device called BreEStim, which uses breathing to control mild electrical stimulation, to see if it can reduce finger stiffness and improve hand function in people who had a stroke at least 6 months ago. Only 4 participants will receive a single 10-20 minut…

This study tests whether a safe, mild electrical current applied to the scalp (tDCS) can make speech therapy work better for people who have trouble speaking after a stroke. 24 participants with apraxia of speech will receive both real and sham stimulation at different times to s…

This study tests whether a personalized brain-training therapy (neurofeedback) can improve arm movement in people who recently had a stroke. About 44 participants will either receive standard or personalized neurofeedback during 15 sessions over three weeks. The goal is to see if…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve word-finding in people who have trouble speaking after a stroke. Researchers will use MRI scans to guide the stimulation and see how the brain responds. The trial involves 45 participants …

This study looks at whether special pelvic stability exercises can improve leg function in people who had a stroke within the past few months. Thirty-four participants will either get pelvic training plus standard leg therapy, or standard therapy alone, for eight weeks. Researche…

This study tests whether a numbing nasal spray can safely reduce severe headaches after a brain aneurysm bleed. About 20 adults in the ICU will receive the spray along with standard pain meds. Researchers will compare pain levels and opioid use before and after treatment to see i…

This study is testing whether a device that sends small electrical pulses to leg muscles can help people with chronic stroke improve their balance and walking. Twenty participants will be exposed to slip- and trip-like disturbances on a treadmill, with and without the stimulation…

This study tests whether combining mindfulness meditation with dual-task training (like walking while doing mental math) can improve thinking and physical skills in people with mild cognitive impairment after a stroke. Sixty participants will be randomly assigned to the combined …

This study tests whether a gentle electrical current applied to the brain can make speech therapy more effective for people with chronic aphasia (trouble speaking or understanding language) after a stroke. About 50 adults who had a stroke at least six months ago will receive eith…

This study tests whether arm therapy done online (telerehabilitation) works as well as the same therapy done in a clinic for people who had a stroke within the last 6 months. 28 participants will be split into two groups, each receiving Constraint-Induced Movement Therapy for 8 w…

This study tests a new robot system (HIWIN MRG-P110) designed to help chronic stroke survivors improve their walking. The robot uses foot pedals to guide leg movements and can adjust how much it helps versus how much the patient must do on their own. Researchers will enroll 60 pe…

This study compares Swiss ball exercises versus kinesthetic training to see which better improves balance and mobility in people who had a stroke at least six months ago. Thirty-six participants aged 45-65 will do supervised exercises for 8 weeks. Balance and movement will be mea…

This study tests whether a home-based arm exercise program, called GRASP, can help stroke survivors improve movement and use of their affected arm. Participants will do exercises at home for one hour daily and attend group sessions three times a week. The goal is to see if this p…

This study is testing whether combining two types of electrical stimulation can help people who have had a stroke lift their toes while walking. Participants will receive mild electrical currents on their scalp and leg while doing walking exercises. The goal is to see if this com…

This study tests whether early training that combines thinking tasks with physical movement can help people recover cognitive and motor skills after a brain aneurysm bleed. The training is done 4-5 times a week for 30 minutes while in the hospital. Researchers will measure memory…

This study tests if a digital app called LEXURE can improve language skills in people who have trouble speaking after a stroke (aphasia). About 116 adults who had a stroke at least 3 months ago will either use the app or do workbook exercises. The goal is to see if the app helps …

This study tests whether a noninvasive brain stimulation technique, timed to the patient's own brain waves, can improve arm and hand movement after an ischemic stroke. Researchers will enroll 144 adults who had a stroke 1-14 days ago and have significant arm weakness. Participant…

This pilot study tests whether a hands-on therapy called Mobilization and Tactile Stimulation (MTS) can help stroke survivors who have unilateral neglect—a condition where they are unaware of one side of their body. Six adults who are at least 20 weeks post-stroke will receive MT…

This study tests a 12-week dance program designed for stroke survivors who have weakness on one side of the body. The program combines movement improvisation and adaptive dance to help improve balance, mobility, confidence, and participation in daily and social activities. Resear…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests a 6-week virtual program called PVI that helps young stroke survivors build personal resources through inclusive volunteering. Researchers want to see if it improves work ability, self-confidence, and emotional well-being. 160 participants aged 18-64 who had a st…

This study tests a program that combines storytelling and practical skills training to help young adults (ages 18-64) who have had a stroke feel more connected and capable in their communities. Over six months, 208 participants will attend eight one-on-one sessions with a facilit…

This small pilot study tests whether a drug called cerebrolysin can help people who have been unconscious for over a month after a hemorrhagic stroke. Twelve adults aged 19 to 80 will receive either the drug or a placebo daily for two weeks. Researchers will measure changes in co…

This study tests a new shoe that makes a clicking sound when you walk, designed to help people with foot drop after a stroke. Foot drop makes it hard to lift the front part of your foot, causing tripping. The shoe gives audio feedback to help you walk more naturally. Fifty adults…

This study is testing whether combining a special movement therapy with mild electrical stimulation can help people who had a stroke regain arm function. Forty participants who had an ischemic stroke 3 to 6 months ago will receive either the combo therapy or standard rehab. The g…

This study looks at whether adding rhythmic breathing exercises to standard balance training can improve balance and trunk control in people who had a stroke 3-6 months ago. Fifty participants will be split into two groups: one gets breathing plus balance training, the other gets…

This pilot study tests whether a 4-week home-based cognitive strategy training program can help adults with chronic stroke become more independent in daily activities like dressing and cooking. Eighteen participants will work with an occupational therapist in their own homes. The…

This study tests a new virtual reality system that uses motion-tracking games to help stroke survivors improve arm and hand function. 56 people who had a stroke within the last 2 to 6 months will either get this VR therapy or standard rehab for 8 weeks. Researchers will measure a…

This study tests whether stimulating the tongue with a non-invasive device can improve arm movement and brain plasticity in people who had a stroke at least six months ago. Participants will do a 4-week strength training program for their affected arm, combined with either real o…

This study tests a special mouth exercise program for people who still have trouble swallowing 12 weeks after a stroke. Researchers want to see if the device can improve swallowing function and quality of life. The trial involves 60 participants and uses a camera test to measure …

This study is testing a device called SynPhNe that stroke survivors can use at home to retrain their hand function. The goal is to see if it improves hand movement compared to standard care alone. The study will include 40 adults who had a stroke at least 6 months ago and have mo…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) can improve arm and hand function in stroke survivors. Thirty adults who had a stroke within the last five years will receive either real taVNS or a sham (fake) stimulation combined with physical …

This study tests whether a non-invasive device called NESA, which delivers tiny electrical currents through the skin, can help people who had a stroke 6 months to 6 years ago. Researchers will measure changes in pain, muscle tightness, balance, sleep, and daily activities in 30 p…

This study tests two treatments for muscle stiffness in the lower leg after a stroke: Botox injections (a single session) and dry needling (12 weekly sessions). Researchers will measure changes in muscle reflexes and thickness in 90 participants across Belgium, Spain, and Canada.…

This study tests whether a new AI-powered algorithm can improve how people with chronic arm weakness from a stroke control a robotic arm brace. Participants will use both the standard control method and the experimental algorithm while moving blocks. The goal is to see if the new…

This study tests whether high-intensity interval training (short bursts of fast walking) is better than moderate-intensity walking for improving walking ability in people who had a stroke at least 6 months ago. 156 participants will be randomly assigned to one of two 12-week exer…

This study tests whether adding gentle vibration to hand exercises helps stroke survivors regain hand movement, feeling, and reduce muscle tightness. About 38 people who had a stroke at least 3 months ago will be randomly assigned to either standard hand exercises or the same exe…

This study tests whether a program of physical activity counseling and a personalized exercise plan can help stroke survivors become more active. Researchers will compare a group receiving this program plus usual care to a group receiving only usual care. The study involves 120 c…

This study tests a web-based program called CARE-CITE that teaches family caregivers how to better support stroke survivors with arm exercises at home. The program includes virtual home visits and phone check-ins over four weeks. Researchers will measure improvements in arm funct…

This study tests a group-based self-management program delivered via telehealth for people who had a mild or moderate stroke within the last 6 months. The program teaches problem-solving and goal-setting skills to improve daily activities and community participation. Researchers …

This study compares three types of walking training for people who have had a stroke: forward walking with body support, backward walking with body support, and virtual reality-assisted walking. The goal is to see which method best improves walking ability, balance, and overall f…

This study tests whether personalized brain stimulation (rTMS) can improve arm movement in people who had a stroke within the past 3 months. About 120 participants will receive either a tailored treatment based on their brain's recovery potential or a standard approach. The goal …

This study tests a new speech therapy technique for people with aphasia (trouble speaking) after a stroke. Instead of copying a therapist's voice, participants will practice speaking along with an AI-cloned version of their own voice. The goal is to see if this personalized appro…

This study tests whether a wearable robot can help people who recently had a stroke recover movement in their legs and improve balance and walking. The robot provides intensive therapy to the ankle, which is often affected. The trial involves 140 participants who had a stroke wit…

This study tests whether a wearable robotic arm device called MyoPro, combined with motor learning therapy, can improve arm function in people who had a stroke at least six months ago and have severe arm weakness. The device reads muscle signals to help move the arm. Sixty partic…

This study is testing whether a 10-week music-based program done at home on a tablet can help people recover from a stroke. The program includes rhythm exercises, singing, playing a xylophone, and listening to music. Researchers will compare 100 stroke survivors who do the music …

This study tests whether a non-invasive brain stimulation technique called high-frequency rTMS can improve cognitive problems that often follow a stroke. Researchers will use brain imaging to see how the treatment affects brain activity. The trial aims to enroll 40 adults aged 35…

This study looks at whether adding music training and group leisure activities to standard hospital rehab helps people recover better after a stroke. About 90 adults who recently had a stroke will be split into three groups: usual rehab, usual rehab plus individual music training…

This study tests whether numbing a nerve in the arm or leg can reduce the severe, hard-to-treat pain some people feel after a stroke. Researchers will give 36 adults either one of two numbing medicines or a saltwater injection, then measure pain changes. The goal is to see if blo…

This study tests whether a digital program on an iPad, combined with learning thinking strategies, can improve mood and mental skills in people who have had a stroke. The study will include 70 adults who had a first stroke at least 6 months ago and now have depression and trouble…

This study compares three rehabilitation approaches for people recovering from a stroke: mirror therapy (using a mirror to trick the brain into thinking the affected limb is moving), cognitive orientation to daily occupational performance (CO-OP, a problem-solving strategy to ach…

This study tests whether a new virtual reality therapy that combines mirror therapy with cooperative tasks can improve arm movement in people who had a stroke at least six months ago. Forty-four participants will be split into groups receiving either standard task-oriented traini…

This study is testing a device called MyHand 2 that helps people who have had a stroke use their affected hand better. The device is worn on the hand and assists with movement. Researchers want to see if it is easy to use and helpful for daily tasks. The study involves 60 adults …

This study is testing whether adding sensory training to a proven arm therapy (Constraint-Induced Movement therapy) can help stroke survivors with mild-to-severe arm and hand weakness. Researchers will enroll 15 adults who are at least 6 months post-stroke. The goal is to see if …

This study tests whether training one arm alone or both arms together is better for recovering arm and hand function after a stroke. Thirty-two adults who had a stroke 6 to 24 months ago will do task-specific exercises for 4 weeks. Researchers will measure motor recovery and hand…

This pilot study tests whether a 12-week sitting Tai Chi program can improve cognitive function, arm movement, balance, and mood in chronic stroke survivors who have memory or thinking problems. About 176 participants (88 stroke survivors and 88 caregivers) will be randomly assig…

This study tests whether using conversational hypnosis during a transoesophageal echocardiogram (a heart ultrasound done through the throat) can make the procedure more comfortable for patients. Researchers will enroll 150 adults and measure their comfort levels right after the e…

This study is for adults 18 and older who have had a stroke or a transient ischemic attack (TIA), often called a mini-stroke. The goal is to collect information from standard medical tests and some extra research tests, like blood draws and brain scans, to better understand how t…

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

This study looks at how certain white blood cells, called monocytes, react to injury from a heart attack or ischemic stroke. Researchers want to learn how these cells sense danger signals and produce substances that might help heart muscle and brain tissue heal. The study involve…

This study investigates whether sarcopenia—age-related muscle loss—is common in older adults during the acute phase of ischemic stroke and whether it influences recovery. Researchers will assess muscle mass and function in 400 patients aged 50 and older within 72 hours of stroke …

This study looks at how shoulder pain on the paralyzed side after a stroke affects arm movement, trunk control, fear of falling, mobility, and independence. Researchers will assess 62 stroke survivors using standard tests and ultrasound. The goal is to better understand the relat…

This study investigates how a recent stroke affects the ability to learn new motor skills that require using both arms or hands together. Researchers will use robotic devices to measure learning and brain imaging to see which brain areas are involved. The goal is to understand wh…

This study investigates whether people who recently had a stroke (within 21 days) can learn new arm movements using a rehabilitation robot called REAplan. Researchers will compare their learning ability with healthy individuals and those who had a stroke long ago. The goal is to …

This study checks whether a free smartphone app called PhysioMaster can reliably measure posture and range of motion in people who have had a stroke. Researchers will compare the app's measurements to those from standard tools like the universal goniometer. Sixty stroke survivors…

This study looks at whether giving antibiotics for just 24 hours around the time of placing a special antibiotic-coated brain drain works as well as giving them for the whole time the drain is in place. The goal is to find the best way to prevent serious brain infections in peopl…

This study investigates whether high-resolution MRI can identify dangerous plaque features in the middle cerebral artery that might predict a second stroke. Researchers will follow 75 patients who had a first stroke due to significant narrowing of this artery, tracking which plaq…

This study follows adults who have had a stroke caused by a blockage in a medium-sized blood vessel in the brain. Researchers will track the treatments patients receive and their recovery over time. The goal is to learn which approaches work best in everyday practice, helping doc…

This study aims to gather crucial information about stroke in Uganda, where the disease is on the rise. Researchers will look at how common stroke is, what factors increase the risk, and how it affects people's quality of life. The goal is to identify what rehabilitation support …

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinkin…

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study looks at how blood levels of common blood thinners (apixaban, dabigatran, edoxaban, and rivaroxaban) change over time in Chinese patients with atrial fibrillation. Researchers will take blood samples before and after stopping the medication for medical procedures. The …

This study investigates whether physical exam findings called somatic dysfunction — impaired function of the body's framework — can be linked to energy expenditure, heart rate variability, and quality of life in people who have had a stroke. Researchers will assess 100 chronic st…

This study collects a wide range of information from stroke survivors and healthy volunteers, including genetic data, brain scans, electrical brain activity, and thinking and memory tests. The goal is to build a model that can predict which stroke survivors are most likely to dev…

This study investigates whether ultrasound measurements of thigh muscle thickness can help detect sarcopenia (muscle loss) and fear of movement in people who have had an ischemic stroke. Researchers will compare ultrasound results with standard tests like handgrip strength and a …

This study explores whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can help improve language recovery in people who have lost speech abilities after a stroke. Researchers will also test the same stimulation in…

This study tests whether a wireless sensor placed on the forehead can accurately measure oxygen levels in the brains of infants in the neonatal intensive care unit (NICU). The wireless device is compared side-by-side with the standard wired monitor in 20 newborns with conditions …

This study is a registry that will follow 1500 adults treated for acute ischemic stroke with Medtronic devices. Researchers will track safety, how well the devices restore blood flow, and whether patients regain independence after 90 days. The goal is to see how these devices wor…

This study looks at how taking a nap helps the brain remember new motor skills, like typing a sequence. Researchers will use brain scans to see what happens during rest and sleep. The study includes adults who have had a stroke and healthy volunteers of different ages. The goal i…

This study tracks 400 people who had a procedure to close a patent foramen ovale (PFO), a small hole between the heart's upper chambers that can raise stroke risk. Researchers want to see how often strokes or mini-strokes return, whether a residual shunt persists, and what factor…

This study aims to create a better way to predict stroke risk in people with atrial fibrillation (an irregular heartbeat) who are already taking direct oral anticoagulants (DOACs), a type of blood thinner. Even with these medications, some patients still have strokes. Researchers…

This study uses a special robot called IntelliArm to measure how arm stiffness, spasticity, and movement change during recovery from a first stroke. Researchers will track 56 people who had a stroke less than a month ago, measuring their arm function with standard tests and robot…

This study tests whether artificial intelligence can predict muscle loss (sarcopenia) in intensive care patients with serious brain conditions like stroke, bleeding, or tumors. Researchers will measure thigh muscle thickness with ultrasound and track nutrition markers over the fi…

This study looks at whether special MRI scans can help predict which people with severe narrowing of brain arteries (70-99% stenosis) are most likely to have another stroke. Participants have already had a minor stroke and are enrolled in a larger treatment trial. They will get a…

This study follows 100 stroke survivors over six months to understand how sitting balance, standing balance, and walking recover. Using wearable sensors and an interactive assessment game, researchers measure movement, coordination, and reaction time. The goal is to identify reco…

This study investigates how two types of assistive devices—exotendon and end-effector—affect finger extension and muscle coordination in 15 chronic stroke survivors and 15 healthy adults. Participants perform finger movements with and without assistance while muscle activity is r…

This study uses transcranial magnetic stimulation (TMS) to investigate how the brain processes language in people who have had a stroke and developed aphasia, as well as in healthy volunteers. Participants receive targeted magnetic pulses to specific brain areas while performing …

This study explores whether a system combining augmented reality (AR) and brainwave monitoring (EEG) can detect and help rehabilitate spatial neglect in stroke survivors. Spatial neglect is a condition where a person ignores one side of their world, often after a stroke. Ten stro…

This study investigates whether silent brain infarcts (small stroke-like spots seen on MRI) are linked to cognitive decline in people who have had a spontaneous intracerebral hemorrhage (a type of brain bleed). Participants undergo cognitive tests, brain MRIs, and blood draws dur…

This large registry study tracks 2,000 adults in China with severe spontaneous brain hemorrhage to compare outcomes of emergency surgery versus conservative (non-surgical) treatment. It focuses on patients who take long-term antiplatelet drugs (like aspirin) to see if surgery is …

This study tests whether a 6-week program that combines a pedometer with phone or video coaching is practical for people who had a stroke at least 6 months ago. 24 participants will track their steps and set goals with an occupational therapist. The main goal is to see if people …

This study aims to learn how patients with severe stroke move during their hospital stay. Fifty adults will wear a small activity tracker (activPAL) that records lying, sitting, standing, and stepping. Researchers will compare this data with standard mobility goals to understand …

This observational study investigates why some people develop epilepsy after a stroke, while others do not. Researchers will compare first-time stroke patients with healthy volunteers using brain imaging (MRI), electrical brain recordings (EEG), and overnight sleep studies. The g…

This study investigates whether monitoring brain blood flow during heart surgery can help predict strokes afterward. Researchers will use non-invasive sensors to track how well the brain regulates its own blood supply during different phases of surgery. The goal is to develop a m…

This study looks at whether a person's personality before a brain injury or stroke influences how well they recover thinking and memory skills. Researchers will follow 250 adults with severe acquired brain injury or stroke, testing their cognitive abilities, daily functioning, an…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This study follows 5000 people admitted to a neuro-intensive care unit with life-threatening brain conditions like bleeding in the brain or severe seizures. Researchers collect medical data and biological samples to better understand how brain injuries progress and what factors h…

This study aims to uncover genetic and environmental risk factors for hemorrhagic stroke, a type of stroke caused by bleeding in the brain. Researchers will analyze DNA, RNA, and blood samples from 1,000 adults who have had such a stroke, comparing them to healthy controls. By id…

This study looks at how stroke survivors with weakness on one side (hemiplegia) perceive internal body signals, like heartbeat, and whether that relates to their balance, touch sensation, and joint position sense. Researchers will assess 60 participants in a single session using …

This study looks at MRI scans of 128 people who have had a brain hemorrhage (bleeding in the brain). Researchers want to see if a specific contrast pattern called a 'spot sign' can help predict which bleeds might get worse. By understanding these patterns, doctors hope to identif…

This study investigates the specific cognitive strengths and weaknesses of children and adults with Sturge-Weber Syndrome (SWS), a rare condition affecting blood vessels in the brain, skin, and eyes. Participants complete a series of tests measuring memory, attention, language, a…

This study uses fMRI and EEG to understand how brain areas that plan movement interact with those that process sound during speech. Researchers will compare healthy adults and people who have had a cerebellar stroke. The goal is to learn how the brain adjusts hearing during speak…

This study explores whether exercising the unaffected leg at home can trigger beneficial brain and spinal changes in people with severe stroke. Participants perform strength and coordination tasks with their stronger leg using a tablet-based system, while researchers measure brai…

This study uses a brain imaging technique called fNIRS to watch how the brain changes during robot-assisted hand therapy in stroke survivors. Researchers will compare two types of robotic devices (end-effector and exoskeleton) to see which one better promotes brain reorganization…

This registry is collecting data from 3,000 adults with atrial fibrillation who undergo a procedure to close off a part of the heart called the left atrial appendage. The goal is to track how well the procedure works to prevent strokes and to identify any complications. Hospitals…

This study tests how Tizanidine, a drug used for muscle stiffness, changes arm movement in people who have had a stroke. Researchers will measure brain activity, muscle responses, and movement patterns in 64 participants. The goal is to understand what limits movement after strok…

This study looks at whether a standard shoulder X-ray can detect bone loss in the weak arm of people who have had a stroke. Researchers will measure bone thickness on X-rays from 65 stroke survivors and compare those measurements to the gold-standard DXA bone density scan. If the…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study uses PET and MRI brain scans to compare the activity of two key brain chemicals—dopamine and acetylcholine—in 30 people who have had a stroke, half with apathy and half without. The goal is to better understand what causes apathy after a stroke, which could eventually …

This observational study is looking at 250 people who have had a stroke or mini-stroke due to narrowing of arteries in the brain. Researchers want to see if a specific platelet protein (FcγRIIa) and blood flow patterns on MRI can help predict who will have another stroke within a…

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study uses a brain imaging technique called MEG to look at how the brain recovers after a minor stroke. Researchers will scan 40 stroke survivors and 15 healthy older adults at 1, 6, and 12 months after the stroke while they perform a naming task. The goal is to understand w…

This study looks at how stroke changes the way the brain handles walking while doing another task, like listening or navigating. Researchers will monitor brain activity in 50 stroke survivors as they walk on different paths and respond to sounds. The goal is to better understand …

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…

This study looks at whether levels of nitric oxide in spinal fluid can predict dangerous blood vessel spasms after a type of brain bleed called subarachnoid hemorrhage. Researchers will compare nitric oxide levels in 40 patients with and without this condition. The goal is to fin…

This study follows 180 adults with cerebral small vessel disease to see how their condition changes over time after a stroke. Researchers will use MRI scans and blood tests to track disease progression and look for links to thinking skills, daily function, and stroke recurrence. …

This study tests whether adding immersive virtual reality (VR) to standard physical therapy helps people who recently had a stroke regain arm movement and improve quality of life. Researchers will also look at blood markers and genes that might predict recovery. About 120 adults …

This study is testing a simple bedside tool called the Falls Decision Rule to help emergency doctors decide whether older adults (65+) need a brain scan after a fall. Researchers will check if the tool accurately identifies who has a serious brain bleed and who does not. The goal…

This study looks at 50 adults who had a stroke caused by a blocked middle brain artery and were treated with a clot-removal procedure called thrombectomy. Researchers will use special MRI scans to measure brain activity and metabolism in the damaged area. The goal is to find earl…

This study is testing three different doses of a non-invasive brain stimulation technique called rTMS in 26 chronic stroke survivors with arm weakness. The goal is to see which dose best boosts brain signals to the hand muscles and improves motor learning. Participants will recei…

This study looks at how changing what stroke survivors see in virtual reality affects their hand movements. 15 chronic stroke survivors and 15 healthy people will do hand exercises in VR while their finger movements and muscle activity are recorded. The goal is to understand how …

After brain surgery, many patients need a breathing machine in the ICU. This study will follow 220 such patients to see how the natural bacteria in their lungs change over time. Researchers will collect airway samples and use advanced lab tests to link those changes to the risk o…

This observational study at Yale University will follow 150 people who have had an ischemic stroke to see how changes in blood pressure affect their recovery. Researchers will use brain scans and thinking tests to understand the connection. The goal is to find better ways to mana…

This study looks at how people who had a stroke more than 6 months ago learn a new walking pattern using distorted visual feedback. Researchers want to see if a short 5-minute exercise session helps them remember the new walking pattern a day later. 80 participants will be split …

This study tests a digital lifestyle platform designed to support patients after they leave inpatient rehabilitation. It includes people with COPD, heart problems, fractures, or minor stroke. Participants use the platform for six months, receiving personalized recommendations and…

This study tests a new set of procedures called the HI-SPEED Protocol, designed to help hospitals evaluate stroke patients faster and decide who needs to be transferred for advanced care. The goal is to reduce the time patients spend in the first hospital before being moved to a …

This study aims to find early warning signs for major chronic diseases like stroke, heart disease, and cancer by following 4,500 healthy adults aged 30-80 in Lishui. Participants will receive regular check-ups and long-term monitoring. The goal is to improve prevention and care a…

This study looks at 150 patients who are unresponsive after a brain bleed (intracerebral hemorrhage). Researchers use EEG to detect hidden brain activity when patients are asked to imagine moving. The goal is to see if this activity can predict who will regain consciousness and h…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This pilot study tests whether a special wire can safely measure blood flow in the brain's smallest blood vessels right after a stroke clot is removed. The goal is to understand why some patients still have disability even when the main artery is reopened. Fifteen adults who had …

This study tests an 8-week online program that teaches stroke survivors how to start their own business. The goal is to help them find meaningful work and improve their confidence and life satisfaction. The program is for adults aged 18-65 who had a stroke and have been out of pa…

This study looks at sleep problems like sleep apnea and insomnia in 226 people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. Participants will use a home sleep test and a smartwatch to track sleep and…

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…

This study looks at how a stroke can disrupt the body's automatic functions, like heart rate and blood pressure control. Researchers will compare 100 people who had a stroke or a mini-stroke using brain scans, blood tests, and heart function tests. The goal is to understand why t…

This study follows 24 people who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers want to see how AF changes over two years by monitoring heart activity, blood markers, and heart structure. The goal is to better understan…

This study compares how well stroke neurologists and a deep learning AI model predict recovery in 250 stroke patients. Researchers will track actual disability at 24 hours and 3 months, then compare those results to predictions made by doctors and the AI. The goal is to understan…

This study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech abilities in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed deep in the brain for less than 30 days to deliver mild electr…

This study compares two rehabilitation methods to improve finger movement in 40 people who had a stroke. One method encourages using any strategy to reach goals, while the other focuses on improving movement technique. Participants will do 10 days of piano training and have brain…

This study aims to create an artificial intelligence (AI) model to help doctors diagnose and predict recovery for people with a bleeding stroke (spontaneous intracerebral hemorrhage). The researchers will use brain scans and other data from 7,100 patients to train the AI. The goa…

This study tests whether a new type of exercise that retrains how muscles work together can improve arm function in people who have had a stroke. Researchers will compare this approach to standard strength training in 74 participants. The goal is to see if changing muscle coordin…

This study follows 600 adults who have had their first stroke to see how their thinking and memory change over time. Researchers will look at factors like brain reserve and daily habits to understand why some people get worse while others stay stable. The goal is to better predic…

This study tests a fast genetic test done in the hospital to see if it helps doctors pick the best blood thinner for stroke patients. Some people have a gene variation that makes the common drug clopidogrel less effective. The test checks for 11 known gene variants and alerts the…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study looks at how changes in brain blood flow affect breathing control during sleep in healthy adults. Researchers will expose participants to normal oxygen and low oxygen levels to see how the brain responds. The goal is to better understand sleep apnea and related conditi…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study is tracking 5,000 people who had a brain bleed from a ruptured aneurysm. Researchers are collecting medical data to find factors that predict complications like delayed brain injury or long-term disability. The goal is to create a computer model that helps doctors fore…

This study tests a new brain scanning method called fNIRS to see if it can predict recovery in unconscious ICU patients with severe stroke or brain injury. Researchers will compare fNIRS results with standard tests in 30 patients and healthy volunteers. If successful, fNIRS could…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study follows 1,875 people who have had an ischemic stroke and are taking blood thinners to prevent another one. Researchers use MRI scans to see if these medications increase the risk of tiny brain bleeds or major bleeding. The goal is to help doctors choose safer treatment…

This pilot study looks at how botulinum toxin (Botox) injections affect the muscles, tendons, and nerves in the feet of people who have had a stroke and developed a tight, twisted foot (equinovarus). Researchers will use special ultrasound and movement tests to track these change…

This study tests whether a mild electrical current applied to the ear can help the brain learn and control hand movements. Researchers want to understand how this stimulation affects brain chemicals that support learning. The study involves 110 adults, including some who have had…

This study is testing a special glove equipped with sensors to measure how well stroke survivors can feel touch. The glove is part of a larger robotic rehabilitation program aimed at improving both movement and thinking skills. Researchers will enroll 126 people who had a stroke …

This study looks at whether an imbalance in gut bacteria is linked to stroke risk and recovery in young adults (ages 18-45). Researchers will analyze stool and blood samples from 60 stroke patients to find patterns that could help predict strokes earlier. The goal is to understan…

This study looks at how swelling around a brain bleed affects recovery in 500 stroke patients. Researchers will use MRI scans and blood tests to understand the swelling's role. The goal is to find new ways to treat this devastating type of stroke.

This study will track how often and how intensely patients with moderate to severe brain injury are moved or exercised while in intensive care units in Scandinavia. Researchers want to see if more movement is linked to better outcomes and safety. About 198 adults on breathing mac…

This study looks at up to 100 young adults (ages 18-55) who have had a stroke to understand how they recover. Researchers will collect detailed health information and samples to see what factors like age, lifestyle, and biology affect recovery. The goal is to test if this detaile…

This study looks at whether a fast genetic test can help doctors pick the best blood-thinning medication for people who have had a minor stroke or a high-risk mini-stroke (TIA). The test checks a gene called CYP2C19, which affects how the body processes certain antiplatelet drugs…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study looks at whether filtering out blue light at night in hospital rooms can reduce inflammation, protect thinking skills, and improve mood and sleep in 80 adults having elective heart surgery. Participants will be randomly assigned to wear blue-blocking glasses or regular…

This study is creating a biological bank of blood samples from 1,000 people with atrial fibrillation (AF) and stroke. Researchers will collect DNA and plasma to study the genetic roots of these conditions. The goal is to better understand why AF leads to stroke and find new drug …

This study tests whether a gentle electrical current applied to the brain (tACS) can improve hand movement in people who had a stroke more than 6 months ago. Researchers will use brain scans and EEG to see how the stimulation changes brain activity. 45 participants (including hea…

This study is developing a checklist to help doctors decide when it's safe to skip a CT scan for head injuries in patients taking blood thinners. Researchers will study 4,000 emergency department patients to find out which symptoms or signs reliably rule out serious brain bleedin…

This study is analyzing blood samples from 500 people who recently had a stroke and comparing them to healthy volunteers. Researchers are looking for specific RNA molecules that could serve as biomarkers to detect stroke and predict how well patients will recover. The goal is to …

This study follows 100 stroke survivors with arm weakness to see how their own sense of arm use changes during intensive rehab. Researchers compare patients' perceptions with actual arm function using standard tests. The goal is to better understand the gap between what patients …

This study collects data from 336 adults aged 18-85 who had an acute ischemic stroke and received a new clot-busting drug called non-immune staphylokinase. Researchers will check how often bleeding in the brain occurs and compare results to the standard drug alteplase. The goal i…

This study examines blood samples from 300 adults who had a stroke and received a procedure to remove the clot. Researchers look for specific RNA molecules that change before and after treatment. The goal is to find markers that can help predict how well patients will recover and…

This study is collecting information from 5,000 people hospitalized for ischemic stroke to see how different treatments affect their recovery. Researchers will track outcomes like disability and stroke recurrence over up to 24 months. The goal is to build models that help predict…

This study tests whether speech therapy delivered via video call works as well as traditional in-clinic therapy for people with aphasia, a language disorder caused by stroke. One hundred adults who had a stroke at least a year ago will receive either remote or in-person therapy. …

This early study tests whether a non-invasive device that gently stimulates a nerve in the ear (taVNS) can change brain activity and genetic markers in people who recently had a stroke. Forty-four participants with arm weakness will receive either real or sham stimulation. Resear…

This small study tests a smartphone app that creates a 'digital twin' of the patient to help manage health after a stroke, moyamoya disease, or cerebral amyloid angiopathy. Twenty adults will either use the app plus standard care, or standard care alone. The goal is to see if pat…