Perceptual disorders

This study tests whether cenobamate, an experimental anti-epileptic drug, can safely reduce primary generalized tonic-clonic (PGTC) seizures when added to a person's usual seizure medications. Adults and adolescents aged 12 and older with PGTC seizures are randomly assigned to re…

This early-stage trial tests an experimental drug called Kamuvudine-8 (K8) for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 30 participants receive eye injections of K8 and are monitored for 26 weeks to check s…

This study tests whether NPI-001 tablets can safely slow or stop vision loss in people with Usher syndrome, a rare genetic condition that causes blindness and hearing loss. About 49 adults will take either the study drug or a placebo for 24 months. The main goal is to see if the …

This study tests whether a combination of a gentle sedation strategy (called eCASH) and early, personalized exercise can prevent muscle weakness that often develops in ICU patients who need a breathing machine. The trial will include 70 adults on ventilators, with half receiving …

This trial tests whether an experimental drug called ONS-5010 (a form of bevacizumab) works as well as an approved drug, Lucentis, for treating wet age-related macular degeneration (AMD). Wet AMD causes rapid vision loss due to abnormal blood vessels leaking fluid in the eye. Abo…

This study tested an experimental drug called SPI-1005 (ebselen) in 254 adults with Meniere's disease, a condition causing hearing loss, ringing in the ears, and dizziness. Participants received either the drug or a placebo for a set period, followed by an open-label phase where …

This study tests whether SPI-1005, a drug containing ebselen, can prevent hearing loss in people with cystic fibrosis who are receiving IV tobramycin for a lung infection. About 40 participants will receive either a placebo or one of three doses of SPI-1005 for 21 days. Researche…

This study tested a new cochlear implant (CI632) in 10 adults who have some low-frequency hearing but poor high-frequency hearing. The goal was to see if the implant improves speech understanding and overall hearing. Participants received the implant and were followed to measure …

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This study tested the long-term safety and effectiveness of pegcetacoplan in 792 people with geographic atrophy, a form of advanced dry age-related macular degeneration that causes vision loss. Participants had previously been in earlier pegcetacoplan trials. The goal was to see …

This early-phase study tested a new drug called ASKG712 in 56 people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The drug is injected into the eye and works by blocking two proteins that fuel abnormal blood vessel growth. The main goals were t…

This study tested whether telehealth can replace in-person clinic visits for older adults who already use hearing aids. 339 participants were randomly assigned to receive hearing care either through telehealth or traditional clinic visits. The goal was to see if telehealth could …

This early-stage study tested a gene therapy called CPK850 in 12 adults with a rare inherited eye disease (RLBP1 retinitis pigmentosa) that causes progressive vision loss and night blindness. The treatment was injected under the retina to deliver a working copy of the faulty gene…

This study tests a smart computer simulation (digital twin) of Saudi streets to train visually impaired people on safe navigation. Participants use 3D audio and a vibrating vest to learn to avoid obstacles. The goal is to see if this high-tech training reduces real-world collisio…

This study tested two types of cochlear implants in 37 adults with severe-to-profound hearing loss who had never used an auditory implant before. The goal was to see how safe the implants are and how well they help people understand speech in quiet and noisy settings. Participant…

This study tested a gene therapy called voretigene neparvovec in 4 Japanese patients with a rare inherited eye disease that causes vision loss. The treatment was given as an injection under the retina to replace the faulty gene. The goal was to see if it could safely improve ligh…

This completed trial tested whether virtual reality training could help children aged 4–7 with mild to moderate amblyopia (lazy eye) see better. 90 children were split into two groups: one used VR vision training software, and the other wore an eye patch for 2 hours daily. Resear…

This study tested a drug called cenobamate in 519 adults with partial onset seizures (focal seizures). Participants took cenobamate or a placebo alongside their usual seizure medications. The goal was to see if cenobamate could safely reduce seizure frequency. Results showed a si…

This early-stage study tested the safety of a new drug called VP-001, given as an injection into the eye, for people with a rare genetic eye disease (PRPF31 mutation) that causes vision loss. Six participants aged 12 and older received multiple doses. The main goal was to check f…

This early-stage study tested a new drug, VP-001, given as an injection into the eye to see if it is safe for people with a rare genetic eye disease caused by a PRPF31 mutation. Seventeen adults took part. The main goal was to check for side effects, not to measure vision improve…

This study tested a pre-filled syringe containing a high dose (8 mg) of the drug aflibercept for two eye conditions: diabetic macular edema and wet age-related macular degeneration. The main goal was to see if retina specialists could prepare and inject the drug easily and safely…

This early-phase trial tested NT-101 eye drops in 20 people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The study aimed to check safety and see if the drops could reduce fluid buildup and improve vision. Participants received either a low or h…

This study checks the long-term safety of an eye injection called avacincaptad pegol for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 278 adults who finished a previous study of this drug will receive the injec…

This Phase 3 trial tested a drug called XEN1101 (azetukalner) in 380 adults with focal-onset seizures that were not well-controlled by other medications. Participants took either XEN1101 or a placebo alongside their usual seizure drugs. The study measured whether XEN1101 reduced …

This study tested an eye injection called tarcocimab in 255 people with diabetic retinopathy, a diabetes complication that can damage vision. Participants received either the drug or a sham (fake) injection. The goal was to see if the drug improves the severity of the disease and…

This study tested an experimental drug called KIO-301, given as an injection into the eye, in 32 adults with retinitis pigmentosa or choroideremia—two inherited conditions that cause progressive vision loss. The main goal was to check safety and tolerability at increasing doses. …

This early-phase trial tested the drug rituximab in 3 people with ocular cicatricial pemphigoid, a rare autoimmune disease that causes scarring in the eye and can lead to blindness. The goal was to see if the drug could stop further scarring when standard treatments had failed. T…

This study looked at whether a cochlear implant is a good value for people who are deaf in one ear or have severe hearing loss in one ear. Participants first tried other hearing devices, and if those didn't work, they were randomly assigned to get a cochlear implant right away or…

This study tested whether a pre-filled syringe of the medicine SB11 (a biosimilar to ranibizumab) is easy for eye doctors to use. Thirty adults with wet age-related macular degeneration, macular edema from retinal vein occlusion, or myopic choroidal neovascularization received on…

This phase II trial tested an experimental drug called ADX-2191 in 8 adults with retinitis pigmentosa caused by specific genetic mutations. Participants received monthly injections into one eye for up to six months. The main goal was to check safety, but researchers also looked a…

This phase 2 trial tested the drug crizanlizumab in 18 people with RVCL, a rare and fatal genetic condition that damages small blood vessels in the brain and eyes. There is currently no treatment for RVCL. The study measured changes in brain lesions on MRI scans to see if the dru…

This study tested an experimental drug called Zimura in 121 people with Stargardt disease, a genetic condition that causes vision loss. Participants received either Zimura injections or a sham procedure. The goal was to see if Zimura could safely slow damage to the retina over 18…

This study tested the safety and effectiveness of brolucizumab, a drug injected into the eye, for treating diabetic macular edema (DME) in 66 Indian patients. DME is a complication of diabetes that can cause vision loss. The study aimed to see how well the drug works in real-worl…

This study tested three different doses of SYL1801 eye drops in 99 people with wet age-related macular degeneration (AMD). The goal was to see if the drops are safe and can improve or maintain vision. Participants used the drops for a set period, and their vision was measured aft…

This early-stage trial tested a gene therapy called EXG102-031 in 12 people with wet age-related macular degeneration (nAMD), a condition where abnormal blood vessels damage central vision. The therapy was injected into the eye to block these vessels. The main goal was to check s…

This study tested a tiny implant called the PRIMA Bionic Vision System in 5 people with advanced dry age-related macular degeneration who had lost central vision. The implant is placed under the retina and uses electrical stimulation to replace damaged light-sensing cells. The go…

This phase 3 trial tested a small, refillable implant placed in the eye that continuously releases the drug ranibizumab to control diabetic retinopathy. The study enrolled 174 people with moderate-to-severe non-proliferative diabetic retinopathy but without swelling in the center…

This study looked at 9 children under 5 who received the BONEBRIDGE BCI 602 hearing implant. The main goal was to check if the implant is safe within the first year after surgery. Researchers also measured how much the implant improved hearing and quality of life. The implant is …

This early-phase trial tested a gene therapy called ZM-01 in 2 boys aged 3 to 18 with X-linked retinoschisis, a rare genetic eye condition that causes vision loss. Each boy received an injection of the therapy into one eye. The main goal was to check safety, but researchers also …

This study looked at 742 people newly diagnosed with wet age-related macular degeneration (nAMD) who received 3 monthly injections of faricimab (Vabysmo) instead of the usual 4. The goal was to see how long the effect lasted before another injection was needed. Researchers tracke…

This study tested two types of cochlear implants in 30 adults with severe-to-profound hearing loss who had never used an implant before. The goal was to see if the devices are safe and help people understand speech better in quiet and noisy settings. Participants received the imp…

This study looked at whether giving exosomes through the nose could help improve vision in 32 children with cortical visual impairment (CVI), a vision problem caused by brain injury. The children received the treatment once a month for six months and were monitored for changes in…

This early-phase trial tested a combination of two drugs—fluvastatin (a cholesterol-lowering statin) and celecoxib (an arthritis drug)—in 20 children and young adults with certain brain tumors (gliomas) that had come back or not responded to treatment. The goal was to find the sa…

This early-phase trial tested an investigational eye injection called OLN324 in 164 adults with either wet age-related macular degeneration (AMD) or diabetic macular edema (DME). The main goal was to check safety and how the drug moves in the body, with a preliminary look at whet…

This Phase 3 trial tests a gene therapy called botaretigene sparoparvovec for X-linked retinitis pigmentosa, a genetic condition that causes progressive vision loss. The study involves 105 participants who receive the therapy via injection under the retina. The main goal is to se…

This study tested a gene therapy called JNJ-81201887 in 305 people with geographic atrophy, a late stage of dry age-related macular degeneration that causes blind spots. The treatment is injected into the eye and aims to slow the growth of damaged areas. Researchers measured chan…

This study tested whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the eye could slow the progression of advanced dry age-related macular degeneration (AMD). Fourteen people with advanced dry AMD received three PRP injections…

This study tested whether special ankle exercises could improve balance and walking in people who had a stroke at least a year ago. 140 participants were split into two groups: one did the ankle training plus standard gait training, the other did standard gait training alone. Aft…

This early-phase study tested a new drug called CUDC-907 in 26 children and young adults (ages 1-21) with cancers that had come back or stopped responding to treatment, including solid tumors, brain tumors, and lymphoma. The main goal was to find a safe dose and check for side ef…

This study tested an investigational drug called RAP-219 in 30 adults with refractory focal epilepsy—seizures that don't respond well to current treatments. Participants took RAP-219 tablets to see if it safely reduces seizure frequency. The trial is now complete, and results wil…

This study tested a new medicine called JL14002 against a standard treatment (ranibizumab) for wet age-related macular degeneration, a leading cause of vision loss. 443 adults aged 50-80 with active disease received injections into the eye. The main goal was to see if JL14002 imp…

This study tested a new medication, LUBT010, against the standard drug Lucentis for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. Six hundred participants received monthly injections into the eye for one year. The goal was to see if LUBT0…

This study followed 42 people who received a gene therapy for X-linked retinitis pigmentosa, an inherited eye disease that causes blindness. The goal was to check the treatment's safety over up to 5 years. Researchers also looked at whether patients' vision and ability to move ar…

This completed Phase 1/2a trial tested a gene therapy called RST-001 (AGN-151597) in 14 people with advanced retinitis pigmentosa, a genetic eye disease that causes severe vision loss. All participants had very poor vision (hand motion or worse) at the start. The study aimed to c…

This study looked at whether adding dexmedetomidine to standard morphine pain relief after cancer surgery helps elderly patients (65-90 years) live longer. 1,500 participants were randomly assigned to receive either morphine alone or morphine plus dexmedetomidine for three days a…

This study tested whether a traditional Chinese herbal pill called Liuwei Dihuang Pill can improve hearing in older adults with age-related hearing loss. 120 people aged 65-75 took either the pill or a placebo for 48 weeks. Researchers measured changes in speech recognition to se…

This early-stage trial tested a new drug called PMC-403 in 17 people with wet age-related macular degeneration (nAMD), a leading cause of vision loss. The drug is injected directly into the eye. The main goal was to check safety and find the best dose for future studies. The tria…

This study tested the drug levetiracetam as the first treatment for seizures in 18 full-term newborns who had brain injury from lack of oxygen at birth. The goal was to find the right dose and check if it is safe and effective at reducing seizure activity on brain recordings. The…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study tested whether an AI tool can help eye doctors diagnose four common retinal diseases (diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and glaucoma) more accurately and quickly. Ten doctors from five hospitals read fundus images both with…

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested a new MRI technique to detect endolymphatic hydrops (fluid buildup) in the inner ear of people with Meniere's disease. The new method uses a special 3D FLAIR sequence without contrast dye, compared to the standard method that requires an injection. The goal was …

This study tested whether a special type of MRI that measures sodium levels in the brain can help locate the exact area causing seizures in people with drug-resistant epilepsy. 78 patients who were already scheduled for epilepsy surgery received a sodium MRI scan. Researchers com…

This study looked for a measurable brain signal (biomarker) that could objectively diagnose chronic tinnitus. Researchers used EEG to record brain activity in 560 adults—some with constant tinnitus and some without. The goal is to replace trial-and-error diagnosis with a personal…

This study tested an artificial intelligence (AI) system called Retina4IRD that helps doctors diagnose inherited retinal diseases, which are rare eye conditions that can cause vision loss. The AI looks at eye images and patient information to suggest which gene might be causing t…

This study tested a new device called CochSyn that measures brain waves to detect hearing damage. Researchers compared results from 65 adults with and without hearing difficulties. The goal was to see if the device can accurately identify different types of hearing loss and be ea…

This study tested a low-cost, smartphone-connected device that checks middle ear health. Researchers compared it to standard equipment in 30 adults and children. The goal is to make ear screening affordable and easy for rural communities, reducing preventable hearing loss.

This study tested a new device called CRYSTALSIGHT that uses eye-tracking and artificial intelligence to monitor macular diseases like age-related macular degeneration and diabetic retinopathy. Twenty participants used the device at home to see if it could accurately track eye mo…

This study tested a new Swiss German speech test for children aged 4 to 6 with normal hearing. The goal was to find typical scores for how well kids hear single and double-syllable words, both in quiet and with background noise. The results will help doctors better assess hearing…

This study tested whether a special eye-tracking device (video-oculography) helps emergency room doctors more accurately diagnose the cause of vertigo or dizziness. About 130 adults with dizziness were randomly assigned to get either the eye-tracking test plus standard care, or s…

This study tested whether a nurse-assisted online eye screening app (Easee) is cost-effective for older adults receiving home healthcare. 234 participants aged 65+ used the app with a nurse's help to check their vision. The goal was to see if this approach reduces eye complaints …

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This study tested whether an oral drug called SPI-1005 could prevent temporary hearing changes caused by listening to loud music through headphones. 83 healthy adults took either the drug or a placebo for 4 days. The drug works by helping the body get rid of harmful chemicals pro…

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered the headset at different stages of care, from admission to after birth. Researchers will measure how many accept and use it,…

This study tested whether a custom-made acrylic palatal stent (like a mouth guard) can reduce pain and bleeding after gum graft surgery. 44 adults who needed a gum graft from the roof of their mouth either received the stent or standard care. The stent aims to protect the healing…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This completed phase 2 trial tested whether oxytocin, given as a nasal spray or through an IV, can reduce pain from heat in healthy adults. Twenty-four participants rated their pain on a 0-10 scale after skin heating. The study also looked at whether age, weight, or sex affect ho…

This study tests an experimental drug called SPI-1005 (ebselen) in adults with Meniere's disease, a condition that causes vertigo, tinnitus, and hearing loss. The trial compares three doses of SPI-1005 against a placebo to see if it safely reduces these symptoms. Researchers will…

This study tested three methods to reduce pain and fear in 166 children aged 5-9 during dental numbing injections: a device that cools and vibrates, gentle tapping near the injection site, and a thinner needle. Researchers measured pain scores, heart rate, and cooperation. The go…

This trial compares two types of nerve blocks—femoral nerve block and adductor canal block—for controlling pain after anterior cruciate ligament (ACL) reconstruction. Participants receive one of the two blocks before surgery, and researchers track their pain levels and painkiller…

This phase 3 trial tests whether intravenous arginine, an amino acid, can shorten painful episodes in children with sickle cell disease. Participants aged 3 to 21 receive either arginine or a placebo alongside standard pain treatment. The study measures how quickly the crisis res…

This completed study tested custom in-the-ear hearing aids in 24 adults with mild-to-moderately severe sensorineural hearing loss. Participants were experienced hearing aid users who tried the study device and compared it to their own hearing aids. The goal was to measure speech …

This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels…

This study tested whether Swedish massage with lavender or chamomile oils can help reduce pain, fear, and anxiety during labor. 90 pregnant women were split into three groups: one got massage with chamomile oil, one with lavender oil, and one with plain carrier oil. Researchers m…

This completed study tested a sound-based therapy for tinnitus (ringing in the ears) in 108 Veterans. Participants used hearing aids that played either notched noise (sound with the tinnitus frequency removed) or broadband white noise. The goal was to see if notched noise could r…

This study tested two ways to numb the shoulder during surgery: the standard interscalene block done by anesthesiologists, and a newer shoulder field block done by surgeons. 64 adults having shoulder surgery were randomly assigned to one method. The goal was to see if the field b…

This study tested a new approach that combines a minimally invasive spine-stabilizing procedure (kyphoplasty) with a single dose of targeted radiation given during surgery. The goal was to see if this combination could better control pain from cancer that has spread to the spine.…

This study tested whether a gas called MEOPA (laughing gas) can help elderly people manage pain during physiotherapy for stiff hips or knees. Six patients aged 65 or older received three sessions of physiotherapy with MEOPA or standard care. The goal was to see if the gas improve…

This study tested a daily, non-invasive brain stimulation technique (tRNS) in 30 adults with chronic tinnitus (ringing in the ears lasting over 6 months). The goal was to see if it could reduce the perceived loudness and annoyance of tinnitus. Participants received stimulation to…

This study tested whether watching an immersive virtual reality (VR) video during IUD insertion can lower pain and anxiety. 90 women took part, with half using VR and half receiving standard care. The goal was to see if VR offers a safe, simple, drug-free way to improve the exper…

This study tested two new features in the MED-EL SONNET 3 audio processor for cochlear implant users: the Focused Beamformer, which improves directional hearing, and the AI Mode Medium, which uses adaptive intelligence to optimize sound processing. Forty experienced cochlear impl…

This study tested whether a specific nerve block (SPSIP block) can reduce pain during and after surgery to implant a pacemaker or defibrillator. Sixty adults were randomly assigned to receive either the nerve block with numbing medicine or a sham injection. Researchers measured p…

This study tested two treatments for chronic tailbone pain (coccygodynia) in 100 adults. One group received osteopathic manual therapy—gentle hands-on techniques to mobilize the tailbone and relax muscles—over 6 weeks. The other group got a nerve block injection guided by X-ray. …

This study compared two types of nerve blocks (supra-inguinal fascia iliaca block and lumbar erector spinae plane block) for pain relief in 84 adults undergoing hip fracture surgery. The goal was to see which block works better for positioning the patient for spinal anesthesia an…

This study tests a 10-week visual rehabilitation program for children with autism spectrum disorder who also have vision problems. The program uses games and activities to improve how children use their eyes and process visual information. Researchers want to see if better vision…

This study compared two ways to control pain during laser treatment for diabetic retinopathy: a numbing injection around the eye versus standard numbing eye drops. Fifty adults with diabetes were split into two groups to receive either the injection or a sham injection with drops…

This completed trial tested a personalized sound therapy for adults with chronic tinnitus, a condition where people hear ringing or buzzing without an external source. 25 participants received either music embedded with tones matched to their tinnitus frequency or low-frequency s…

This study tested whether a nerve block (PECS II) or local anesthesia works better for pain after breast cancer surgery, without using opioids. 124 women undergoing breast surgery were randomly assigned to receive one of the two methods. Researchers measured pain, nausea, and opi…

This study tested a new medicine called HTX-034 to see if it can control pain after bunion surgery better than the standard local anesthetic. 78 adults having bunion surgery received either HTX-034 or the standard treatment. The goal was to measure pain levels and safety over the…

This study tested three non-drug treatments—cognitive behavioral therapy, a breathing exercise, and psychoeducation—to see which best reduces the distress caused by tinnitus (ringing in the ears). Seventy adults with tinnitus were randomly assigned to one of the three approaches.…

This study tested whether a non-opioid pain regimen, including a long-acting numbing shot (HTX-011) and standard pain relievers like ibuprofen and acetaminophen, could help people avoid opioids after hernia surgery. About 209 adults scheduled for open inguinal hernia repair took …

This study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which a…

This study tested whether a numbing injection into the abdominal wall muscles (called a TAP block) can reduce pain for people with acute appendicitis waiting for emergency surgery. 105 adults in the emergency department received the block, and researchers measured how much pain m…

This study tested a small, disposable device that gently stimulates nerves in the ear to see if it could reduce the amount of strong painkillers (opioids) needed after open abdominal or pelvic surgery. 286 adults who had surgery for cancer or a liver transplant took part. The goa…

This study compared two types of nerve blocks for pain control after breast surgery: the serratus posterior superior intercostal plane block and the PECS II block. One hundred adults aged 21 to 70 were enrolled. Researchers measured how much morphine patients needed in the first …

This study tested whether listening to music during a daily cleaning procedure can reduce pain in children aged 6 months to 15 years in a pediatric intensive care unit. Each child experienced the cleaning twice—once with music and once without—and pain was measured using a standa…

This study tested an oral soft capsule of nalbuphine, a painkiller, for people recovering from hemorrhoid surgery. 106 adults took either the drug or a placebo for up to 2 days. Researchers measured pain levels and how much extra pain relief was needed. The goal was to see if the…

This completed trial tested whether combining online acceptance and commitment therapy (ACT) with customized sound therapy helps people with tinnitus and insomnia. 164 adults were split into two groups: one received both therapies, the other only sound therapy. The goal was to se…

This study looked at two different speech therapies for children aged 6-8 who have cochlear implants. Twelve children received either perceptual training or phonetic placement therapy for 12 hours over 8 weeks. The goal was to see which therapy better improves speech clarity and …

This study tested whether giving the sedative dexmedetomidine during lung surgery (without a breathing tube) can reduce coughing and pain. 144 adults took part. Researchers measured cough severity and the need for other painkillers. The goal is to make recovery smoother and more …

This study tested a smartphone app that plays music with a special low-frequency beat (theta auditory beat stimulation) to see if it can reduce the stress and annoyance of tinnitus. 54 adults with chronic tinnitus used the app for 24 minutes a day for 4 weeks. The app's effect wa…

This pilot study tested whether adding virtual reality (VR) to a standard educational program helps people with chronic pain and central sensitization. 128 participants completed eight weekly sessions that combined pain education, mindfulness, and VR activities. The study measure…

This study tested a telephone helpline designed to support people with opioid dependence. The helpline offered education, coping strategies, and referrals to medication-assisted treatment. Researchers enrolled 31 participants and measured satisfaction with the service. The goal w…

This completed study tested whether an ultrasound-guided nerve block (TAP block) provides better pain relief after C-section than standard pain medicine. 100 women aged 20-50 who had a C-section took part. Researchers measured pain scores to see which method worked better.

This study tested three different balance exercise programs in 45 adults with dizziness from a chronic inner ear condition. One group did standard head and eye exercises, another watched 2D moving patterns, and a third used 3D virtual reality. All groups practiced for 6 weeks, an…

This study looked at 120 boys aged 4 months to 12 years having urogenital surgery. It compared an opioid-free caudal block (using bupivacaine) with an opioid-supplemented penile nerve block (using fentanyl) to see which provides better pain control and less post-surgery delirium.…

This study tested a speech therapy called ASSIST for children aged 4 to 9 with childhood apraxia of speech, a disorder that makes it hard to plan speech movements. Fifty-one children received 16 hours of individual therapy using repetition and cues. The goal was to see if the the…

This study tested if a local pain injection (liposomal bupivacaine) works as well as an epidural for pain relief after open gynecologic surgery. 106 adults participated. The goal was to see if the injection could provide similar pain control and recovery while being more cost-eff…

This study compared two types of nerve blocks (serratus posterior superior intercostal plane block and deep serratus anterior plane block) to see which provides better pain relief after breast surgery. Sixty-two adults having a mastectomy received one of the two blocks with bupiv…

This study tested whether a simple breathing technique called box breathing can help reduce anxiety, pain, and nausea in patients undergoing a procedure called ERCP. Seventy adults were randomly assigned to either learn the breathing technique or receive standard care. The techni…

This study tested whether a home-based balance therapy program is practical for children aged 4-17 with inner-ear problems that cause dizziness and balance issues. Twenty-one children did balance exercises at home for 8 weeks, with weekly check-ins from a physical therapist. The …

This study tested two different nerve blocks to manage pain after shoulder surgery. 60 adults were randomly assigned to receive either an interscalene block or an infraspinatus-teres minor block. The goal was to see which block reduces the need for strong painkillers and causes f…

This completed trial tested whether giving dexmedetomidine or lidocaine continuously during gallbladder surgery can control pain afterward and reduce the need for opioids. 64 adults undergoing laparoscopic cholecystectomy were randomly assigned to receive one of the two drugs. Th…

This study compared two ultrasound-guided nerve blocks—external oblique intercostal block and erector spinae plane block—for pain after laparoscopic gallbladder removal. Sixty adults received one of the blocks before surgery, and researchers measured their opioid use and pain sco…

This study looked at 82 adults who had hip surgery and received a nerve block (PENG block) for pain. One group got the pain medicine as a manual injection every 4 hours, while the other got it through a pump continuously. Researchers compared pain levels, opioid use, and recovery…

This study compared two types of nerve blocks—ISPB and ESPB—for pain relief after elective posterior cervical spine surgery. 102 adults received one of the blocks with bupivacaine, and researchers measured how much opioid painkiller they needed during and after surgery. The goal …

This study tested whether playing WiiFit games is more effective than standard balance exercises for people with dizziness and balance problems caused by inner ear issues. 42 adults aged 18-65 took part in a 4-week program. The goal was to see if the fun, interactive nature of Wi…

This study tested a special earmuff device that swaps sound from your left ear to your right ear and vice versa, called auditory mirror therapy. Researchers wanted to see if this sound-flipping trick could reduce the distress, loudness, and annoyance of chronic tinnitus. 56 adult…

This study tested two types of eye exercises—gaze stabilization and optokinetic training—in 32 adults aged 35-55 with chronic dizziness from inner ear problems. The goal was to see which better improves dizziness, balance, and confidence in daily activities. Results help guide th…

This study tested whether eye and neck exercises can reduce dizziness and uncontrolled eye movements in young adults with benign paroxysmal positional vertigo (BPPV). Fifty-six participants did either eye exercises alone or combined eye and neck exercises for six weeks. The goal …

This study looked at 60 women having planned cesarean deliveries to compare two pain relief methods: giving morphine through the spinal needle versus a numbing injection near the belly muscles. The main goal was to see how many women needed extra pain medicine in the first 24 hou…

This study tested two treatments for neck pain caused by muscle knots (myofascial pain syndrome). Forty adults received either high-intensity laser therapy or shockwave therapy, plus standard physical therapy, over 4 weeks. The goal was to see which treatment better reduces pain …

This study tested whether wearing virtual reality goggles showing relaxing nature scenes and music during IUD insertion could reduce pain and anxiety. 70 women were randomly assigned to either VR or standard care. Researchers measured pain, anxiety, comfort, and vital signs. The …

This study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potenti…

This study tested whether adding nalbuphine to the standard spinal anesthetic levobupivacaine helps control pain after total hip replacement. Sixty adults were split into two groups: one received levobupivacaine alone, the other received levobupivacaine plus nalbuphine. Researche…

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study tested whether an ultrasound-guided belly muscle nerve block (TAP block) can reduce pain and movement during a minimally invasive heart valve replacement (TAVI). Fifty adults having elective TAVI received either the block plus sedation or sedation alone. The goal was t…

This study tested a one-day educational workshop for people with chronic non-cancer pain who take high doses of opioids. The workshop, led by a team of doctors, psychologists, and pharmacists, provided information on opioid risks and taught coping strategies. Researchers wanted t…

This study tested whether a quick, inexpensive cooling spray can reduce pain during routine finger-prick blood sugar tests in emergency room patients. 80 adults each received both the spray and a placebo before separate tests, then rated their pain. The goal is to find a simple w…

This study tested whether a parent-child mandala painting activity during chemotherapy could reduce fear and pain in children with cancer and ease the burden on their caregivers. 108 children aged 5-12 and their parents took part, with half doing six 30-minute painting sessions o…

This study looked at 80 adults having elective lower back surgery to see which pain relief method works better: injecting local anesthetic near the surgical site or a nerve block called ESP. The goal was to improve recovery quality and reduce the need for strong painkillers in th…

This study looked at vision problems in people with Parkinson's disease compared to healthy individuals. Researchers tested eye and visual skills, then had some Parkinson's patients do simple eye exercises. The goal was to see if these exercises could slow vision decline or reduc…

This study tested two numbing methods for a common clubfoot procedure in infants: a needle-free jet injection that works in 1-2 minutes versus a topical cream that takes 30 minutes. Researchers measured pain using a standard scale, heart rate, and oxygen levels in 107 babies. The…

This study tested a specially designed video game to help children with amblyopia (lazy eye) follow their eye-patch therapy more consistently. 34 children participated, and the game aimed to make rehabilitation exercises more enjoyable and easier to stick with. The goal was to se…

This small proof-of-concept study tested a non-invasive device that uses sound and light to help people with hemianopia (blindness in half of the visual field). Five adults with stable hemianopia underwent training sessions where they were exposed to matching sound and visual cue…

This study looked at whether adding Epidiolex (a CBD-based medicine) to usual treatment can improve seizures, behavior, sleep, and quality of life in people aged 1 to 65 with tuberous sclerosis complex (TSC). 79 participants took the drug and were monitored for changes in symptom…

This study tested whether giving acetaminophen (Tylenol) through an IV works better than pills for pain after lumbar spine surgery. 166 adults having a specific type of back fusion surgery were randomly assigned to receive either IV or oral acetaminophen. The goal was to see if t…

This study tested whether a daily capsule combining etoricoxib and diacerein can reduce pain and improve function in adults with knee or hip osteoarthritis. Over 60 days, 123 participants took either the test combination or an active comparator (meloxicam plus diacerein). Researc…

This completed study tested two versions of a cooled radiofrequency procedure to relieve chronic knee pain from osteoarthritis. Ten adults with moderate to severe pain received either the standard or a revised nerve-targeting technique. Researchers measured pain, knee function, q…

This completed study tested a 7-week, peer-led program for adults with spinal cord injury and chronic pain. The program combined education about pain neuroscience with body-based tools like red light therapy, massage, and guided movement. Twelve participants attended group sessio…

This small study tested whether taking aspirin and ketamine together by mouth can help people with treatment-resistant depression. Fifteen adults who had not gotten better with standard antidepressants received the combination alongside their usual medication. Researchers measure…

This study tested whether injecting a long-lasting numbing medicine (bupivacaine) into surgical sites just before waking up from anesthesia could reduce pain and the need for strong painkillers after jaw surgery. 102 adults having jaw surgery took part. Researchers measured pain …

This study tested a device called Soricle that combines mild nerve stimulation with sound to help people with tinnitus, a condition where you hear ringing or noise in your ears. 36 adults with subjective tinnitus used the device daily for 8 weeks. The goal was to see if it reduce…

This study tested whether listening to personally chosen music can reduce pain and anxiety during dental drilling. Thirty adults picked a relaxing song and had their heart rate, blood pressure, and pain levels measured with and without music. The goal is to see if music can be a …

This study looked at whether adding breathing training to a standard exercise program can help adults with long-term back or neck pain. 183 people took part in a 12-week program. One group did only exercise, another added breathing exercises with biofeedback, and a third got gene…

This study tested a hearing aid feature called AutoFocus360, which automatically points microphones toward whoever is speaking. Thirty adults with mild to moderate hearing loss listened to audio clips and compared AutoFocus360 to standard settings. The goal was to see if it made …

This study tested a device that sends sound from the non-hearing ear to a cochlear implant in the other ear. 16 older adults with one cochlear implant used the device to see if it improved their speech understanding in noisy settings. The goal was to also see if it improved quali…

This study looked at using a heat-based technique called thermocoagulation in 100 children aged 1.5 to 17 years with focal epilepsy that doesn't respond to medication. During a brain monitoring procedure, doctors applied small heat lesions to the area where seizures start, aiming…

This study tested whether two combinations of migraine medications can reduce the impact of moderate-to-severe tinnitus. 78 adults were randomly assigned to receive either nortriptyline plus topiramate, verapamil plus paroxetine, or a placebo. The main goal was to see if these dr…

This study tested whether a single dose of S-ketamine, given during surgery, could lower the amount of morphine patients needed for pain in the first 24 hours after laparoscopic gynecologic surgery. 53 relatively healthy adults took part. The goal was to see if S-ketamine could i…

This completed clinical trial tested whether a dietary supplement called Tisina complex could improve cognitive health in people with mild cognitive impairment and tinnitus. About 84 adults aged 30 to 75 took either the supplement or a placebo for 90 days. Researchers measured ch…

This pilot study tested a portable TENS device for reducing menstrual pain in 34 women with primary dysmenorrhea. Participants used the device on their lower abdomen during pain episodes for up to three cycles. The goal was to see if this drug-free approach could ease pain and im…

This pilot study tested a device called NaviFUS that uses focused ultrasound to stimulate the brain in 12 adults with drug-resistant epilepsy. The goal was to see if it is safe and can reduce seizure frequency. Participants kept seizure diaries and reported any side effects over …

This study tested a device that sends a very mild electrical current to the brain (tDCS) to see if it can safely reduce seizures in people with epilepsy that doesn't respond to medication. 127 participants aged 9 and older received either real or fake (sham) stimulation for 10 se…

This study looked at whether adding a nerve block (called ESP block) to general anesthesia helps people undergoing lower back surgery. 50 adults were split into two groups: one got the nerve block plus anesthesia, the other got anesthesia alone. The goal was to see if the nerve b…

This study tested a metacognitive strategy training for 45 stroke survivors who have trouble paying attention to one side of their world (called neglect). The training aimed to improve their self-awareness and ability to do daily tasks. Results will show if this approach reduces …

This study tested whether listening to different types of music can reduce pain and anxiety from a cold water challenge in 40 healthy young adults. Participants immersed their hand in cold water while in silence or while listening to music with different emotional tones and rhyth…

This study tested whether using virtual reality goggles or squeezing a stress ball can help reduce pain during episiotomy repair (stitches after childbirth). 112 women were randomly assigned to use VR, a stress ball, both, or standard care. The goal was to see which method works …

This study tested two ways of giving epidurals to 102 pregnant women in labor: a standard method and a newer one called dural puncture epidural (DPE). The goal was to see which provides faster pain relief and better satisfaction. Results help doctors choose the best option for ma…

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This completed Phase 4 trial tested whether a turmeric extract (curcumin) can reduce pain after total laparoscopic hysterectomy. 126 participants took either liposomal curcumin or a placebo before and after surgery. The main goal was to measure pain levels 24 hours after the oper…

This study tested whether speech-language teletherapy can improve language outcomes in deaf or hard-of-hearing children aged 0-27 months. Researchers enrolled 210 children, some publicly insured and some privately insured, and gave some access to an 18-month teletherapy program. …

This study tested whether ketamine, a drug that blocks certain brain signals, can help people with tinnitus (ringing in the ears). 42 adults with chronic tinnitus received both ketamine and a placebo on different days. Researchers used brain scans to measure changes in brain chem…

This study compared two pain relief methods for people undergoing lower back decompression surgery. One group received a nerve block (erector spinae plane block), while the other received ketamine through an IV. Researchers measured how well patients recovered using a quality-of-…

This study tested if freezing the nerves between the ribs (cryoablation) could reduce hospital stay compared to standard epidural pain medicine in 50 young people aged 12-24 having Nuss surgery for pectus excavatum (sunken chest). The goal was to see which method controls pain be…

This study tested whether playing a xylophone during an IV insertion can help hospitalized children aged 3 to 6 feel less pain and fear. 64 children were randomly assigned to either play the toy with a nurse or receive standard care. Researchers measured pain, fear, and parent sa…

This study tested whether osteopathic manual therapy—gentle hands-on techniques for muscles and joints—can reduce the discomfort and loudness of tinnitus in people whose symptoms change with movement. Fifty-four adults with tinnitus for at least six months received either real os…

This study compared two types of pain blocks given before surgery to children aged 6 months to 12 years having lower belly or groin surgery. The blocks use numbing medicine to reduce pain after the operation. Researchers measured how much extra pain medicine the children needed a…

This early-stage study tested whether an experimental pill called PIPE-791 is safe and can lower pain in adults with long-term osteoarthritis knee pain or chronic low back pain. 43 participants stopped their usual pain meds, then took either the study drug or a placebo daily for …

This study looked at two different nerve blocks to control pain after thigh lift surgery. 42 adults received either a quadratus lumborum block or a lumbar plexus block. Researchers measured pain levels and how long it took for patients to need extra pain medicine.

This study tested whether a gel (LAT gel) applied to cuts can numb them as well as the standard numbing shots (lidocaine) before getting stitches. 70 adults with simple cuts in the emergency department took part. The goal was to see if the gel causes less pain during application …

This study tested whether wearing a virtual reality headset showing a nature video could reduce pain and anxiety in 90 adults undergoing coronary angiography, a heart procedure where patients are awake. One group watched the VR video during the procedure, while the other received…

This study tested whether adding ketoprofen to standard paracetamol (acetaminophen) can better control pain in patients receiving brachytherapy for cervical or upper airway/digestive tract cancers. Sixty-eight adults were randomly assigned to receive either paracetamol alone or p…

This study tested whether playing specific sounds can temporarily reduce the loudness of tinnitus (ringing in the ears). Forty-five adults with chronic tinnitus listened to personalized sound clips for 3 minutes and 20 minutes. Researchers measured how much the tinnitus quieted d…

This pilot study tested a non-invasive white noise device called TinniSoothe in 20 UK veterans with persistent tinnitus. Participants wore the device around their neck during the day and docked it at night for at least one month. The goal was to see if it reduces tinnitus symptom…

This study tested whether using a vibrating device, alone or with a cold gel pack, could reduce pain and anxiety when chest tubes are removed after coronary artery bypass surgery. 93 patients were split into three groups: vibration only, vibration plus cold, or standard care. Res…

This study looked at whether a cochlear implant in the poorer ear can help adults with hearing loss in one ear who already use a hearing aid in the better ear. Forty adults who had trouble with standard hearing aids received a cochlear implant. Researchers measured word understan…

This study tested an eye drop (POS) in 200 adults who had poor night vision after LASIK or similar eye surgery. The goal was to see if the drops could help them see better in dim light, reducing problems like glare and halos. Participants used the drops for 15 days and had their …

This study tested a structured program to help children and teens with autism, developmental delays, or intellectual disabilities cooperate during eye exams. Twenty participants attended six training sessions that used practice in a mock clinic, rewards like snacks or toys, and o…

This study looked at whether a cochlear implant in the deaf ear helps adults who have good hearing in one ear but severe hearing loss in the other. 59 adults received an implant and were tested on understanding speech in quiet and noise, locating sounds, and overall benefit. The …

This study tested a smartphone app called e-PainSupport for people receiving home hospice care. The app helps patients and their caregivers report pain levels to nurses and learn about pain management. Researchers wanted to see if using the app could reduce pain intensity. The st…

This study tested a personalized vision therapy program for 38 children aged 4-18 with amblyopia (lazy eye) that did not respond to standard treatments like patching. The therapy was tailored to each child's visual and cognitive skills, aiming to improve how the brain processes v…

This study tested two non-drug treatments for long-lasting low back pain: muscle energy techniques (gentle muscle stretches) and Pilates exercises. 72 adults aged 20-50 with pain lasting at least 2-3 months did 60-minute sessions four times a week for six weeks. The goal was to s…

This study tested whether using a stress ball during active labor can reduce pain and improve comfort. 78 pregnant women were split into two groups: one used a stress ball during contractions, the other received standard care. Researchers measured pain, comfort, and self-efficacy…

This study tested whether placing full-term newborns in a soft, supportive "nest" of pillows before, during, and after a heel prick blood test reduces their pain. 59 healthy newborns participated; 29 were nested and 30 received standard care. Pain was measured using the Neonatal …

This study compared two types of nerve blocks (serratus anterior plane block and serratus posterior superior intercostal plane block) for pain after video-assisted lung surgery. 60 adults aged 18-65 were enrolled. Researchers measured pain levels and patient satisfaction to see w…

This study tested whether a 15-minute talk with a clinical pharmacist helps people manage pain after getting a pacemaker. The pharmacist gave personalized advice on medications, side effects, and when to take pills. 60 adults who had pacemaker surgery took part. The study looked …

This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patien…

This study looked at 90 adults having knee replacement surgery to see which nerve block technique works better for pain control and getting patients moving sooner. One group got a fascia iliaca plane block, the other got a combination of adductor canal and IPACK blocks. Researche…

This study tested a new non-opioid pain medicine called HTX-011 in 116 people having knee replacement surgery. Everyone received the medicine as part of a pain plan that did not include opioids. The goal was to see how well it controlled pain after surgery. The study is complete,…

This study tested whether a simple home-based thigh exercise can reduce knee pain in older adults with osteoarthritis. Fifty people aged 60 to 85 did daily 10-second thigh squeezes for 28 days, and some also used topical gels like CBD or arnica. The goal was to see if this low-co…

This study tested a hearing care program for older adults with both hearing loss and dementia. Speech-language pathologists delivered the program at home. The goal was to see if better hearing could reduce troubling symptoms like agitation and improve quality of life. 77 people t…

This early study tested a new implant device for people with severe tinnitus (ringing in the ears). Nine adults received the implant to see if it was safe and could reduce their symptoms. The study measured side effects and used questionnaires to track changes in tinnitus severit…

This study tested a special stitching technique during C-sections to see if it reduces pain and helps women get out of bed sooner. 60 women having their first C-section took part. The new method aims to put less tension on the tissue, which may lead to less pain and faster recove…

This study looked at 120 adults having gallbladder surgery to see if the position they are in when getting a nerve block (called an ESP block) affects pain after surgery. Patients were placed on their side, stomach, or sitting up during the block. The goal was to find which posit…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

This study tested an experimental pain medication called HTX-011 in 430 adults recovering from bunion surgery. The goal was to see if it reduces pain better than standard treatments. Participants received the drug locally at the surgery site, and pain levels were tracked for 24 h…

This study looked at 51 women in labor who wanted an epidural for pain relief. Researchers compared two standard ways of numbing the skin (injecting lidocaine under the skin or into the skin) before inserting the epidural needle. The goal was to see which method caused less pain …

This study tested whether injecting the numbing drug bupivacaine into the vaginal cuff during vaginal hysterectomy reduces pain after surgery. Forty-eight women were randomly assigned to receive either the injection or standard care. Pain levels were measured over 24 hours using …

This study looked at whether adjusting hearing aids helps older adults (60+) communicate more easily and with less mental tiredness. Sixty people with hearing loss who had never used hearing aids took part. Researchers measured listening effort, fatigue, and sentence recognition …

This study compared two types of nerve blocks—serratus posterior superior intercostal plane block and thoracic paravertebral block—for pain relief after mastectomy. Sixty women received one of the blocks along with standard painkillers. Researchers measured pain scores and opioid…

This study looked at whether adding a nerve block near the breastbone to a standard chest wall block could reduce painkiller use after breast reduction surgery. 90 women were split into three groups: one got no nerve block, one got a standard block, and one got both blocks. Resea…

This study tested a medical device that automatically gives the pain drug remifentanil during surgery, based on heart rate, blood pressure, and a pain index. 52 adults having burn surgery took part. The goal was to see if the device could reduce the total amount of pain medicine …

This study compared two types of nerve blocks (TAP and ESPB) to standard pain medication (tramadol) for people with acute appendicitis in the emergency department. The goal was to see if these blocks could reduce pain before surgery and lower the need for opioids. The trial inclu…

This study tested whether adding health and wellness coaching through a mobile app could help people with hearing loss get more satisfaction from their hearing aids. Thirty-four participants used the app to work with a health coach and track their progress. The goal was to see if…

This study tested whether a dietary supplement could improve dry eye symptoms by changing the bacteria in the gut. Twenty adults with dry eye disease took the supplement for 8 weeks. Researchers measured tear production and eye surface health before and after treatment. The goal …

This completed study tested whether manual therapy (hands-on treatment) on the neck can reduce tinnitus in people whose ringing ears are linked to neck pain. 31 adults with somatic tinnitus received either manual therapy or neck exercises. The goal was to see if treating the neck…

This study looked at whether a treatment called transscleral lutein iontophoresis (TSLI) is safe and helpful for people with a specific type of age-related macular degeneration (AMD) that includes reticular pseudodrusen. Thirty participants received the treatment, and their visio…

This study tested whether a special nerve block called the erector spinae plane (ESP) block can improve pain control after flexible ureteroscopy, a common surgery for kidney stones. 70 adults were randomly assigned to receive either the ESP block plus standard pain care or standa…

This study tested whether adding pain neuroscience education (PNE) to standard physiotherapy helps people with myofascial pain syndrome, a condition causing muscle knots and pain. Forty adults aged 18-50 were split into two groups: one got only physiotherapy, the other also recei…

This study looked at two types of nerve blocks (TFP and QLB) to see which one works better for pain after lower belly surgery in children aged 3 to 7. The goal was to reduce pain and the need for extra pain medicine. 66 children took part, and researchers measured their pain scor…

This study tested whether a smartphone app helps people with dizziness do their prescribed balance exercises more consistently. Thirty adults with various vestibular disorders were randomly assigned to use the app or keep a paper diary. The researchers measured how often particip…

This study tested whether adding alcohol to a standard numbing and steroid injection could provide better pain relief for people with sacroiliac joint pain. Fifty-four adults with chronic low back pain from the sacroiliac joint received an ultrasound-guided injection, with or wit…

This study tested whether injections of incobotulinum toxin A (similar to Botox) into muscles around the ear can relieve tinnitus, a persistent ringing in the ears. Forty-one adults with tinnitus for at least two months received either the drug or a placebo injection. The main go…

This study looked at whether teaching elite volleyball players about the science of pain could help them manage chronic shoulder pain. Forty players took part, with some receiving six weeks of pain education in addition to their regular training. The results showed that those who…

This study looked at whether a computer algorithm could improve how a cochlear implant is set for people who have one implant and a hearing aid in the other ear. Nine adults with severe hearing loss took part. The goal was to see if the new settings helped them hear better in qui…

This study tested whether combining mild electrical brain stimulation (tRNS) with white noise can temporarily reduce tinnitus symptoms. 35 adults with chronic tinnitus received either the combined treatment or brain stimulation alone. Researchers measured changes in tinnitus loud…

This study tested an herbal compound in 108 adults who had trouble sleeping and tinnitus (ringing in the ears) but did not want to take sleeping pills. Participants took either a low dose, high dose, or placebo daily for 3 months. Researchers measured changes in sleep quality and…

This study tested a new bimodal Bluetooth streaming feature for people who use a MED-EL cochlear implant in one ear and a Starkey hearing aid in the other. Ten participants tried the feature for one week and then completed a survey about their listening experience. The goal was t…

This study tested whether adding ketamine or magnesium sulfate to a standard numbing medicine (levobupivacaine) can improve pain control after breast cancer surgery. Sixty adults undergoing mastectomy received one of the two add-ons via a nerve block. The main goal was to see if …

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This study tested whether wearing eye masks and earplugs at night for three nights could help prevent confusion (delirium) and reduce pain in children aged 6-12 in the pediatric intensive care unit (PICU). 74 children were randomly assigned to either wear the sleep aids or receiv…

This study looked at whether a specific nerve block (recto-intercostal fascial plane block) can reduce pain after epigastric hernia repair. Forty adults having elective surgery received either the block or standard care. The goal was to see if the block delayed the need for extra…

This study looked at whether working with a care manager (patient navigator) and using an online pain coping program can help people with chronic pain improve how they manage their pain and daily activities. The study included 32 adults who had daily pain for at least 3 months an…

This study tested whether people with tinnitus can tell if they are receiving real or fake ultrasound stimulation of the vagus nerve in the ear. Twenty adults with constant tinnitus for at least six months took part. The goal was to see how well the blinding worked and what side …

This study tested whether letting women listen to their own chosen music during embryo transfer could lower anxiety and pain. 42 IVF patients were randomly assigned to either listen to music through noise-canceling headphones or receive standard care. Researchers measured anxiety…

This study tested whether wearing prism goggles during pointing exercises can reduce pain in people with Complex Regional Pain Syndrome (CRPS) type I. Fifty-four patients with CRPS after a wrist fracture or surgery were split into two groups: one used real prism goggles, the othe…

This study tested whether adding a single dose of the muscle relaxant tizanidine to a nerve block (ESP block) improves pain control after mastectomy. 90 patients were randomly assigned to receive either the nerve block alone or the nerve block plus tizanidine before surgery. The …

This study tested a new way to adjust cochlear implants for people who are deaf in one ear but have some hearing in the other. Researchers used an evolutionary algorithm to customize the frequency settings of the implant. The goal was to help participants understand speech better…

This study tested whether a nerve block called an erector spinae plane (ESP) block can reduce pain and the need for strong painkillers after a kidney transplant. Forty adults having a kidney transplant were randomly assigned to receive either the ESP block or no block. All patien…

This study tested whether putting lignocaine (a numbing medicine) inside the abdomen during gynecologic open surgery can reduce pain afterward. 112 women having surgery like hysterectomy or cystectomy took part. The goal was to see if this approach lowers pain scores and the need…

This study tested a new, less invasive surgical method for placing a bone-anchored hearing device (Ponto implant) in 52 adults with hearing loss. The goal was to see if the implant stayed securely in place without causing skin problems or pain. The approach aims to make the proce…

This study compared two types of nerve blocks given before hip fracture surgery to see which provides better pain relief afterward. 77 older adults received either a sacral erector spinae plane block or a supra-inguinal fascia iliaca block. Researchers measured pain scores, opioi…

This study tested two different pain-relief mixtures given as a nerve block before hip surgery. One group received nalbuphine plus bupivacaine, the other dexamethasone plus bupivacaine. The goal was to see which combination provided longer pain relief and reduced the need for ext…

This study tested two types of nerve blocks to manage pain after cancer surgery on the upper belly. 70 adults received either an erector spinae plane block or an external oblique intercostal plane block with the same numbing medicine. Researchers measured how much extra morphine …

This study tested two different ultrasound-guided nerve blocks to see which provides better pain relief after breast removal surgery. Eighty-eight women received either a PECS II or MTP block before surgery, and their pain levels were tracked for 24 hours. The goal was to find a …

This study tested two methods of delivering a pain-blocking injection (TAP block) after laparoscopic upper abdominal surgery: one guided by ultrasound and the other by the surgical camera. Sixty adults aged 18-70 took part, and researchers measured their pain levels and need for …

This study tested whether applying scents (like lavender) during heel blood collection can reduce crying, pain, and stress in newborns. 120 healthy full-term babies were randomly assigned to receive a scent or not. Researchers measured crying time, heart rate, and a standard pain…

This study looked at 90 adults having shoulder surgery to compare two types of nerve blocks for pain relief. One block targets the shoulder area directly, while the other targets a nearby muscle. The goal was to see which method provides better pain control and reduces the need f…

This study tested two drug-free methods—deep breathing and virtual reality—to see which better reduces pain and anxiety during blood draws. 264 adults were randomly assigned to one of the two techniques or standard care. The goal is to find a simple, effective option for patients…

This study tested whether Kinesio Tape, a stretchy tape applied to the skin, can reduce pain, swelling, and jaw stiffness after removing impacted lower wisdom teeth. Thirty adults were divided into three groups: one received a dexamethasone injection, one got Kinesio Tape, and on…

This study tested a new sound processor, the Osia 3, against the current Osia 2 model in 12 adults with hearing implants. Participants completed hearing tests and rated sound quality with both devices. The goal was to see if the new processor improves speech understanding in nois…

This study tested whether using virtual reality (VR) during the removal of a tube from the groin after a heart procedure could reduce pain and anxiety. One hundred adults were randomly assigned to either wear VR goggles showing calming scenes or receive standard care. Researchers…

This pilot study tested whether prolonged exposure teletherapy can help adults with psychogenic nonepileptic seizures (PNES) and PTSD. Forty-four participants received either the teletherapy or standard education about PNES. The goal was to see if the therapy reduces seizure freq…

This study tested three different pain-blocking methods in 75 children aged 2 to 7 having hernia surgery. The goal was to see which method works best to keep kids comfortable after the operation. Researchers measured pain levels, how much extra pain medicine was needed, and any s…

This study compared two methods of pain relief after cesarean section: injecting numbing medicine into the belly and surgical wound versus giving morphine through a spinal injection. The goal was to see which approach reduces the need for extra painkillers in the first 24 hours. …

This study tested whether mirror therapy—a technique using visual feedback from a mirror to trick the brain—works better than routine physical therapy for people with Complex Regional Pain Syndrome (CRPS), a chronic pain condition often after injury. Fifty-two adults aged 40-65 w…

This study tested a nerve block called the high-thoracic erector spinae plane block to see if it could reduce pain and improve diaphragm function after posterior cervical spine surgery. 50 adults undergoing this surgery received either the block or standard care. The goal was to …

This study tested whether applying ice packs over surgical incisions every 4 hours for up to 72 hours can improve patients' recovery after chest, abdomen, or groin surgery. 196 adults were randomly assigned to receive cryotherapy plus standard care or standard care alone. The mai…

This study looked at whether showing cartoons or playing music during tooth extractions can lower pain and anxiety in children aged 6 to 12. Sixty kids were randomly assigned to watch cartoons, listen to music, or receive standard care. Researchers measured heart rate, oxygen lev…

This study compared two types of nerve blocks — the erector spinae plane block and the retrolaminar block — for controlling pain after major breast cancer surgery. Ninety women between 18 and 60 years old took part. Researchers measured pain scores and how much opioid painkiller …

This study looked at whether chewing gum (with or without sugar) can help children aged 7 to 12 feel less pain and fear during a blood draw. A total of 144 kids were randomly assigned to chew sugared gum, sugar-free gum, or no gum at all. Researchers measured pain, fear, and cryi…

This study looked at whether adding dexmedetomidine to standard morphine pain relief after cancer surgery could lower the chance of delirium (sudden confusion) in patients aged 65 and older. A total of 1500 participants were randomly assigned to receive either morphine alone or m…

This study tested whether a new sound processor (Osia 3) helps adults with hearing loss or single-sided deafness hear better than the current model (Osia 2). Twenty-nine adults who already have a bone-anchored implant tried both processors. Researchers measured speech understandi…

This study tested whether a TENS device, which uses mild electrical pulses, can reduce pain during a prostate biopsy. 84 men were randomly assigned to receive TENS plus local anesthetic, a sham TENS device plus local anesthetic, or local anesthetic alone. Participants reported th…

This study tested whether wearing virtual reality glasses during IUD insertion can lower pain and anxiety. 70 women were randomly assigned to either use the VR headset or receive standard care. Pain and anxiety were measured right after the procedure. The goal is to find a simple…

This study looked at whether acupuncture can help manage pain for people visiting the emergency department with common painful conditions like back pain or abdominal pain. About 290 adults were split into two groups: one received acupuncture, the other got usual care. The goal wa…

This study tested whether a smartphone app could provide the same relief for chronic tinnitus as face-to-face counseling. 42 adults with constant ringing in their ears received either app-based or in-person counseling over six weeks. The goal was to see if the app could reduce th…

This study tested whether a nerve block called the external oblique intercostal plane block could reduce the amount of opioid painkiller needed during laparoscopic gallbladder removal. 80 adults having elective surgery received the block before the procedure. Researchers measured…

This study compared water-based rehabilitation to standard land-based exercises for people who had ACL knee surgery. Twenty participants completed six sessions over 2-3 weeks. Researchers measured walking patterns, muscle function, and knee symptoms to see if the water program of…

This study tested a single injection of a long-acting painkiller called SDE in 221 adults recovering from hemorrhoid surgery. Half received the drug and half a placebo. Researchers measured pain levels and how much extra pain medicine was needed over 48 hours. The goal was to see…

This study tested whether breathing exercises and using a stress ball during dressing changes can reduce pain, anxiety, and improve comfort in burn patients. 210 adults with burns on 15% or less of their body took part. Researchers measured pain, anxiety, comfort, and vital signs…

This study tested two different nerve blocks to see which one works better for pain after shoulder surgery. Sixty adults having arthroscopic shoulder surgery received either an interscalene block or a serratus posterior superior intercostal plane block. The main goal was to see h…

This study tested whether a special laser (940-nm diode) applied right after gum graft surgery can reduce pain and help the wound heal faster. 36 healthy adults received either the laser plus a protective mouth stent or just the stent alone. Researchers measured pain, painkiller …

This study tested whether a new behind-the-ear audio processor (SONNET 3) is more satisfying for people who already use a cochlear implant. Twenty experienced users tried the new design and reported their satisfaction. The goal was to see if small design changes improve daily com…

This study tested two non-drug methods to reduce pain, fear, and anxiety in children aged 4 to 6 getting intramuscular injections in a pediatric emergency department. One method used a flat, bumpy plastic device called ShotBlocker pressed against the skin before the shot. The oth…

This study tested a daily dietary supplement called ACEMg (Soundbites) in 64 adults with hearing loss or tinnitus. Participants took the supplement for 24 weeks and completed hearing tests and symptom surveys at home using a smartphone app. The goal was to see if the supplement c…

This study compared two types of pain-relief injections (posterior quadratus lumborum block and transversalis fascia plane block) in 54 children aged 1 to 7 years undergoing orchiopexy. Researchers measured how long it took for children to need their first painkiller after surger…

This study tested whether elastic therapeutic taping can reduce pain after open-heart surgery (CABG). 195 patients were randomly assigned to receive real tape, placebo tape, or another supportive treatment near the surgical site. Neither patients nor researchers knew who got whic…

This study looked at two methods to control pain after breast-conserving surgery: an ultrasound-guided nerve block (ESPB) and local wound infiltration (LWI). 66 adult women took part, and researchers measured how much morphine they needed in the first 24 hours after surgery. The …

This study tested whether an ultrasound-guided nerve block (ESP block) given before spinal surgery for scoliosis can lower pain and the need for strong painkillers after the operation. Eleven teenagers took part, with half receiving the block plus general anesthesia and half rece…

This study tested whether a non-invasive brain stimulation technique called rTMS, guided by MRI scans, could reduce severe hallucinations in people with schizophrenia who don't respond to medication. 85 participants received either MRI-guided or standard rTMS over 5 days. The goa…

This study tested whether a combination of a specific jaw muscle technique and neck exercises could reduce pain and improve jaw function in people with temporomandibular disorder (TMD) and teeth grinding (bruxism). Sixty adults with TMD and bruxism were split into two groups: one…

This study tested whether medical hypnosis can reduce anxiety and pain in patients undergoing electroneuromyography (ENMG), a nerve test that can be uncomfortable. Six anxious adults were enrolled and received either hypnosis or standard care. Researchers measured pain and anxiet…

This study tested a new type of nerve block called the PENG block in 60 adults having hip surgery. The goal was to see if it reduces pain and the need for opioid painkillers after the operation. The block targets nerves around the hip joint while avoiding leg muscle weakness.

This study tested whether repetitive transcranial magnetic stimulation (rTMS) can help people with chronic, severe tinnitus (ringing in the ears). Sixty-four adults received either real or fake rTMS at different intensities. The goal was to see if the treatment reduces tinnitus l…

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This study tests an open-source speech-processing platform, called the Master Hearing Aid, as a wearable hearing aid for people with sensorineural hearing loss. Participants will wear the device in real-world settings and adjust it to their liking, then complete speech perception…

This study surveys intensive care unit (ICU) doctors and nurses across Europe and Israel about their understanding of palliative care and local laws regarding end-of-life decisions. The goal is to measure how aware clinicians are of palliative care practices and the legal framewo…

This study followed 20 adults aged 55 and older with geographic atrophy, an advanced form of age-related macular degeneration that causes central vision loss. Researchers measured how the damaged area in the eye changed over nearly 4 years using eye exams and photos. The goal was…

This study looked at whether a simple test measuring how fast eyes recover in the dark can help track early to middle dry age-related macular degeneration (AMD). Researchers followed 217 adults aged 50 and older, with or without AMD, for up to 5 years. The goal was to see if chan…

This study looks at what people with age-related macular degeneration (AMD) know about their disease and what they need to manage it better. Researchers will survey and interview 118 patients to understand their knowledge, daily challenges, and support needs. The goal is to use t…

This study aims to find the genetic causes of hereditary hearing loss and balance disorders. Researchers will study families with these conditions, collecting medical history, blood or cheek swabs, hearing and balance tests, and sometimes scans. The goal is to identify genes and …

This study tested whether a sing-along song can help visually impaired individuals aged 6 to 20 learn to brush their teeth better. Forty participants in Nepal were split into two groups: one received standard audio-tactile instruction, and the other heard a song with the same ins…

This study tested whether a computer model could find the best combination of active electrodes in a cochlear implant to improve speech understanding. Fourteen adults with cochlear implants tried different settings, including ones recommended by the model, and their speech recogn…

This study aimed to understand why people with cochlear implants vary in how well they understand speech. Researchers measured electrical interactions between the implant's electrodes in 17 adults with hearing loss. They compared these measurements to each person's ability to rec…

This study compared two different eye imaging machines (Clarus and Optos) to see how well they measure geographic atrophy, a form of vision loss from age-related macular degeneration. Researchers enrolled 62 patients and took images with each device, then compared the measurement…

This study looked at how cannabidiol (CBD) interacts with tacrolimus, a drug used to prevent organ rejection in transplant patients. Researchers wanted to understand how to adjust doses for better health outcomes. The study involved 57 healthy adults and those with chronic kidney…

This study followed 57 people with age-related macular degeneration (AMD) for up to 5 years to see how their eyes adjust to darkness. Participants had yearly eye exams and dark adaptation tests, where they sat in a dark room and pressed a button when they saw a light. The goal wa…

This study looked at whether a tool called the Surgical Pleth Index (SPI), which measures stress during surgery, can predict how much pain a person will feel after waking up from a brain operation. 52 adults having craniotomy were monitored, and their pain scores and painkiller u…

This study looks back at 20 years of medical records from 25 people who had a freezing treatment (cryotherapy) for retinal hemangioblastoma, a rare eye tumor often linked to von Hippel-Lindau disease. Researchers want to see how well the treatment controlled the tumors and affect…

This study tested whether virtual reality (VR) training could help deaf and hard-of-hearing students learn vocational skills better than traditional methods. 48 students aged 17-20 with profound hearing loss participated in a 6-week program using 360-degree VR simulations of hote…

This study is testing a new wearable device that uses focused ultrasound to stimulate nerves in the arms and legs. Researchers want to see if it's comfortable and easy to use in 15 healthy adults aged 20-40. Participants will complete nine sessions involving cold water and pressu…

This study tested whether doctors could safely and correctly use a new prefilled syringe (SCD411) for eye injections. It included 33 adults with wet age-related macular degeneration, retinal vein occlusion, diabetic macular edema, or diabetic retinopathy. The main goal was to see…

This completed study tested an oral form of the painkiller nalbuphine, called PHN131, in 16 healthy adults. The goal was to see how the body absorbs and processes the pill compared to the injected version. Researchers also monitored safety by checking vital signs like blood press…

This study looked at how patients view the routine pain checks they receive after planned surgery. Researchers surveyed and interviewed 312 adults to understand whether these checks feel supportive or stressful, and how that affects trust in nurses and willingness to report pain.…

This study tested how well adults with hearing loss understand speech in noisy settings using hearing aids alone versus hearing aids paired with a remote microphone. Nineteen experienced hearing aid users participated. The goal was to compare different remote microphone systems t…

This study looked at how ketorolac, a non-steroidal anti-inflammatory drug (NSAID) used for pain after cesarean delivery, affects platelet function and blood clotting. Researchers measured clotting in 40 women undergoing scheduled C-sections using special blood tests. The goal wa…

This study looked at how low doses of LSD change the way healthy adults make decisions based on what they see. Thirty participants completed computer tasks that tested their ability to predict and respond to visual patterns. The goal was to understand how LSD influences brain sig…

This small study tested whether adding exercise (stationary biking) to standard sensory training could improve sensation and reduce pain after nerve injuries in the arm or hand. Seven adults who had a nerve injury between 2010 and 2025 took part. The goal was to see if this appro…

This study looked at 40 healthy women ages 18-35 to see if different phases of the menstrual cycle affect walking patterns, pelvic movement, and sleep quality. Participants were tested during early follicular, ovulation, and luteal phases using a special walkway sensor and a slee…

This study looked at how different shoe heel heights affect walking patterns in 30 healthy adults aged 18-35. Participants walked barefoot, with 2 cm heels, and with 6 cm heels while sensors measured their gait and pelvic movements. The goal was to understand biomechanical change…

This study looked at 183 parents of children with hearing impairments to understand how their psychological resilience relates to their disaster preparedness. Parents completed surveys measuring their resilience and how ready they feel for disasters. The goal is to find ways to b…

This pilot study looked at how weight loss affects bone density in overweight or obese men. 44 men either followed a reduced-calorie diet to lose weight or maintained their weight for 6 months. Researchers measured changes in bone density and quality to see if weight loss has any…

This study followed 516 older adults in France for 8 years to see how many develop age-related macular degeneration (AMD), a leading cause of blindness. Researchers used eye exams and imaging to track the disease and look for risk factors like genetics and lifestyle. The goal is …

This study looked at how nerve cells in the eye are lost in people with multiple sclerosis (MS) even when there is no active inflammation. Researchers followed 64 adults with relapsing-remitting MS who were already part of a larger study. By using special eye scans over time, the…

This study tested two different methods for programming cochlear implants in 17 adults with hearing loss. The goal was to see if a new, faster fitting method works as well as the standard one for understanding speech in quiet and noisy settings. Results will help improve how impl…

This study examined how vision loss progresses in people with geographic atrophy, an advanced form of dry age-related macular degeneration. Researchers analyzed past medical records and eye images from 60 patients to see which retinal changes are linked to faster vision decline. …

Infantile spasms are a type of seizure that can harm development if not treated quickly, but they are often mistaken for normal movements. This study tested a computer program that learns from parent-recorded videos to tell the difference between these seizures and harmless movem…

This completed study collected eye images from 1,000 people with intermediate age-related macular degeneration (AMD) to create a detailed database. Researchers will analyze these images to find signs that predict whether the disease will worsen to advanced stages. The goal is to …

This study looked at whether the muscle relaxant tizanidine affects the acoustic reflex, which is your ear's natural way of protecting itself from loud sounds. 48 adults who were already taking tizanidine had their hearing and reflex tested before and after one week of treatment.…

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This completed study used PET scans to examine brain changes in 20 people with asymmetric hearing loss who received a cochlear implant. Participants performed hearing and voice perception tests while their brain activity was measured. The goal was to understand how the central au…

This study looked at how to improve care for dizzy patients in the emergency department. Over 90,000 adults participated. The goal was to help doctors use proven tests and treatments for common causes of dizziness like BPPV. The study tested new training and tools to make sure pa…

This completed study looked at whether healthcare professionals in Saudi Arabia received and understood safety materials about the epilepsy drug Depakine (sodium valproate). Researchers surveyed 455 doctors, pharmacists, and gynecologists to measure their knowledge and behavior. …

This study looked at how deaf children ages 18 to 60 months learn new words in American Sign Language (ASL). Researchers used eye-tracking and behavior tests to see if kids assume each object has only one sign (mutual exclusivity) or if bilingual deaf children expect two words—on…

This study looked at whether cochlear implants, which help restore hearing, can also improve thinking and memory in adults aged 65 and older with hearing loss. Researchers gave 37 participants a series of cognitive tests before surgery and again at 6 months, 12 months, and 5 year…

This completed study tested three different intensities of gentle neck movements designed to stimulate the vagus nerve in 128 healthy adults. Researchers measured changes in heart rate, balance, pain sensitivity, and digestion (via stool samples). The goal was to find the best 'd…

This early-phase study looked at how a single dose of cannabidiol (CBD) affects brain inflammation and pain sensitivity in 28 healthy adults. Researchers used brain scans to measure inflammation and a skin cream test to check pain response. The goal was to understand CBD's potent…

This study looked at how a low dose of the sedative drug dexmedetomidine affects pain signals in the brain. Researchers used brain scans to measure changes in fluid flow. 17 healthy adults took part. The goal was to understand the drug's pain-relieving effects, not to test a new …

This study looked back at medical records of 55 people who received a specific type of cochlear implant and also use an acoustic earhook. Researchers measured how well they understood words and sentences in quiet settings over the long term. The goal was to confirm how well the s…

This study tested a simple way for adult survivors of childhood cancer to get their hearing checked. Instead of going to a hospital, participants took a hearing test at a local hearing aid shop. The goal was to see if this approach could help more survivors find out if they have …

This study looked at whether a genetic marker called COMT can predict how well a person responds to hypnosis for pain after surgery. Researchers tested a new, faster method to read this gene from saliva or blood samples. The goal is to one day use a simple genetic test to persona…

This study looked at how blood pressure and heart rate change in the hour after an epileptic seizure. Researchers measured these vital signs at several time points in 1,100 people with epilepsy. The goal was to better understand the body's response right after a seizure, which ma…

This study looked at how much of a burden patients feel from repeated anti-VEGF eye injections for three different eye diseases: wet age-related macular degeneration, retinal vein occlusion, and diabetic macular edema. Researchers surveyed 393 patients about their treatment burde…

This study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…

This study tested a program designed to improve psychological hardiness (like resilience and commitment) in hard-of-hearing female students in Saudi Arabia. 25 students took part, with some receiving the program and others continuing their usual activities. The goal was to see if…

This study tested a new portable, wireless EEG monitor called NeuroBell on 17 full-term newborns who already needed brain monitoring. The goal was to see if the new device records brain signals as well as standard EEG machines. The study did not treat any condition, but aimed to …

This study followed 294 knee replacement patients to see how often they experienced sudden, severe pain after their nerve block wore off. Researchers tracked pain levels, sleep quality, and patient satisfaction. The goal was to better understand this 'rebound pain' and improve pa…

This study tested whether community health navigators who use American Sign Language (ASL) via videoconferencing could help deaf, deafblind, and hard-of-hearing adults complete recommended cancer screenings. The 184 participants were aged 45-80 and had early hearing loss. The nav…

This study tested a new way to program cochlear implants in 47 children aged 4 to 12. Instead of the standard method, doctors used CT scans to see exactly where the implant's electrodes sit inside the ear, then turned off any poorly placed ones. The goal was to see if this person…

This study looked at 52 adults with dizziness and balance problems from a one-sided inner ear disorder. Researchers measured how well people functioned before and after a standard balance therapy program. The goal was to see if things like dizziness severity or personal factors c…

This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat (ENT) procedures. Researchers compared those who received opioid pain medication to those who received non-opioid alternatives. 160 adults participated, and the main go…

This study tested a medicine called cenobamate in 26 children with partial-onset seizures. The goal was to see how the drug moves through the body and if it is safe. The study did not aim to cure or control seizures long-term, but to gather important information for future use.

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

This study tested whether an audio-based educational program about puberty could improve self-concept and healthy behaviors in visually impaired teenage girls. Forty-six girls aged 12-18 from two schools in Egypt took part. The program used simple Arabic audio sessions and Braill…

This study collected walking data from 110 healthy children aged 3 to 15 to create a reference database for a new gait index called Ker-EGI Kids. Researchers placed 28 stickers on each child's legs to record muscle activity while they walked. The goal is to establish what normal …

This study looked at proteins in the eye fluid of 100 people with wet age-related macular degeneration (AMD). The goal was to measure certain growth factors that might explain why about 37% of patients do not respond well to standard anti-VEGF injections. Researchers collected a …

This study looked at whether functional MRI (fMRI) can help doctors diagnose Auditory Processing Disorder (APD) in children aged 7 to 18. APD makes it hard for kids to understand sounds even though their ears work normally. Researchers compared brain scans of children with APD, c…

This completed pilot study looked at 46 older adults with Alzheimer's disease to see if age-related hearing loss is linked to trouble finding words. Participants took a computer test to measure word-finding ability and answered a hearing questionnaire. The goal was to better unde…

This study tested whether using an indoor air purifier changes health measures like heart rate, sleep, and oxygen levels. 42 healthy adults wore Apple Watches while using a real or fake (sham) air purifier at home. The goal was to see if cleaner air makes a short-term difference …

This study looked at whether using feedback and spacing out practice sessions can help children aged 5 to 9 who are deaf or hard of hearing learn new words more efficiently. Thirteen children took part in word-learning exercises to see which methods worked best. The goal was to f…

This completed study enrolled 186 people with mild to moderate hearing loss to understand how damage to inner ear sensory cells and auditory neurons affects speech understanding, especially in noisy environments. Participants were fitted with hearing aids and tested on speech rec…

This study tested a new type of camera that can see individual cells in the retina, which standard clinical cameras cannot do. Five people with retinal disease (inherited degeneration or toxicity) had their eyes scanned with the device. The goal was to compare image quality and o…

This study tested French versions of three hearing and quality-of-life questionnaires (PEACH, SSQ-C, SSQ-P) in 101 children and teens aged 1 to 17. The goal was to see if these tools are reliable and accurate for measuring hearing performance and quality of life in French-speakin…

This study looked at why children with hereditary epidermolysis bullosa (a rare condition causing fragile skin and painful blisters) often do not take prescribed opioid painkillers before baths and bandage changes. Researchers interviewed 10 children and their parents to understa…

This study looked at 98 adults with severe-to-profound hearing loss to see if they also have balance problems. Since the inner ear controls both hearing and balance, researchers used special tests to measure how well the balance system works. The goal was to understand if hearing…

This study tested whether using real-ear measurements (REM) to fit hearing aids leads to better outcomes than using the manufacturer's default settings. 101 first-time hearing aid users participated. Researchers measured hearing ability, satisfaction, and cost-effectiveness to se…

This study looked at 77 people with Alzheimer's or frontotemporal dementia to understand why some lose awareness of their condition (anosognosia). Researchers used EEG and brain scans to measure how the brain responds to mistakes and emotional signals. The goal is to find brain m…

This study looked at how well people can sense and copy the speed of their knee movement, with and without vision. Sixty healthy adults tried to match two different speeds (slow and fast) while either keeping their eyes open or closed. The goal was to understand how vision contri…

This study measured the thickness of the conjunctiva and Tenon's capsule (outer eye layers) in 736 people with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME), and in healthy volunteers of similar age. Researchers used a special eye scanner (SD…

This completed study with 120 adults undergoing brain surgery tested whether brain wave patterns and vital signs like blood pressure can show pain from skull pin fixation. Researchers compared three pain management methods: a scalp nerve block, IV opioids, and a local anesthetic …

This study tested a mobile app called OASES that guides nurses and clinical officers in rural Uganda through emergency care steps for severe diarrhea, breathing problems, and seizures. About 15 clinicians used the app during simulated patient scenarios to see if it helped them fo…

This study tested a virtual reality (VR) system to measure how quickly stroke survivors react to objects on their left or right side. Researchers compared these VR results with standard paper tests for spatial neglect. The goal was to see if VR can reliably assess attention probl…

This early-stage study tested a new drug called CG001419 in 72 healthy adults to see if it is safe and how the body processes it. The drug is being developed for pain relief. Participants took single or multiple doses, and some took it with food to check for effects. The study is…

This study looked back at the medical records of 134 adults with chronic cancer pain to see how well different pain management strategies worked. Researchers measured pain severity using a standard 0–10 scale and noted the types of pain and treatments used. Because it was a revie…

This study looked back at records of 126 people who had total knee replacement and received nerve blocks for pain. The goal was to compare different nerve block techniques to see which one provides better pain relief, fewer complications, and faster recovery. The findings could h…

This completed study looked at 150 children with severe to profound hearing loss to find how many have a specific genetic form called DFNB9. Researchers collected medical and genetic data from routine care. The goal was to better understand this condition and pave the way for fut…

This study looked at 91 people with a type of bleeding in the eye caused by age-related macular degeneration (AMD). It compared two treatments: surgery followed by anti-VEGF injections, or a gas injection followed by anti-VEGF injections. The goal was to see which approach helps …

This study tested a new method for programming cochlear implants called Focused Multipolar Stimulation (FMS). Researchers compared two ways to set up the implant: one using objective measurements and another based on the user's feedback. The goal was to see which approach helps a…

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study tested whether a 3D-printed model of pain biochemistry helps nursing students understand pain mechanisms and stay motivated. 90 students were split into two groups: one used the 3D model, the other used standard PowerPoint slides. Researchers measured knowledge and mot…

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This study looked at whether adding a brain wave monitor (pEEG) to standard sedation checks helps reduce delirium and time on a breathing machine in ICU patients. Researchers followed 150 adults on ventilators who needed sedation. They compared those who got both the brain monito…

This completed study looked at electronic health records from over 3,300 adults with tinnitus across three hospitals in China. Researchers aimed to identify risk factors and develop models to predict different tinnitus subtypes. The goal is to improve diagnosis and personalized c…

This study looked for early signs of epilepsy in children with autism and tested whether a structured exercise program could influence those signs. Fifty children aged 10-15 with autism, epilepsy, or both took part. Researchers analyzed blood, sleep, brain activity, and thinking …

This study explored whether a parent's anxiety before their child's surgery influences the child's own anxiety and pain after the operation. Researchers measured anxiety in 81 parents and their children aged 2-6 undergoing groin surgery. The goal was to see if easing parental wor…

This study looked at 30 patients with a type of age-related macular degeneration (AMD) to see how treatment affects the barrier between blood and eye fluid. Researchers measured protein levels in the eye fluid before and during anti-angiogenic therapy. The goal was to better unde…

This study collected information from nearly 1,000 people in France with inherited retinal diseases (IRDs) to better understand the genetics behind these conditions. Researchers looked at genetic test results and disease types to help build a national registry. The goal is to imp…

This completed study looked at 72 newborns who had seizures shortly after birth. Researchers measured inflammation markers in their blood and tracked whether they later developed epilepsy. The goal was to understand if inflammation plays a role in epilepsy risk after neonatal sei…

This study asked over 1,000 emergency doctors in Europe what they would prescribe for a patient with sudden belly pain. The patient's race was changed to see if it affected the doctor's choice to give morphine. The goal was to understand if racial bias plays a role in pain manage…

This study checked whether hot air balloon pilots, who are exposed to burner noise and air pressure changes, have more hearing, eustachian tube, or balance problems than other adults. About 105 pilots and non-pilots took part in safe, non-invasive hearing and balance tests. The g…

This study tested two different tablet forms of an experimental pain drug (LTG-001) in 14 healthy adults to see how well each is absorbed. Participants took single doses of each version, and researchers measured drug levels in the blood. The goal was to find which formulation wor…

This study looked at 52 adults having cosmetic breast surgery to see if things like self-esteem, anxiety, and personality traits affect how much pain they feel afterward. Before surgery, participants filled out questionnaires about their mental state and pain expectations. After …

This completed study looked at how the inner ear responds to sound during and after cochlear implant surgery in 88 participants. Researchers used a noninvasive test called electrocochleography to measure electrical activity in the cochlea. The goal was to see if these measurement…

This study tested a simple hearing screening for head and neck cancer survivors who had chemotherapy and radiation. 55 adults completed a hearing questionnaire and a quick hearing test. The goal was to see if the screening was practical and helpful for catching hearing problems e…

This study looked at how children with and without hearing loss use eye gaze and facial expressions to improve speechreading (lip-reading). Researchers tested 140 children aged 8–11 with cognitive and speechreading tasks, and some children with hearing loss trained using a specia…

This study tested a new mobile app feature that helps cochlear implant users measure how loud different sounds feel. Twenty adults with cochlear implants used the app at home and in the clinic. The goal was to see if the app could collect accurate loudness data, which could make …

This study looked at two ways of monitoring wet age-related macular degeneration (AMD) using eye scans: standard OCT B-scans and a newer technique called OCT angiography. The goal was to see if the newer scan could better detect when the disease is active, helping doctors decide …

This study looked at 50 older adults (65+) having major surgery to see if using a computer-controlled sedation method (target-controlled infusion, or TCI) helps protect thinking and memory after the operation. Participants were split into two groups: one received TCI and the othe…

This study looked at how two common steroids, methylprednisolone and dexamethasone, affect the time it takes for children to recover from muscle relaxants used during surgery. Sixty children aged 5 to 12 received one of the steroids or a placebo before their operation. The goal w…

This study looked at whether musical pitch training can improve music appreciation and hearing in people with cochlear implants. 120 teenage and adult implant users took part, with some receiving musical training and others visual training as a comparison. The goal was to underst…

This study tested a device called ANI that measures heart rate changes to assess comfort in patients who cannot speak, such as those in end-of-life care. Twenty non-communicating patients in a palliative care unit were monitored during a painful procedure. The device's readings w…

This study looked at how much children with hearing loss and their caregivers understand about what caused the hearing loss. Researchers asked 156 participants to fill out questionnaires about the type and cause of their hearing loss and whether knowing the cause matters to them.…

This study aims to create an algorithm that detects epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers will use data from 40 epilepsy patients who had seizures recorded during long-term video-EEG monitoring. The goal is to see how accu…

This study looked at how deaf people who were born deaf process reading in their brains. Researchers used brain scans to compare deaf and hearing readers. The goal was to understand how the brain adapts to reading without ever hearing speech sounds. 60 adults who are deaf and hav…

This completed study surveyed 250 adults with vestibular disorders (like vertigo) across Belgium, France, and the US. Participants filled out questionnaires about dizziness, anxiety, and thinking problems, while doctors provided routine test results. The goal is to link symptoms …

This study looked at 142 people with hard-to-treat high blood pressure who had a procedure called renal denervation, which uses energy to calm overactive kidney nerves. Researchers compared two types of sedation—dexmedetomidine versus a fentanyl-propofol combination—to see which …

This study looked at how children aged 8 to 17 with two cochlear implants locate sounds in three-dimensional space. Using virtual reality and motion tracking, researchers measured pointing accuracy and head movements during sound tasks. The goal was to better understand spatial h…

This study tested how well BD NRFit spinal needles and syringes work in real-world medical settings. A total of 161 patients receiving anesthesia or pain relief procedures were included. Researchers measured successful needle placement, syringe function, and safety issues like he…