Experimental eye injection aims to restore sight in rare blindness conditions
NCT ID NCT05282953
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested an experimental drug called KIO-301, given as an injection into the eye, in 32 adults with retinitis pigmentosa or choroideremia—two inherited conditions that cause progressive vision loss. The main goal was to check safety and tolerability at increasing doses. Researchers also looked for signs that the drug might improve vision.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
KIO-301 (an experimental drug injected into the eye)
What this could lead to
If it works, this could point toward a treatment that restores some vision in people with inherited retinal diseases.
What could go wrong
This is an early-phase trial with only 32 participants, so results may not apply to everyone. The drug is injected directly into the eye, which carries risks like inflammation or infection.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Harley Eye Clinic
North Adelaide, South Australia, 5006, Australia
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Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
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Save Sight Institute
Sydney, New South Wales, 2001, Australia