New eye drug OLN324 tested for wet AMD and diabetic swelling

NCT ID NCT07484074

Completed Disease control Sponsor: Ollin Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tested an investigational eye injection called OLN324 in 164 adults with either wet age-related macular degeneration (AMD) or diabetic macular edema (DME). The main goal was to check safety and how the drug moves in the body, with a preliminary look at whether it might improve vision. Participants received either OLN324 or an existing treatment (faricimab) to compare results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

OLN324 (eye injection)

What this could lead to

If successful, this could lead to a new treatment option for wet AMD and diabetic macular edema, potentially reducing the need for frequent eye injections.

What could go wrong

This is an early Phase 1b trial focused on safety, so it is too soon to know if OLN324 works. The drug may not prove effective or could cause unexpected side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

diabetic macular edema macular degeneration wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA (DME) NEOVASCULAR (WET) AGE-RELATED MACULAR DEGENERATION

Contacts and locations

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Locations

Abilene, TX

Abilene, Texas, 79606, United States
Arecibo, Puerto Rico

Arecibo, 00612-4368, Puerto Rico
Arlington, TX

Arlington, Texas, 76012, United States
Austin, TX

Austin, Texas, 78705, United States
Bellaire, TX

Bellaire, Texas, 77401, United States
Dallas, TX

Dallas, Texas, 75231, United States
Fort Myers, FL

Fort Myers, Florida, 33912, United States
Germantown, TN

Germantown, Tennessee, 38138, United States
Glendale, CA

Glendale, California, 91204, United States
Grand Rapids, MI

Grand Rapids, Michigan, 49546, United States
Hagerstown, MD

Hagerstown, Maryland, 21740, United States
Katy, TX

Katy, Texas, 77494, United States
Oak Forest, IL

Oak Forest, Illinois, 60452, United States
Pasadena, CA

Pasadena, California, 91107, United States
Phoenix, AZ

Phoenix, Arizona, 85016, United States
Plano, TX

Plano, Texas, 75075, United States
Reno, NV

Reno, Nevada, 89502, United States
Round Rock, TX

Round Rock, Texas, 78681, United States
Sacramento, CA

Sacramento, California, 95825, United States
Saint Petersburg, FL

St. Petersburg, Florida, 33711, United States
San Antonio, TX

San Antonio, Texas, 78240, United States
San Marcos, TX

San Marcos, Texas, 78666, United States
Schertz, TX

Schertz, Texas, 78154, United States
Springfield, OR

Springfield, Oregon, 97477, United States
The Woodlands, TX

The Woodlands, Texas, 77384, United States
Tulsa, OK

Tulsa, Oklahoma, 74114, United States
Wake Forest, NC

Wake Forest, North Carolina, 27587, United States
Walnut Creek, CA

Walnut Creek, California, 94598, United States
Waterford, CT

Waterford, Connecticut, 06385, United States
Winter Haven, FL

Winter Haven, Florida, 33880, United States