New combo shot may slash opioid use after hernia repair
NCT ID NCT03907176
First seen Jun 06, 2026 · Last updated Jun 23, 2026 · Updated 5 times
Summary
This study tested whether a non-opioid pain regimen, including a long-acting numbing shot (HTX-011) and standard pain relievers like ibuprofen and acetaminophen, could help people avoid opioids after hernia surgery. About 209 adults scheduled for open inguinal hernia repair took part. The main goal was to see how many people did not need an opioid prescription up to 15 days after surgery.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Anaheim Clinical Trials, LLC
Anaheim, California, 92801, United States
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Baylor University Medical Center
Dallas, Missouri, 75246, United States
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Baylor University Medical Center
Dallas, Texas, 75246, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Cleveland Clinic Fairview
Cleveland, Ohio, 44111, United States
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Endeavor Clinical Trials, LLC
San Antonio, Texas, 78229, United States
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Hermann Drive Surgical Hospital
Houston, Texas, 77004, United States
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Horizon Clinical Research
La Mesa, California, 91942, United States
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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JBR Clinical Research
Draper, Utah, 84020, United States
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M3 Emerging Medical Research, LLC
Durham, North Carolina, 27704, United States
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Medical Research of Westchester, Inc
Miami, Florida, 33144, United States
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Midwest Clinical Research Center, LLC
Dayton, Ohio, 45417, United States
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Montefiore Hutchinson Campus
The Bronx, New York, 10461, United States
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Parkview Community Hospital
Riverside, California, 92503, United States
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Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104, United States
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Plano Surgical Hospital
Plano, Texas, 75093, United States
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Professional Health Care of Pinellas
St. Petersburg, Florida, 33713, United States
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Rutgers - New Jersey Medical School
Newark, New Jersey, 07103, United States
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Sharp Grossmont Hospital
La Mesa, California, 91942, United States
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Stony Brook University Hospital
Stony Brook, New York, 11794, United States
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Summit Medical Group Oregon-Bend Memorial Clinic
Bend, Oregon, 97701, United States
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The Ohio State University Wexner Medical Center - University Hospital
Columbus, Ohio, 43210, United States
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Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
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UPMC Passavant
Pittsburgh, Pennsylvania, 15237, United States
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UPMC Shadyside Hospital
Pittsburgh, Pennsylvania, 15232, United States
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University of California, Irvine Medical Center
Orange, California, 92868, United States
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University of Louisville Hospital
Louisville, Kentucky, 40202, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Yale University School of Medicine
New Haven, Connecticut, 06510, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
HTX-011 (ZYNRELEF) – a combination of bupivacaine and meloxicam, plus ibuprofen and acetaminophen
What this could lead to
If successful, this could offer a way to manage pain after hernia surgery without relying on opioids, reducing addiction risk.
What could go wrong
This is an open-label study, so results may be biased. It only looks at one surgery type, and the regimen may not work for everyone or for more painful procedures.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.