New combo shot may slash opioid use after hernia repair

NCT ID NCT03907176

Completed Symptom relief Sponsor: Heron Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a non-opioid pain regimen, including a long-acting numbing shot (HTX-011) and standard pain relievers like ibuprofen and acetaminophen, could help people avoid opioids after hernia surgery. About 209 adults scheduled for open inguinal hernia repair took part. The main goal was to see how many people did not need an opioid prescription up to 15 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HTX-011 (ZYNRELEF) – a combination of bupivacaine and meloxicam, plus ibuprofen and acetaminophen
What this could lead to: If successful, this could offer a way to manage pain after hernia surgery without relying on opioids, reducing addiction risk.
What could go wrong: This is an open-label study, so results may be biased. It only looks at one surgery type, and the regimen may not work for everyone or for more painful procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

agnosia Hernia Hernia, Inguinal pain agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA

Contacts and locations

Locations

Anaheim Clinical Trials, LLC

Anaheim, California, 92801, United States
Baylor University Medical Center

Dallas, Missouri, 75246, United States
Baylor University Medical Center

Dallas, Texas, 75246, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cleveland Clinic Fairview

Cleveland, Ohio, 44111, United States
Endeavor Clinical Trials, LLC

San Antonio, Texas, 78229, United States
Hermann Drive Surgical Hospital

Houston, Texas, 77004, United States
Horizon Clinical Research

La Mesa, California, 91942, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
JBR Clinical Research

Draper, Utah, 84020, United States
M3 Emerging Medical Research, LLC

Durham, North Carolina, 27704, United States
Medical Research of Westchester, Inc

Miami, Florida, 33144, United States
Midwest Clinical Research Center, LLC

Dayton, Ohio, 45417, United States
Montefiore Hutchinson Campus

The Bronx, New York, 10461, United States
Parkview Community Hospital

Riverside, California, 92503, United States
Penn Presbyterian Medical Center

Philadelphia, Pennsylvania, 19104, United States
Plano Surgical Hospital

Plano, Texas, 75093, United States
Professional Health Care of Pinellas

St. Petersburg, Florida, 33713, United States
Rutgers - New Jersey Medical School

Newark, New Jersey, 07103, United States
Sharp Grossmont Hospital

La Mesa, California, 91942, United States
Stony Brook University Hospital

Stony Brook, New York, 11794, United States
Summit Medical Group Oregon-Bend Memorial Clinic

Bend, Oregon, 97701, United States
The Ohio State University Wexner Medical Center - University Hospital

Columbus, Ohio, 43210, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
UPMC Passavant

Pittsburgh, Pennsylvania, 15237, United States
UPMC Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States
University of California, Irvine Medical Center

Orange, California, 92868, United States
University of Louisville Hospital

Louisville, Kentucky, 40202, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Yale University School of Medicine

New Haven, Connecticut, 06510, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.