New combo may ease post-mastectomy pain without strong drugs

NCT ID NCT07022353

Completed Symptom relief Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding a single dose of the muscle relaxant tizanidine to a nerve block (ESP block) improves pain control after mastectomy. 90 patients were randomly assigned to receive either the nerve block alone or the nerve block plus tizanidine before surgery. The goal was to see if the combination delays the need for extra pain medication and lowers pain scores in the first 24 hours.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tizanidine (a muscle relaxant) and an erector spinae plane (ESP) nerve block
What this could lead to: If it works, this combination could offer better pain relief after mastectomy, reducing the need for strong opioids and improving recovery.
What could go wrong: This is a small, single-center trial with 90 participants. The results may not apply to all patients, and the nerve block requires skilled placement. Side effects from tizanidine or the block are possible.

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Conditions

The condition(s) this trial relates to.

agnosia breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MASTECTOMY PATIENT

Contacts and locations

Locations

Oncology Centre

Al Mansurah, Egypt

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