New eye injection targets two causes of vision loss in wet AMD
NCT ID NCT05456828
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tested a new drug called ASKG712 in 56 people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The drug is injected into the eye and works by blocking two proteins that fuel abnormal blood vessel growth. The main goals were to check safety and how the drug moves through the body, with some early looks at vision outcomes. The trial has been completed, but results are not yet public.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ASKG712 (a protein that blocks two growth factors involved in abnormal blood vessel growth in the eye)
- What this could lead to
- If successful, this could lead to a new treatment option for wet age-related macular degeneration that targets two pathways at once, potentially offering better or longer-lasting vision protection.
- What could go wrong
- This is an early Phase 1/2a study with only 56 participants, so safety and effectiveness are not yet proven. The treatment is injected directly into the eye, which carries risks like infection or inflammation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Shanghai General Hospital
Shanghai, Shanghai Municipality, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Longer-Lasting eye injection could cut treatment visits for macular disease
- Can a new eye injection save vision in wet AMD?
- Eye injection aims to tame leading causes of blindness
- Higher-Dose eye injection may help wet AMD patients who Didn't respond to standard treatments
- New eye drug aims to save sight in wet AMD
- Withdrawn study sought better way to time eye injections