Perceptual disorders

This study tests an oral drug, AV078, in people aged 12 and older with tuberous sclerosis complex (TSC) whose seizures are not controlled by standard medications. Participants are randomly assigned to receive AV078 or a placebo for 12 weeks. The goal is to see if AV078 safely red…

This study tests a gene therapy called OPGx-RDH12 for people with Leber Congenital Amaurosis (LCA) caused by mutations in the RDH12 gene, a rare condition that leads to severe vision loss from a young age. The treatment is given as a single injection under the retina in the worse…

This study compares activating a cochlear implant on the day of surgery versus the usual two-week wait. About 100 adults receiving a cochlear implant will be randomly assigned to one of the two groups. Researchers will track how quickly the implant settings stabilize, hearing imp…

This phase 3 trial tests whether NPI-001, taken twice daily for 24 months, can slow the loss of light-sensing cells in the eyes of adults with Usher syndrome, a genetic condition that causes both hearing and vision loss. About 80 participants will receive either the drug or a pla…

This study tests whether a training program that pairs sounds with visual cues can help people who have lost part of their vision due to brain damage (cortical blindness). Participants will do 12 sessions where they see and hear stimuli in their blind area, plus virtual reality t…

This study looks at whether a wearable insulin patch pump, guided by a continuous glucose monitor, can better control high blood sugar caused by high-dose steroids in people with sudden hearing loss and diabetes or prediabetes. About 44 participants will be randomly assigned to e…

This early study tests a new surgical device called the Microtable® Stereotactic System for cochlear implants. The device uses a custom-made frame to guide a drill precisely to the inner ear, potentially making surgery faster, less painful, and better at preserving taste. The stu…

This trial tests a single injection of a gene therapy called ZVS101e for people with Bietti crystalline dystrophy, a rare inherited eye disease that leads to progressive vision loss. The therapy uses a harmless virus to deliver a working copy of the CYP4V2 gene to cells in the ey…

This study tests a liquid form of the seizure drug zonisamide in children aged 1 month to 17 years who have partial-onset seizures. The goal is to find the right dose and check for side effects. About 40 children will take the medicine for up to 12 weeks, with a follow-up visit o…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This study will test a newer bone conduction implant, the Osia system, against an older one, the Baha Connect system, in 20 adults with mixed or conductive hearing loss. Participants already have a Baha implant and will switch to the Osia system. Researchers will measure speech u…

This study tests an oral drug called STL303 for geographic atrophy, a form of dry age-related macular degeneration that causes a blind spot in central vision. About 300 adults aged 60 and older will receive either STL303 or a placebo pill for up to 2 years. The goal is to see if …

This study tests whether a remote dietary program can help people with early to intermediate age-related macular degeneration (AMD) lower their blood sugar and increase protective nutrients called carotenoids. About 32 participants will receive coaching to improve their eating ha…

This trial tests a new device called the enVVe system, a catheter-based artificial valve placed in leg veins to treat chronic venous insufficiency. The study will enroll 220 people with severe symptoms like skin changes or leg ulcers. Participants are randomly assigned to receive…

This Phase 2a trial tests SCAI-005 eye drops in 50 adults with wet age-related macular degeneration (AMD). Participants will receive either a low dose, high dose, or placebo drops three times daily. The study aims to see if the drops can reduce retinal swelling and control the di…

This early-stage trial tests a gene therapy called AGX-08 for geographic atrophy, an advanced form of age-related macular degeneration that causes vision loss. The study will involve 24 people aged 50 and older, each receiving a single injection into one eye. The main goal is to …

This study is for people with Bietti's crystalline dystrophy, a rare genetic eye disease that causes vision loss. They have already received the gene therapy VGR-R01 in one eye. Now, researchers want to test if giving the same treatment to the other eye is safe and can improve vi…

This early-stage trial tests a new cell therapy called Rincell-1 for adults with certain types of hearing loss who are getting a cochlear implant. The study will compare the safety and early effectiveness of receiving the cell therapy plus the implant versus the implant alone. Ab…

This study will test the drug faricimab, given as eye injections, in 50 people with wet age-related macular degeneration (nAMD). The goal is to see if it improves vision and eye health. Participants will receive 4 initial doses, then more as needed. The study is observational, me…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study looks at whether a home monitoring app can help people with wet age-related macular degeneration (eAMD) safely extend the time between Aflibercept injections. About 80 adults already receiving this treatment will use the app and have regular eye exams over one to two y…

This study tests a non-invasive laser treatment called photobiomodulation for people with early age-related macular degeneration (AMD) who have a specific type of deposit in the eye called reticular pseudodrusen. The treatment uses low-energy light to stimulate cells and reduce i…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This early study tests whether stimulating a nerve cluster behind the cheekbone (the pterygopalatine ganglion) is safe and doable for people with geographic atrophy, a severe form of age-related macular degeneration that causes blind spots. Sixty-two adults will receive either re…

This study tests whether adding echothiophate iodide eye drops to standard atropine therapy can improve vision in children aged 3 to 18 with refractory amblyopia (lazy eye that hasn't improved with standard treatment). Twenty participants will use atropine nightly for 12 weeks, a…

This study tests a new medicine called AIV007 for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. About 35 participants will receive either AIV007 or the standard treatment Eylea. The goal is to see if AIV007 can improve vision and reduce t…

This study tests whether adding specially designed digital games to standard eye-patch therapy can improve vision and motivation in children aged 4 to 7 with lazy eye (amblyopia). Sixty-six children will either wear an eye patch alone or combine it with a touchscreen or augmented…

This study tests whether injecting steroids directly into the inner ear can improve hearing in people with sudden, severe hearing loss that hasn't responded to standard treatment. Researchers will compare this method to standard steroid injections behind the eardrum. The trial in…

This study tests an investigational drug called OCUL101 for people with wet age-related macular degeneration (AMD), a condition that causes blurry vision and can lead to blindness. OCUL101 targets two proteins involved in the disease to reduce abnormal blood vessel growth and inf…

This early-stage trial tests a single injection of ZM-02, a gene therapy, in 21 people aged 6 to 60 with advanced retinitis pigmentosa, a genetic condition that causes progressive vision loss. Participants are randomly assigned to receive either a low or high dose of ZM-02 or a s…

This phase 3 trial tests whether adding Sanhuang Jingshiming Pills (a traditional Chinese herbal medicine) to standard ranibizumab injections can reduce the number of injections needed for wet age-related macular degeneration. About 450 adults aged 50-85 with active wet AMD will …

This study tests whether a natural supplement from Dunaliella alga, rich in 9-cis beta-carotene, can improve vision in adults with retinitis pigmentosa. Forty-one participants will take the supplement or a placebo for 3 months, then switch after a 6-month break. Researchers will …

This study will test three new types of cochlear implants in 66 adults with severe hearing loss. The goal is to see if the implants improve speech understanding and overall hearing quality. Participants will receive the implant as part of their normal care, and researchers will t…

This phase 3 trial tests whether a new drug, QL1207H, works as well as the standard treatment Eylea for wet age-related macular degeneration, a leading cause of vision loss. About 356 adults aged 50 and older with active disease will receive injections every 4 weeks for 3 doses, …

This early-stage trial tests whether tiny particles from stem cells can help treat severe sudden hearing loss. Nine adults will receive injections into the ear alongside standard care. The study checks for safety and whether hearing improves compared to a common steroid treatment…

This study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…

This study follows up 18 people who received umbilical cord stem cells or conditioned medium for retinitis pigmentosa, a rare eye disease that causes vision loss. Researchers will check vision, eye structure, and safety five years after the injection. The goal is to see if the tr…

This study tests whether stem cells from umbilical cord tissue can safely slow vision loss in people with retinitis pigmentosa, an inherited eye disease. Thirty participants will receive one of two doses injected around the eye and be monitored for six months. The main goals are …

This early-stage trial tests whether transplanting lab-grown retinal cells (made from stem cells) into the eye is safe for people with late-stage age-related macular degeneration. Nine participants will receive the cell transplant and be monitored for side effects and any improve…

This early-stage trial tests a new drug called GB10, given as an eye injection, for people with wet age-related macular degeneration (AMD). The study will include 48 participants and aims to check safety and find the right dose. It is not yet recruiting and is too early to know i…

This study tests a new, non-invasive treatment for dry age-related macular degeneration (AMD), a common cause of vision loss in older adults. About 94 people aged 50 and older with dry AMD will use a red-light device at home twice daily for three months. Researchers will check if…

This study tests whether mirabegron, a drug used for overactive bladder, can help people with dry age-related macular degeneration (AMD). Researchers will give 312 patients aged 50-80 either mirabegron or a standard bladder drug for 12 months and check for changes in the retina. …

This phase 4 trial will test the drug faricimab (Vabysmo) in 64 people with wet age-related macular degeneration (AMD). Participants will receive eye injections every 4 weeks for 4 doses, then a treat-and-extend schedule based on disease activity. The study also measures biomarke…

This study tests a stronger dose (8 mg) of the drug aflibercept in Chinese patients with polypoidal choroidal vasculopathy (PCV), a type of wet age-related macular degeneration that can cause rapid vision loss. About 174 people who have not been treated before will receive three …

This phase 3 trial tests whether adding aspirin and folic acid to standard treatment can improve recovery from sudden sensorineural hearing loss. The idea is that these drugs may improve blood flow to the inner ear. The study will enroll 142 adults with recent hearing loss and tr…

This early-stage trial tests a single injection of a gene therapy drug called UGX202 in 6 adults with advanced retinitis pigmentosa, a genetic condition that causes vision loss. The main goal is to check if the treatment is safe and tolerable over 52 weeks. Researchers will also …

This study tests an experimental pill (EG-301) taken daily for at least 6 months in 90 people with dry age-related macular degeneration (AMD) and geographic atrophy. Participants are randomly assigned to receive either standard AREDS2 supplements alone or AREDS2 plus EG-301. The …

This early-stage trial tests whether adding the drug valproate to standard patching therapy can improve vision in children aged 8 to 17 with lazy eye (amblyopia). Participants will take valproate or a placebo daily for 8 weeks while patching the stronger eye. The study aims to se…

This study tests whether virtual reality (VR) therapy works better than standard balance exercises for people with long-term dizziness. Researchers will enroll 40 adults aged 18-70 who have had dizziness for over 3 months due to inner ear problems. Participants will receive eithe…

This study tests whether a powder made from a special alga can help preserve or improve vision in teenagers with retinitis pigmentosa, a genetic eye disease that causes vision loss. Thirty participants aged 12-18 will take the alga extract daily for one year. The study will measu…

This study tests faricimab, a drug injected into the eye, for people with type 3 wet age-related macular degeneration (AMD), a condition that can cause rapid vision loss. Over 76 weeks, 30 participants will receive initial monthly doses, then a personalized schedule where injecti…

This early-stage trial tests EXG202, a gene therapy given as a single injection into the eye for people with wet age-related macular degeneration (AMD). The goal is to see if it is safe and can produce a protein that blocks abnormal blood vessel growth long-term, potentially redu…

This trial tests an artificial intelligence system called QiLin that helps doctors decide when to give anti-VEGF injections for retinal diseases like wet AMD, DME, and RVO. About 200 patients who have completed initial treatment will be randomly assigned to have their doctor use …

This study tests whether artificial intelligence (AI) can accurately help diagnose and triage patients with hearing loss and tinnitus, conditions affecting millions in the UK. Researchers will compare AI recommendations to those made by ear, nose, and throat doctors for 1,500 adu…

This study tests a compact, handheld eye imaging device that takes pictures of the eye in seconds. Researchers want to see if it is easy to use, mobile, and reliable. The device will be tested on 70 people with eye complaints, and the images will be compared to official diagnoses…

This study tests a new prototype device that measures brain responses to speech sounds in infants. Researchers will compare brain responses between infants with normal hearing and those with hearing loss, both with and without hearing aids. The goal is to see if the device can ac…

This study will test a new, non-invasive eye scanner called wide field OCTA in 200 people with various eye diseases, including age-related macular degeneration, diabetic retinopathy, and dry eye. The goal is to see if this device can provide better images of blood vessels in the …

This study will test a new artificial intelligence (AI) system that reads eye scans (OCT) to diagnose common blinding eye diseases like diabetic retinopathy, glaucoma, and age-related macular degeneration. Researchers will collect 2000 eye scans from patients at Peking Union Medi…

This study tests whether wearable augmented reality (AR) glasses can diagnose vertigo as accurately as standard eye-movement exams. About 200 adults with vertigo will try both methods during one visit. If successful, AR glasses could make vertigo assessment faster and more access…

This study tests whether a structured referral tracking program helps adults in Pakistan complete follow-up eye care after community screenings. 500 participants will receive either standard referral or extra support like counseling and weekly reminders. The goal is to prevent bl…

This study tests a program to help farmworkers protect their hearing from loud machinery. About 200 farmworkers and supervisors will take part. The program includes a video, group talk, and hands-on earplug training. Researchers will measure noise exposure and survey participants…

This study tests a culturally tailored Talking Circles program to prevent noise-induced hearing loss in Native American adults. 400 tribal members will join group discussions and hearing tests over 12 months. The goal is to increase hearing protection use and knowledge through co…

This pilot study tests a short, culturally adapted training to help farmworkers use earplugs correctly and prevent hearing loss from loud noise. Fifteen farmworkers will receive the training and have their earplug fit measured before and after. The goal is to see if the training …

This study tests whether levetiracetam, a seizure medication, works as well as magnesium sulfate to prevent seizures in pregnant people with severe preeclampsia. About 1,240 participants at 32 weeks or more will be randomly assigned to one of the two drugs. The goal is to see if …

This study tests whether a mobile app that combines digital cognitive behavioral therapy (CBT) with personal mental health coaching can reduce anxiety in adults with hearing or mobility disabilities. Participants use either the active program or a sham version for 8 weeks, with f…

This study tests whether a combination of two sedatives, esketamine and dexmedetomidine, can better control agitation and shorten delirium in intensive care unit (ICU) patients who are on non-invasive breathing support. The trial will enroll 388 adults with hyperactive delirium a…

This study tests a non-invasive technique called temporal interference stimulation to boost deep sleep in people with epilepsy. Researchers will compare 4 nights of real stimulation to 4 nights of sham (fake) stimulation in up to 16 patients. The goal is to see if better sleep ca…

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Resea…

This trial tests a program called ENCompaSS that combines education, phone coaching, and self-management tips to help Veterans with long-term back pain. Participants are randomly assigned to either the program plus usual care or usual care alone. The study measures whether the pr…

This study will test whether a 4-week daily music therapy app can reduce chronic pain and improve quality of life in 25 youth with sickle cell disease. Participants will either use the app or receive standard educational materials. Researchers will also look at changes in immune …

This study tests a personalized music program for people who wear hearing aids but are unhappy with how music sounds. Researchers will create a custom frequency profile for each participant and add it to their hearing aids as a dedicated music setting. The trial includes 66 adult…

This study compares sound therapy, cognitive behavioral therapy (CBT), and their combination to help people with chronic tinnitus (ringing in the ears). Sixty adults aged 18-65 with stable health will be randomly assigned to one of three groups for six weeks. The goal is to see w…

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This study tests whether giving patients a printed opioid prescription instead of sending it directly to the pharmacy can reduce opioid use after total hip replacement. About 100 adults will be randomly assigned to receive either the standard pain regimen with automatic pharmacy …

This pilot study compares two standard-of-care radiofrequency ablation (RFA) techniques for chronic knee pain caused by osteoarthritis. Adults already scheduled for knee RFA are randomly assigned to receive either a standard 3-target or a novel 6-target nerve ablation protocol. T…

This study tests a speech therapy called DTTC-Connect for children aged 3 to 12 with childhood apraxia of speech, a disorder that makes it hard to say words clearly. The therapy focuses on helping children move from saying single words to speaking in phrases. Sixty-eight children…

This pilot study will test whether oral ketamine can control pain as well as oxycodone in emergency department patients who need extra pain medication. Sixty adults with certain types of pain will be randomly assigned to receive either drug. Researchers will measure changes in pa…

This study tests a home-based eye movement therapy (optokinetic stimulation) for people with spatial neglect after a stroke. Spatial neglect makes it hard to pay attention to one side of the world, often leading to falls. The therapy involves watching moving dots on a computer sc…

This study compares two types of nerve blocks—quadro-iliac plane block and supra-inguinal fascia iliaca compartment block—for pain after total hip replacement. Sixty adults scheduled for hip surgery will receive one of the blocks along with spinal anesthesia. Researchers will mea…

This study tests whether giving scheduled morphine alongside patient-controlled pain relief can prevent the intense 'rebound pain' that often occurs when a nerve block wears off after orthopaedic surgery. About 100 adults having arm or leg surgery will be randomly assigned to rec…

This study tests a device called BreEStim that uses electrical stimulation timed with your breathing to reduce nerve pain after spinal cord injury. About 66 adults with long-term spinal cord injury and stable pain will receive either active or sham treatment. The goal is to see i…

This study tests whether adding cyclobenzaprine, a muscle relaxant, to standard pain medicines (ibuprofen, acetaminophen, and short-term narcotics) improves pain control and reduces narcotic use after minimally invasive hysterectomy. About 36 women undergoing laparoscopic hystere…

This study compares two ways to manage pain after open inguinal hernia repair: an ultrasound-guided nerve block (TFPB) versus surgical wound infiltration with local anesthetic. About 104 adults will be randomly assigned to one method. The goal is to see which reduces opioid use a…

This study compares two types of nerve blocks used to manage pain after total hip replacement. Sixty adults having hip replacement will receive either a quadro-iliac plane block or a PENG block combined with a lateral femoral cutaneous nerve block. Researchers will measure pain s…

This study tests whether a numbing injection called a superficial parasternal intercostal plane block (SPIPB) can widen the internal thoracic artery, making it easier for surgeons to harvest during coronary artery bypass grafting (CABG). The trial involves 50 adults aged 22 to 65…

This study tests whether giving scheduled morphine doses alongside on-demand pain relief can prevent the severe 'rebound pain' that often occurs when a nerve block wears off after orthopedic surgery. One hundred adults having arm or leg surgery will be randomly assigned to receiv…

This study looks at whether giving a nerve block (serratus anterior plane block) before or after mastectomy surgery leads to better recovery and less pain. Eighty women having a mastectomy will be randomly assigned to receive the block either before the surgeon makes the first cu…

This clinical trial will compare Sahrmann exercises and McGill exercises in 42 adults with non-specific low back pain. Participants will be randomly assigned to one of the two exercise programs, alongside standard physical therapy. The study aims to see which approach better redu…

This study tests whether a special ultrasound-guided nerve block can lower the amount of strong painkillers (opioids) needed after breast reduction surgery. About 80 women will be randomly assigned to receive either standard pain treatment alone or standard treatment plus the ner…

This study tests whether a paracervical block (an injection near the cervix) containing ketorolac and lidocaine can reduce pain during placement of osmotic dilators, which are used to prepare the cervix for a second-trimester abortion. About 76 participants will be randomly assig…

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This study tests whether taking omega-3 fatty acids before and after gallbladder surgery can lower the amount of morphine needed for pain. Forty adults will receive either omega-3 supplements or a placebo, plus a small dose of morphine after surgery. Researchers will measure tota…

This study tests if a new pain medicine called tegileridine works as well as morphine for teenagers recovering from scoliosis surgery. About 171 teens will receive either tegileridine or morphine through a pump they control. Researchers will compare pain levels and side effects o…

This study looks at two methods to control pain after hindfoot surgery: a single nerve block injection versus a small tube (catheter) that delivers numbing medicine continuously for days. The goal is to see which approach reduces pain, cuts down on opioid use, and helps people re…

This study tests whether a cochlear implant placed just outside the inner ear, near the round window, can safely reduce severe tinnitus that has not responded to standard treatments. Six adults with long-term, high-impact tinnitus will receive the implant in a two-step procedure.…

This study tests a special anesthesia method that uses fewer opioids during spine surgery in people aged 65 and older. The goal is to see if it lowers pain and the need for strong painkillers after surgery. Half the participants will get this opioid-sparing anesthesia, and the ot…

This study tests whether a long-acting form of the numbing drug bupivacaine (liposomal bupivacaine) can reduce pain and the need for strong opioid painkillers after lung transplant surgery. 88 adults receiving a double lung transplant will get an intercostal nerve block either wi…

This study tests whether manual acupuncture can reduce the burden of acute tinnitus compared to sham acupuncture or usual care. Researchers will enroll 180 adults with bothersome tinnitus lasting 2 weeks to 6 months. Participants receive 10 sessions over 4 weeks, and outcomes foc…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study compares ketamine to morphine for treating acute pain in children visiting the emergency department. Over 1,000 children with abdominal pain or broken bones will receive either drug. The goal is to see if ketamine works as well as morphine but with fewer side effects.

This trial tests whether a combined nerve block can improve pain relief after total knee replacement while preserving leg strength. 240 adults scheduled for knee surgery will receive either the combined block or a standard saphenous nerve block. Researchers will measure opioid us…

This study will test whether adding music therapy to standard physical therapy helps children with spastic cerebral palsy improve their concentration and walking. Forty children aged 5 to 7 will either receive physical therapy alone or physical therapy combined with rhythmic musi…

This study tests if a special augmented reality (AR) training program can improve vision in people aged 12 to 55 with lazy eye (amblyopia). It compares the AR method to the standard treatment of patching the stronger eye. The goal is to see if the AR approach is safer and more ef…

This study looks at two different methods to control pain after total knee replacement. One method combines two nerve blocks given by an anesthesiologist, while the other uses a nerve block plus a local painkiller injection by the surgeon. Researchers will review the medical reco…

This study tests a coordinated rehab program for 74 veterans with head and neck cancer. The program combines standard swallowing therapy with proactive hearing and balance checks and a nurse assessment to find other rehab needs. The goal is to reduce stress and improve well-being…

This small study tests a wearable device called Octane Aether that sends magnetic pulses to the lower back. 24 adults with chronic low back pain will use the device at home for 60 minutes daily over 10 weeks. The goal is to see if it reduces pain compared to a sham (inactive) dev…

This study tests if giving a long-lasting numbing medicine in two different places around the ribs and chest wall can reduce pain and the need for strong painkillers after robotic lung surgery. About 300 adults having this surgery will be randomly assigned to receive the numbing …

This study explores whether giving only pain medicine (remifentanil) without sedatives is safe and feasible for adults in the ICU after brain surgery. The goal is to avoid side effects of sedatives, like confusion or hiding signs of brain problems. Sixty-five participants will be…

This study tests whether injecting a long-lasting numbing medicine (Exparel mixed with bupivacaine) into the penis before placing an inflatable penile implant can reduce post-surgery pain and the need for opioid painkillers. One hundred men with erectile dysfunction who are getti…

This study will compare two pain medications, buprenorphine and oxycodone, in about 282 adults with injuries to at least two body areas. The goal is to see which provides better pain control with fewer risks. Participants will receive one of the two drugs as part of a standard pa…

This study looks at three different ways to give methadone during heart surgery to find the best dose for controlling pain afterward. About 69 adults having planned heart surgery will take part. Researchers will measure methadone levels in the blood and ask about pain to see whic…

This pilot study tests a device called the NOL monitor, which measures pain levels during spine surgery. Doctors use it to decide when to give more pain medicine. The goal is to see if this approach reduces the amount of opioids needed during and after surgery, and helps patients…

This study tests a new ultrasound-guided pain block for high-risk children (ages not specified) having anal or penile surgery. The goal is to see if this block can delay or replace strong pain medicines that can cause breathing or heart problems. Sixty children will be enrolled, …

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This study tests a hearing rehabilitation program called Hear2Share for elderly people in nursing homes who have hearing loss. The program uses a simple hearing device and is run by nursing home staff. Researchers will measure how well participants can hear words and how often th…

This study compares three pain management approaches for 120 adults undergoing coronary artery bypass surgery: standard painkillers alone, standard plus a parasternal nerve block, or standard plus both parasternal and adductor canal blocks. The goal is to see if adding these nerv…

This study compares a web-based exercise program to traditional home exercises for people with non-specific low back pain. Thirty adults aged 18-45 with moderate pain will follow an 8-week program using an app. Researchers will measure changes in pain, function, and quality of li…

This study will test whether high-intensity interval training (HIIT) on a stationary bike can improve walking, balance, and thinking in people with multiple sclerosis (MS). Forty adults with mild to moderate MS will be randomly assigned to either HIIT or moderate-intensity contin…

This study compares two types of nerve blocks (rectus sheath block and transversus abdominis plane block) to see which provides better pain relief after laparoscopic weight-loss surgery. About 96 adults aged 20-60 will be randomly assigned to receive one of the blocks after gener…

This study tests a special gel (HA35) applied to the jaw at night to relieve pain and muscle tightness from temporomandibular joint disorder (TMD). About 30 adults with TMD will use the gel nightly for 8-12 hours. Researchers will check how well it reduces pain and tension after …

This study tests whether training the sense of touch can reduce pain and improve daily function in people with chronic low back pain. 66 adults aged 25-45 with persistent pain will be split into three groups: device-based training, manual training, or standard physical therapy. T…

This study tests whether injecting tramadol, with or without dexamethasone, into the knee joint after arthroscopy can reduce pain and the need for extra painkillers. About 135 adults having minor knee surgery will be randomly assigned to receive one of two drug combinations or a …

This study tests whether a gel made from hyaluronan (HA35) can safely reduce gum pain and swelling after dental procedures. About 30 adults will chew on gel-soaked cotton balls for 30 minutes. Researchers will measure pain and swelling changes at 1, 30, and 60 minutes after appli…

This study tests whether giving lidocaine through a vein during and after liver surgery can reduce side effects like nausea, vomiting, and breathing problems caused by opioid painkillers. About 312 adults having planned open liver surgery will be randomly assigned to receive eith…

This study tests whether a small device that sends mild electrical pulses through the skin (TENS) can reduce pain during a prostate biopsy. About 140 men will get either a real TENS device or a fake one, along with standard numbing medicine. The goal is to see if TENS makes the p…

This study tests whether a four-week physiotherapy program and a meditation app can reduce headache pain and improve quality of life in 78 adults with frequent or chronic tension-type headaches. Participants will be split into groups receiving physiotherapy, meditation, or both. …

This study tests how well a noise-reduction feature called ForwardFocus works in two different sound processors for adults with cochlear implants. 26 veterans and non-veterans will use each processor and take speech tests in background noise. The goal is to see if the newer proce…

This study tests whether Ai Chi, a slow, controlled water exercise program, can help people with long-term dizziness from inner ear problems. 38 adults will either do standard home exercises or add Ai Chi sessions in a pool over 4 weeks. Researchers will measure changes in balanc…

This study tests whether special eye and balance exercises can reduce dizziness, motion sickness, and improve quality of life in people with inner-ear balance problems. Thirty-two adults with motion sickness or vertigo will do either standard habituation exercises or a new optoki…

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

This study tests whether cognitive functional therapy (CFT) can reduce disability in people with chronic low back pain after spinal surgery. 90 adults aged 18-75 who have had surgery at least 3 months ago and still have pain will receive either CFT or a sham treatment. The main g…

This study tests a conversational AI system called Fudan Tinnitus Doctor (FTD) for adults with chronic tinnitus. About 256 participants will use either the AI chatbot or a standard digital education program for 30 days. Researchers will measure changes in tinnitus severity, sleep…

This study tests whether watching 3D movies, combined with standard patching therapy, improves depth perception and vision in children aged 4 to 14 with amblyopia (lazy eye). Half the children will receive patching alone, while the other half will also attend weekly 3D movie sess…

This study tests two common painkillers, indomethacin and paracetamol, given before egg retrieval in IVF. 177 women aged 18-45 will rate their pain after the procedure. The goal is to find a better way to manage pain during this common fertility treatment.

This study aims to find the best dose of morphine given with spinal anesthesia to control pain after a cesarean section. Researchers will compare four different doses in 180 women to see which provides the longest pain relief with the fewest side effects like nausea and itching. …

This study tests whether listening to a 1- or 2-minute guided mindfulness audio can reduce pain in people waiting for orthopedic care. 300 adults will be randomly assigned to one of two mindfulness exercises or a control. The goal is to see if a brief, easy-to-use technique can m…

This study tests whether a gentle electrical stimulation of the ear (taVNS) given before a standard epidural steroid injection can improve pain relief for people with cervical radiculopathy—a pinched nerve in the neck causing arm pain. Eighty adults will be randomly assigned to r…

This study tests whether a non-invasive brain stimulation technique called tDCS can safely improve vision in 100 children aged 4-14 with lazy eye (amblyopia) that hasn't improved with standard patching. Children will receive either real or sham tDCS over three sessions, and their…

This study tests whether a single one-hour educational session with an audiologist can help people with hyperacusis (extreme sensitivity to sound) feel more comfortable around everyday noises. Five participants will track their sound exposure and sensitivity for one month using a…

This study will test whether a video game that guides children through breathing exercises can reduce pain, fear, and anxiety during a routine blood draw. About 60 children aged 7 to 12 will be randomly assigned to either play the breathing game during the procedure or receive st…

This study tests whether an AI-powered mobile app can help people with hearing loss monitor and adjust their hearing aids on their own. The goal is to reduce the need for clinic visits and improve hearing in real-world environments. The trial will involve 120 adults who are start…

This study tests a training technique that uses repeated flashes of light and bursts of sound to help people who have lost part of their vision after a stroke. The goal is to see if this training can improve how much they can see and how their brain responds. The study will inclu…

This study tests a new wind noise canceller for hearing aids that aims to reduce bothersome wind sounds while keeping speech clear. About 25 adults with mild to moderate-severe hearing loss will compare the new canceller to an older version by listening to recordings and choosing…

This study compares two types of pain-relieving injections for people having knee replacement surgery. One uses a long-acting drug called liposomal bupivacaine, and the other uses a mix of five different medications. The goal is to see which approach provides better pain control …

This study compares different numbing methods to reduce pain during dental cavity treatment. About 204 adults with tooth decay will receive either a light-based device, a numbing gel, or a placebo before local anesthesia. Researchers will measure pain during and after the procedu…

This study tests whether acupuncture can reduce the severity of chronic tinnitus (ringing in the ears) in adults. Researchers will compare 72 tinnitus patients with healthy volunteers, and track changes in symptoms and brain activity after 10 acupuncture sessions. The goal is to …

This study tests three common pain relievers (ibuprofen, paracetamol, and tenoxicam) against a placebo to see which works best during shock wave treatment for kidney stones. About 160 adults will rate their pain at several points during the procedure. The goal is to find the safe…

This study tests two different drugs—dexmedetomidine and low-dose ketamine—given during weight-loss surgery to see which one reduces pain and the need for morphine afterward. Ninety adults having bariatric surgery will be randomly assigned to one of the two drugs or a placebo. Th…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests whether using a virtual reality headset or a smartphone during burn dressing changes can lower pain and anxiety. 99 adults with second-degree burns will be randomly assigned to VR, smartphone, or standard care. Pain and anxiety are measured right after the dressi…

This study tests whether an AI-powered app can improve follow-up for patients recovering from surgery with a continuous nerve block for pain. 166 adults will use either the AI app or a standard automated messaging system. The goal is to see if the AI reduces the number of times p…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study tests whether lactoferrin, a natural protein found in milk, can help manage pain after a cesarean section. Ninety women having planned C-sections will receive either lactoferrin or a placebo before and after surgery, alongside standard painkillers. The goal is to see i…

This study tests a device called TUNES, which delivers gentle electrical stimulation through a menstrual disc to nerves near the uterus. The goal is to see if it can reduce pain and the need for pain medication in 60 women after uterine fibroid embolization. Participants will be …

This study looks at whether adding osteopathic manual therapy (a type of hands-on body treatment) to standard vision therapy can help people with eye coordination problems that cause eyestrain, blurred vision, and headaches. The trial will involve 100 adults who work on screens a…

This study tests dexmedetomidine, a sedative that doesn't slow breathing, in 246 premature babies on ventilators. The goal is to see if it reduces the need for opioids, shortens time on the breathing machine, and improves long-term brain development. Babies will receive the drug …

This study tests whether a procedure called sacroplasty can help older adults recover faster from sacral fractures. Sacroplasty involves injecting cement into the broken bone to stabilize it. The trial will compare this procedure to standard care like pain medication and physical…

This study tests whether injecting a small amount of lidocaine (a numbing medicine) around the ear and jaw can reduce tinnitus severity and related disability. Thirty adults with normal hearing and no other ear conditions will receive the injections and be followed for three mont…

This study looks at whether special posture exercises or a wearable sensor can help improve mild vision problems in university students with forward head posture. 72 participants will be split into three groups to compare different training methods. The goal is to see if correcti…

This study is testing a smartphone app called I-STAMP that helps people with advanced cancer keep track of their pain and medications. About 73 participants will use the app and rate how easy it is to use and how helpful it is. The goal is to see if the app can make managing canc…

This study compares continuous regional anaesthesia (a numbing medicine delivered through a tiny tube near the nerves) with standard pain management for people who have war-related leg injuries. About 150 adults will take part, and researchers will measure pain levels and opioid …

This pilot study tests an online program for parents of children with hearing loss who have recently had cochlear implant surgery. The program combines education about implant care and communication strategies with Acceptance and Commitment Therapy (ACT) to help parents manage st…

This study tests if using a cotton-tipped applicator to hold the eyelid open during eye injections is less painful and faster than the standard metal speculum. About 120 adults with certain eye conditions will take part. The goal is to improve comfort and satisfaction without com…

This study compares two pain relief methods for people undergoing total knee replacement: injecting numbing medicine into the knee area versus blocking several nerves around the knee. The goal is to see which method reduces the need for strong painkillers like opioids in the firs…

This study tests whether neurofeedback — a type of brain training using real-time brainwave feedback — can reduce musculoskeletal pain in people with chronic inflammatory bowel disease (IBD). Eighty adults with IBD and persistent pain will be randomly assigned to either 8 session…

This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control g…

This study tests if a new treatment—mild nerve stimulation on the ear plus personalized music—can reduce the annoyance of chronic tinnitus (ringing in the ears) better than standard therapy. About 386 adults with bothersome tinnitus for at least 6 months will be randomly assigned…

This study tests whether watching a 360° relaxing nature video through a VR headset during a Pap smear can lower pain and anxiety. Sixty women aged 18–65 will be randomly assigned to either the VR group or standard care. Researchers will measure pain and anxiety levels to see if …

This study tests whether a special light therapy (photobiomodulation) can reduce pain and improve jaw function in people with myofascial temporomandibular disorder (TMD), a condition causing muscle pain in the face and jaw. About 140 adults will be split into three groups: light …

This study will compare three types of anesthesia for people having ankle surgery: total intravenous anesthesia with a nerve block, general anesthesia with a nerve block, and spinal anesthesia. The goal is to see which method allows patients to recover and leave the hospital the …

This study tests whether using a smartwatch and mobile app, along with standard care, can help adults with chronic low back pain manage their symptoms better. Eighty adults will be split into two groups: one gets standard treatment alone, the other also uses a smartwatch and app …

This study tests whether adding low-dose ketamine to standard morphine pain pumps helps teens use less morphine after scoliosis surgery. About 114 patients aged 10-18 will be randomly assigned to get either the combo or morphine alone. The goal is to see if the combo reduces opio…

This study tests whether a special way of talking by nurses can help adults with burns feel less pain and worry during dressing changes. About 62 people will be split into two groups: one gets the special comfort talk, the other gets usual care. The goal is to see if simple, supp…

This study explores how visual impairment affects movement and daily activities, and tests a wearable system called VIS4ION that provides audio and touch cues to help users navigate. Researchers will enroll 150 adults with visual impairment and healthy controls to see if the devi…

This study tests if using scalp nerve blocks and a drug called dexmedetomidine can reduce the need for strong opioid painkillers and prevent confusion after brain tumor surgery. About 2000 adults having brain surgery will be randomly assigned to receive one or both treatments, or…

This study tests an investigational drug called Omega-DEK plus L-carnitine in 34 children aged 3 to 6 with childhood apraxia of speech (CAS). The study lasts 20 weeks and first gives everyone the treatment, then randomly assigns some to a placebo to see if the treatment helps mai…

This study tests whether rimegepant, a drug used for migraines, can quickly reduce dizziness from conditions like vestibular migraine. About 370 adults with moderate to severe dizziness will receive either rimegepant plus betahistine or betahistine alone. The main goal is to see …

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This clinical trial tests whether transcranial magnetic stimulation (TMS) can restore vision in adults with severe retinal degeneration. Over 100 participants will receive either real TMS or a sham (fake) treatment for five days, and their eyesight will be checked up to a year la…

This study compares two injections—botulinum toxin (Botox) and local anesthetic—to see which better relieves pain from nerve damage (neuroma) after limb injury or amputation. About 100 adults with moderate to severe pain will receive one injection and be followed for 8 weeks. The…

This study tests whether Emotional Freedom Techniques (EFT) — a therapy that combines tapping on specific body points with focused thoughts — can help people recovering from coronary artery bypass surgery. Researchers will compare 33 patients who receive EFT plus standard care ag…

This study tests whether adding neostigmine to a standard numbing medicine (bupivacaine) in a belly-wall nerve block can improve pain control after cesarean delivery. About 58 women having planned C-sections will receive either the combo or the standard block alone. The goal is t…

This study tests whether using a cold spray or a Buzzy device (a vibrating cold pack) can reduce pain and fear during penicillin injections. Ninety adults receiving intramuscular penicillin will be randomly assigned to one of three groups: cold spray, Buzzy device, or standard ca…

This early-stage trial will give a single 10 mg dose of psilocybin to 70 adults recovering from trauma surgery who also have opioid use disorder. Researchers want to see if it's safe and practical to give psilocybin in the hospital, and how it affects pain, mood, and opioid use o…

This study tests two non-drug methods—a device called ShotBlocker and a tapping technique called Helfer—to see if they can reduce pain and fear during hormone injections in breast cancer patients. 99 women will be randomly assigned to one of three groups. The goal is to find a si…

This study tests a combination of two pain-relief methods—a sedative drug called dexmedetomidine and a local anesthetic injected into the scalp—for people undergoing brain tumor surgery. The goal is to see if this approach reduces the need for strong opioid painkillers after surg…

This study tests if giving the numbing drug bupivacaine through a chest tube can reduce pain after minimally invasive lung surgery. About 249 adults having video-assisted thoracoscopic surgery will receive either a low or high dose of bupivacaine, or a placebo. The main goal is t…

This study will test whether teaching patients to mindfully listen to jazz music for 15 minutes can lower their pain while they wait in the emergency department. The researchers will enroll 60 adults with neck or back pain and compare the music approach to a standard mindful pain…

This study tests whether umPEALUT, a supplement that reduces inflammation, can help people with tinnitus. The researchers believe that inflammation in the ear and brain may cause or worsen the phantom sounds. One hundred adults with tinnitus will receive either the supplement or …

This study tests whether meditation or a health education program can improve quality of life and mental health for people with irreversible age-related vision loss and their caregivers. About 150 participants will be assigned to either meditation training or health classes, both…

Frozen shoulder causes pain and stiffness. A common treatment called hydrodistension injects fluid into the shoulder joint to stretch it, but it can be painful. This study tests whether giving a nerve block first can reduce that pain and improve results. Fifty adults with frozen …

This trial tests two different nerve block methods to control pain after laparoscopic gallbladder removal. Sixty adults undergoing elective surgery will receive either a newer single-puncture block or an external oblique intercostal plane block, while a control group gets only st…

This study tests whether a mix of nitrous oxide (laughing gas) and oxygen can reduce pain during in-office bladder Botox injections for overactive bladder. About 96 adult women will receive either the gas plus standard numbing medicine or a sham mask plus standard care. Participa…

This study compares opioid-free anesthesia to standard opioid-based anesthesia for people having laparoscopic pancreatic surgery. The goal is to see if avoiding opioids leads to less pain and lower opioid use after surgery. Two hundred adults aged 18-80 will take part, and resear…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study tests a new device called Medstrom that monitors pain, sedation, and muscle relaxation all in one during laparoscopic colon cancer surgery. Thirty patients will be randomly assigned to either the Medstrom device or standard monitoring. The goal is to see if the device …

This study compares opioid-free anesthesia to standard opioid anesthesia in 200 adults undergoing pancreatic surgery. The goal is to see if avoiding opioids during surgery can still control pain well and reduce the need for painkillers afterward. Participants will have their pain…

This study looks at whether taking a daily supplement of lutein, zeaxanthin, and meso-zeaxanthin (natural pigments found in plants) can improve contrast sensitivity—the ability to see subtle differences in light and dark—in healthy Chinese adults aged 35 and older. Over 12 months…

This study tests whether two common antioxidants, N-Acetylcysteine (NAC) and Alpha-Lipoic Acid (ALA), can improve pain control and reduce the need for strong painkillers after laparoscopic appendix removal. 180 adults aged 18-65 undergoing this surgery will receive either NAC, AL…

This study compares two nerve block techniques—dual external oblique fascial plane block and erector spinae plane block—for pain control after percutaneous nephrolithotomy (PCNL), a surgery to remove large kidney stones. Ninety adults will be randomly assigned to receive one of t…

This study tests whether adding a painkiller (ketorolac) to a standard sedative (midazolam) makes flexible bronchoscopy more comfortable and safer for patients. Flexible bronchoscopy is a procedure where a thin tube is inserted into the lungs to diagnose or treat problems, but it…

This study tests whether wearing virtual reality (VR) glasses during needle insertion can reduce pain and anxiety in hemodialysis patients. 150 adults with end-stage kidney disease will either receive standard care or watch a calming 360-degree underwater video through VR goggles…

This early study tests whether a wearable ultrasound device can safely stimulate retinal cells and help restore vision in people with age-related macular degeneration or retinitis pigmentosa. Five participants will receive short ultrasound pulses while reporting what they see. Th…

This study tests whether Meta AI glasses, connected to the Be My Eyes network, can help people with permanent vision loss walk and move around more easily. The glasses describe scenes and objects in real time. Fifty participants will use the glasses and report changes in their qu…

This study compares two ways to insert a cochlear implant: using a robotic device or the standard manual method. Researchers want to see which approach leads to better hearing one year after surgery. The study will enroll 32 adults with hearing loss, randomly assigning them to on…

This study tests whether a simple questionnaire-based pain calculator can help doctors choose the right pain medication for women undergoing in-office gynecologic procedures like IUD insertion or biopsy. About 200 participants will either get pain meds based on the calculator or …

This study tests whether watching 3D movies can improve depth perception and vision in children aged 4 to 12 who still have some vision loss from lazy eye (amblyopia) despite prior treatment. Forty children will be randomly assigned to watch three movies in either 3D or 2D, then …

This study tests whether patching the stronger eye in the morning (8-10 AM) or evening (5-7 PM) works better for improving vision in children with lazy eye (amblyopia). About 100 children aged 4-8 will wear an eye patch for 2-6 hours daily over 6 months. The goal is to see if tim…

This study tests whether adding lidocaine, a numbing medicine, to standard pain treatment can lower the amount of strong opioids needed during severe sickle cell pain crises. About 104 adults with sickle cell disease who are in the intensive care unit for a pain crisis will take …

This study tests whether a 12-week mobile app therapy called Multimodal Acoustic Therapy (MAT) can improve how well children and teens with cochlear implants perceive music and enjoy it. Twenty-five participants aged 10 to 19 will use the app at home and be followed for another 1…

This study tests whether a device that gently stimulates a nerve in the ear can help reduce the amount of strong painkillers (opioids) needed after major abdominal surgery. About 108 adults will receive either the real stimulation or a sham version while in the intensive care uni…

This study tests whether a nerve block (injecting numbing medicine near the cheekbone) can control pain after tonsillectomy in children aged 3-9, reducing the need for opioids. Sixty kids having tonsil surgery for sleep apnea will be randomly assigned to get either the nerve bloc…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce pain in sedated patients in the intensive care unit (ICU). Forty adults on ventilators and receiving morphine will receive either real or fake tDCS. The goal is to see if tDCS can lower pai…

This Phase 2 trial tests a topical anesthetic marker applied to the skin to reduce pain from needle pricks. Twenty adults will have the marker applied to their forearm, and pain will be measured every 10 minutes for 40 minutes compared to untreated skin. The goal is to see how we…

This study tests whether a 20-minute hot water foot bath can reduce pain and help patients pass gas sooner after laparoscopic gallbladder removal. 62 adults will be randomly assigned to receive the foot bath or standard care. The goal is to see if this simple, drug-free method im…

This study tests a new pain management system for people recovering from incarcerated mixed hemorrhoid surgery. The system includes pain medicine before surgery, traditional Chinese medicine treatments, and personalized nursing. Researchers want to see if it reduces pain and comp…

This study looks at different ways to manage pain after a type of kidney stone surgery called PCNL. Researchers will track how much opioid pain medicine patients need and their pain levels. The goal is to find which method works best to reduce pain and limit opioid use.

This study tests two quick, drug-free mental techniques—body-scan mindfulness and guided imagery—to see if they can lower acute pain in adults staying in short-stay hospital wards. 160 participants will be randomly assigned to one of these techniques or a brief educational sessio…

This study will test whether rinsing with cold water (15-20°C) reduces mouth soreness and improves comfort compared to room-temperature water in 200 head and neck cancer patients undergoing radiotherapy. Participants will rinse four times daily for six weeks. The goal is to see i…

This study compares three common pain relief methods for people having laparoscopic gallbladder surgery: numbing the surgical area with bupivacaine, a nerve block in the back (ESP block), or a small dose of morphine into the spinal fluid. The goal is to see which method reduces p…

This study tests two different ultrasound-guided nerve blocks to see which one provides better pain relief after breast cancer surgery. 70 adults aged 18-65 will be randomly assigned to receive one of the two blocks. The goal is to reduce the need for strong painkillers and impro…

This study will observe 120 adults undergoing video-assisted thoracoscopic surgery (VATS) to compare three pain management approaches: a nerve block (SPSIPB), an epidural, and standard opioid painkillers. Researchers will measure pain scores and how much extra pain medicine patie…

This study looks at whether a common procedure for varicose veins—called endovenous ablation—can also reduce knee pain in people aged 80 and older. The researchers will follow 50 participants for one year after treatment, measuring pain and knee function. The goal is to see if im…

This study looks at whether giving a scalp nerve block before a craniotomy (brain surgery) can lower pain after surgery and reduce the need for strong painkillers. Researchers will compare giving the block before the first cut versus after. The study plans to enroll 64 adults age…

This study tests whether listening to music during a transperineal prostate biopsy can lower pain and anxiety. About 78 men over age 50 with suspected prostate cancer will be randomly assigned to have music or no music during the procedure. The goal is to see if music helps patie…

This study compares three types of physical therapy for adults aged 20-60 with prolonged shoulder pain. Participants are randomly assigned to routine therapy, tendon-specific exercises, or therapy that also addresses psychological factors. The goal is to see which approach best h…

This pilot study tests a mixed-reality VR headset to help diagnose and treat 'neglect' — a condition where brain injury patients ignore one side of their world. Five adults with stroke, tumor, or trauma will use the device at home to track and improve their attention. The goal is…

This study tests whether watching an educational video before surgery, plus using virtual reality (a relaxing forest walk) or listening to music during the procedure, can lower anxiety and pain for people having ingrown toenail surgery. About 175 adults will be split into three g…

This study tests whether a long-acting form of the painkiller bupivacaine (called liposomal bupivacaine) can reduce the need for opioid pain medicine after laparoscopic liver, gallbladder, or pancreas surgery. Sixty adults aged 18–80 will receive either the long-acting painkiller…

This study tests whether small changes—like playing calming music, showing a relaxing video, or giving numbing gel at the right time—can reduce pain and anxiety during a bladder cancer exam or treatment. About 378 adults with bladder cancer will be randomly assigned to receive on…

This study looks at whether watching a virtual reality (VR) video can help children aged 7 to 12 feel less pain and fear when getting an IV. About 150 kids having day surgery will be randomly placed into one of three groups: watching an aquarium video, a kaleidoscope video, or ge…

This study compares a new non-opioid drug called suzetrigine (Journavx) to the opioid Norco for pain after wisdom tooth removal or jaw surgery. It involves 76 adults aged 18-45. The goal is to see if suzetrigine controls pain just as well without the risk of addiction or breathin…

This study tests whether using a virtual reality (VR) headset can reduce anxiety before total knee replacement surgery and lessen pain afterward. 64 patients will watch educational videos about the operating room before surgery and relaxing nature videos after surgery. The goal i…

This study tests whether a single injection of the numbing drug ropivacaine around nerves can reduce pain and the need for narcotic pain pills in children and teens after ACL knee surgery. About 160 participants aged 13 and older will either receive the nerve block or not during …

This study tests a miniaturized smart contact lens in 32 people—some healthy, some with Stargardt's disease—to see if it is comfortable and easy to use. The lens tracks eye movements to help with vision tasks. Researchers will check for side effects and ask participants how they …

This study tests two different nose sprays—dexmedetomidine and ketamine—to see which one better calms children aged 2 to 6 before surgery. Sixty kids will receive one of the two sprays, and researchers will measure how sleepy they get and how easily they separate from their paren…

This study tests whether injecting a local anesthetic (mepivacaine) into the ligaments around the cervix can reduce pain during an outpatient hysteroscopy. About 70 women who have never had a hysteroscopy will be randomly assigned to receive either the anesthetic or a placebo. Th…

This study tests whether Su Jok therapy—a technique using hand massage and seeds on specific points—can lower pain in newborns during a heel lance blood test. Sixty-six full-term babies will be randomly assigned to receive the therapy or standard care. Pain will be measured using…

This study tests whether wearing a virtual reality headset with calming scenes and hypnotic speech can lower pain and anxiety during minimally invasive leg artery surgery done under local anesthesia. About 90 adults with peripheral artery disease will take part. The main goal is …

This study tests whether automated text message reminders can encourage people with hearing loss to get hearing aids. Researchers will enroll 190 adults who have been recommended for hearing aids but do not yet use them. Participants will receive texts with basic information abou…

This study tests a new care pathway for adults getting a cochlear implant. Instead of the usual nine clinic visits in the first year, the new plan uses early activation of the implant and remote monitoring visits. The goal is to see if this approach is at least as good for hearin…

This study compares a computer-controlled anesthetic device (SleeperOne) to a traditional syringe for numbing kids' teeth before extraction. 28 children aged 3-5 will be randomly assigned to one method. Pain, anxiety, and heart rate will be measured to see if the device makes the…

This study tests whether letting children watch cartoons or giving them a gentle foot massage before surgery can reduce their nausea, pain, and anxiety. About 105 children aged 4 to 6 will be assigned to one of three groups: watching a cartoon, receiving reflexology, or standard …

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works in people. Participants will be monitored for safety and any effects. The study is still ongoing, and details about who can join are not yet …

This study looks at whether people who better understand the risks and steps of their upcoming lung procedure (endobronchial ultrasound) need less propofol, a sedative. Researchers will ask participants questions about what they understood from the consent process and measure the…

This study investigates whether auditory and cognitive training can help adults with cochlear implants understand speech better. Researchers will enroll 100 experienced implant users and randomly assign them to different training programs. The goal is to see if these intervention…

This study will see if setting up vision centers in rural South Asian communities helps more people get the eye care they need. Researchers will compare communities that get a vision center right away with those that wait. They will check if more people get glasses and if their e…

This observational study aims to understand why individuals perceive colours and visual rivalry differently. Researchers will test 128 adults using computer-based tasks to measure colour perception and binocular rivalry (when each eye sees a different image). They will also explo…

This observational study will compare dental caries (tooth decay) experiences and quality of life between visually impaired and sighted children aged 6 to 14. Researchers will use a special questionnaire to measure how cavities affect daily life, and will also count decayed, miss…

This study will follow 40 older adults (age 60+) with severe hearing loss who have or will receive a cochlear implant. Researchers want to see if the implant improves social interaction and thinking skills. Participants will fill out questionnaires, wear a small audio recorder fo…

This study aims to develop new methods to help veterans with vision loss caused by age-related macular degeneration. About 20 veterans aged 50 and older with reduced vision will take part. Researchers will measure how well they recognize objects and how their brains respond befor…

This study follows 800 people who are already scheduled to receive ketamine infusions for chronic pain as part of their regular care. Researchers will use surveys to track pain levels, opioid use, and overall well-being for up to 16 weeks. A comparison group includes patients who…

This study aims to create a tool that predicts age-related hearing loss using artificial intelligence and blood samples. Researchers will analyze 15 years of data from 1,000 older adults and also test 100 seniors for proteins linked to memory problems. The goal is to identify ris…

This study will see if outdoor activities like rafting, canyoning, and kayaking can help teens with and without disabilities feel more included and connected. About 35 teens aged 12–16 will take part, with some doing the activities and others not. Researchers will measure changes…

This study will follow over 3,000 older adults for three years to see how age-related hearing loss is connected to dementia. Researchers will use hearing tests, cognitive assessments, and blood markers to build a 'Hearing Health Clock' and early screening tools. The goal is to be…

This study looks at how temporary noise exposure at levels allowed by law (around 85 dB) affects hearing and thinking in 40 healthy adults aged 18-35. Participants will be exposed to different noise patterns, including with rest breaks, to see if breaks help reduce auditory fatig…

This study looks at how well people who have had a stroke can imagine movements (motor imagery) and how that relates to their neglect, arm function, daily activities, and quality of life. Researchers will assess 50 participants using tests and questionnaires. The goal is to bette…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This study will compare four different non-surgical bone conduction hearing devices in 20 adults aged 18 to 84 with mixed or conductive hearing loss. The goal is to see which device provides the best hearing improvement by measuring hearing thresholds. The results could help guid…

This study tests whether a gentle magnetic pulse called cTBS can improve attention in people who, after a stroke, ignore one side of their surroundings. Sixty adults with right-brain stroke and left-sided neglect will receive real or fake stimulation to the cerebellum or brain's …

This pilot study will test whether over-the-counter (OTC) hearing aids are practical and acceptable for older adults with mild-to-moderate hearing loss who are at risk for dementia. Forty participants aged 50 and older will either use the hearing aids right away or wait three mon…

This study surveys 600 health sciences students (excluding audiology majors) to see what they know and think about hearing loss and hearing aids. Participants fill out a 29-item questionnaire. The goal is to find gaps in knowledge so that education can be improved.

This study tests whether a personalized care approach helps patients with chronic macular diseases (like wet age-related macular degeneration and diabetic macular edema) attend their regular eye injection appointments. Many patients skip these vital treatments, risking further vi…

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study will test whether using virtual reality headsets raises the risk of seizures in adolescents and adults with epilepsy. Forty participants will wear a VR headset while their brain activity is recorded with EEG, comparing periods with the display off, on, and with hand co…

This study surveys 300 primary care professionals in Spain to understand their knowledge and beliefs about musculoskeletal pain. Researchers want to see if healthcare workers unintentionally reinforce fear and disability in patients with chronic pain. The results will help design…

This study looks at whether giving eye doctors AI-generated measurements from retinal images helps them write more accurate and complete reports. About 29 ophthalmologists and trainees will be randomly assigned to use AI tools or just the original images. A panel of senior expert…

This study looks at how platinum-based chemotherapy can cause permanent hearing loss in cancer patients, and whether people from poorer backgrounds are more affected. Researchers will test hearing and thinking skills in 172 patients from North West England before and after treatm…

This study tests whether using ChatGPT alongside traditional bedside training helps nursing students learn pain management better. 156 students will be randomly assigned to either AI-assisted or standard teaching. Researchers will measure changes in knowledge, attitudes, competen…

This study will test two methods for programming electric acoustic stimulation (EAS) in cochlear implant users who still have some natural hearing. One method uses electrical measurements from the inner ear, while the other uses standard hearing tests. The goal is to see which ap…

This study follows 120 people with laryngeal cancer to see how their quality of life, voice, swallowing, pain, and mood change before treatment and at 3, 6, and 12 months after. Researchers will use questionnaires to track these changes. The goal is to better understand recovery …

This study will look at what happens when a standalone eye center becomes part of a government hospital in Kalaiya, Nepal. Researchers will track changes in how many patients visit, follow up, and get referrals, and ask patients and staff what they think. The goal is to learn if …

This study will enroll 400 older adults (over 60) having heart surgery to see if genetic differences affect how well methadone and oxycodone work and their side effects. Researchers will measure pain, nausea, breathing problems, and sedation. The goal is to personalize pain treat…

This study looks at 35 industrial workers who have hearing problems from loud noise at work. Researchers will test their balance and ask about daily activities to see if hearing loss affects how steady they feel. The goal is to understand if hearing issues are linked to balance t…

This study asks children aged 6-16, their parents, and clinicians to vote on the most important research topics in pediatric anesthesia and perioperative medicine. Over 1,000 participants in Switzerland will complete online surveys to create a ranked list of the top 10 priorities…

This early-phase study tests whether the drug Cobenfy KarXT can change brain activity linked to memory in 50 adults with epilepsy who are already scheduled for brain surgery. Participants will take either the drug or a placebo on separate days and perform memory tasks while their…

This study looks at how brain processes like attention and inhibition help people adapt after hearing loss. Researchers will use EEG to measure brain waves in 90 adults receiving cochlear implants, comparing them to normal-hearing participants. The goal is to find brain markers t…

This study looks at a new way to assess pain in intensive care patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to adjust pain medicine more safely. Researchers will compare data from 400 adults to see if the ne…

This study will test a new ultrasound device called Accuro 3S that provides live guidance during epidural or spinal needle placement. Researchers want to see if it reduces the number of needle attempts and improves accuracy compared to standard methods. The trial will enroll 50 p…

This study investigates the connection between temporomandibular joint (TMJ) disorders and tinnitus (ringing in the ears). Researchers will use 3D jaw imaging and hearing tests in 50 adults to see if jaw bone shape and arthritis are linked to tinnitus. The goal is to better under…

This study will observe 50 adults undergoing total knee replacement to see how different anesthesia methods affect pain and painkiller use in the first 48 hours after surgery. Participants receive either general anesthesia with a nerve block, spinal anesthesia with a nerve block,…

This study looks at 10 adults over 50 with hearing loss and one weak balance ear. It compares implanting the device in the weak-balance ear versus the good-balance ear. The goal is to see if choosing the weaker side helps reduce dizziness after surgery.

This study at Stanford University will test how the brain responds when visual information is turned into patterns of sound or touch. Two hundred blind and sighted participants will use special devices (BrainPort and AI Sight) for 5 weeks. Researchers will use brain scans and per…

This study aims to see if virtual reality tests can better measure how age-related macular degeneration affects daily life compared to standard eye exams. Researchers will enroll 60 participants, including healthy adults and those with the eye condition. The goal is to develop a …

This study looks at children born prematurely who had retinopathy of prematurity (ROP), a disease that can cause blindness. Some were treated with laser, others with injections, and some had ROP but no treatment. Researchers will compare their vision and retina structure to see w…

This study looks at whether measuring the stapedius reflex (a tiny ear muscle reflex) can help program cochlear implants in children aged 0 to 7. Currently, programming relies on behavioral responses, which can be hard to get from very young kids. The researchers will test the re…

This study compares lung function and breathing muscle strength between children with hearing loss and healthy children aged 7–16. Researchers want to see if hearing loss affects more than just hearing—possibly impacting breathing and physical development. The goal is to better u…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study will test whether a low power LASER, used for pain relief, can also change heart rate and the body's automatic nervous system. Researchers will monitor 45 healthy volunteers before, during, and after LASER treatment. They will also use a numbing gel to see if the effec…

This study looks at whether objective measurements, like the stapedius reflex, can help doctors program cochlear implants more precisely. Currently, tuning relies on patients describing what they hear, which can be subjective. Researchers will test 60 adults with severe hearing l…

This study looks at how mental health issues, like depression or anxiety, affect people with mild cognitive impairment (MCI). Researchers will study 118 adults aged 50-72 to see how these issues impact their awareness of memory problems, social life, and work. The goal is to bett…

This pilot study will test two new eye imaging devices (R1 and HighRes OCT) against a standard device in 97 adults with healthy eyes or eye diseases like macular degeneration and diabetic retinopathy. Researchers will compare image quality and how well key eye structures are seen…

This study aims to see if elderly patients with age-related macular degeneration (AMD) find a new web-based eye-tracking system easy and acceptable to use at home. The system is designed to help patients monitor their vision without frequent clinic visits. Thirty patients aged 55…

This study looks at whether exercising at different times of day changes how we feel pain. Fifty-six healthy adults will do a 12-minute high-intensity workout in both the morning and evening. Researchers will measure pain thresholds before and after exercise to see if time of day…

This study will follow 200 children with epilepsy to find clues—like brain scans or EEG patterns—that show which kids are likely to become resistant to standard seizure medications. The goal is to catch these cases early and consider alternative treatments such as a ketogenic die…

This study will track 139 newborns who have seizures in their first month of life to learn how common these seizures are, what causes them, and how the babies fare during their hospital stay. Researchers will use exams, blood tests, and brain scans to gather information. The goal…

This study looks back at medical records of 200 people with inherited retinal diseases, like retinitis pigmentosa and Stargardt disease. Researchers will analyze vision tests and eye scans to see how these diseases progress and how genetics affect symptoms. The goal is to find be…

This study looks at two types of nerve blocks—TAP and rectus sheath—used to manage pain after a hysterectomy through a bikini-line cut. Researchers will measure how much of the incision each block numbs and compare pain scores and morphine use. About 30 women having planned surge…

This study looks at how low body temperature during lung cancer surgery (using a tiny camera) affects pain and complications after the operation. About 144 adults having this surgery will have their temperature tracked continuously. The goal is to understand if getting cold durin…

This study looks at whether shifting text to a different part of the eye can help people with central vision loss read faster and more accurately. Researchers will test 100 participants with conditions like macular degeneration using various reading tasks. The goal is to find bet…

This study will test whether a specially designed card game can improve knowledge and health beliefs about HPV in hearing-impaired adults. Forty participants will be randomly assigned to play the card game or receive standard education. The goal is to see if this fun, visual meth…

This study looks at whether turning down the volume of anesthesia alarms can help surgical trainees think more clearly during practice surgeries. About 26 surgeons-in-training will perform simulated procedures with either standard or quieter alarms. Researchers will measure menta…

This study looks at how opioid painkillers affect the success of immunotherapy in 100 people with advanced lung cancer who have moderate to severe pain. Researchers want to see if better pain control helps immunotherapy work better, and whether opioids themselves change the treat…

This study will look at 30 people with macular dystrophy to see how different eye tests—like OCT scans, mfERG, and standard vision tests—relate to each other. The goal is to better understand how these tests can track vision changes. No treatment is being tested; this is purely a…

This study will follow 50 adults with varicose veins and chronic knee pain who are scheduled for standard vein treatment (laser or radiofrequency ablation). Researchers will measure changes in knee pain, stiffness, and function before and after the procedure. The goal is to see i…

This study will observe 100 adults who receive the Sentio bone conduction hearing system as part of their normal care. The device is implanted under the skin and sends sound vibrations through the skull to the inner ear. Researchers will track how often the device is used success…