One-Shot gene therapy aims to end monthly eye injections for wet AMD
NCT ID NCT07178249
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This early-stage trial tests EXG202, a gene therapy given as a single injection into the eye for people with wet age-related macular degeneration (AMD). The goal is to see if it is safe and can produce a protein that blocks abnormal blood vessel growth long-term, potentially reducing the need for frequent anti-VEGF injections. About 60 participants aged 50 and older with active wet AMD will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- EXG202 (gene therapy injection)
- What this could lead to
- If successful, this one-time gene therapy could reduce or eliminate the need for frequent eye injections for wet AMD, helping maintain vision with less hassle.
- What could go wrong
- This is an early phase I/II trial with only 60 participants, so safety and effectiveness are not yet proven. Gene therapy carries risks like inflammation or immune reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New hope for wet AMD patients: a simple pill may drain stubborn eye fluid
- Gene therapy could end frequent eye injections for wet AMD
- Gene therapy for wet AMD: could this mean fewer eye injections?
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- Elderly AMD patients to test Easy-to-Use home vision tracker