Perceptual disorders

This study tests the safety of a drug called ASP3021 (avacincaptad pegol) for people in Japan with geographic atrophy, an advanced form of age-related macular degeneration that causes vision loss. Twenty participants will receive monthly injections into the affected eye for 12 mo…

This pilot study tests whether injections of platelet-rich plasma (PRP) made from a patient's own blood can help preserve vision in people with retinitis pigmentosa or a related condition called EMAP. Thirty participants receive three injections over four months, and researchers …

This study tests whether a daily pill called BHV-7000 can reduce seizures in adults with refractory focal epilepsy—a type of epilepsy that doesn't respond well to current medications. About 390 participants will receive either a low dose, a higher dose, or a placebo for 8 weeks. …

This pilot study tests whether adalimumab, an anti-inflammatory drug, can help preserve vision in people with retinitis pigmentosa or a related condition called EMAP. Thirty participants will receive three injections into the eye over four months. The main goal is to see if the t…

This study is testing a device called the BONEBRIDGE, a bone conduction implant that helps people with certain types of hearing loss hear better. The implant is placed under the skin behind the ear during surgery and works by sending sound vibrations through the skull bone direct…

This study tests whether metformin, a widely used diabetes drug, can safely slow vision loss in people with ABCA4 retinopathy (Stargardt disease). Fifty-five participants aged 12 and older will take metformin by mouth for 24 months, with regular eye exams to track changes. The go…

This phase 3 trial tests EYP-1901, a new eye injection that may last longer than current treatments for wet age-related macular degeneration (AMD). About 400 people with wet AMD will receive either EYP-1901 or standard aflibercept injections over 2 years. The main goal is to see …

This phase 3 trial tests EYP-1901, a new eye injection that may last longer than current treatments for wet age-related macular degeneration (AMD). About 400 participants will receive either EYP-1901 or the standard drug aflibercept. The goal is to see if EYP-1901 can maintain or…

This study tests whether adding perampanel (Fycompa) to current epilepsy medications can reduce seizures in children aged 1 month to 18 years. About 100 children with specific epilepsy syndromes or partial-onset seizures will receive the drug. The main goal is to see if at least …

This study tests a gene therapy called laruparetigene zovaparvovec (AGTC-501) in 10 males aged 12-50 with X-linked retinitis pigmentosa, a genetic condition that leads to vision loss. The therapy is injected into both eyes to deliver a working copy of the RPGR gene. The main goal…

This study compares a targeted drug called selumetinib to standard chemotherapy (carboplatin/vincristine) in children aged 2 to 21 with neurofibromatosis type 1 (NF1) and low-grade glioma, a type of brain tumor. The goal is to see if selumetinib works as well or better at control…

This study tests a single injection of ZVS101e, a gene therapy that delivers a working copy of the CYP4V2 gene directly into the retina. It is for adults with Bietti's crystalline dystrophy, a rare inherited condition that leads to progressive vision loss. The trial will check wh…

This study tests a single injection of ZVS101e gene therapy for people with Bietti's crystalline dystrophy, a rare inherited condition that leads to progressive vision loss. The therapy delivers a working copy of the CYP4V2 gene directly to the retina. Researchers will measure wh…

This study provides ZVS101e, a gene therapy, to 32 people with Bietti crystalline corneoretinal dystrophy (BCD) who were in the control group of a previous Phase III trial. The therapy uses a harmless virus to deliver a working gene to the eye, aiming to slow vision loss. The mai…

This phase 3 trial tests whether an oral antioxidant called N-acetylcysteine (NAC) can slow the loss of vision in people with retinitis pigmentosa, an inherited eye disease that causes gradual blindness. About 485 adults aged 18 to 65 are taking NAC or a placebo for several years…

This study follows 158 people in France who are prescribed Epidyolex (a cannabidiol-based medicine) for seizures as part of their normal care. Researchers will track how long people stay on the treatment, side effects, seizure frequency, and changes in daily functioning and quali…

This early-stage study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with advanced or recurrent solid tumors that have specific genetic changes. The main goal is to find the safest dose with the fewest side effects. The…

This early-phase study tested a new drug called BHV-7000 in 5 people with epilepsy who have a brain implant (RNS) that records brain activity. The goal was to see if the drug reduces abnormal electrical activity linked to seizures. Participants took the drug for 4 weeks, and thei…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study is a follow-up to a Phase 3 trial testing a gene therapy called AAV5-hRKp.RPGR for people with X-linked retinitis pigmentosa, a genetic eye disease that causes vision loss. The treatment aims to slow or stop vision decline by delivering a working copy of the RPGR gene …

This study tests a gene therapy called botaretigene sparoparvovec in the second eye of people with X-linked retinitis pigmentosa, a genetic condition that causes vision loss. The 24 participants previously received the therapy in one eye and are now being followed for safety and …

This study looks at a rare disease called KSHV-associated multicentric Castleman's disease (MCD), caused by a virus. Researchers are testing several drug combinations, including chemotherapy and antivirals, to see if they can control the disease. The study also tracks how the dis…

This Phase 3 study tests a gene therapy called AAV5-hRKp.RPGR in 4 Japanese people with X-linked retinitis pigmentosa, a genetic condition that causes progressive vision loss. The therapy is injected into the eye to deliver a working copy of the RPGR gene. The main goal is to che…

This study follows about 111 people with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex who are taking Epidyolex (a CBD oral solution) for seizures. Researchers track how many stay on the drug for a year and how many seizure-free days they have. It's an o…

This study tests a device called the PRIMA System, which includes an implant placed under the retina and a special visual processor worn by the patient. The goal is to help people with advanced dry age-related macular degeneration (geographic atrophy) regain some central vision. …

This study follows 629 older adults for 3 years to see if using hearing aids and getting hearing rehab can slow down memory loss and lower the risk of dementia. Participants were already in an earlier trial and now continue with hearing care or a delayed treatment. The goal is to…

This phase 3 trial tests a single injection of 4D-150 gene therapy in 480 adults with wet age-related macular degeneration (AMD). The goal is to see if one treatment can control the disease as well as or better than standard aflibercept injections given every few weeks. Participa…

This study looks at how safe and tolerable the drug pegcetacoplan (Syfovre) is for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 300 patients who are already prescribed the drug by their doctor will be followed …

This study compares fentanyl and hydromorphone (Dilaudid) for sedating patients on mechanical ventilators in the ICU. About 300 adults will be randomly assigned to one of the two drugs. The main goal is to see if one leads to lower total opioid use. The results could help guide s…

This study tests an experimental drug called VP-001 for people with a rare genetic eye disease that causes vision loss. The drug is injected into the eye and aims to slow or stop further damage. Researchers will check safety and measure any changes in eyesight over about two year…

This study tests a new totally implantable cochlear implant system (TICI G2) that has a microphone under the skin, so you can hear without any external devices. Researchers will enroll 18 adults with sensorineural hearing loss to see how well the internal microphone works over ti…

This early-stage study tests a new drug called EYE201, given as three eye injections over 12 weeks, to see if it is safe and can help reduce swelling in the back of the eye. It includes people with three different eye conditions that cause vision loss: branch retinal vein occlusi…

This study tests an experimental implant (AR-14034) that slowly releases medication inside the eye to treat wet age-related macular degeneration (AMD). The goal is to see if it is safe and can work as well as or better than standard anti-VEGF injections, which require frequent do…

This Phase 3 trial tests a single injection of Ixo-vec gene therapy in 311 people with wet age-related macular degeneration (AMD). The goal is to see if it can maintain or improve vision as well as standard aflibercept injections, but with fewer follow-up treatments. Participants…

This pilot study aimed to test whether a mixture of dexamethasone, hyaluronic acid, and a green dye could be safely injected into the ear to treat certain types of hearing loss that don't improve with standard treatments. The plan was to enroll 26 adults with sudden hearing loss,…

This early-stage trial tests a new oral drug called OCT-980 for people with a specific inherited eye disease (autosomal dominant retinitis pigmentosa) that causes gradual vision loss and blindness. The study first gives a single dose to healthy volunteers to check safety, then mu…

This early-phase trial tests an experimental drug called nL-FLVC-001 in a single person with posterior column ataxia with retinitis pigmentosa (PCARP), a rare genetic condition that causes vision loss and coordination problems. The drug is an antisense oligonucleotide injected in…

This phase 3 trial tests whether a daily injection of elamipretide can slow vision loss in people with dry age-related macular degeneration (AMD). About 313 adults aged 55 and older with early dry AMD will receive either the drug or a placebo for 96 weeks. The main goal is to see…

This study planned to test a small telescope implant inside the eye for people with severe vision loss from advanced age-related macular degeneration (AMD). The device was meant to improve central vision by magnifying images onto healthy parts of the retina. However, the trial wa…

This study tests the long-term safety and effectiveness of XEN1101 (azetukalner) in 880 adults with focal or tonic-clonic seizures. Participants who completed earlier studies will take XEN1101 capsules for up to 6 years. Researchers will track side effects and changes in monthly …

This study tests whether a cochlear implant can safely and effectively restore hearing in people who become deaf in one ear after surgery to remove a benign tumor (vestibular schwannoma) or to treat Meniere's disease. Fifteen participants will receive the implant during their sur…

This study tests a drug called selumetinib in children and young adults with low grade glioma that has come back or not responded to other treatments. The drug works by blocking certain enzymes that help tumor cells grow. The goal is to find the best dose and see if it can shrink…

This study tests a gene therapy called SPVN06 for retinitis pigmentosa, an inherited eye disease that causes gradual vision loss. The treatment is given as a single injection under the retina. The trial includes 33 adults with advanced disease and will check safety and whether it…

This study tests a new medicine called BI 771716 for geographic atrophy, an advanced form of age-related macular degeneration that causes vision loss. About 202 adults aged 50 and older will receive either the new drug or an existing treatment (pegcetacoplan) as eye injections. T…

This early-stage study tests the safety of an experimental drug called RO7669330, given as an injection into the eye, for people with geographic atrophy (GA) due to age-related macular degeneration (AMD). The study involves 27 participants and will monitor side effects and eye he…

This phase 3 trial tests whether a refillable eye implant delivering ranibizumab can be safely used every 36 weeks instead of every 24 weeks for people with wet age-related macular degeneration. About 451 participants who have already responded to standard injections will receive…

This study tests whether monthly eye injections of ANX007 can prevent significant vision loss in people with dry age-related macular degeneration (AMD) that has progressed to geographic atrophy. About 659 participants will receive either the drug or a sham injection. The main goa…

This study tests a new drug called zifibancimig for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The drug is given either as an eye injection or through a small implant placed in the eye that releases the drug over time. The trial involv…

This study checks the long-term safety of the drug BHV-7000 in about 660 adults whose focal epilepsy has not been controlled by other treatments. Participants who completed an earlier study will continue taking the drug while doctors watch for side effects and lab changes. The go…

This early-stage trial tests an experimental drug called OCU-10-C-110, given as an eye injection, in 24 people with wet age-related macular degeneration (nAMD). The main goal is to check safety and tolerability at different doses. Researchers will monitor for side effects over ti…

This study tests whether faricimab, an already-approved eye injection, can be given every 24 weeks (about twice a year) to people newly diagnosed with wet age-related macular degeneration (AMD). The trial involves 274 participants and will measure how well vision is maintained ov…

This study tests a stem cell therapy called OpRegen for people with advanced dry age-related macular degeneration (geographic atrophy). Researchers inject retinal pigment epithelium cells derived from human embryonic stem cells into the eye to see if they can safely replace damag…

This Phase 3 study tests two new drugs, tarcocimab tedromer and tabirafusp tedromer, against the standard treatment aflibercept for wet age-related macular degeneration (AMD). The trial involves 675 participants who have not been treated before. The goal is to see if the new drug…

This study tests a one-time gene therapy called RGX-314 for wet age-related macular degeneration (AMD), a leading cause of vision loss. The treatment aims to help the eye produce its own medicine to stop leaky blood vessels, potentially replacing the need for repeated eye injecti…

This study tests a new type of cochlear implant that is completely hidden under the skin, with no external processor. It is designed for adults with severe hearing loss who do not get enough benefit from hearing aids. The implant picks up sound through a microphone under the skin…

This Phase 3 study tests whether fenfluramine (ZX008) can safely reduce seizures in 87 children and adults with CDKL5 deficiency disorder, a rare genetic condition causing severe epilepsy. Participants receive either the drug or a placebo, followed by an open-label extension wher…

This study tests whether a pre-filled syringe is as safe as the traditional vial when giving the medicine bevacizumab for certain eye diseases. About 120 people with wet age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion will receive inject…

This program offers an experimental treatment called OCU400 to up to 75 adults with retinitis pigmentosa (RP) who cannot join the main Phase 3 study. Participants must be 18 or older, have a confirmed genetic diagnosis of RP (except a specific mutation), and have remaining light-…

This study checks the long-term safety of a gene therapy called EXG102-031 in 12 people with wet age-related macular degeneration (AMD), a condition that can cause severe vision loss. Participants already received the gene therapy in an earlier study and will be monitored for up …

This study follows 100 people with vestibular schwannoma (a non-cancerous ear tumor) who previously received a gene therapy called AAVAnc80-antiVEGF. Researchers will monitor for late side effects and measure tumor size changes over time using MRI scans. The goal is to understand…

This study tests a gene therapy called AGTC-501 in males aged 12 to 50 with X-linked retinitis pigmentosa, a genetic eye disease that causes vision loss. Participants receive one of two doses of the therapy or no treatment, and researchers measure changes in vision under low ligh…

This study follows 30 people who previously received a gene therapy (AAVAnc80-hOTOF) for hearing loss caused by otoferlin gene mutations. Researchers will monitor safety over the long term, checking for late side effects, and measure hearing improvements using brain response test…

This study tests a new gene therapy called OCU410ST for people with Stargardt disease, an inherited eye condition that causes vision loss. Early results show the treatment slowed damage to the retina by nearly half and improved or stabilized eyesight in all treated patients. The …

This early feasibility trial tests a new retinal implant called PRIMA in 5 people with advanced dry age-related macular degeneration who have lost central vision. The device is surgically placed in the eye to stimulate remaining retinal cells. Researchers are checking if it is sa…

This study looks at the long-term safety of everolimus in people with tuberous sclerosis complex (TSC) who have seizures that are hard to control. Participants are already taking everolimus and benefiting from it in an earlier study. The goal is to see if the drug remains safe an…

This phase 3 trial is testing the safety and tolerability of the drug cenobamate (Xcopri) in 140 children aged 2 to 17 with partial-onset (focal) seizures. Researchers will monitor side effects, lab results, and drug levels in the blood. The study is open-label, meaning everyone …

This study tests a bone marrow transplant method that avoids harsh chemotherapy and radiation for people with dyskeratosis congenita, a genetic disorder causing bone marrow failure. The goal is to fix the blood system without worsening lung or liver disease or raising cancer risk…

This study follows 25 people aged 2 to 65 with cerebral palsy or brain damage from lack of oxygen who have already received a new gene therapy given as a nose spray. The therapy delivers 15 genes meant to repair the brain, reduce inflammation, and improve movement and thinking. R…

This study tests a new painless nerve growth factor eye drop (CHF6467) in 36 children and young adults with optic pathway glioma, a brain tumor that often causes vision loss. The goal is to see if the drops can protect or improve vision without the pain side effects of standard n…

This study tests a fully implanted cochlear implant called Acclaim CI in 56 adults with severe to profound hearing loss. The goal is to see if it helps them hear words better than before and to check for any medical problems. Participants get the implant and are followed for up t…

This early-phase study is testing whether stem cell therapies and experimental drugs can help repair inner ear damage in people with hearing loss or tinnitus. Researchers will monitor 120 adults over time using hearing tests and symptom surveys. The goal is to see if these regene…

This study compares cochlear implants to hearing aids in 80 children aged 4 to 14 with hearing loss in one ear. Researchers measure how well kids understand speech and hear in noise before and after getting an implant. The goal is to see if the implant provides better hearing tha…

This study tests a drug called tinlarebant in 60 people with Stargardt disease, a genetic condition that causes vision loss. The goal is to see if the drug can slow damage to the retina and preserve eyesight. Participants take the drug or a placebo, and researchers measure change…

This study is testing a new device called a multichannel vestibular implant for people who have lost most or all of their balance function due to inner ear damage. The implant electrically stimulates the balance nerve to help improve stability and vision during movement. Up to 30…

This study tests whether a personalized, data-driven hearing rehabilitation program can improve hearing, thinking, and quality of life in older adults with mild to moderate hearing loss. Two hundred first-time hearing aid users will be randomly assigned to either the new personal…

This phase 3 trial tests a gene therapy called LX101 in 30 people with inherited retinal dystrophy caused by RPE65 mutations. Participants receive a single injection of LX101 into the eye, while a control group gets no treatment. The study measures changes in functional vision an…

This study tests a gene therapy called OCU400 for people with retinitis pigmentosa, an inherited eye disease that causes vision loss. The treatment is injected under the retina to help light-sensitive cells work better. The trial enrolled 140 people aged 3 and older and measures …

This early study tests a gene therapy called LX101 in 9 people with a rare inherited eye disease caused by RPE65 gene mutations. The therapy delivers a working copy of the gene into the retina via a single injection. The main goals are to check safety and see if it can improve vi…

This phase 2 trial tests a gene therapy called LX102 for wet age-related macular degeneration (nAMD), a leading cause of vision loss. The therapy is injected under the retina and aims to produce a protein that blocks abnormal blood vessel growth, potentially reducing the need for…

This early-stage trial tests a combination treatment for retinitis pigmentosa, a genetic disease that causes blindness. Ten adults receive a single injection of GS030 gene therapy into one eye, then use special glasses that send light signals to the treated retina. The main goal …

This phase 2 study tests the drug sirolimus (rapamycin) in 7 people with idiopathic multicentric Castleman disease who have not improved with standard therapy. The goal is to see if sirolimus can improve symptoms like fatigue, fever, and night sweats, and shrink enlarged lymph no…

This study tests whether cenobamate, already approved for epilepsy, works well when used alone in adults with partial-onset seizures. About 49 participants will take either 100 mg or 200 mg daily, and researchers will track how many become seizure-free for 26 weeks. The goal is t…

This study tests a gene therapy called RGX-314 for wet age-related macular degeneration (AMD), a leading cause of vision loss. The treatment is given as one or two injections into the eye and aims to produce proteins that block abnormal blood vessel growth, potentially replacing …

This study tests a new gene therapy for people with chronic granulomatous disease (CGD), a genetic disorder that weakens the immune system and makes them prone to serious infections. The treatment takes the patient's own blood stem cells, adds a missing gene in the lab, and puts …

This early-phase trial tests a single injection of a gene therapy called RTx-015 in 10 adults with retinitis pigmentosa or choroideremia, two inherited conditions that cause vision loss. The therapy delivers a gene that makes retinal cells produce a light-sensitive protein, poten…

This study tests whether a device called Sonablate can safely use high-intensity focused ultrasound (HIFU) to treat vein problems like varicose veins, leg ulcers, and certain birth defects. About 30 adults with these conditions will receive the treatment, which does not involve c…

This study tests a drug called BI 1584862 in 150 adults aged 50+ with geographic atrophy, an advanced form of age-related macular degeneration that causes blind spots. Participants receive either the drug or a placebo for 1 year. Doctors track changes in the retina using special …

This study tests whether switching wet AMD patients who don't respond well to the standard 2mg dose of aflibercept (Eylea) to a higher 8mg dose can extend the time between injections while keeping vision stable. Fifty adults who have already had at least four 2mg injections will …

This early-stage trial tests a single injection of ABI-110 gene therapy into the eye for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The goal is to see if it is safe and can reduce the need for frequent anti-VEGF injections by helping t…

This pilot study tests deep brain stimulation (DBS) of the medial pulvinar, a new target in the brain, for people with drug-resistant epilepsy who have not improved with other treatments. Twelve adults aged 18 to 60 will receive the stimulation and track their seizures for 12 mon…

This study follows 23 people with wet age-related macular degeneration who received a single dose of ADVM-022 gene therapy in an earlier trial. Researchers are checking how safe the treatment is over time and whether it continues to control the disease, potentially reducing the n…

This early-stage trial is testing whether it is safe to inject a person's own bone marrow stem cells into their eye to treat vision loss from conditions like macular degeneration and diabetic retinopathy. Fifteen adults with severe vision loss will receive the injection and be mo…

This early-stage trial tests a one-time gene therapy injection (NG101) for wet age-related macular degeneration. The therapy uses a harmless virus to deliver a gene that makes a drug inside the eye, aiming to reduce the need for repeated anti-VEGF injections. About 20 adults aged…

This study tests whether adding a daily supplement (vitamins D, K, C, magnesium, zinc, copper) to pulsed electromagnetic field therapy helps women aged 45-55 heal faster from a wrist fracture. Sixty women will either use the device alone or the device plus supplement for 30 days.…

This study follows 18 people who already received RetinoStat, a gene therapy for wet age-related macular degeneration, to see if it remains safe over time. Researchers track side effects and vision changes. The goal is to understand long-term risks, not to test if the treatment w…

This trial is testing a combined cochlear and vestibular implant (CVI) in 13 people who have lost both hearing and balance function due to bilateral vestibulopathy. The implant stimulates the nerves for hearing and balance to see if it can improve stability, vision during movemen…

This study tests a single injection of a new drug called AC102 into the ear, comparing it to standard steroid pills for sudden hearing loss. About 210 adults with hearing loss in one ear will take part. The goal is to see if the injection improves hearing better than steroids, wi…

This study tests a brain-responsive neurostimulation system in 24 people aged 12 and older with Lennox-Gastaut syndrome whose seizures are not controlled by medication. The device detects and responds to seizure activity in the brain to reduce drop seizures. The goal is to see if…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This early-stage trial tests a gene therapy called KH658 for people with wet age-related macular degeneration (AMD). The treatment aims to deliver a protein that blocks abnormal blood vessel growth, potentially reducing the need for frequent eye injections. Nine participants aged…

This phase 3 study is testing the long-term safety and effectiveness of LP352 (Bexicaserin) in 324 children and adults with developmental and epileptic encephalopathy (DEE), including Dravet and Lennox-Gastaut syndromes. Participants who completed earlier studies will receive LP3…

This Phase 3 trial tests whether a daily pill called tinlarebant can slow the growth of geographic atrophy, an advanced form of age-related macular degeneration that causes blind spots. About 429 adults with the condition will receive either the drug or a placebo for up to 2 year…

This early-stage trial tests a gene therapy called KH631 for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The treatment aims to deliver a protein that blocks harmful blood vessel growth, potentially reducing the need for frequent eye inj…

This study tests an experimental drug called RP1 that is injected directly into skin cancer tumors. The goal is to see if it can shrink or eliminate the cancer before surgery. Up to 12 adults with a type of skin cancer called cutaneous squamous cell carcinoma will take part. The …

This Phase 3 trial tests a gene therapy called VGR-R01 for Bietti crystalline dystrophy, a rare inherited condition that leads to progressive vision loss. The study will enroll 45 adults who receive either the gene therapy injection under the retina or a control treatment. Resear…

This early-stage trial tests a gene therapy called VGR-R01 for Bietti Crystalline Dystrophy, a rare inherited eye disease that leads to progressive vision loss. The study involves 12 adults who receive the therapy via injection into the eye. The main goal is to check safety and t…

This study was designed to see if a small device placed in the inner ear during acoustic neuroma surgery can keep the cochlea from filling with scar tissue. If successful, patients who lose hearing from the surgery could still get a cochlear implant later. The study was withdrawn…

This study is testing the long-term safety of a once-daily drug called vormatrigine in 700 adults with focal or generalized tonic-clonic seizures. Participants must have already taken vormatrigine in a previous trial or program. The main goal is to check for side effects and chan…

This study compares two drugs, aflibercept and brolucizumab, for wet age-related macular degeneration (AMD). Instead of the usual three monthly loading doses, it tests starting with longer intervals between injections right away. The goal is to see if this approach works just as …

This study tests a gene therapy called OCU410 for geographic atrophy, a severe form of dry age-related macular degeneration that causes vision loss. About 60 adults aged 50 and older will receive a single injection of OCU410 into the eye. Researchers will monitor safety and check…

This study tests an experimental drug called AVD-104, given as an eye injection, for people with geographic atrophy, a late stage of dry age-related macular degeneration that causes blind spots. The trial involves 300 participants and aims to see if the drug is safe and can slow …

This study compares two drugs, Avastin and Eylea, given as eye injections for wet age-related macular degeneration (AMD). The main goal is to see which drug requires fewer injections over two years while still controlling the disease. Researchers will also check vision, eye thick…

This study tests whether KHK4951 eye drops can safely improve vision in people with wet age-related macular degeneration (nAMD), a leading cause of vision loss. About 180 participants will use the drops or a placebo for several months. The goal is to see if the drops reduce fluid…

This study tests a higher dose of the drug aflibercept (8 mg) given as an eye injection every 4 weeks to people with wet age-related macular degeneration (nAMD) or diabetic macular edema (DME). The goal is to see if this dosing schedule is safe and works well for those who have a…

This study is testing the long-term safety of a high-dose antioxidant called N-Acetylcysteine (NAC) in 30 adults with retinitis pigmentosa, an inherited eye disease that causes gradual vision loss and blindness. Participants take 1800 mg of NAC twice daily for two years, with reg…

This study tests a custom-made drug called an antisense oligonucleotide, designed specifically for one person with retinal dystrophy caused by a PRPH2 gene mutation. The drug aims to correct the genetic error and potentially slow vision loss. The trial involves only one participa…

This phase II trial tests the drug rituximab (Rituxan) as a first treatment for multicentric Castleman disease, a rare immune disorder, in 15 adults in Malawi. Some high-risk patients also receive etoposide. The study aims to see if rituximab is safe and works better than standar…

This study looks at how well the drug cenobamate works for adults with focal seizures that don't improve with at least two other epilepsy medicines. Researchers are collecting data from Italian clinics and a compassionate use program to measure seizure reduction and side effects.…

This study aimed to transplant insulin-producing cells into the front chamber of the eye for people with type 1 diabetes and poor vision. The goal was to see if the procedure was safe for the eye. However, the trial was withdrawn before enrolling any participants, so no results a…

This early study will test whether weak electrical currents applied to the head can help diagnose balance disorders like vestibular schwannoma and vestibular neuritis. Researchers will measure how 30 people with these conditions sway or move in response to the stimulation. The go…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests whether using artificial intelligence (AI) to screen for diabetic eye disease during regular primary care visits helps more people get timely eye exams and follow-up care. About 1,700 adults with diabetes who haven't had an eye exam in the past year will take par…

This study is testing a smartphone app called NEDS EyeCTester to see if it can help detect active eye disease early in people with conditions like optic nerve or macular disease. About 100 participants will use the app at home, and researchers will compare the results to standard…

This study tests whether an AI-assisted screening tool can detect visual impairment more accurately and efficiently than traditional methods in community settings. About 400 adults aged 50 and older will undergo vision screening and provide feedback. The goal is to see if the AI …

This study tests a new, ultra-high-resolution eye scanner that combines two imaging techniques to see the retina in 3D. Researchers will scan 10 healthy adults and 40 people with early or intermediate age-related macular degeneration (AMD). The goal is to improve early detection …

This study tests a device called AVIGA that tracks eye movements to detect vision problems in people with wet age-related macular degeneration (AMD). Researchers will compare the device's results with standard eye exams to see if it can reliably spot disease activity. The goal is…

This study tests an advanced ultrasound otoscope, a device that uses sound waves to look inside the ear and detect fluid behind the eardrum. Researchers will compare its readings to the surgeon's findings during ear tube surgery in 300 children up to 12 years old. The goal is to …

This study aimed to test whether an oral drug called SPI-1005 (ebselen) could prevent temporary hearing loss caused by loud noise. Researchers planned to enroll adults aged 18-50 with a history of noise exposure and give them the drug or a placebo for 7 days, then measure hearing…

This study was designed to test whether an oral drug called SPI-1005 could prevent hearing loss and ringing in the ears caused by platinum-based chemotherapy. It was planned for adults with advanced lung or head and neck cancer. The study was withdrawn before enrolling any partic…

This study tests whether sodium thiosulfate can prevent hearing loss in children and young adults (ages 1 month to 39 years) who are receiving cisplatin chemotherapy for relapsed or hard-to-treat liver tumors and other embryonal cancers. Some participants also get vorinostat. The…

This study tests whether listening to special audio fairy tales before sleep can improve speech, motor skills, and independence in a child with autism and central auditory processing disorder. The child stays at home with their mother, avoiding clinic stress. Early results from t…

This study investigates whether whole-body vibration (WBV) therapy, added to standard exercise, can improve balance, walking, thinking, and the ability to do two things at once in people with Parkinson's disease. Participants will be randomly assigned to receive either low-freque…

This study tests whether a targeted nerve block (retrolaminar block) provides better pain relief after lumbar discectomy than the standard method of injecting pain medicine into the surgical wound. 130 adults having elective single-level herniated disc surgery will be randomly as…

This pilot study tests whether stroboscopic vision training glasses can enhance visual and athletic performance in high school softball players. The glasses flicker between clear and opaque, briefly removing visual information to train the connection between eyes, brain, and body…

This small study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a lower electric current than standard electroconvulsive therapy (ECT), aiming to avoid memory and thinking problems. Eight adults aged 25-64 wil…

This study tests whether phentolamine eye drops can improve vision in low light for people who had laser eye surgery and now see glare, halos, or starbursts at night. About 200 adults will use the drops or a placebo every evening for two weeks. The main goal is to see if more peo…

This study looks at whether auto-captioning glasses are easy and helpful for adults with NF2-related schwannomatosis who have hearing loss. Eighteen participants will use the glasses for 12 weeks and report their experience through surveys and interviews. The goal is to see if th…

This study tests whether a very low dose of naltrexone, a drug usually used for addiction, can reduce pain and other symptoms in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either the drug or a placebo for six months. The main goal is to…

This study tests an 8-week program called PhYoMind, which blends physiotherapy, yoga postures, breathing exercises, and mindfulness, against home exercise alone in 40 adults with fibromyalgia. The goal is to see if the combined approach reduces disability, pain, fatigue, and stre…

This study tests whether group psychotherapy can help parents of children with Leber congenital amaurosis (LCA) feel better emotionally and handle stress. Forty parents will take part, with half joining therapy groups and the other half serving as a comparison. Researchers will m…

This study tests whether wearing a virtual reality headset during laser treatment for varicose veins can lower anxiety and pain. About 100 adults will use VR during the procedure, and researchers will measure their heart rate, blood pressure, and comfort levels. The goal is to se…

This study tests two types of exercises to help people who get dizzy, nauseous, or have blurry vision from using computers for long hours. 46 computer users will do either head-movement or eye-movement exercises for 4 weeks. The goal is to see which exercise better reduces sympto…

This study tests a speech therapy method called Rapid Syllable Transition (ReST) in children aged 5 to 8 with childhood apraxia of speech, a condition that makes it hard to say sounds correctly. The goal is to see if the therapy is practical and helps improve speech clarity and m…

This study tests a computer dashboard that helps doctors and nurses in the Neonatal Intensive Care Unit (NICU) manage pain in newborn babies. The dashboard shows real-time data to flag when a baby may be in discomfort. Researchers will compare pain levels in 1,250 babies before a…

This study tests whether a quadratus lumborum (QL) nerve block can reduce pain and the need for opioid painkillers after hip replacement surgery. 80 adults having a first-time hip replacement will receive the block, and their pain scores and opioid use will be tracked for 48 hour…

This study tests a single injection of F14, a long-acting form of the painkiller celecoxib, in 100 people undergoing total knee replacement. The goal is to see if it safely controls pain as part of a standard pain management plan. Participants receive the injection during surgery…

This study looks at whether cochlear implants are safe and effective for adults with severe hearing loss in both ears who currently don't meet standard implant criteria. Fifty participants will receive an implant and be followed for 6 months to measure improvements in word recogn…

This study tests a therapy called Dynamic Temporal and Tactile Cuing (DTTC) to help children with childhood apraxia of speech, a disorder that makes it hard to plan and coordinate speech movements. The trial involves 72 children and measures how well they can say treated and new …

This study looks at whether training parents to help with speech therapy at home improves outcomes for children with childhood apraxia of speech (CAS). Forty children aged 2 to 7 will receive standard speech therapy twice a week for 8 weeks. Some parents will get direct coaching …

This study tests two medications, dexmedetomidine and tramadol, given before hemorrhoid surgery to see which one better reduces anxiety and pain. Ninety adults will receive one of the drugs or a placebo before spinal anesthesia. Researchers will measure anxiety levels and pain sc…

This study tests whether adding a superficial cervical plexus block to standard care reduces opioid use and pain in children aged 3 months to 18 years undergoing ear surgery (cochlear implant or tympanomastoidectomy). Half the children get the block plus standard care, the other …

This study tests new speech-enhancement software in cochlear implants to help adults with hearing loss understand speech better in noisy places. About 150 adult cochlear implant users will compare the new algorithms to the standard ones. The goal is to see if the new software imp…

This study planned to compare two approaches for managing pain after shoulder surgery: neurofeedback training (a technique that teaches you to control your brain activity) and a standard pain management program. The goal was to see which method better reduces pain, improves shoul…

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

This study looks at whether terpenes—natural compounds found in plants—can reduce pain when taken alone or with THC. Researchers will test 45 adults who use cannabis regularly to measure pain relief and any feelings of being high or drug liking. The goal is to find safer ways to …

This pilot study tests a compounded DMSO-based ear drops and cream for adults with bothersome tinnitus linked to long-COVID or post-COVID-19 vaccine injury. Twenty participants who have not improved with at least two prior treatments will use the ear drops every 4 days and apply …

This study was designed to test a new pain medicine called HTX-011 in children and teens (ages 3 to 17) after hernia surgery. The goal was to see how well it controls pain and how safe it is. However, the study was withdrawn before any participants were enrolled, so no results ar…

This study tests whether adding balance training, education, and vestibular rehab to the standard Epley maneuver helps people with benign paroxysmal positional vertigo (BPPV) more than the maneuver alone. Forty-six adults with BPPV will receive either the combined approach or sta…

This study aimed to see if freezing certain nerves during minimally invasive heart surgery could lower pain afterward. It planned to enroll adults having mitral valve or atrial septal defect repair. However, the trial was withdrawn before any participants were enrolled, so no dat…

This trial tests whether a Pain and Coordination Plan (PAC-plan) can reduce opioid use and improve quality of life in adults who have had surgery after an accidental injury. Participants receive the plan at hospital discharge, which includes an opioid management plan, a follow-up…

This study tests whether motivational interviewing, a counseling style that encourages behavior change, can help new hearing aid users wear their devices more often and feel better about their hearing. Researchers will enroll 180 adults who are new to hearing aids and compare tho…

This study looks at whether adding dexamethasone or dexmedetomidine to the usual numbing medicine (bupivacaine) can improve pain relief after shoulder arthroscopy. About 100 adults having elective shoulder surgery will take part. The goal is to reduce pain and help recovery.

This study tests whether a gentle, low-level electric current applied to specific brain areas can improve speech and language difficulties in people with primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS). The treatment is called high-definition transcrani…

This study aimed to compare an oral morphine tablet to a nasal spray painkiller (sufentanil) for treating severe acute pain in emergency departments. It planned to enroll adults with severe pain, measuring pain levels 30 minutes after treatment. However, the study was withdrawn b…

This pilot study aimed to test whether immersive virtual reality (VR) exercises could help people with multiple sclerosis who experience dizziness, balance issues, and fatigue. Participants would have been randomly assigned to either VR-based vestibular rehab or conventional exer…

This study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can improve speech recovery in people with aphasia after stroke or brain injury. Twelve adults with apraxia of speech will receive either active or sham stimulation during 16 wee…

This study tests whether a numbing injection near the glossopharyngeal nerve, combined with topical anesthesia, can help people recover faster after surgery for obstructive sleep apnea. The trial involves 80 adults with moderate to severe sleep apnea who are scheduled for palatop…

This study tests whether online group counseling sessions can help people with chronic tinnitus. Researchers want to see if e-health works as well as traditional in-person sessions. 150 adults with subjective, chronic tinnitus will participate. The main goal is to measure changes…

This study aimed to see if a computer-based cognitive training program could improve spatial thinking, balance, and quality of life in people with long-term dizziness from inner ear problems. The training was meant to be used alongside standard physical therapy. However, the stud…

This study tests a device that uses real-time sound feedback to help people with vision loss fix their gaze on a target. Participants hear sounds that guide their eyes back to center when they drift. The goal is to improve the quality of eye imaging by reducing blur from eye move…

This study tests a mobile app called iPREPARED that helps patients and their caregivers prepare for a hospital stay. The app provides videos and tips to prevent or reduce delirium, a sudden confused state common in older adults. Researchers want to see if the app is easy to use a…

This study compares a new numbing gel (chloroprocaine HCl 3%) to standard eye drops plus a shot for pain relief during eye injections. About 236 adults with conditions like diabetic macular edema or age-related macular degeneration will take part. The goal is to see if the gel wo…

This study tests a new therapy that uses moving sounds to help stroke survivors with spatial neglect — a condition where they ignore one side of space. 18 participants will either get standard rehab or standard rehab plus dynamic auditory cueing for 4 weeks. The goal is to see if…

This study tests two telehealth-based treatments—brief pain education and 10 weeks of physical therapy—to help 500 adults with chronic low back pain. The goal is to improve pain management and reduce opioid use in community health centers. Participants receive sessions via phone …

This study looks at whether a special ear therapy (Bagua auriculotherapy) can help reduce pain and anxiety in women having a hysteroscopy, a procedure to look inside the uterus. About 132 women aged 20 to 45 will receive this ear treatment along with standard care. The goal is to…

This study tests whether a long-acting numbing medication (liposomal bupivacaine) can better control pain after septorhinoplasty (nose surgery) compared to standard numbing drugs or a placebo. About 72 adults having nose surgery will receive one of three treatments at the end of …

This study tests whether an 8-week auditory-cognitive training program can improve speech recognition and cognitive function in older adults (60+) who have had a cochlear implant for 3 months to 3 years. Participants will do computer-based listening and thinking exercises at home…

This study looks at whether a combination of over-the-counter pain relievers (like ibuprofen and acetaminophen) can control pain after wisdom tooth removal just as well as, or better than, prescription opioids. About 1,800 people having their wisdom teeth removed will be randomly…

This study tests whether combining motor skill training with a non-invasive spinal stimulation can improve walking, balance, and strength while reducing muscle spasticity in people with incomplete spinal cord injury. Twenty-eight participants will do a series of standing exercise…

This study compares three ways to manage pain after lower abdominal surgery: a spinal injection of morphine, a nerve block in the abdominal wall, or standard painkillers. Sixty-six adults having surgery through a midline incision will be randomly assigned to one of these groups. …

This pilot study tests a new approach for misophonia, a condition where common sounds like chewing or breathing cause extreme distress. Sixty adults with moderate to severe misophonia will learn emotion regulation skills and receive one of two types of brain stimulation (rTMS) ov…

This study compares two types of nerve blocks (superficial vs. deep) for pain relief after breast surgery. 58 women will receive one of the two blocks, and researchers will measure how much pain medication they need in the first 24 hours. The goal is to find which block provides …

This study tests different automatic sound management features on MED-EL cochlear implants to see which helps adults hear speech best in background noise. About 20 experienced cochlear implant users will listen to sentences in noise and report what they hear. The goal is to find …

This study tests whether injecting a low dose of ketamine directly into the jaw during surgery can reduce pain, swelling, and nausea afterward. Forty adults having corrective jaw surgery will receive either ketamine plus standard anesthetic or standard anesthetic alone. Researche…

This study is testing a full-spectrum cannabis extract containing CBD and THC in 36 women with fibromyalgia, a condition causing widespread pain, fatigue, and sleep problems. Participants will receive different doses over six months to see if it improves symptoms and quality of l…

This study tests whether adjusting the frequency settings of a cochlear implant based on a person's ear anatomy can improve hearing and quality of life. Fifty new cochlear implant users with some hearing in their other ear will try two different settings and complete hearing test…

This early study tests whether vaporized cannabigerol (CBG) and THC can help with pain and appetite. Twenty occasional cannabis users will receive different doses of CBG and THC, alone or together, and report their pain tolerance, hunger, and any side effects. The goal is to see …

This study tests a home-based program called HOBSCOTCH-PTE for people with epilepsy caused by a traumatic brain injury. The program aims to improve quality of life, memory, and thinking skills, and also helps support their caregivers. The study includes 160 adults with post-traum…

This study looks at whether a special pain management plan (called ERAS) helps people recover better after gallbladder removal surgery. It compares patients who got the ERAS plan with those who had standard pain treatment. The goal is to see if the ERAS plan reduces pain, shorten…

This study looks at whether adding pelvic floor muscle exercises to deep breathing can help reduce pain during periods in women with primary dysmenorrhea. Forty women will be split into two groups: one doing both exercises, the other only deep breathing. Researchers will measure …

This study tests whether watching a custom 360-degree virtual reality video during dressing changes can lower pain, anxiety, and the need for opioid painkillers in adults recovering from burn surgery. Eighty participants will wear VR headsets while their bandages are changed and …

This study tests whether adding an interactive screen (MYRO) to standard therapy helps people who had a stroke and have trouble paying attention to one side of their world (left neglect). About 30 adults with a recent stroke will be split into two groups: one gets standard therap…

This study tests a hearing care program for older Korean Americans (age 60+) who have hearing loss but do not use hearing aids. The program includes a low-cost sound amplifier and communication training, delivered in the community. Researchers will compare participants who get th…

This study tests experimental sound coding strategies that may improve hearing for adult cochlear implant users. About 120 participants will compare the new strategies to their current settings, focusing on understanding speech in noisy environments. The goal is to find ways to m…

This study tests a device called Buzzy Bee that vibrates and cools the skin to distract children during a dental numbing shot. About 30 healthy kids aged 4-12 will try both the Buzzy Bee and standard care to see which hurts less. The goal is to make dental visits easier for child…

This study tests whether giving magnesium sulfate during prostate surgery can lower pain and reduce the need for strong painkillers. About 68 adults having robotic prostate surgery will either receive magnesium or not, as part of their standard anesthesia. Researchers will compar…

This study tests a new cochlear implant that slowly releases a drug called dexamethasone to reduce swelling and tissue damage after surgery. The goal is to see if this helps the implant work better and improve hearing in adults with severe hearing loss. About 56 adults will recei…

This study tests a new cochlear implant that slowly releases dexamethasone, a drug that reduces inflammation after surgery. The goal is to see if it works better than a standard implant for adults with severe hearing loss. About 48 adults will be randomly assigned to get either t…

This study tests a treatment called transcorneal electrical stimulation to see if it can improve vision in people with retinitis pigmentosa, an eye disease that causes vision loss. Twenty-one adults with the condition received the therapy, and researchers measured changes in thei…

This study tests whether acupressure (applying pressure to specific points on the body) and back massage can reduce pain, fatigue, and improve sleep quality in women recovering from a cesarean section. About 111 new mothers will receive these non-drug treatments after surgery. Th…

This study explores whether wearing prismatic goggles that shift vision can improve emotional awareness (alexithymia) and visual-spatial abilities in people with Parkinson's disease. Researchers will also use brain scans and tear tests to understand how the brain adapts and to fi…

This study tests whether a brief education and self-management program with home exercises can reduce pain and improve daily function in adults with long-lasting jaw pain (TMD) as effectively as more intensive hands-on physiotherapy. Forty adults aged 18–65 with jaw pain for at l…

This study tests an 8-week exercise program designed for deaf adults aged 60 and older. The classes are taught in American Sign Language and meet twice a week. Researchers will measure balance, leg strength, walking speed, and confidence to see if the program helps reduce fall ri…

This study tests whether a medication applied directly during shoulder replacement surgery (ZYNRELEF) can reduce the need for strong painkillers after the operation, compared to the standard method of using a nerve block with a catheter. About 86 adults having shoulder replacemen…

This study aimed to see if a lidocaine injection or a lidocaine patch works better for muscle pain in the neck and back. It was designed for adults visiting the emergency department. However, the study was withdrawn before any participants were enrolled.

This study planned to test whether a 6-day course of oral methylprednisolone after total knee replacement could improve pain, sleep, and knee movement. Participants would also receive a steroid injection during surgery. The study was withdrawn before enrolling anyone, so no concl…

This study tests whether yoga can reduce nerve pain caused by chemotherapy in cancer survivors. About 227 participants will either take yoga classes twice a week for 8 weeks, attend educational sessions, or receive standard care. Researchers will measure pain, balance, fall risk,…

This study tests if acupuncture can reduce nerve pain caused by chemotherapy in cancer survivors. About 255 people who finished chemo at least three months ago will receive either real or sham acupuncture. The goal is to see if this drug-free approach can ease pain and improve da…

This study compares a simple sterile water injection into the skin with intravenous morphine for relieving severe kidney stone pain. 150 adults with confirmed stones and high pain levels will receive either one or four water injections or morphine. Pain is measured over 90 minute…

This study tests whether adding a nerve stimulator to standard ultrasound guidance improves the quality of nerve blocks for upper limb surgery. 82 adults having elective arm surgery will be randomly assigned to receive the block with or without the stimulator active. Researchers …

This study tests whether giving patients a pain education booklet and video before knee or hip replacement surgery helps them feel less anxious and have less pain afterward. About 70 adults scheduled for elective joint replacement will be randomly assigned to receive the educatio…

This small study tests whether low-intensity focused ultrasound (LIFU) can safely reduce seizures in people with temporal lobe epilepsy that doesn't improve with medication. Six participants with implanted brain electrodes will receive both real and sham ultrasound sessions. The …

This study aimed to see if a tiny dose of buprenorphine/naloxone (a medicine used for opioid addiction) could help control pain after surgery in people who already take strong painkillers. It was designed for adults having orthopedic or general surgery. However, the study was wit…

This study looks at two different nerve-block methods to control pain after hip surgery. One group gets a standard block that numbs the hip joint, while the other gets an extra block for the thigh skin. The goal is to see which method reduces pain, lowers the need for pain medici…

This study is testing whether hearing aids alone or hearing aids with a tinnitus masker can improve hearing and reduce tinnitus symptoms in adults with hearing loss and tinnitus. One hundred participants will wear hearing aids for 6 months, with the masker turned on after 3 month…

This study tests whether a gentle electrical current applied to specific points on the skin (AcuTENS) can reduce pain and anxiety during a prostate biopsy. About 53 men having their first biopsy will receive either active AcuTENS or a placebo device, on top of standard numbing me…

This study aimed to test a closed-loop sound therapy for people with chronic tinnitus (ringing in the ears) or hyperacusis (sensitivity to sound). The therapy was designed to retrain the brain's response to sounds. However, the trial was withdrawn before any participants were enr…

This study looks at whether adding a low-dose dexmedetomidine infusion to standard pain management can lower the amount of narcotics needed and reduce side effects like nausea and itching in teenagers having posterior spinal fusion for scoliosis. About 160 adolescents with idiopa…

This study tests whether using special communication technology (AAC) alongside speech therapy helps children who are deaf or hard of hearing develop language faster. Half of the 154 children will use AAC tools, while the other half continue their usual therapy. Researchers will …

This study tests whether adding the anti-nausea drug ondansetron to a standard saline wash during gallbladder surgery can better control pain and nausea afterward. Forty adults having their gallbladder removed will be randomly assigned to receive either a plain saline wash or one…

This study tests two numbing medicines, ropivacaine and lidocaine, in 40 adults with end-stage kidney disease who need surgery to create a blood vessel connection (fistula) for dialysis. Patients are randomly assigned to receive one of the two drugs during surgery, and neither th…

This study looks at whether traditional exercises like Tai Chi and Baduanjin can help people with hearing loss feel better physically and mentally. About 90 adults with severe hearing loss will be split into three groups: one doing Tai Chi, one doing Baduanjin, and one doing regu…

This study compares two types of nerve blocks (PECS II-PIFB vs. SAPB) to see which provides better pain relief for women undergoing modified radical mastectomy. Seventy women aged 18-65 will be enrolled, and the main goal is to measure how much extra pain medicine they need in th…

This study looks at whether traditional exercises like Tai Chi and Baduanjin can help visually impaired university students improve their balance, mood, and quality of life. Ninety participants will be split into three groups: Tai Chi, Baduanjin, or regular physical education cla…

This study compares personalized electro-acupuncture and auricular-acupuncture against usual care for treating chronic pain in adults with musculoskeletal pain or fibromyalgia. Participants are split into three groups: two receive different acupuncture methods, and one receives s…

This study tests a program called COMPASS-NP for home care workers who have chronic pain. The program combines pain education, coping strategies, and safety tips, led by a trained peer. About 140 workers will take part to see if it reduces how much pain interferes with their work…

This study compares two procedures to relieve chronic tailbone pain (coccydynia) that is not related to cancer. About 74 adults aged 20-70 who have not responded to standard medical treatment will be split into two groups. One group will receive conventional radiofrequency ablati…

This study aimed to compare two over-the-counter hearing aids—the Lexie B3 Pro and a competitor—in adults with mild to moderate hearing loss. Participants would have tested each device and reported their experiences. However, the trial was withdrawn before any participants were e…

This study aims to see if a self-fitting over-the-counter (OTC) hearing aid works as well as a professionally fitted prescription device for adults with mild-moderate hearing loss. The research involves three phases: validating a hearing test, checking user experience, and a rand…

This study tests a method called conditioning open-label placebo (COLP) to help patients with spinal cord injury, multiple injuries, or burns use fewer opioids while still getting the same pain relief. About 66 adults in intensive rehab will receive a placebo alongside their regu…

This study tests whether adding acupuncture to standard pain care can reduce the need for strong opioid painkillers in people with multiple myeloma, Hodgkin disease, or non-Hodgkin lymphoma who are getting high-dose chemotherapy. About 299 adults will be randomly assigned to rece…

This study tests a non-invasive device that delivers sound through headphones and gentle electrical pulses to the tongue, aiming to ease tinnitus. Twenty adults with chronic tinnitus will use the device for 60 minutes daily over 12 weeks. The main goal is to see if people find th…

This study looks at whether using Montage or Montage-CT devices to close the breastbone after heart surgery can lower the need for strong painkillers like opioids. Researchers will review records from 150 adults who had planned heart surgery. They will compare opioid use and reco…

This study tests whether common migraine medications can reduce the impact of sudden tinnitus (ringing in the ears) in 100 adults aged 25 to 85. Participants receive the drugs and complete questionnaires about their symptoms, plus brain scans to look for changes. The goal is to f…

This study tests a pair of smart glasses called NEXA that can read brain signals through dry electrodes. The glasses aim to predict epileptic seizures in real time and alert the wearer with vibrations, lights, or sounds. Researchers will test the device on 47 adults with epilepsy…

This study compares two types of nerve blocks for pain after repeat lumbar spine surgery. 64 adults aged 40-70 will receive either a caudal epidural block alone or a combined lumbar sympathetic block with caudal epidural. Pain levels will be measured before and after surgery to s…

This early-phase study tests whether donepezil, a drug used for Alzheimer's, can improve speech recognition in adults who already use a cochlear implant. Researchers think the drug may help the brain adapt to the implant's signals. Fifty participants will receive either donepezil…

This study tests two different head-and-body rotation procedures done in a mechanical chair to treat a common inner-ear condition called BPPV, which causes brief but intense spinning sensations. 128 adults with confirmed BPPV will be randomly assigned to either the standard Epley…

This study looks at whether cannabis oil can help reduce pain and improve sleep and quality of life in people with fibromyalgia who have not found relief from other treatments. Researchers will track pain levels, side effects, and how well patients stick to the treatment. The goa…

This study tests whether using a virtual reality headset (HypnoVR) can help reduce pain and anxiety during labor. Seventy women in Tunis will be randomly assigned to use the headset or receive standard care. Researchers will measure pain and anxiety levels before and after the in…

This study tests whether adding dexamethasone (a steroid) to a standard numbing injection (TAP block) can improve pain control after laparoscopic gallbladder removal. About 100 adults will receive either the standard numbing medicine or the numbing medicine plus dexamethasone. Th…

This early-phase trial tests whether an FDA-approved drug called glycerol phenylbutyrate (PBA) can improve vision in people with a rare form of color blindness caused by mutations in the ATF6 gene. Only 2 participants are enrolled, and they will take PBA three times daily while t…

This study tests whether using a kaleidoscope can reduce pain, anxiety, and fear in children aged 6-14 with cancer who are getting subcutaneous injections. The kaleidoscope is used as a distraction during the procedure. The study involves 72 children and compares their pain and f…

This study tests whether donepezil, a drug used for dementia, can help people with chronic tinnitus (ringing in the ears). 70 adults with long-term tinnitus received either donepezil or a placebo for 3 months. Researchers measured changes in tinnitus severity using standard quest…

This study tests two simple, drug-free treatments for chronic tinnitus (ringing in the ears) that hasn't improved with standard medical care. 45 adults will be split into three groups: one gets 10 sessions of mild electrical stimulation to a nerve in the ear, another does specifi…

This study tests a pain management toolkit for nursing home residents. The toolkit includes non-drug methods like massage, relaxation, exercise, music, and aromatherapy. Researchers will see if it helps staff manage pain better and improves residents' comfort and quality of life.…

This study follows 68 people aged 12 and older who have ABCA4 gene mutations, which can cause vision loss from diseases like Stargardt disease. Over 10 years, researchers will collect blood and skin samples and perform detailed eye exams to understand how the disease progresses. …

This study follows 110 people who previously took part in the AREDS or AREDS2 trials to see how age-related macular degeneration (AMD) and cataracts change over time. Participants get a yearly eye exam, including vision tests and eye photos, and may give a blood sample. The goal …

This observational study will follow 2,500 adults with vision loss from nAMD or DME who are already prescribed aflibercept 8 mg by their doctors. Researchers will collect data from routine visits over up to 24 months to see how vision changes. The goal is to understand how well t…

This study aimed to see if how well a person can fix their gaze relates to signs of active disease on eye scans in patients with age-related macular degeneration (ARMD) treated with antiVEGF injections. Researchers planned to follow patients for two years, measuring fixation qual…

This study follows people with advanced dry age-related macular degeneration who previously received a one-time injection of the experimental treatment VOY-101. Researchers are monitoring participants over the long term to check for any side effects related to the treatment. The …

This study follows 400 people with intermediate age-related macular degeneration (AMD) for about 3 years. Researchers watch how the disease advances to more severe stages and test if measuring the loss of light-sensing cells in the eye can be a useful way to track the disease. No…

This natural history study follows 259 children, adolescents, and adults with Neurofibromatosis Type 1 (NF1) for up to 10 years. Researchers will track tumor growth, monitor quality of life, and perform genetic testing to better understand how the disease changes over time. The g…

This study aims to find the genes that cause inherited hearing loss by analyzing DNA from 24,000 people in large Pakistani families. Researchers will compare affected and unaffected family members to identify new deafness genes. The goal is to improve genetic testing and counseli…

This study looks at X-linked juvenile retinoschisis (XLRS), a rare inherited eye disease that causes vision loss in young males. Researchers will examine 351 participants, including affected males and female carriers, using eye exams, retinal photos, and genetic tests. The goal i…

This study follows 80 people aged 8 to 50 with Stargardt disease, a genetic eye condition that causes vision loss. Researchers will monitor how the disease changes over time using eye imaging. The goal is to better understand the disease and prepare for future clinical trials.

This study looks at whether a 3-month non-surgical program—including patient education, supervised exercise, and diet counseling—can help people with knee osteoarthritis avoid knee replacement surgery while maintaining their quality of life. Researchers will follow 2,500 patients…

This study was designed to see if a new method of measuring the visual field—by projecting vision zones on the ground—helps people with retinitis pigmentosa understand their remaining sight and improve their walking rehabilitation. The trial was withdrawn before enrolling any par…

This study is collecting long-term, real-world data from about 6,000 adults being treated with Roche eye medications (Faricimab or the Port Delivery System with Ranibizumab) for conditions like wet age-related macular degeneration and diabetic macular edema. The goal is to unders…

This study collects information from about 889 people with inherited retinal diseases (IRDs) to understand how vision changes over time. Participants have their eyesight and visual field tested regularly. The goal is to learn more about the natural course of these rare eye condit…

This study looks at how people with long-term dizziness (chronic vestibulopathy) walk and keep their balance, comparing them to healthy volunteers. Researchers will measure things like step length, sway, and fear of falling using special equipment and tests. The goal is to better…

This study follows 88 deaf or hard-of-hearing children who, as toddlers, were randomly assigned to receive a 6-month parent coaching program or standard care. Researchers want to see if the early coaching leads to better language, reading, and social skills when the children reac…

This study looks at how the brain creates and recalls memories by recording brain activity in people with epilepsy who already have electrodes placed for surgery. Participants play memory games on a laptop while their brain signals are recorded, and sometimes small electrical pul…

This study aims to help adults aged 40 and older in Upper Manhattan get better eye care. It will offer free eye screenings at local health centers and senior centers, and provide support like scheduling appointments and transportation. The goal is to see if this extra help leads …

This pilot study tests whether older adults with intermediate age-related macular degeneration (AMD) can eat 2 or 4 whole eggs daily for 5 months. The main goal is to see if people can stick with the diet, not to prove eggs improve vision. Researchers will also measure changes in…

This study aimed to see if using real-time ultrasound during a thoracic epidural block makes the procedure more reliable. It was designed for adults with chest or abdominal pain or rib fractures. The study was withdrawn before enrolling any participants, so no results are availab…

This study follows 1,000 patients in China who are already receiving faricimab for diabetic macular edema, retinal vein occlusion, or wet age-related macular degeneration. Researchers will collect data from routine clinic visits over one year to see how well the drug works and ho…

This observational study examines how aflibercept 8 mg, an injection into the eye, is used in routine care for patients in Japan with age-related macular degeneration or diabetic macular edema. Researchers will analyze claims data from about 3000 patients to understand patient ch…

This study looks at how fentanyl changes brain activity using EEG (a brain wave test) in 20 adults having surgery. Researchers want to find a specific brain signal linked to fentanyl and see if it relates to how much people like the drug. No new treatment is tested—only brain pat…

This study looks back at the medical records of 600 adults who received a single shot of morphine into the spine before surgery. The goal is to understand how often side effects like breathing problems, itching, and nausea happen. By learning more, doctors hope to make pain manag…

This study aims to understand how diet affects the eyes and skin by measuring natural pigments called carotenoids. Researchers will use non-invasive methods to check levels in the eye and skin, and also test blood in some participants. Anyone age 7 or older having a routine eye e…

This study tests a new type of cochlear implant that uses light instead of electricity to stimulate the hearing nerve. Researchers hope light can target smaller nerve groups, leading to clearer sound. The trial involves 30 adults who are already having ear surgery for tumor remov…

This study looks at whether hearing aids programmed to match a person's unique listening style can improve speech understanding in noisy environments. Thirty adults with sensorineural hearing loss will attend a 2-hour lab visit, where they will listen to sentences in noise with b…

This study aims to find better ways to measure how retinitis pigmentosa (a genetic eye disease that causes vision loss) progresses over time. Researchers will use advanced imaging and vision tests in 40 people with specific genetic forms of the disease. The goal is to identify re…

This study is testing whether taking a tiny sample of fluid from the front of the eye is safe for people with dry age-related macular degeneration (AMD). Researchers will analyze proteins in the fluid to see if they change over time. The study includes 50 adults aged 50 to 89, so…

This study looks at how common Charles Bonnet Syndrome (CBS) is in people with vision loss from conditions like macular degeneration or glaucoma. CBS causes complex visual hallucinations without mental illness. Researchers will survey 640 participants to measure how often it happ…

This study looks at how to better check vision in older adults (65+) who come to the hospital after a fall. Falls are common and costly, and poor eyesight can double the risk of falling again. Researchers will talk to patients, carers, and health professionals to develop a practi…

This study follows 100 people aged 60-85 with mild memory or movement problems to see if losing smell, hearing, or balance speeds up cognitive decline. Researchers will test these senses and track thinking skills and quality of life for 5 years. The goal is to understand which se…

This study looks at how small differences in certain genes affect how people respond to propofol, a common anesthesia drug. Researchers want to understand why some people wake up faster or have more side effects than others. The goal is to help doctors give safer, more personaliz…

This study looks at whether people with a MED-EL cochlear implant can use a smartphone app to check their hearing from home instead of going to the clinic. About 50 participants will try the remote check and report how well it works, how much time and money it saves, and how easy…

This study aimed to understand how exposure to HIV and antiretroviral therapy in the womb might affect hearing in children who are HIV-free. Researchers planned to test hearing abilities in healthy infants born full-term. However, the study was withdrawn before enrolling any part…

This study aims to develop a new way to measure how the spine moves during walking in children, both healthy and those with scoliosis. Researchers will use a special camera system and reflective markers placed on the skin to track movement. The goal is to create a reliable and ea…

This study follows 50 people with a rare inherited eye condition called PRPF31-related retinal dystrophy (RP11) to see how their vision changes over time. Researchers will measure things like visual acuity, retinal thickness, and quality of life using eye exams and questionnaires…

This study looks at a rare, inherited eye disease called CNGB1 retinitis pigmentosa that causes gradual vision loss and blindness. Researchers want to learn how the disease progresses by using eye exams and imaging tests over three years. The goal is to find the best ways to meas…

This study explores whether an Apple Watch can track walking, heart rate, breathing, and sleep in people with glioblastoma, a serious brain cancer. The goal is to see if the watch can detect symptom changes before they become serious, like seizures or blood clots. Twenty-five pat…

This study tests a device that uses changes in pupil size to measure pain and how well opioid painkillers are working. The goal is to replace subjective pain scores with an objective measurement, helping doctors prescribe opioids more safely. The study includes 40 children and yo…

This study looks at whether a special parent training program can help families with deaf or hard of hearing children aged 3 to 6. The program teaches positive parenting strategies to prevent behavior problems. About 295 parents will take part, and researchers will measure change…

This study, run by Apple and the University of Michigan, tracks headphone and environmental sound exposure in 300,000 US adults using iPhones and Apple Watches. Participants answer surveys and take hearing tests through the Research app. The goal is to understand how everyday sou…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study tests a new technique that lets a cochlear implant stimulate the entire cochlea without needing a longer electrode. The goal is to see if this improves speech understanding and sound quality for people with hearing loss. About 40 adults who already qualify for a cochle…

This study follows 103 adults with a genetic eye condition called retinitis pigmentosa caused by EYS mutations. Researchers will track changes in vision and eye structure over 4 years. The goal is to better understand how the disease progresses so that future clinical trials can …

This study follows 12 adults with severe retinitis pigmentosa, a genetic eye disease that causes vision loss. Researchers want to find out which vision tests people with very low sight can reliably perform and how their vision changes over one year. The goal is to improve future …

This study looks at whether a 14-week elective course that uses films and discussions about social justice can help medical students better understand their own emotions and feel more empathy for others. About 60 medical students will take part, with some taking the course and ot…

This study looks at whether common balance tests can tell doctors why a person is having trouble with balance. Researchers will test 330 people, including healthy volunteers and patients with stroke, vision problems, inner ear issues, spine problems, or spinal cord damage. The go…

This study looks at how the brain changes and adapts after losing central vision, which happens in conditions like macular degeneration. Researchers are testing different training tasks in 120 healthy adults aged 18-30 to measure improvements in eye movements and focus. The goal …

This study tests whether a special technology tool can help deaf or hard-of-hearing children ages 3-10 improve their language skills. About 114 children will be randomly assigned to use the tool or continue their usual therapy. Researchers will measure changes in vocabulary, sent…

This study followed 602 people who had a stroke to see how many later had seizures. Researchers looked at blood tests, brain scans, and EEG recordings to find clues that might predict who is at risk. The goal is to better understand why some stroke survivors develop epilepsy.

This study follows 127 people with a genetic eye condition called USH2A-related retinal degeneration, which can cause vision loss and hearing problems. Researchers measure changes in vision, retinal sensitivity, and mobility over several years. The goal is to understand how the d…

This study looks at whether a tiny device placed under the scalp can safely and comfortably track seizures in adults with mild to moderate intellectual disability and epilepsy. Nine participants will wear the monitor for up to 6 months, and researchers will compare the device's r…

This study follows 44 people with a rare genetic form of Usher syndrome caused by PCDH15 mutations. Over 48 months, researchers measure how their vision changes using eye exams and imaging. The goal is to identify the best ways to track disease progression, which will help design…

This study tests a new computer-based visual training task for people who have lost part of their vision due to a stroke. Participants watch moving patterns on a screen and learn to detect motion direction, with the goal of improving visual abilities. The study first checks if th…

This study looks at how stimulating a nerve in the ear affects pupil size during cochlear implant surgery. Researchers will measure pupil dilation in 30 adults to learn more about the vagus nerve's role in hearing. The goal is to gather knowledge, not to treat hearing loss direct…

This study follows 46 people with gyrate atrophy, a rare genetic condition that causes vision loss, over 4 years. Researchers measure ornithine levels in the blood and track changes in the retina using eye scans and photos. The goal is to learn how the disease progresses under st…

This study is testing whether wearable sensors can reliably monitor movement problems in people with progressive supranuclear palsy (PSP) and related frontotemporal disorders. About 60 participants will wear pendant-like devices for 12 months to track their activity. The goal is …

This study was designed to see if changing the sound of your own footsteps—by making them louder or softer—could affect how stable you are while walking. The researchers planned to test healthy adults who could walk for 30 minutes. However, the study was withdrawn before enrollin…

This study looks at whether managing cochlear implant care remotely (via phone or app) works as well as going to the clinic. About 148 adults with hearing loss will be followed for a year after their implant is activated. The goal is to see if remote care saves time and money whi…

This study tests whether stimulating the visual part of the brain can create visual sensations in blind volunteers. Five adults who are blind will have a device implanted in their skull to deliver tiny electrical pulses. The goal is to learn where and how much stimulation is need…

This study tests a hearing program for older adults who don't have easy access to hearing care. During a primary care visit, participants are screened for hearing loss and then randomly assigned to either get counseling on affordable listening devices or be referred to standard a…

This study tests whether a computer program (machine learning) can predict pain in children aged 1 to 3 after day surgery. Researchers will record details like age, weight, and parent anxiety before surgery, then note the child's pain scores and vital signs after surgery. No extr…

This early-stage trial tests the safety of an experimental oral drug called iQ-007 in 72 healthy volunteers. The drug is designed to help control seizures by boosting the brain's ability to clear excess glutamate, a chemical linked to epilepsy. The study does not yet test if it w…

This study aimed to see if a team of doctors, nurses, and pharmacists working together could help people recover better after anorectal surgery. It planned to compare standard care with this team-based approach in 126 adults. However, the study was withdrawn before any participan…

This study planned to test whether playing specially designed video games at home could improve the ability of older adults with high-frequency hearing loss to understand speech in noisy environments. Participants would have played either an immersive audiomotor game or an audito…

This study looks at a specific type of blood vessel growth under the retina, called non-exudative type 1 macular neovascularization (MNV), in people with age-related macular degeneration (AMD). Researchers want to see if these vessels actually help preserve vision rather than har…

This study aims to find out if changes in blood markers can predict whether exercise helps improve vision. Researchers will compare aerobic exercise to balance training in 14 sedentary adults aged 18 to 89 with vision disorders. The goal is to understand how exercise might protec…

This study looks at how the brain's visual system changes in the year after a stroke that damages the vision center. Researchers will measure vision and brain structure over time, and give participants a home-based computer training program that asks them to detect moving dots. T…

This study follows 61 people who previously used the REVISYON SDS 100 device for mild-to-moderate cataract. Researchers will check for side effects and measure vision changes over about 20 months. No new treatment is given; the goal is to see if the device stays safe and works we…

This study looks at how deaf children in kindergarten through 3rd grade develop sign language skills. Eight children from a school for the deaf will receive special sign instruction and have their language progress tracked daily. The goal is to understand how teaching methods aff…

This study looks at whether a special training program for teachers can help deaf children learn sign language better. About 150 teachers and their deaf students (ages 4-12) are taking part. Teachers are split into two groups: one gets the new training, the other continues as usu…

This study looks at the eye care needs of children and adolescents with special needs, who are much more likely to have vision problems than other kids. Researchers will interview parents and teachers to find out what makes it hard or easy to get eye care. The goal is to identify…

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This study follows 300 patients with chronic eye conditions like glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy who recently received treatment. Researchers will measure changes in eye pressure, vision, and other outcomes over time. The goal is to unde…

This study offers free vision screenings to underserved adults over 40 living in affordable housing in Harlem and Washington Heights. The goal is to find eye problems like glaucoma, cataracts, and diabetic retinopathy early and connect people with follow-up care. About 749 partic…

This study looks at how the brain handles visual information by measuring eye movements in healthy adults. Researchers will show images on a screen and track participants' eye movements using a special camera. The goal is to better understand normal vision, not to treat any disea…

This study is working to create a simple screening test to find cerebral vision impairment (CVI) in babies and young children. CVI is a leading cause of vision problems in kids, often linked to brain injuries or conditions. Researchers will study 600 children to better understand…

This study follows 39 adults with severe hearing loss who are getting a cochlear implant. Researchers will test their hearing and balance at several points over two years, using both objective tests and patient questionnaires. The goal is to better understand how the implant affe…

This study looks at whether women from different backgrounds have equal access to ambulance services during pregnancy, birth, and after having a baby. Researchers will analyze data from 18,000 women in Manchester, UK, comparing those who used an ambulance with those who didn't, a…

This study looks at whether alexithymia—trouble recognizing or describing emotions—is linked to how often women get migraines. Researchers will track 350 female migraine patients aged 12-65 using questionnaires. The goal is to understand if emotional awareness affects migraine se…

This study aimed to see if adding dry needling and soft tissue massage to standard care could reduce pain and the need for painkillers after ACL reconstruction. It planned to follow patients for four weeks after surgery. However, the study was withdrawn before enrolling any parti…

This study is looking at how genetics, diet, lifestyle, and medications work together to influence the risk of age-related macular degeneration (AMD), a leading cause of vision loss. Researchers will collect blood samples and health information from 1,800 adults in Portugal. The …

This study is testing a special eye test called microperimetry to see if it can detect early signs of dry age-related macular degeneration and diabetic retinopathy. Researchers will measure how sensitive the central retina is to light and compare it with standard scans. The goal …

This study follows 300 adults with focal epilepsy who are starting an additional anti-seizure medication (ASM) alongside their current treatment. Researchers will track changes in seizure frequency and quality of life over 12 months in everyday clinical settings. The goal is to s…

This study planned to test a wearable device called EpiCare@Home that records brain activity, heart rate, and movement to detect focal seizures. It was designed for people with epilepsy, both in the hospital and at home. However, the study was withdrawn before enrolling any parti…

This study reviews the medical records of 2,000 people in Upper Egypt who applied for visual disability certification between 2020 and 2024. Researchers will analyze eye exams and tests to find the most common diseases causing severe vision loss. The goal is to understand which c…