Can a pill save your sight? new trial targets blinding eye disease

NCT ID NCT05949593

Ongoing Disease control Sponsor: Belite Bio, Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether a daily pill called tinlarebant can slow the growth of geographic atrophy, an advanced form of age-related macular degeneration that causes blind spots. About 429 adults with the condition will receive either the drug or a placebo for up to 2 years. The main goal is to see if the drug reduces the rate of vision loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tinlarebant (a tablet taken daily)
What this could lead to: If it works, this could slow vision loss from geographic atrophy, a leading cause of blindness in older adults.
What could go wrong: This is a late-stage trial, but the drug may not slow vision loss enough to matter. Side effects from daily medication are possible.

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Conditions

The condition(s) this trial relates to.

dry age related macular degeneration Geographic Atrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GEOGRAPHIC ATROPHY

Contacts and locations

Locations

Belite Study Site

Phoenix, Arizona, 85020, United States
Belite Study Site

Arcadia, California, 91007, United States
Belite Study Site

Beverly Hills, California, 90211, United States
Belite Study Site

Huntington Beach, California, 92467, United States
Belite Study Site

Los Angeles, California, 90033, United States
Belite Study Site

Palo Alto, California, 94303, United States
Belite Study Site

San Diego, California, 92093, United States
Belite Study Site

Lakeland, Florida, 33805, United States
Belite Study Site

Hagerstown, Maryland, 21740, United States
Belite Study Site

Saint Louis Park, Minnesota, 55416, United States
Belite Study Site

Westbury, New York, 11590, United States
Belite Study Site

Cary, North Carolina, 27511, United States
Belite Study Site

Durham, North Carolina, 27710, United States
Belite Study Site

Wake Forest, North Carolina, 27587, United States
Belite Study Site

Portland, Oregon, 97239, United States
Belite Study Site

Philadelphia, Pennsylvania, 19107, United States
Belite Study Site

Sewickley, Pennsylvania, 15143, United States
Belite Study Site

Germantown, Tennessee, 38138, United States
Belite Study Site

Abilene, Texas, 79606, United States
Belite Study Site

Dallas, Texas, 75231, United States
Belite Study Site

San Antonio, Texas, 78240, United States
Belite Study Site

Warrenton, Virginia, 20186, United States
Belite Study Site

Chatswood, New South Wales, 2067, Australia
Belite Study Site

Strathfield, New South Wales, 2135, Australia
Belite Study Site

Brisbane, Queensland, 4101, Australia
Belite Study Site

Adelaide, South Australia, 5000, Australia
Belite Study Site

East Melbourne, Victoria, 3002, Australia
Belite Study Site

Crawley, Western Australia, 6009, Australia
Belite Study Site

Beijing, Beijing Municipality, 100044, China
Belite Study Site

Chengdu, Sichuan, 610093, China
Belite Study Site

Beijing, 10005, China
Belite Study Site

Beijing, 100730, China
Belite Study Site

Guandong, 510060, China
Belite Study Site

Zhejiang, 325027, China
Belite Study Site

Ostrava, 70852, Czechia
Belite Study Site

Prague, 14000, Czechia
Belite Study Site

Prague, 14059, Czechia
Belite Study Site

Dijon, 21000, France
Belite Study Site

Écully, 69130, France
Belite Study Site

Lyon, 69317, France
Belite Study Site

Marseille, 130008, France
Belite Study Site

Basel, 4031, Switzerland
Belite Study Site

Lausanne, 1001, Switzerland
Belite Study Site

Taichung, 40447, Taiwan
Belite Study Site

Taipei, 100, Taiwan
Belite Study Site

Taoyuan, 33305, Taiwan
Belite Study Site

Great Yarmouth, NR31 6LA, United Kingdom
Belite Study Site

Harrow, HA1 3UJ, United Kingdom
Belite Study Site

London, EC1V 2PD, United Kingdom

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