Gene therapy shot could end frequent eye injections for wet AMD
NCT ID NCT05984927
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests a one-time gene therapy injection (NG101) for wet age-related macular degeneration. The therapy uses a harmless virus to deliver a gene that makes a drug inside the eye, aiming to reduce the need for repeated anti-VEGF injections. About 20 adults aged 50-89 with active disease will receive a single subretinal injection and be monitored for safety and vision changes over several years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NG101 gene therapy (a single injection into the eye using a harmless virus to deliver a drug-making gene)
- What this could lead to
- If it works, this could mean fewer anti-VEGF injections for wet AMD patients, potentially lasting years from one treatment.
- What could go wrong
- This is an early (phase 1/2a) small trial with only 20 people. Gene therapy carries risks like inflammation or vision loss, and long-term effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for AGE-RELATED MACULAR DEGENERATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cincinnati Eye Institute
Cincinnati, Ohio, 45242, United States
-
Retina Consultants of Texas
Bellaire, Texas, 77401, United States
-
Sunnybrook Ophthalmology and Vision Services
Toronto, Ontario, M4N 3M5, Canada
-
Vancouver Coastal Health Research Institute
Vancouver, British Columbia, V5Z 3N9, Canada
-
Vitreous Retina Macula Specialists of Toronto
Toronto, Ontario, M8X 2X3, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a VR maze reveal hidden vision loss in macular degeneration?
- Can a new eye injection save vision in wet AMD?
- A new eye camera may spot stressed cells before vision loss begins
- A sharper look at the retina: new imaging technology may spot eye disease earlier
- Eye injection aims to tame leading causes of blindness
- Could light therapy help save sight in dry macular degeneration?