One shot to save sight? gene therapy trial aims to end monthly eye injections
NCT ID NCT05657301
First seen Jan 04, 2026 · Last updated Apr 28, 2026 · Updated 20 times
Summary
This early-stage trial tests a gene therapy called KH631 for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The treatment delivers a protein that blocks abnormal blood vessel growth, potentially replacing the need for regular eye injections. About 25 adults aged 50-85 who have previously responded to standard anti-VEGF therapy will receive a single dose to check safety and tolerability.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Kanghong Investigative Site
Phoenix, Arizona, 85016, United States
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Kanghong Investigative Site
Lemont, Illinois, 60439, United States
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Kanghong Investigative Site
Boston, Massachusetts, 02114, United States
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Kanghong Investigative Site
Reno, Nevada, 89502, United States
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Kanghong Investigative Site
Cherry Hill, New Jersey, 08034, United States
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Kanghong Investigative Site
Germantown, Tennessee, 38138, United States
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Kanghong Investigative Site
Dallas, Texas, 75231, United States
Conditions
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