New eye drug could cut wet AMD shots to just twice a year

NCT ID NCT06795048

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study tests whether faricimab, an already-approved eye injection, can be given every 24 weeks (about twice a year) to people newly diagnosed with wet age-related macular degeneration (AMD). The trial involves 274 participants and will measure how well vision is maintained over 100 weeks. If it works, it could greatly reduce the burden of frequent eye injections for patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: faricimab (Vabysmo) eye injection
What this could lead to: If successful, this could allow people with wet AMD to receive treatment only twice a year instead of monthly, while maintaining or improving vision.
What could go wrong: This is a phase 4 study, so faricimab is already approved. However, not all patients may respond well to the extended dosing, and eye injections carry risks like infection or inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD)

Contacts and locations

Locations

Adelaide Eye and Retina Centre

Adelaide, South Australia, 5000, Australia
Asan Medical Center

Seoul, 05505, South Korea
Augenzentrum Prof. Koch GmbH

Frankfurt, 60549, Germany
Augenzentrum am St Franziskus-Hospital

Münster, Germany
Azienda Ospedaliera Universitaria "Luigi Vanvitelli";UOC Oculistica

Napoli, Sicily, 80138, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti

Torrette - Ancona, The Marches, 60126, Italy
Azienda ospedaliero - universitaria Sant'Andrea;UOC Oculistica

Rome, Lazio, 00189, Italy
Azienda ospedaliero universitaria Policlinico Riuniti di Foggia;SC Oculistica

Foggia, Apulia, 71122, Italy
Cardiff and Vale University Health Board

Cardiff, CF14 4XW, United Kingdom
Centre For Eye Research Australia

East Melbourne, Victoria, 3002, Australia
Centre Ophtalmologique de L'Odeon

Paris, 75006, France
Centre Retine Gallien

Bordeaux, 33000, France
Centres Ophtalmologique St Exupéry

Saint-Cyr-sur-Loire, 37540, France
Charles Retina Institute

Germantown, Tennessee, 38138, United States
China Medical University Hospital

Taichung, 404332, Taiwan
Clinica Baviera

Madrid, 28046, Spain
Clinique de l'Union

Saint-Jean, 31240, France
Ctr for Retina & Macular Dis

Winter Haven, Florida, 33880, United States
Eye and ENT hospital, Fudan University

Shanghai, China
Florida Retina Institute

Orlando, Florida, 32806-1101, United States
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Lombardy, 20122, Italy
Hopital Edouard Herriot - CHU Lyon

Lyon, 69437, France
Hopital Lariboisiere

Paris, 75010, France
Hopital du Saint Sacrement

Québec, Quebec, G1S 4L8, Canada
Hospital General de Catalunya

Sant Cugat de Valles, Barcelona, 08190, Spain
Hospital Universitario Puerta de Hierro

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Taiwan
Liverpool University Hospitals NHS Foundation Trust

Liverpool, L7 8XP, United Kingdom
Medizinische Hochschule Hannover, Klinik für Augenheilkunde

Hanover, 30625, Germany
Moorfields Eye Hospital NHS Foundation Trust

London, EC1V 2PD, United Kingdom
National Taiwan University Hospital

Zhongzheng Dist., 10002, Taiwan
New Cross Hospital

Wolverhampton, WV10 0QP, United Kingdom
New England Retina Consultants

Springfield, Massachusetts, 01107, United States
NewcastleUniversity& The Newcastle upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne, NE1 4LP, United Kingdom
Oftalvist

Burjassot, Valencia(España), Valencia, 46100, Spain
Orange County Retina Medical Group

Santa Ana, California, 92705, United States
Ospedale San Giuseppe

Milan, Lombardy, 20123, Italy
Peking University People's Hospital

Beijing, 100044, China
Pusan National University Hospital

Busan, 49241, South Korea
Retina Associates of New Jersey

Teaneck, New Jersey, 07666, United States
Retina Consultants of Texas

Schertz, Texas, 78154, United States
Retina Institute of Ottawa

Ottawa, Ontario, K2B 7E9, Canada
Retina Specialists Victoria

Rowville, Victoria, 3178, Australia
Retinal Vitreal Consultants

Chicago, Illinois, 60616, United States
Seoul National University Bundang Hospital

Seongnam-si, 13620, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
Sichuan Provincial People's Hospital

Chengdu, 610072, China
Sierra Eye Associates

Sparks, Nevada, 89434, United States
Singapore Eye Research Institute

Singapore, 168751, Singapore
St James University Hospital

Leeds, LS9 7TF, United Kingdom
St. Joseph's Health Care

London, Ontario, N6A 4V2, Canada
Strathfield Retina Clinic

Strathfield, New South Wales, 2135, Australia
Sydney Eye Hospital

Sydney, New South Wales, 2000, Australia
Tan Tock Seng Hospital

Singapore, 308433, Singapore
The Lions Eye Institute

Nedlands, Western Australia, 6009, Australia
Tongji Hosp, Tongji Med. Col, Huazhong Univ. of Sci. & Tech

Wuhan, 430030, China
Toronto Retina Institute

Toronto, Ontario, M3C 0G9, Canada
Toronto Western Hospital

Toronto, Ontario, M5T 2S8, Canada
Universitatsklinikum Ulm, Augenklinik und Poliklinik

Ulm, 89075, Germany
University Retina and Macula Associates, PC

Lemont, Illinois, 60439, United States
Universitätsklinikum Würzburg, Augenklinik und Poliklinik

Würzburg, 97080, Germany
Vision Research Center at Eye Associates of New Mexico

Albuquerque, New Mexico, 87109, United States
West China Hospital of Sichuan University

Chengdu, 610041, China
Yeungnam University Medical Center

Daegu, 42415, South Korea
Zhongshan Ophthalmic Center, Sun Yat-sen University

Guangzhou, 510060, China

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