New epilepsy drug shows promise for kids in early trial
NCT ID NCT04015141
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding perampanel (Fycompa) to current epilepsy medications can reduce seizures in children aged 1 month to 18 years. About 100 children with specific epilepsy syndromes or partial-onset seizures will receive the drug. The main goal is to see if at least half of the children experience a 50% or greater drop in seizure frequency.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Perampanel (also known as Fycompa), an oral medication
What this could lead to
If successful, this could provide a new add-on treatment option to help control seizures in children with epilepsy.
What could go wrong
This is an early phase 2 study with only 100 children, so results may not confirm effectiveness or safety for broader use. Side effects are possible, and the drug is not a cure.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHRU Rennes
Rennes, France
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CHUS - H. Clinico U. de Santiago
Santiago de Compostela, Spain
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Centre Hospitalier Universitaire de Toulouse
Toulouse, France
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Centre Neurologique William Lennox
Ottignies, Brabant Wallon, Belgium
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Child Neurology Consultants of Austin
Austin, Texas, 78731, United States
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Children's Hospital of Michigan
Detroit, Michigan, 48201, United States
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Children's Hospital of Richmond at VCU - CHoR-PIN
Richmond, Virginia, 23298, United States
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Children's Specialty Group
Norfolk, Virginia, 23510, United States
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Childrens Hospital Colorado
Aurora, Colorado, 80045, United States
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Complejo Hospitalario de Navarra
Pamplona, Spain
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David Geffen School of Medicine at UCLA
Los Angeles, California, 90095, United States
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Dayton Children's Hospital
Dayton, Ohio, 45404, United States
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Dr. Von Haunersches Kinderspital
Munich, Germany
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Fakultni nemocnice Brno
Brno, Czechia
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Hopital Necker
Paris, France
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Hopitaux de La Timone
Marseille, Bouches-du-Rhone, France
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Hopitaux de Paris CHU Hopital Robert Debre - Inserm U676
Paris, France
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Hospital Clinico San Carlos
Madrid, Spain
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Hospital General Universitario Gregorio Marañon
Madrid, Spain
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Hospital Universitario Virgen del Rocio - PPDS
Seville, Spain
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Hôpital Pellegrin-Enfants
Bordeaux, France
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Hôpital Universitaire des Enfants Reine Fabiola
Brussels, Brussels Capital, Belgium
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Kleinwachau Sächsisches Epilepsiezentrum Radeberg Gemeinnützige Gmbh
Radeberg, Germany
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Meridian Clinical Research-(Savannah Georgia)
Savannah, Georgia, 31406, United States
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Nicklaus Children's Hospital
Miami, Florida, 33155, United States
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Northeast Regional Epilepsy Group
Hackensack, New Jersey, 07601, United States
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Pediatric Epilepsy and Neurology Specialists
Tampa, Florida, 33607, United States
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Road Runner Research Ltd
San Antonio, Texas, 78249, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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UZ Brussel
Brussels, Brussels Capital, Belgium
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UZ Gent
Ghent, Oost-Vlaanderen, Belgium
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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Universitätsklinikum Freiburg
Freiburg im Breisgau, Germany
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Universitätsklinikum Jena
Jena, Germany
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Wake Forest Baptist Medical Center - PPDS
Winston-Salem, North Carolina, 27157, United States