Could a tiny implant replace monthly eye shots for wet AMD?

NCT ID NCT05769153

Ongoing Disease control Sponsor: Alcon Research Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental implant (AR-14034) that slowly releases medication inside the eye to treat wet age-related macular degeneration (AMD). The goal is to see if it is safe and can work as well as or better than standard anti-VEGF injections, which require frequent doctor visits. About 139 people with wet AMD will receive either the implant or standard injections, and their vision will be tracked for nearly a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AR-14034 sustained-release implant
What this could lead to: If successful, this implant could reduce the need for frequent eye injections for wet AMD, offering longer-lasting treatment with fewer clinic visits.
What could go wrong: This is an early-phase trial (Phase 1/2) with only 139 participants, so safety and effectiveness are not yet proven. The implant may not work as well as current injections or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD)

Contacts and locations

Locations

Associated Retina Consultants - Gilbert

Gilbert, Arizona, 85297, United States
Associated Retina Consultants - Phoenix

Phoenix, Arizona, 85020, United States
Austin Clinical Research, LLC

Austin, Texas, 78750, United States
Austin Research Center for Retina

Austin, Texas, 78705, United States
Austin Retina Associates

Austin, Texas, 78705, United States
Austin Retina Associates (San Marcos)

San Marcos, Texas, 78666, United States
Azul Vision Pasadena

Pasadena, California, 99107, United States
Berkeley Eye Center

Houston, Texas, 77027, United States
Carolina Eyecare Physicians LLC

Mt. Pleasant, South Carolina, 29464, United States
Center for Retina and Macular Disease

Winter Haven, Florida, 33880, United States
Erie Retina Research

Erie, Pennsylvania, 16507, United States
Eye Associates of Pinellas

Pinellas Park, Florida, 33782, United States
Eye Research Foundation

Newport Beach, California, 92663, United States
Florida Retina Institute

Jacksonville, Florida, 32216, United States
Florida Retina Institute

Orlando, Florida, 32806, United States
Mid Florida Eye Center

Mt. Dora, Florida, 32757, United States
MidAtlantic Retina Research

Philadelphia, Pennsylvania, 19107, United States
Mississippi Retina Associates

Madison, Mississippi, 39110, United States
NYC Retina - Queens

Forest Hills, New York, 11375, United States
Northern California Retina Vitreous Associates Medical Group

Mountain View, California, 94040, United States
Pacific Northwest Retina

Burlington, Washington, 98233, United States
Retina Associates of Orange County

Laguna Hills, California, 92653, United States
Retina Associates of SW PC

Tucson, Arizona, 85704, United States
Retina Consultants of Carolina

Greenville, South Carolina, 29605, United States
Retina Consultants of Southern Colorado

Colorado Springs, Colorado, 80809, United States
Retina Consultants of Texas - San Antonio

San Antonio, Texas, 78251, United States
Retina Group of New England | Waterford

Waterford, Connecticut, 06385, United States
Retina Research Center of Southern Utah

St. George, Utah, 84790, United States
Retina Research Institute of Texas

Abilene, Texas, 79606, United States
Retina Specialty Institute

Pensacola, Florida, 32503, United States
Southeast Retina Center

Augusta, Georgia, 30909, United States
Star Vision Research

Burleson, Texas, 76028, United States
Texas Retina Associates

Dallas, Texas, 75231, United States
Texas Retina Associates - Arlington

Arlington, Texas, 76012, United States
The Retina Partners

Encino, California, 91436, United States
Thomas Eye Group Main Office

Sandy Springs, Georgia, 30328, United States
Trinity Research Group

Dothan, Alabama, 36301, United States
Twin Cities Eye Consultants

Coon Rapids, Minnesota, 55433, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University Retina and Macula Associates, PC

Oak Forest, Illinois, 60452, United States
Verum Research, LLC

Eugene, Oregon, 97401, United States
Vision Research Center Eye Associates of New Mexico

Albuquerque, New Mexico, 87109, United States

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