Could a tiny implant replace monthly eye shots for wet AMD?
NCT ID NCT05769153
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an experimental implant (AR-14034) that slowly releases medication inside the eye to treat wet age-related macular degeneration (AMD). The goal is to see if it is safe and can work as well as or better than standard anti-VEGF injections, which require frequent doctor visits. About 139 people with wet AMD will receive either the implant or standard injections, and their vision will be tracked for nearly a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AR-14034 sustained-release implant
What this could lead to
If successful, this implant could reduce the need for frequent eye injections for wet AMD, offering longer-lasting treatment with fewer clinic visits.
What could go wrong
This is an early-phase trial (Phase 1/2) with only 139 participants, so safety and effectiveness are not yet proven. The implant may not work as well as current injections or could cause unexpected side effects.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Associated Retina Consultants - Gilbert
Gilbert, Arizona, 85297, United States
-
Associated Retina Consultants - Phoenix
Phoenix, Arizona, 85020, United States
-
Austin Clinical Research, LLC
Austin, Texas, 78750, United States
-
Austin Research Center for Retina
Austin, Texas, 78705, United States
-
Austin Retina Associates
Austin, Texas, 78705, United States
-
Austin Retina Associates (San Marcos)
San Marcos, Texas, 78666, United States
-
Azul Vision Pasadena
Pasadena, California, 99107, United States
-
Berkeley Eye Center
Houston, Texas, 77027, United States
-
Carolina Eyecare Physicians LLC
Mt. Pleasant, South Carolina, 29464, United States
-
Center for Retina and Macular Disease
Winter Haven, Florida, 33880, United States
-
Erie Retina Research
Erie, Pennsylvania, 16507, United States
-
Eye Associates of Pinellas
Pinellas Park, Florida, 33782, United States
-
Eye Research Foundation
Newport Beach, California, 92663, United States
-
Florida Retina Institute
Jacksonville, Florida, 32216, United States
-
Florida Retina Institute
Orlando, Florida, 32806, United States
-
Mid Florida Eye Center
Mt. Dora, Florida, 32757, United States
-
MidAtlantic Retina Research
Philadelphia, Pennsylvania, 19107, United States
-
Mississippi Retina Associates
Madison, Mississippi, 39110, United States
-
NYC Retina - Queens
Forest Hills, New York, 11375, United States
-
Northern California Retina Vitreous Associates Medical Group
Mountain View, California, 94040, United States
-
Pacific Northwest Retina
Burlington, Washington, 98233, United States
-
Retina Associates of Orange County
Laguna Hills, California, 92653, United States
-
Retina Associates of SW PC
Tucson, Arizona, 85704, United States
-
Retina Consultants of Carolina
Greenville, South Carolina, 29605, United States
-
Retina Consultants of Southern Colorado
Colorado Springs, Colorado, 80809, United States
-
Retina Consultants of Texas - San Antonio
San Antonio, Texas, 78251, United States
-
Retina Group of New England | Waterford
Waterford, Connecticut, 06385, United States
-
Retina Research Center of Southern Utah
St. George, Utah, 84790, United States
-
Retina Research Institute of Texas
Abilene, Texas, 79606, United States
-
Retina Specialty Institute
Pensacola, Florida, 32503, United States
-
Southeast Retina Center
Augusta, Georgia, 30909, United States
-
Star Vision Research
Burleson, Texas, 76028, United States
-
Texas Retina Associates
Dallas, Texas, 75231, United States
-
Texas Retina Associates - Arlington
Arlington, Texas, 76012, United States
-
The Retina Partners
Encino, California, 91436, United States
-
Thomas Eye Group Main Office
Sandy Springs, Georgia, 30328, United States
-
Trinity Research Group
Dothan, Alabama, 36301, United States
-
Twin Cities Eye Consultants
Coon Rapids, Minnesota, 55433, United States
-
University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
-
University Retina and Macula Associates, PC
Oak Forest, Illinois, 60452, United States
-
Verum Research, LLC
Eugene, Oregon, 97401, United States
-
Vision Research Center Eye Associates of New Mexico
Albuquerque, New Mexico, 87109, United States