Scientists track vision loss in rare genetic eye disease to pave way for future treatments
NCT ID NCT05573984
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows 50 people with a rare inherited eye condition called PRPF31-related retinal dystrophy (RP11) to see how their vision changes over time. Researchers will measure things like visual acuity, retinal thickness, and quality of life using eye exams and questionnaires. The goal is to better understand the disease's natural course and identify the best ways to measure improvement in future treatment trials.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this study could identify key measures of disease progression, helping design future clinical trials for treatments targeting this form of retinal dystrophy.
- What could go wrong
- This is an observational study, not testing any treatment. It may not lead directly to a therapy, and results may not apply to all forms of retinitis pigmentosa.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre For Eye Research Australia (CERA) - Retinal Gene Therapy Unit
East Melbourne, Australia
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Lions Eye Institute
Nedlands, Western Australia, 6009, Australia
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Oregon Health and Science University - Casey Eye Institute
Portland, Oregon, 97239, United States
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Retina Foundation of the Southwest
Dallas, Texas, 75321, United States
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University of California San Francisco
San Francisco, California, 94143, United States
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University of Florida Health
Jacksonville, Florida, 32209, United States
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University of Michigan Kellogg Eye Center
Ann Arbor, Michigan, 48105, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- A sharper look at the retina: new imaging technology may spot eye disease earlier
- Stem cell eye transplant aims to halt blindness from rare genetic disease
- Could stem cells restore sight in damaged eyes?
- Gene therapy injection aims to restore sight in rare blindness
- Ground-Level vision test could help retinitis pigmentosa patients walk better