New eye drug implant could reduce injections for wet AMD

NCT ID NCT04567303

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new drug called zifibancimig for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The drug is given either as an eye injection or through a small implant placed in the eye that releases the drug over time. The trial involves 177 participants and aims to check safety and how well the drug works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zifibancimig (a drug given as an eye injection or through an eye implant)
What this could lead to: If it works, this could lead to a new treatment option for wet age-related macular degeneration that requires fewer eye injections.
What could go wrong: This is an early phase 1/2 trial with only 177 people, so it is not yet proven safe or effective. Side effects from the eye implant or injections are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

macular degeneration wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MACULAR DEGENERATION

Contacts and locations

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Locations

Associated Retina Consultants

Phoenix, Arizona, 85020, United States
Associated Retinal Consultants

Royal Oak, Michigan, 48073, United States
Austin Clinical Research LLC

Austin, Texas, 78750, United States
Austin Research Center for Retina

Austin, Texas, 78705, United States
Barnet Dulaney Perkins Eye Center

Mesa, Arizona, 85206, United States
Carolina Eyecare Physicians

Mt. Pleasant, South Carolina, 29464, United States
Charles Retina Institute

Germantown, Tennessee, 38138, United States
Cumberland Valley Retina Consultants

Hagerstown, Maryland, 21740, United States
Duke Eye Center

Durham, North Carolina, 27705, United States
Emanuelli Research and Development Center LLC

Arecibo, 00612, Puerto Rico
Envision Ocular, LLC

Bloomfield, New Jersey, 07003, United States
Foundation for Vision Research

Grand Rapids, Michigan, 49546, United States
Graystone Eye

Hickory, North Carolina, 28602, United States
Johns Hopkins Med

Baltimore, Maryland, 21287, United States
Maine Eye Center

Portland, Maine, 04101, United States
Mid Atlantic Retina - Wills Eye Hospital

Philadelphia, Pennsylvania, 19107, United States
OSU Eye Physicians & Surgeons

Columbus, Ohio, 43212, United States
Orange County Retina Med Group

Santa Ana, California, 92705, United States
Piedmont Eye Center

Lynchburg, Virginia, 24502, United States
Retina Associates of Florida, LLC

Tampa, Florida, 33609, United States
Retina Center of Texas

Southlake, Texas, 76092, United States
Retina Consultants of Texas

Bellaire, Texas, 77401, United States
Retina Consultants of Texas

Houston, Texas, 77030, United States
Retina Group of Washington

Chevy Chase, Maryland, 20815, United States
Retina Vit Surgeons/Central NY

Liverpool, New York, 13088, United States
Retina Vitreous Assoc of FL

St. Petersburg, Florida, 33711, United States
Retinal Consultants Med Group

Sacramento, California, 95841, United States
Sierra Eye Associates

Reno, Nevada, 89502, United States
Southeast Retina Center

Augusta, Georgia, 30909, United States
Southeastern Retina Associates

Knoxville, Tennessee, 37922, United States
Southern Vitreoretinal Assoc

Tallahassee, Florida, 32308, United States
Southwest Retina Consultants

Durango, Colorado, 81303, United States
Spokane Eye Clinical Research

Spokane, Washington, 99204, United States
Tennessee Retina PC.

Nashville, Tennessee, 37203, United States
The Retina Institute

St Louis, Missouri, 63128, United States
The Retina Partners

Encino, California, 91436, United States
University Retina and Macula Associates, PC

Oak Forest, Illinois, 60452, United States
VitreoRetinal Surgery, PLLC.

Saint Louis Park, Minnesota, 55416, United States
Wagner Kapoor Institute

Norfolk, Virginia, 23502, United States

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