One shot could replace dozens: gene therapy trial for blinding eye disease

NCT ID NCT06856577

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 29 times

Summary

This Phase 3 study tests a single injection of a gene therapy called Ixo-vec in 311 people with wet age-related macular degeneration, a leading cause of vision loss. The goal is to see if one treatment can control the disease as well as or better than current standard-of-care eye injections given every few months. Participants receive either Ixo-vec or an active comparator, and vision is tracked over two years.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Adverum Clinical Site 100

    Beverly Hills, California, 90211, United States

  • Adverum Clinical Site 107

    The Woodlands, Texas, 77384, United States

  • Adverum Clinical Site 108

    Bellaire, Texas, 77401, United States

  • Adverum Clinical Site 109

    Bakersfield, California, 93309, United States

  • Adverum Clinical Site 110

    Philadelphia, Pennsylvania, 19107, United States

  • Adverum Clinical Site 116

    Lakewood, Colorado, 80228, United States

  • Adverum Clinical Site 120

    St. Petersburg, Florida, 33711, United States

  • Adverum Clinical Site 122

    West Columbia, South Carolina, 29169, United States

  • Adverum Clinical Site 123

    Abilene, Texas, 79606, United States

  • Adverum Clinical Site 124

    Pompano Beach, Florida, 33064, United States

  • Adverum Clinical Site 126

    Phoenix, Arizona, 85053, United States

  • Adverum Clinical Site 127

    Austin, Texas, 78705, United States

  • Adverum Clinical Site 131

    Spokane, Washington, 99204, United States

  • Adverum Clinical Site 140

    Sacramento, California, 95825, United States

  • Adverum Clinical Site 144

    Rapid City, South Dakota, 57701, United States

  • Adverum Clinical Site 159

    Tucson, Arizona, 85704, United States

  • Adverum Clinical Site 162

    McAllen, Texas, 78503, United States

  • Adverum Clinical Site 163

    Southaven, Mississippi, 38671, United States

  • Adverum Clinical Site 164

    Riverside, California, 92505, United States

  • Adverum Clinical Site 165

    Waterford, Connecticut, 06385, United States

  • Adverum Clinical Site 167

    Detroit, Michigan, 48201, United States

  • Adverum Clinical Site 168

    Jacksonville, Florida, 32216, United States

  • Adverum Clinical Site 169

    Fullerton, California, 92835, United States

  • Adverum Clinical Site 171

    Teaneck, New Jersey, 07666, United States

  • Adverum Clinical Site 172

    Encino, California, 91436, United States

  • Adverum Clinical Site 175

    Santa Barbara, California, 93103, United States

  • Adverum Clinical Site 176

    Fort Lauderdale, Florida, 33308, United States

  • Adverum Clinical Site 178

    Phoenix, Arizona, 85021, United States

  • Adverum Clinical Site 179

    Oak Forest, Illinois, 60452, United States

  • Adverum Clinical Site 181

    Erie, Pennsylvania, 16507, United States

  • Adverum Clinical Site 182

    Augusta, Georgia, 30909, United States

  • Adverum Clinical Site 183

    South Miami, Florida, 33143, United States

  • Adverum Clinical Site 184

    Deerfield Beach, Florida, 33064, United States

  • Adverum Clinical Site 185

    San Antonio, Texas, 78240, United States

  • Adverum Clinical Site 186

    Durham, North Carolina, 27705, United States

  • Adverum Clinical Site 187

    Wausau, Wisconsin, 54403, United States

  • Adverum Clinical Site 188

    Houston, Texas, 77030, United States

  • Adverum Clinical Site 189

    Walnut Creek, California, 94598, United States

  • Adverum Clinical Site 190

    St Louis, Missouri, 63128, United States

  • Adverum Clinical Site 193

    Tampa, Florida, 33617, United States

  • Adverum Clinical Site 194

    Dallas, Texas, 75231, United States

  • Adverum Clinical Site 195

    Carmel, Indiana, 46032, United States

  • Adverum Clinical Site 196

    Asheville, North Carolina, 28803, United States

  • Adverum Clinical Site 197

    Hagerstown, Maryland, 21740, United States

  • Adverum Clinical Site 198

    Springdale, Arkansas, 72764, United States

  • Adverum Clinical Site 199

    Lynchburg, Virginia, 24502, United States

  • Adverum Clinical Site 200

    Denver, Colorado, 80222, United States

  • Adverum Clinical Site 201

    Campbell, California, 95008, United States

  • Adverum Clinical Site 202

    Torrance, California, 90503, United States

  • Adverum Clinical Site 204

    Hagerstown, Maryland, 21740, United States

  • Adverum Clinical Site 205

    Carmel, Indiana, 46032, United States

  • Adverum Clinical Site 207

    Oak Park, Illinois, 60304, United States

  • Adverum Clinical Site 208

    Charleston, South Carolina, 29414, United States

  • Adverum Clinical Site 209

    Wake Forest, North Carolina, 27587, United States

  • Adverum Clinical Site 211

    Greensboro, North Carolina, 27401, United States

  • Adverum Clinical Site 212

    Sacramento, California, 95841, United States

  • Adverum Clinical Site 213

    Orlando, Florida, 32806, United States

  • Adverum Clinical Site 214

    Lakeland, Florida, 33805, United States

  • Adverum Clinical Site 215

    Redlands, California, 92374, United States

  • Adverum Clinical Site 216

    Madison, Mississippi, 39110, United States

  • Adverum Clinical Site 218

    Katy, Texas, 77494, United States

  • Adverum Clinical Site 219

    Winston-Salem, North Carolina, 27103, United States

  • Adverum Clinical Site 220

    Hickory, North Carolina, 28602, United States

  • Adverum Clinical Site 221

    Fort Myers, Florida, 33912, United States

  • Adverum Clinical Site 222

    Ladson, South Carolina, 29456, United States

  • Adverum Clinical Site 223

    Gilbert, Arizona, 85297, United States

  • Adverum Clinical Site 224

    Huntington Beach, California, 92647, United States

  • Adverum Clinical Site 225

    Liverpool, New York, 13088, United States

  • Adverum Clinical Site 227

    Burleson, Texas, 76028, United States

  • Adverum Clinical Site 228

    Schertz, Texas, 78154, United States

  • Adverum Clinical Site 229

    Scottsdale, Arizona, 85255, United States

  • Adverum Clinical Site 230

    Pensacola, Florida, 32503, United States

  • Adverum Clinical Site 231

    The Woodlands, Texas, 77384, United States

  • Adverum Clinical Site 232

    San Marcos, Texas, 78666, United States

  • Adverum Clinical Site 234

    Cary, North Carolina, 27511, United States

Conditions

Explore the condition pages connected to this study.