Gene therapy shot could end monthly eye injections for wet AMD

NCT ID NCT06856577

Ongoing Disease control Sponsor: Adverum Biotechnologies, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests a single injection of Ixo-vec gene therapy in 311 people with wet age-related macular degeneration (AMD). The goal is to see if it can maintain or improve vision as well as standard aflibercept injections, but with fewer follow-up treatments. Participants receive either Ixo-vec or aflibercept, and their vision is tracked over two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ixoberogene soroparvovec (Ixo-vec) gene therapy
What this could lead to: If it works, this could offer a one-time treatment for wet AMD, reducing or eliminating the need for regular eye injections.
What could go wrong: This is still an early Phase 3 trial with 311 participants. The gene therapy may not improve vision as hoped, and there are risks from the injection itself, such as inflammation or infection.

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Conditions

The condition(s) this trial relates to.

blindness (disorder) eye disorder wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD) WET AMD

Contacts and locations

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Locations

Adverum Clinical Site 100

Beverly Hills, California, 90211, United States
Adverum Clinical Site 107

The Woodlands, Texas, 77384, United States
Adverum Clinical Site 108

Bellaire, Texas, 77401, United States
Adverum Clinical Site 109

Bakersfield, California, 93309, United States
Adverum Clinical Site 110

Philadelphia, Pennsylvania, 19107, United States
Adverum Clinical Site 116

Lakewood, Colorado, 80228, United States
Adverum Clinical Site 120

St. Petersburg, Florida, 33711, United States
Adverum Clinical Site 122

West Columbia, South Carolina, 29169, United States
Adverum Clinical Site 123

Abilene, Texas, 79606, United States
Adverum Clinical Site 124

Pompano Beach, Florida, 33064, United States
Adverum Clinical Site 126

Phoenix, Arizona, 85053, United States
Adverum Clinical Site 127

Austin, Texas, 78705, United States
Adverum Clinical Site 131

Spokane, Washington, 99204, United States
Adverum Clinical Site 140

Sacramento, California, 95825, United States
Adverum Clinical Site 144

Rapid City, South Dakota, 57701, United States
Adverum Clinical Site 159

Tucson, Arizona, 85704, United States
Adverum Clinical Site 162

McAllen, Texas, 78503, United States
Adverum Clinical Site 163

Southaven, Mississippi, 38671, United States
Adverum Clinical Site 164

Riverside, California, 92505, United States
Adverum Clinical Site 165

Waterford, Connecticut, 06385, United States
Adverum Clinical Site 167

Detroit, Michigan, 48201, United States
Adverum Clinical Site 168

Jacksonville, Florida, 32216, United States
Adverum Clinical Site 169

Fullerton, California, 92835, United States
Adverum Clinical Site 171

Teaneck, New Jersey, 07666, United States
Adverum Clinical Site 172

Encino, California, 91436, United States
Adverum Clinical Site 175

Santa Barbara, California, 93103, United States
Adverum Clinical Site 176

Fort Lauderdale, Florida, 33308, United States
Adverum Clinical Site 178

Phoenix, Arizona, 85021, United States
Adverum Clinical Site 179

Oak Forest, Illinois, 60452, United States
Adverum Clinical Site 181

Erie, Pennsylvania, 16507, United States
Adverum Clinical Site 182

Augusta, Georgia, 30909, United States
Adverum Clinical Site 183

South Miami, Florida, 33143, United States
Adverum Clinical Site 184

Deerfield Beach, Florida, 33064, United States
Adverum Clinical Site 185

San Antonio, Texas, 78240, United States
Adverum Clinical Site 186

Durham, North Carolina, 27705, United States
Adverum Clinical Site 187

Wausau, Wisconsin, 54403, United States
Adverum Clinical Site 188

Houston, Texas, 77030, United States
Adverum Clinical Site 189

Walnut Creek, California, 94598, United States
Adverum Clinical Site 190

St Louis, Missouri, 63128, United States
Adverum Clinical Site 193

Tampa, Florida, 33617, United States
Adverum Clinical Site 194

Dallas, Texas, 75231, United States
Adverum Clinical Site 195

Carmel, Indiana, 46032, United States
Adverum Clinical Site 196

Asheville, North Carolina, 28803, United States
Adverum Clinical Site 197

Hagerstown, Maryland, 21740, United States
Adverum Clinical Site 198

Springdale, Arkansas, 72764, United States
Adverum Clinical Site 199

Lynchburg, Virginia, 24502, United States
Adverum Clinical Site 200

Denver, Colorado, 80222, United States
Adverum Clinical Site 201

Campbell, California, 95008, United States
Adverum Clinical Site 202

Torrance, California, 90503, United States
Adverum Clinical Site 204

Hagerstown, Maryland, 21740, United States
Adverum Clinical Site 205

Carmel, Indiana, 46032, United States
Adverum Clinical Site 207

Oak Park, Illinois, 60304, United States
Adverum Clinical Site 208

Charleston, South Carolina, 29414, United States
Adverum Clinical Site 209

Wake Forest, North Carolina, 27587, United States
Adverum Clinical Site 211

Greensboro, North Carolina, 27401, United States
Adverum Clinical Site 212

Sacramento, California, 95841, United States
Adverum Clinical Site 213

Orlando, Florida, 32806, United States
Adverum Clinical Site 214

Lakeland, Florida, 33805, United States
Adverum Clinical Site 215

Redlands, California, 92374, United States
Adverum Clinical Site 216

Madison, Mississippi, 39110, United States
Adverum Clinical Site 218

Katy, Texas, 77494, United States
Adverum Clinical Site 219

Winston-Salem, North Carolina, 27103, United States
Adverum Clinical Site 220

Hickory, North Carolina, 28602, United States
Adverum Clinical Site 221

Fort Myers, Florida, 33912, United States
Adverum Clinical Site 222

Ladson, South Carolina, 29456, United States
Adverum Clinical Site 223

Gilbert, Arizona, 85297, United States
Adverum Clinical Site 224

Huntington Beach, California, 92647, United States
Adverum Clinical Site 225

Liverpool, New York, 13088, United States
Adverum Clinical Site 227

Burleson, Texas, 76028, United States
Adverum Clinical Site 228

Schertz, Texas, 78154, United States
Adverum Clinical Site 229

Scottsdale, Arizona, 85255, United States
Adverum Clinical Site 230

Pensacola, Florida, 32503, United States
Adverum Clinical Site 231

The Woodlands, Texas, 77384, United States
Adverum Clinical Site 232

San Marcos, Texas, 78666, United States
Adverum Clinical Site 234

Cary, North Carolina, 27511, United States

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