New shot could ease pain after knee surgery for days

NCT ID NCT04860635

Terminated Symptom relief Sponsor: Arthritis Innovation Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a single injection of F14, a long-acting form of the painkiller celecoxib, in 100 people undergoing total knee replacement. The goal is to see if it safely controls pain as part of a standard pain management plan. Participants receive the injection during surgery and are monitored for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: F14 (sustained release celecoxib)
What this could lead to: If it works, this could provide a longer-lasting pain relief option after knee replacement, reducing the need for frequent pain pills.
What could go wrong: This is an early-phase, single-arm study with no placebo group, so results may not prove effectiveness. The trial is currently suspended, and safety risks are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA

Contacts and locations

Locations

Endeavor Clinical Trials

San Antonio, Texas, 78229, United States
Panorama Orthopedics & Spine Center

Denver, Colorado, 80401, United States

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