New shot could ease pain after knee surgery for days
NCT ID NCT04860635
First seen Jan 05, 2026 · Last updated Jun 23, 2026 · Updated 33 times
Summary
This study tests a single injection of F14, a long-acting form of the painkiller celecoxib, in 100 people undergoing total knee replacement. The goal is to see if it safely controls pain as part of a standard pain management plan. Participants receive the injection during surgery and are monitored for side effects.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Endeavor Clinical Trials
San Antonio, Texas, 78229, United States
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Panorama Orthopedics & Spine Center
Denver, Colorado, 80401, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
F14 (sustained release celecoxib)
What this could lead to
If it works, this could provide a longer-lasting pain relief option after knee replacement, reducing the need for frequent pain pills.
What could go wrong
This is an early-phase, single-arm study with no placebo group, so results may not prove effectiveness. The trial is currently suspended, and safety risks are still being evaluated.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.