One-Time eye injection could slow blindness in retinitis pigmentosa
NCT ID NCT05748873
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests a gene therapy called SPVN06 for retinitis pigmentosa, an inherited eye disease that causes gradual vision loss. The treatment is given as a single injection under the retina. The trial includes 33 adults with advanced disease and will check safety and whether it can slow vision decline over up to 5 years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SPVN06 gene therapy (a single injection under the retina)
What this could lead to
If it works, this could slow or stop vision loss in people with retinitis pigmentosa, preserving sight for years.
What could go wrong
This is an early-phase trial with only 33 people, so success is not guaranteed. The injection itself carries risks like infection or retinal damage, and the therapy may not work for all genetic types.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for RETINITIS PIGMENTOSA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Bascom Palmer Eye Institute/University of Miami
Miami, Florida, 33136, United States
-
CHNO XV-XX Paris - CIC 1423
Paris, 75012, France
-
Casey Eye Institute
Portland, Oregon, 97239, United States
-
Mass Eye and Ear
Boston, Massachusetts, 02114, United States
-
Retina Foundation of the Southwest
Dallas, Texas, 75231, United States
-
UPMC Eye Center
Pittsburgh, Pennsylvania, 15213, United States