Higher-Dose eye injection shows promise for two leading causes of vision loss
NCT ID NCT06491914
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a higher dose of the drug aflibercept (8 mg) given as an eye injection every 4 weeks to people with wet age-related macular degeneration (nAMD) or diabetic macular edema (DME). The goal is to see if this dosing schedule is safe and works well for those who have already been treated with similar medications. About 1,118 adults will take part, and researchers will track side effects and serious side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Advanced Research, LLC
Deerfield Beach, Florida, 33064, United States
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Austin Retina Associates
Austin, Texas, 78705, United States
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Austin Retina Associates
Round Rock, Texas, 78681, United States
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California Eye Specialists Medical Group, Inc.
Pasadena, California, 91107, United States
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California Retina Consultants
Bakersfield, California, 93309, United States
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Center for Retina and Macular Disease
Winter Haven, Florida, 33880, United States
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Charleston Neuroscience Institute LLC
Ladson, South Carolina, 29456, United States
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Cincinnati Eye Institute
Cincinnati, Ohio, 45242, United States
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Cumberland Valley Retina Consultants-Ophthalmology
Hagerstown, Maryland, 21740, United States
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Deep Blue Retina Clinical Research PLLC
Southaven, Mississippi, 38671, United States
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Emanuelli Research and Development Center
Arecibo, 00612, Puerto Rico
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Eye Associates of Pinellas
Pinellas Park, Florida, 33782, United States
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Eye care Center of Northern Colorado doing business as Advanced Vision Research Institute
Longmont, Colorado, 80503, United States
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EyeHealth Northwest
Portland, Oregon, 97225, United States
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Florida Retina Consultants
Lakeland, Florida, 33805, United States
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Florida Retina Institute - Jacksonville
Jacksonville, Florida, 32216, United States
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Florida Retina Institute - Orlando
Orlando, Florida, 32806, United States
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Georgia Retina
Marietta, Georgia, 30060, United States
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Illinois Retina Associates
Oak Park, Illinois, 60304, United States
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Mid Atlantic Retina
Bethlehem, Pennsylvania, 18017, United States
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Mid Atlantic Retina Specialists Hagerstown
Hagerstown, Maryland, 21740, United States
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North Carolina Retina Associates
Wake Forest, North Carolina, 27587, United States
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Opthalmic Consultants of Boston
Boston, Massachusetts, 02114, United States
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Pacific Northwest Retina
Bellevue, Washington, 98004, United States
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Palmetto Retina Center
West Columbia, South Carolina, 29169, United States
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Retina Associates of Cleveland - Beachwood
Beachwood, Ohio, 44122, United States
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Retina Consultants Texas
The Woodlands, Texas, 77384, United States
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Retina Consultants of Hawaii, Inc.
‘Aiea, Hawaii, 96701, United States
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Retina Consultants of Minnesota
Edina, Minnesota, 55435, United States
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Retina Consultants of Southern California
Redlands, California, 92374, United States
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Retina Consultants of Southern Colorado
Colorado Springs, Colorado, 80909, United States
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Retina Consultants of Texas
Beaumont, Texas, 77707, United States
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Retina Consultants of Texas
Katy, Texas, 77494, United States
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Retina Consultants of Texas
San Antonio, Texas, 78240, United States
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Retina Consultants of Texas - Houston
Bellaire, Texas, 77401, United States
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Retina Consultants of Texas Brown Retina Institute
San Antonio, Texas, 78251, United States
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Retina Group of New England
Waterford, Connecticut, 06385, United States
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Retina Research Institute of Texas
Abilene, Texas, 79606, United States
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Retina Specialists of Beverly Hills
Beverly Hills, California, 90212, United States
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Retina Speciality Institute - Pensacola, Florida
Pensacola, Florida, 32503, United States
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Retina Vitreous Associates of Florida
Tampa, Florida, 33617, United States
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Retina Vitreous Associates of Florida Saint Petersburg
St. Petersburg, Florida, 33711, United States
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Salehi Retina Institute dba Retina Associates of Southern California
Huntington Beach, California, 92647, United States
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Sewickley Eye Group
Sewickley, Pennsylvania, 15143, United States
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South Coast Retina Center
Long Beach, California, 90807, United States
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Southwest Retina Consultants
El Paso, Texas, 79902, United States
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Tennessee Retina, PC
Nashville, Tennessee, 37203, United States
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Texas Retina Associates - Dallas
Dallas, Texas, 75231, United States
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Tulsa Retina Consultants
Tulsa, Oklahoma, 74114, United States
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University Retina and Macula Associates PC - Lemont
Lemont, Illinois, 60439, United States
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Vision Research Center Eye Associates of New Mexico
Albuquerque, New Mexico, 87109, United States
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Vitreoretinal Consultants of NY - Westbury
Westbury, New York, 11590, United States
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Vrmg Inc
Sacramento, California, 95825, United States
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Win Retina - Arcadia
Arcadia, California, 91006, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Longer-Lasting eye injection could cut treatment visits for macular disease
- Can a new eye injection preserve vision in south asians with diabetes?
- Could a biosimilar eye injection offer a new way to treat diabetic macular edema?
- Can a new eye injection save vision in wet AMD?
- Can a steroid implant boost the effect of standard eye injections for hard-to-treat diabetic macular edema?
- Eye injection aims to tame leading causes of blindness