Could a common numbing drug replace opioids after liver surgery?
NCT ID NCT07590830
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving lidocaine through a vein during and after liver surgery can reduce side effects like nausea, vomiting, and breathing problems caused by opioid painkillers. About 312 adults having planned open liver surgery will be randomly assigned to receive either lidocaine or a placebo. The goal is to see if lidocaine can make recovery smoother and safer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- lidocaine
- What this could lead to
- If it works, this could offer a safer way to manage pain after liver surgery, reducing nausea, vomiting, and breathing problems caused by opioids.
- What could go wrong
- This is a Phase 4 trial, but lidocaine's benefit for liver surgery specifically is not yet proven. It may not reduce side effects more than placebo, and there are always risks with any drug.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre 01 - CHU de RENNES, Hôpital Pontchaillou
Rennes, 35000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre 02 - CH Louis Pasteur, Les Hôpitaux de Chartres
Le Coudray, 28630, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre 03 - CHU de Clermont-Ferrand, Hôpital Estaing
Clermont-Ferrand, 63100, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre 04 - Centre Hospitalier Départemental de la Vendée
La Roche-sur-Yon, 85000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre 05 - CHU de Lille
Lille, 59000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre 06 - Centre Léon Bérard
Lyon, 69008, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre 07 - CHU Nice, Hôpital Archet 2
Nice, 06200, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre 08 - AP-HP - Sorbonne Université, Hôpital de la Pitié-Salpêtrière
Paris, 75013, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre 09 - CHU Toulouse, Hôpital Rangueil
Toulouse, 31400, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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