New pill RAP-219 tested for stubborn seizures
NCT ID NCT06377930
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested an investigational drug called RAP-219 in 30 adults with refractory focal epilepsy—seizures that don't respond well to current treatments. Participants took RAP-219 tablets to see if it safely reduces seizure frequency. The trial is now complete, and results will help determine if further testing is warranted.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- RAP-219 oral tablet
- What this could lead to
- If successful, RAP-219 could offer a new treatment option for people with hard-to-control focal epilepsy, potentially reducing seizure frequency.
- What could go wrong
- This is a small, early-phase (Phase 2A) open-label study with no placebo group, so results may not confirm effectiveness. Side effects and lack of long-term data are also concerns.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Baylor College of Medicine
Houston, Texas, 770300, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Consultants in Epilepsy and Neurology, PLLC
Boise, Idaho, 83702, United States
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IU Health Neuroscience Center, Goodman Hall
Indianapolis, Indiana, 46202, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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NYU Langone Comprehensive Epilepsy Center
New York, New York, 10016, United States
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The University of Kansas Medical Center Epilepsy Clinic
Kansas City, Kansas, 66160, United States
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Thomas Jefferson University
Philadelphia, Pennsylvania, 19107, United States
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University of Pennsylvania - Department of Neurology
Philadelphia, Pennsylvania, 19104, United States
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University of Texas Health Science Center, Houston
Houston, Texas, 77030, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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Yale University
New Haven, Connecticut, 06519, United States
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