Epidiolex shows promise for easing seizures and behavior issues in TSC

NCT ID NCT05864846

Completed Symptom relief Sponsor: Jazz Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding Epidiolex (a CBD-based medicine) to usual treatment can improve seizures, behavior, sleep, and quality of life in people aged 1 to 65 with tuberous sclerosis complex (TSC). 79 participants took the drug and were monitored for changes in symptoms and daily functioning. The goal was to see if Epidiolex helps with the full range of TSC-related challenges, not just seizures.

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Conditions

The condition(s) this trial relates to.

Behavior tuberous sclerosis tuberous sclerosis 1 visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TUBEROUS SCLEROSIS COMPLEX ASSOCIATED NEUROPSYCHIATRIC DISEASE

Contacts and locations

Locations

Alberta Children's Hospital

Calgary, Alberta, T3B 6AB, Canada
Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
BC Children's Hospital

Vancouver, British Columbia, V6H 3V4, Canada
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Evelina London Children's Hospital Guys St Thomas' NHS Foundation Trust, the Guy's Hospital

London, England, SE1 7EH, United Kingdom
Le Bonheur Children's Hospital

Memphis, Tennessee, 38103, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Minnesota Epilepsy Group

Roseville, Minnesota, 55113, United States
Nicklaus Children's Health, Miami

Miami, Florida, 33155, United States
Sheffield Children's NHS Foundation Trust

Sheffield, 2TH, United Kingdom
The Children's Memorial Health Institute

Warsaw, 04-736, Poland
The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada
University Hospitals Bristol NHS Foundation Trust

Bristol, BS1 3NU, United Kingdom
University of Florida Health - Department of Neurology

Gainesville, Florida, 32608, United States
University of Texas Health Science Center - San Antonio

San Antonio, Texas, 78229, United States
University of Texas Health Science Center at Houston - Clinical Research Unit

Houston, Texas, 77030, United States
University of Virginia, Charlottesville

Charlottesville, Virginia, 22903, United States
Yale University School of Medicine

New Haven, Connecticut, 06519, United States

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